The Immunology Of Cellular Stress Proteins

Author : Willem Van Eden,Ruurd Van Der Zee,Cristina Bonorino
Publisher : Frontiers E-books
Page : 90 pages
File Size : 41,8 Mb
Release : 2014-10-05
Category : Immunologic diseases. Allergy
ISBN : 9782889193257

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The immunology of cellular stress proteins by Willem Van Eden,Ruurd Van Der Zee,Cristina Bonorino Pdf

Stress proteins or heat-shock proteins (HSP) are evolutionary conserved proteins present in every prokaryotic and eukaryotic cell. Their main function is to protect cells and proteins from damage under stressful circumstances. The latter circumstances do include the cell and protein damaging effects of inflammation. The discovery of mycobacterial HSP60 being a critical antigen in the model of adjuvant arthritis, has led to studies that showed the immuno-dominance of microbial HSP60 and the potential of the microbial HSP induced repertoire of antibodies and T cells to cross-recognize the self-HSP homologues of stressed cells. Since then, the research in the immunology of stress proteins started to comprise a widening spectrum of topics with potential medical relevance. Interestingly, since stress proteins have their activities in both innate and adaptive immunity, they are key elements in the cross-roads between both arms of the immune system. Stress proteins or HSP can be considered as functional 'biomarkers' of inflammation. They are up-regulated locally during inflammation and interestingly, they seem to function as targets for anti-inflammatory regulatory T cells. In experimental models of autoimmunity, mainly arthritis, administration of HSP peptides have been shown to suppress disease. First clinical trials have shown the anti-inflammatory nature of T cell responses to Hsp. In type I diabetes and in rheumatoid arthritis, parenteral and oral administration of Hsp peptides were shown to induce a bias in pro-inflammatory T cells, switching them in the direction of regulatory cytokine production (IL4, IL5 and IL10). In addition a raised level of a marker of natural T regulatory cells, the transcription factor FoxP3, was noted in the RA trial. Other inflammatory diseases or diseases with inflammatory components which feature the immune imprint of the up-regulated Hsp are atherosclerosis, inflammatory bowel diseases, multiple sclerosis and atopic diseases such atopic dermatitis and allergic asthma.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 50,9 Mb
Release : 2014
Category : Electronic
ISBN : OCLC:1368435358

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The Immunology of Cellular Stress Proteins by Anonim Pdf

Stress proteins or heat-shock proteins (HSP) are evolutionary conserved proteins present in every prokaryotic and eukaryotic cell. Their main function is to protect cells and proteins from damage under stressful circumstances. The latter circumstances do include the cell and protein damaging effects of inflammation. The discovery of mycobacterial HSP60 being a critical antigen in the model of adjuvant arthritis, has led to studies that showed the immuno-dominance of microbial HSP60 and the potential of the microbial HSP induced repertoire of antibodies and T cells to cross-recognize the self-HSP homologues of stressed cells. Since then, the research in the immunology of stress proteins started to comprise a widening spectrum of topics with potential medical relevance. Interestingly, since stress proteins have their activities in both innate and adaptive immunity, they are key elements in the cross-roads between both arms of the immune system. Stress proteins or HSP can be considered as functional 'biomarkers' of inflammation. They are up-regulated locally during inflammation and interestingly, they seem to function as targets for anti-inflammatory regulatory T cells. In experimental models of autoimmunity, mainly arthritis, administration of HSP peptides have been shown to suppress disease. First clinical trials have shown the anti-inflammatory nature of T cell responses to Hsp. In type I diabetes and in rheumatoid arthritis, parenteral and oral administration of Hsp peptides were shown to induce a bias in pro-inflammatory T cells, switching them in the direction of regulatory cytokine production (IL4, IL5 and IL10). In addition a raised level of a marker of natural T regulatory cells, the transcription factor FoxP3, was noted in the RA trial. Other inflammatory diseases or diseases with inflammatory components which feature the immune imprint of the up-regulated Hsp are atherosclerosis, inflammatory bowel diseases, multiple sclerosis and atopic diseases such atopic dermatitis and allergic asthma.

Author : Stuart K. Calderwood
Publisher : Springer Science & Business Media
Page : 464 pages
File Size : 44,6 Mb
Release : 2009-02-13
Category : Science
ISBN : 9780387397177

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Cell Stress Proteins by Stuart K. Calderwood Pdf

This book surveys the current knowledge concerning the expression and function of stress proteins in different organisms, ranging from prokaryotes to humans. It provides an overview of the diversity and complex evolutionary history of cell stress proteins and describes their function and expression in different eukaryote models. The book will appeal to researchers and scientists in biochemistry, cell biology, microbiology, immunology, and genetics.

