Cell Stress Proteins

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Cell Stress Proteins

Stuart K. Calderwood
Cell Stress Proteins Book PDF

Author : Stuart K. Calderwood
Publisher : Springer Science & Business Media
Page : 464 pages
File Size : 50,5 Mb
Release : 2009-02-13
Category : Science
ISBN : 9780387397177

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Cell Stress Proteins by Stuart K. Calderwood Pdf

This book surveys the current knowledge concerning the expression and function of stress proteins in different organisms, ranging from prokaryotes to humans. It provides an overview of the diversity and complex evolutionary history of cell stress proteins and describes their function and expression in different eukaryote models. The book will appeal to researchers and scientists in biochemistry, cell biology, microbiology, immunology, and genetics.

Stress Proteins

David S. Latchman
Stress Proteins Book PDF

Author : David S. Latchman
Publisher : Springer Science & Business Media
Page : 436 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642582592

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Stress Proteins by David S. Latchman Pdf

This work is concerned with a group of proteins which were originally consid ered to be an esoteric phenomenon but which have now been shown to play critical roles both in normal and stressed cells as well as being involved in a variety of human diseases. It is the purpose of this work to give a comprehen sive view of these proteins and their various aspects. After an introductory chapter providing an overview of these proteins, the work is divided into four main sections each of which deals with one important aspect of these proteins. Thus, the first section contains a series of chapters which describe individual stress proteins and their roles in particular biological phenomena. Evidently, the induction of these proteins by elevated tempera ture or other stresses is their defining feature and the second section of this book therefore considers the regulation of stress protein gene expression both by stressful stimuli such as elevated temperature or ischaemia and by non stressful stimuli such as cytokines.

Cellular Trafficking of Cell Stress Proteins in Health and Disease

Brian Henderson,A. Graham Pockley
Cellular Trafficking of Cell Stress Proteins in Health and Disease Book PDF

Author : Brian Henderson,A. Graham Pockley
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 47,5 Mb
Release : 2012-11-19
Category : Medical
ISBN : 9789400747401

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Cellular Trafficking of Cell Stress Proteins in Health and Disease by Brian Henderson,A. Graham Pockley Pdf

Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.

Stress Proteins

Milton J. Schlesinger,M. Gabriella Santoro,Enrico Garaci
Stress Proteins Book PDF

Author : Milton J. Schlesinger,M. Gabriella Santoro,Enrico Garaci
Publisher : Springer Science & Business Media
Page : 125 pages
File Size : 50,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642758157

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Stress Proteins by Milton J. Schlesinger,M. Gabriella Santoro,Enrico Garaci Pdf

All living organisms are exposed to rapidly changing environmental conditions which may lead to external stress. How organisms cope with stress - especially on the molecular level - is explained in Stress Proteins. Cells react to external stress - where the temperature-induced reaction known as "heat shock response" is the best studied example of stress - by activating special genes and subsequently synthesizing stress proteins. Surprisingly, this stress response is not only similar for all types of stress but even the involved stress proteins are virtually identical in all organisms from prokaryotic to eukaryotic cells, from bacteria to humans. This universality shows that stress proteins are vital for surviving and indicates that these proteins play an essential role in normal cell functions, in cell growth and metabolism. This explains the great interest in stress response research.

Cellular Trafficking of Cell Stress Proteins in Health and Disease

Brian Henderson,A. Graham Pockley
Cellular Trafficking of Cell Stress Proteins in Health and Disease Book PDF

Author : Brian Henderson,A. Graham Pockley
Publisher : Springer
Page : 298 pages
File Size : 55,5 Mb
Release : 2012-11-20
Category : Medical
ISBN : 9400747411

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Cellular Trafficking of Cell Stress Proteins in Health and Disease by Brian Henderson,A. Graham Pockley Pdf

Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.

Heat Shock Proteins and Stress

Alexzander A. A. Asea,Punit Kaur
Heat Shock Proteins and Stress Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer
Page : 315 pages
File Size : 40,9 Mb
Release : 2018-10-24
Category : Science
ISBN : 9783319907253

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Heat Shock Proteins and Stress by Alexzander A. A. Asea,Punit Kaur Pdf

The book Heat Shock Proteins and Stress provides the most comprehensive review on contemporary knowledge on the role of HSP in Stress. Using an integrative approach to understanding the regulation of HSP responses, the contributors provide a synopsis of novel mechanisms by which HSP responses are regulated under normal physiological and pathophysiological conditions. Key basic and clinical research laboratories from major universities and academic medical hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychologists, Human Physiology, Zoologists, Botanists, Biotechnology, Molecular Medicine, Infectious Diseases Experts and Pathologists.

