Cellular And Molecular Control Of Neuronal Migration

Author : Laurent Nguyen,Simon Hippenmeyer
Publisher : Springer Science & Business Media
Page : 194 pages
File Size : 44,6 Mb
Release : 2013-11-18
Category : Medical
ISBN : 9789400776876

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Cellular and Molecular Control of Neuronal Migration by Laurent Nguyen,Simon Hippenmeyer Pdf

Cellular and Molecular Control of Neuronal Migration provides an up-to-date collection of reviews on the molecular and cellular principles of neuronal migration in the mammalian brain. Over the last decades a rich catalogue of signaling molecules controlling neuronal migration has been compiled, and within this book an international panel of experts provides up-to-date discussions of the state of knowledge how these distinct signaling pathways regulate various aspects of neuronal migration. This book introduces the reader to the latest discoveries and concepts of neuronal migration enabled through the application of most sophisticated methods and cutting edge experimental approaches. Cellular and Molecular Control of Neuronal Migration also provides an update on the underlying cellular and molecular basis of neurodevelopmental migration disorders in human patients for all interested neuroscientists and clinicians.

Author : Anonim
Publisher : Academic Press
Page : 1081 pages
File Size : 51,8 Mb
Release : 2013-05-06
Category : Science
ISBN : 9780123973474

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Cellular Migration and Formation of Neuronal Connections by Anonim Pdf

The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity

Author : Gundela Meyer
Publisher : Springer Science & Business Media
Page : 123 pages
File Size : 55,5 Mb
Release : 2007-02-03
Category : Medical
ISBN : 9783540366898

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Genetic Control of Neuronal Migrations in Human Cortical Development by Gundela Meyer Pdf

The early steps in corticogenesis are decisive for the correct unfolding of neurogenesis, neuronal migration and differentiation under tight genetic control. In this monograph, the author outlines the main events in human preplate formation according to their timetable of appearance and the expression of developmentally relevant gene products. Also examined are the gradual transformation of the preplate into the cortical plate, and the establishment of the transient compartments of the foetal cortical wall.

Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Page : 412 pages
File Size : 48,5 Mb
Release : 2015-12-01
Category : Medical
ISBN : 9781498766579

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Translational Research in Traumatic Brain Injury by Daniel Laskowitz,Gerald Grant Pdf

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 40,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Michael E. Selzer,Stephanie Clarke,Leonardo G. Cohen,Gert Kwakkel (Professor),Robert H. Miller (Professor)
Publisher : Cambridge University Press
Page : 693 pages
File Size : 50,8 Mb
Release : 2014
Category : Nervous system
ISBN : 9781107011670

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Textbook of Neural Repair and Rehabilitation by Michael E. Selzer,Stephanie Clarke,Leonardo G. Cohen,Gert Kwakkel (Professor),Robert H. Miller (Professor) Pdf

In two freestanding volumes, the Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. Revised throughout, bringing the book fully up to date, this volume, Neural Repair and Plasticity, covers the basic sciences relevant to recovery of function following injury to the nervous system, reviewing anatomical and physiological plasticity in the normal central nervous system, mechanisms of neuronal death, axonal regeneration, stem cell biology, and research strategies targeted at axon regeneration and neuron replacement. New chapters have been added covering pathophysiology and plasticity in cerebral palsy, stem cell therapies for brain disorders and neurotrophin repair of spinal cord damage, along with numerous others. Edited and written by leading international authorities, it is an essential resource for neuroscientists and provides a foundation for the work of clinical rehabilitation professionals.

Author : Mario Manto,Donna L. Gruol,Jeremy Schmahmann,Noriyuki Koibuchi,Ferdinando Rossi
Publisher : Springer
Page : 0 pages
File Size : 55,9 Mb
Release : 2012-08-04
Category : Medical
ISBN : 9400713320

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Handbook of the Cerebellum and Cerebellar Disorders by Mario Manto,Donna L. Gruol,Jeremy Schmahmann,Noriyuki Koibuchi,Ferdinando Rossi Pdf

Our knowledge of cerebellar functions and cerebellar disorders, called ataxias, is increasing considerably. Studies of the cerebellum are now a central focus in neuroscience. During the last four decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and biology of mental processes, behavioral symptoms, and emotion. It is now accepted that the cerebellum acts as a cognitive operator in learning, perception, and attention. Moreover, major improvements in our assessment of in vivo cerebellar architecture using imaging techniques have occurred. A typical example is the accurate description of cerebellar anatomy during fetal development with MRI, a progress which has direct impacts on patient care. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias. More than 20 new genes have been identified these last 10 years. Only for dominant ataxias, more than 30 diseases have now been unravelled. The number of ataxic disorders will increase with aging, the cerebellum being the structure of the brain with the most important loss of neurons with age. More than 300 different cerebellar disorders are encountered during daily practice, but we are missing a single source of information explaining their pathogenesis. Despite the immense amount of knowledge acquired about the cerebellar circuitry these last years, a large book covering the neuroscience of the cerebellum is missing. The goal of this endeavour is to bring up to date information relevant for basic science and also for clinical activities. To reach this goal, the most renowned authors are gathered in a unique and in-depth book with a format of a handbook. We emphasize the connections between molecular findings, imaging features, behavioural/neuropsychological aspects, and clinical implications.