Author : Brian Henderson,A. Graham Pockley
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 51,5 Mb
Release : 2012-11-19
Category : Medical
ISBN : 9789400747401

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Cellular Trafficking of Cell Stress Proteins in Health and Disease by Brian Henderson,A. Graham Pockley Pdf

Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.

Author : Heitor A. Paula-Neto,Renata Meirelles Pereira,Leticia A. Carneiro
Publisher : Frontiers Media SA
Page : 130 pages
File Size : 45,7 Mb
Release : 2019-11-28
Category : Electronic
ISBN : 9782889631421

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Producing, sensing and responding to cellular stress in immunity by Heitor A. Paula-Neto,Renata Meirelles Pereira,Leticia A. Carneiro Pdf

Cellular stress, being considered as any disturbance in cellular physiology, is a fundamental aspect of tissue and body capacity to adapt to the ever changing environment. It also surges as a consequence of tissue injury or invasion of the body by pathogens. Since the immune system was developed to sense and respond to these deleterious processes, it is reasonable to consider that immune cells are capable of sensing and responding to signs of cellular stress. Moreover, cells of the immune system undergo cellular stress during an immune response. This Research Topic presents a series of articles focusing on how cellular stress influences the outcome of immune responses, covering not only how cellular stress can be a fundamental process during immune cell activation and function, but also how cells of the immune system are capable of sensing and being influenced by factors produced by stressed cells.

Author : Brian Henderson,A. Graham Pockley
Publisher : Springer
Page : 298 pages
File Size : 44,8 Mb
Release : 2012-11-20
Category : Medical
ISBN : 9400747411

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Cellular Trafficking of Cell Stress Proteins in Health and Disease by Brian Henderson,A. Graham Pockley Pdf

Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.

Author : Willem Van Eden,Douglas B. Young
Publisher : CRC Press
Page : 606 pages
File Size : 46,5 Mb
Release : 2020-11-25
Category : Medical
ISBN : 9781000148510

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Stress Proteins in Medicine by Willem Van Eden,Douglas B. Young Pdf

Provides a thorough overview of current knowledge of stress proteins in both normal and disease physiology and evaluates the potential for developing novel diagnostic, prophylactic, and therapeutic approaches to control human disease based on the latest stress-protein research.

Author : Robert J. Binder,Pramod K. Srivastava
Publisher : Springer
Page : 185 pages
File Size : 40,7 Mb
Release : 2018-04-09
Category : Medical
ISBN : 9783319690421

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Heat Shock Proteins in the Immune System by Robert J. Binder,Pramod K. Srivastava Pdf

Experts from around the world review the current field of the immunobiology of heat shock proteins, and provide a comprehensive account of how these molecules are spearheading efforts in the understanding of various pathways of the immune system. This one-stop resource contains numerous images to both help illustrate the research on heat shock proteins, and better clarify the field for the non-expert. Heat shock proteins (HSPs) were discovered in 1962 and were quickly recognized for their role in protecting cells from stress. Twenty years later, the immunogenicity of a select few HSPs was described, and for the past 30 years, these findings have been applied to numerous branches of immunology, including tumor immunology and immunosurveillance, immunotherapy, etiology of autoimmunity, immunotherapy of infectious diseases, and expression of innate receptors. While HSPs can be used to manipulate immune responses by exogenous administration, they appear to be involved in initiation of de novo immune responses to cancer and likely in the maintenance of immune homeostasis.

Author : Alexzander A.A. Asea,Antonio De Maio
Publisher : Springer Science & Business Media
Page : 356 pages
File Size : 54,6 Mb
Release : 2007-09-05
Category : Medical
ISBN : 9781402055850

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Heat Shock Proteins: Potent Mediators of Inflammation and Immunity by Alexzander A.A. Asea,Antonio De Maio Pdf

This book provides the most up-to-date review on new mechanisms and provides exciting insights into how heat shock proteins modulate the hosts’ immune response. Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step-wise fashion take the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provide answers as to its biological significance to the host.