Stress Response

Stephen M. Keyse
Stress Response Book PDF

Author : Stephen M. Keyse
Publisher : Springer Science & Business Media
Page : 480 pages
File Size : 47,7 Mb
Release : 2007-10-26
Category : Science
ISBN : 9781592590544

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Stress Response by Stephen M. Keyse Pdf

Mammalian cells have evolved a complex multicomponent machinery that enables them to sense and respond to a wide variety of potentially toxic agents present in their environment. These stress responses are often associated with an increased cellular capacity to tolerate normally lethal levels of an insult. The realization that the mammalian stress response may be intimately linked with many human diseases, including rheumatoid arthritis, ischemia, fever, infection, and cancer, has led to an explosion of interest in this research area. Stress Response: Methods and Protocols brings together a diverse array of practical methodologies that may be employed to address various aspects of the response of mammalian cells to environmental stress. The p- tocols are carefully described by authors who have both devised and succe- fully employed them, and they represent a mixture not only of well-established techniques, but also new technologies at the leading edge of research. The areas covered include the detection and assay of stress-induced damage, the acti- tion of signal transduction pathways, stress-inducible gene expression, and stress protein function. Although no volume of this size can be comprehensive and the topics covered reflect a personal choice, it is hoped that it will prove of subst- tial interest and use to a wide range of research workers in the field.

Stress-Inducible Cellular Responses

U. Feige,R.I. Morimoto,Barbara Polla
Stress Inducible Cellular Responses Book PDF

Author : U. Feige,R.I. Morimoto,Barbara Polla
Publisher : Birkhäuser
Page : 487 pages
File Size : 53,5 Mb
Release : 2013-03-11
Category : Science
ISBN : 9783034890885

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Stress-Inducible Cellular Responses by U. Feige,R.I. Morimoto,Barbara Polla Pdf

This book will deal with heat shock proteins and more generally with stress-related inducible gene expression as a pleiotropic adaptive response to stress. It presents a textbook-like overview of the field not only to heat shock experts, but to physiologists, pharmacologists, physicians, neuropsychologists and others as well. It is intended to be a state-of-the-art and perspective book rather than an up-to-date presentation of recent data. It should provide a basis for new experimetal approaches to fields at the edge of the classical heat shock field. Drugs, UV irradiation and environmental toxics will be considered as important modulators of the stress response. Radical scavengers such as superoxide dismutases and inducible regulatory proteins of metallic ion status such as ferritin as well as immunophilins and protein disulfide isomerases will be considered within the frame of stress proteins. The potential practical applications of heat shock proteins in toxicology and medicine for the diagnosis, prognosis and eventually therapy of clinical conditions associated with an increased oxidative burden will be outlined. The role of heat shock proteins in the modulation of immune responses will also be included. The book considers heat shock from a broad perspective including fields for which heat-shock may become of importance in the very near future such as cellular responses to environmental stresses and complex stress responses under specific conditions. It was also felt timely to incorporate a whole section on medical and technological applications of stress proteins. The book will be invaluable for all those working on stress and is intended for every "stress laboratory" as a source of knowledge and perspectives.

The Big Book on Small Heat Shock Proteins

Robert M. Tanguay,Lawrence E. Hightower
The Big Book on Small Heat Shock Proteins Book PDF

Author : Robert M. Tanguay,Lawrence E. Hightower
Publisher : Springer
Page : 610 pages
File Size : 54,8 Mb
Release : 2015-06-15
Category : Medical
ISBN : 9783319160771

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The Big Book on Small Heat Shock Proteins by Robert M. Tanguay,Lawrence E. Hightower Pdf

Based upon a workshop entitled “The Small HSP World” held in Québec 2-5 October 2014. Twenty-five scientists provided chapters for the book. The chapters are from the best scientists currently working in this field. These colleagues include Arrigo, Benesch, Benjamin, Buchner-Haslbeck-Weinkauf, Benndorf, Boelens, Carra, Chang, Currie, Ecroyd, Emanuelsson, Fu, Garrido, Golenhofen, Gusev, Hightower, Kampinga, Lavoie, MacRae, Quinlan, Tanguay, Vierling, Vigh, Weeks and Wu. Briefly, the book starts with the structure of small heat shock proteins, moving to their functions and finishing with their involvement in diseases. Although this is quite broad, the structural aspect will be the unifying theme of the book.

Stress Proteins

Milton J. Schlesinger,M. Gabriella Santoro,Enrico Garaci
Stress Proteins Book PDF

Author : Milton J. Schlesinger,M. Gabriella Santoro,Enrico Garaci
Publisher : Springer
Page : 123 pages
File Size : 54,6 Mb
Release : 1991-03-28
Category : Science
ISBN : 3540527761

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Stress Proteins by Milton J. Schlesinger,M. Gabriella Santoro,Enrico Garaci Pdf

All living organisms are exposed to rapidly changing environmental conditions which may lead to external stress. How organisms cope with stress - especially on the molecular level - is explained in Stress Proteins. Cells react to external stress - where the temperature-induced reaction known as "heat shock response" is the best studied example of stress - by activating special genes and subsequently synthesizing stress proteins. Surprisingly, this stress response is not only similar for all types of stress but even the involved stress proteins are virtually identical in all organisms from prokaryotic to eukaryotic cells, from bacteria to humans. This universality shows that stress proteins are vital for surviving and indicates that these proteins play an essential role in normal cell functions, in cell growth and metabolism. This explains the great interest in stress response research.

The immunology of cellular stress proteins

Willem Van Eden,Ruurd Van Der Zee,Cristina Bonorino
The immunology of cellular stress proteins Book PDF

Author : Willem Van Eden,Ruurd Van Der Zee,Cristina Bonorino
Publisher : Frontiers E-books
Page : 90 pages
File Size : 53,8 Mb
Release : 2014-10-05
Category : Immunologic diseases. Allergy
ISBN : 9782889193257

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The immunology of cellular stress proteins by Willem Van Eden,Ruurd Van Der Zee,Cristina Bonorino Pdf

Stress proteins or heat-shock proteins (HSP) are evolutionary conserved proteins present in every prokaryotic and eukaryotic cell. Their main function is to protect cells and proteins from damage under stressful circumstances. The latter circumstances do include the cell and protein damaging effects of inflammation. The discovery of mycobacterial HSP60 being a critical antigen in the model of adjuvant arthritis, has led to studies that showed the immuno-dominance of microbial HSP60 and the potential of the microbial HSP induced repertoire of antibodies and T cells to cross-recognize the self-HSP homologues of stressed cells. Since then, the research in the immunology of stress proteins started to comprise a widening spectrum of topics with potential medical relevance. Interestingly, since stress proteins have their activities in both innate and adaptive immunity, they are key elements in the cross-roads between both arms of the immune system. Stress proteins or HSP can be considered as functional 'biomarkers' of inflammation. They are up-regulated locally during inflammation and interestingly, they seem to function as targets for anti-inflammatory regulatory T cells. In experimental models of autoimmunity, mainly arthritis, administration of HSP peptides have been shown to suppress disease. First clinical trials have shown the anti-inflammatory nature of T cell responses to Hsp. In type I diabetes and in rheumatoid arthritis, parenteral and oral administration of Hsp peptides were shown to induce a bias in pro-inflammatory T cells, switching them in the direction of regulatory cytokine production (IL4, IL5 and IL10). In addition a raised level of a marker of natural T regulatory cells, the transcription factor FoxP3, was noted in the RA trial. Other inflammatory diseases or diseases with inflammatory components which feature the immune imprint of the up-regulated Hsp are atherosclerosis, inflammatory bowel diseases, multiple sclerosis and atopic diseases such atopic dermatitis and allergic asthma.

Small Stress Proteins

A.-P. Arrigo,W.E.G. Müller
Small Stress Proteins Book PDF

Author : A.-P. Arrigo,W.E.G. Müller
Publisher : Springer Science & Business Media
Page : 277 pages
File Size : 53,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642563485

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Small Stress Proteins by A.-P. Arrigo,W.E.G. Müller Pdf

This book gives a comprehensive survey of the current knowledge of the expression and function of small stress proteins (sHsps) in different organisms, from prokaryotes to humans. It provides an overview of the diversity and complex evolutionary history of sHsps and describes their function and expression in different eukaryote models. Additional chapters discuss the role of sHsps in pathological conditions and gene therapy approaches towards a control of sHsp expression levels.

Heat Shock Proteins in Cancer

Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca
Heat Shock Proteins in Cancer Book PDF

Author : Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca
Publisher : Springer Science & Business Media
Page : 400 pages
File Size : 46,5 Mb
Release : 2007-09-09
Category : Medical
ISBN : 9781402064012

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Heat Shock Proteins in Cancer by Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca Pdf

Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.

Stress Proteins in Medicine

Willem Van Eden,Douglas B. Young
Stress Proteins in Medicine Book PDF

Author : Willem Van Eden,Douglas B. Young
Publisher : CRC Press
Page : 606 pages
File Size : 47,8 Mb
Release : 2020-11-25
Category : Medical
ISBN : 9781000148510

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Stress Proteins in Medicine by Willem Van Eden,Douglas B. Young Pdf

Provides a thorough overview of current knowledge of stress proteins in both normal and disease physiology and evaluates the potential for developing novel diagnostic, prophylactic, and therapeutic approaches to control human disease based on the latest stress-protein research.

Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks

Peter Csermely,László Vígh
Molecular Aspects of the Stress Response Chaperones Membranes and Networks Book PDF

Author : Peter Csermely,László Vígh
Publisher : Springer Science & Business Media
Page : 218 pages
File Size : 46,5 Mb
Release : 2007-08-09
Category : Science
ISBN : 9780387399751

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Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks by Peter Csermely,László Vígh Pdf

This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.