Author : Willem van Eden
Publisher : Birkhäuser
Page : 287 pages
File Size : 42,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783034880282

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Heat Shock Proteins and Inflammation by Willem van Eden Pdf

Heat shock proteins (HSP) have received ample interest by immunologists over recent years. Initially they were found to be dominantly immunogenic microbial antigens. The connection with inflammation was established when it was uncovered that T cells specific for these antigens have a crucial role in the induction and regulation of experimental arthritis. Since then, the raised presence of immunity to HSPs in virtually all conditions of inflammation, including autoimmune diseases, transplant rejection and atherosclerosis, has emphasised the critical significance of immunity to HSPs in inflammatory diseases.

Author : Alexzander A. A. Asea,Bente K. Pedersen
Publisher : Springer Science & Business Media
Page : 431 pages
File Size : 49,5 Mb
Release : 2009-12-10
Category : Medical
ISBN : 9789048133819

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Heat Shock Proteins and Whole Body Physiology by Alexzander A. A. Asea,Bente K. Pedersen Pdf

Heat Shock Proteins and Whole Body Physiology is an exciting new book in the Heat Shock Proteins series which provides the most up-to-date review on novel mechanisms insights into the important role played by heat shock proteins in human physiology. Written by leaders in the field of heat shock protein exercise physiology, neuroscience and aging, the chapters systematically and in a step wise fashion takes the reader through the fascinating mechanisms by which heat shock proteins modulate human disease and pathophysiology and provides answers as to its biological significance to the host. Section I, introduces the readers to the role played by heat shock proteins in various diseases and disorders (Heat Shock Proteins and Disease). Section II, addresses the role heat shock proteins play in psychological disorders including post traumatic stress disorders and learning (Heat Shock Proteins and Psychological Stress). Section III, present a detailed review of the role played by heat shock proteins in exercise physiology (Heat Shock Proteins and Exercise Physiology). This book is a must read for heat shock protein researchers, graduate and postgraduate fellows in the field of Medicine in general and specialities in Excersie Physiology, Neuroscience, Immunology, Aging and Pathology.

Author : Fabrizio Antonangeli,Francesca Velotti,Ola Grimsholm,Marianna Nicoletta Rossi
Publisher : Frontiers Media SA
Page : 126 pages
File Size : 45,7 Mb
Release : 2021-05-10
Category : Medical
ISBN : 9782889667536

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Cellular Stress and Inflammation: How the Immune System Drives Tissue Homeostasis by Fabrizio Antonangeli,Francesca Velotti,Ola Grimsholm,Marianna Nicoletta Rossi Pdf

Author : David S. Latchman
Publisher : Springer Science & Business Media
Page : 436 pages
File Size : 54,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642582592

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Stress Proteins by David S. Latchman Pdf

This work is concerned with a group of proteins which were originally consid ered to be an esoteric phenomenon but which have now been shown to play critical roles both in normal and stressed cells as well as being involved in a variety of human diseases. It is the purpose of this work to give a comprehen sive view of these proteins and their various aspects. After an introductory chapter providing an overview of these proteins, the work is divided into four main sections each of which deals with one important aspect of these proteins. Thus, the first section contains a series of chapters which describe individual stress proteins and their roles in particular biological phenomena. Evidently, the induction of these proteins by elevated tempera ture or other stresses is their defining feature and the second section of this book therefore considers the regulation of stress protein gene expression both by stressful stimuli such as elevated temperature or ischaemia and by non stressful stimuli such as cytokines.

Author : Yong-Soo Bae,Eui-Cheol Shin,Yoe-Sik Bae,Willem van Eden
Publisher : Frontiers Media SA
Page : 143 pages
File Size : 54,8 Mb
Release : 2019-04-09
Category : Electronic
ISBN : 9782889458134

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Stress and Immunity by Yong-Soo Bae,Eui-Cheol Shin,Yoe-Sik Bae,Willem van Eden Pdf

The "Stress and Immunity" Research Topic includes two distant and seemingly unrelated forms of stress: physicochemical stress and psychological stress. In both forms of stress the body adapts to the changes in the environment. The different chapters of this eBook deal with aspects relevant for the fascinating interplay of various distinct stressors with the immune system.

Author : Peter Csermely,László Vígh
Publisher : Springer Science & Business Media
Page : 218 pages
File Size : 52,9 Mb
Release : 2007-08-09
Category : Science
ISBN : 9780387399751

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Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks by Peter Csermely,László Vígh Pdf

This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.