Author : Irwin B. Levitan,Leonard K. Kaczmarek
Publisher : Oxford University Press, USA
Page : 640 pages
File Size : 50,6 Mb
Release : 2002
Category : Molecular neurobiology
ISBN : 0195145232

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The Neuron by Irwin B. Levitan,Leonard K. Kaczmarek Pdf

Intended for use by advanced undergraduate, graduate and medical students, this book presents a study of the unique biochemical and physiological properties of neurons, emphasising the molecular mechanisms that generate and regulate their activity.

Author : National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Publisher : National Academies Press
Page : 195 pages
File Size : 45,6 Mb
Release : 1992-01-01
Category : Medical
ISBN : 9780309045292

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Discovering the Brain by National Academy of Sciences,Institute of Medicine,Sandra Ackerman Pdf

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Author : Yuki Hirota,Victor Borrell,Chiaki Ohtaka-Maruyama
Publisher : Frontiers Media SA
Page : 217 pages
File Size : 53,6 Mb
Release : 2021-06-30
Category : Science
ISBN : 9782889669301

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The Extracellular Environment in Controlling Neuronal Migration During Neocortical Development by Yuki Hirota,Victor Borrell,Chiaki Ohtaka-Maruyama Pdf

Author : Federico Bermudez-Rattoni
Publisher : CRC Press
Page : 368 pages
File Size : 51,8 Mb
Release : 2007-04-17
Category : Psychology
ISBN : 9781420008418

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Neural Plasticity and Memory by Federico Bermudez-Rattoni Pdf

A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq

Author : Brian K. Hall
Publisher : Springer Science & Business Media
Page : 322 pages
File Size : 52,5 Mb
Release : 2013-03-14
Category : Science
ISBN : 9781475730647

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The Neural Crest in Development and Evolution by Brian K. Hall Pdf

A discussion of the neural crest and neural crest cells, dealing with their discovery, their embryological and evolutionary origins, their cellular derivatives - in both agnathan and jawed vertebrates or gnathostomes - and the broad topics of migration and differentiation in normal development. The book also considers what goes wrong when development is misdirected by mutations, or by exposure of embryos to exogenous agents such as drugs, alcohol, or excess vitamin A, and includes discussions of tumours and syndromes and birth defects involving neural crest cells.

Author : H. -J Marthy
Publisher : Springer Science & Business Media
Page : 370 pages
File Size : 50,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781468450927

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Cellular and Molecular Control of Direct Cell Interactions by H. -J Marthy Pdf

The NATO Advanced Study Institute on "Cellular and Molecular Control of Direct Cell Interactions in Developing System" has been attended by 15 invited main lecturers and 60 participants. According to its purpose senior scientists, postdoctoral trainees and graduate students working in areas like biology, biochemistry, electrophysiology, medicine etc . . . could discuss their common interest in the various structural, ultrastructural, molecular and functional aspects of cell interactions in developing in vivo and in vitro systems. Whereas the topics of the first week have been mostly concerned with the general aspects of cell interactions in embryogenesis (section I and II of this book), the second week has been mainly devoted to the structures and functions of the direct cell contact sites at the membrane level as gap junctions, including electrophysiological aspects, dye coupling and selective cell-cooperation in some model systems as the neuro-muscular junctions (section III-V of this book). A multidisciplinary and stepwise approach, from initial cell contacts in early embryogenesis up to well defined selective cell cooperation, appeared to be an efficient means to provide answers to the question of how cells control, in a dynamic system as given in a differentiating embryo, their multiple temporary and permanent interactions so necessary for ordered cell positioning, cell linking and well established cell-to-cell communication.

Author : Jennifer Cynthia Shieh
Publisher : Stanford University
Page : 200 pages
File Size : 41,9 Mb
Release : 2010
Category : Electronic
ISBN : STANFORD:dj352gy7333

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The Role of Endocytosis in Neuronal Migration by Jennifer Cynthia Shieh Pdf

Disruptions in neuronal migration have been implicated in a variety of human mental disorders, including epilepsy, autism, and schizophrenia. Despite the critical role of migration during nervous system development, the basic physical and cytoskeletal mechanisms of coordinated neuronal movement have not yet been fully characterized. A migrating neuron moves with morphologically distinct steps: a single leading process extends ahead of a stationary cell soma, followed by the formation of a cytoplasmic dilation ahead of the nucleus, subsequent movement of the nucleus into the dilation, and retraction of the cell rear. The temporal and spatial regulation of adhesion is important for the proper progression of these steps. I investigated the role of endocytosis in regulating adhesion during neuronal migration. Using genetic and pharmacological methods to disrupt endocytosis either in vitro or in vivo leads to altered neuronal migration. Introducing dominant negative clathrin or dynamin into the developing cortex delays radial migration in vivo. Pharmacologically inhibiting clathrin or dynamin reduces the velocity of anterior subventricular zone (SVZa) neurons migrating in a three-dimensional matrix in vitro. Components of clathrin endocytic machinery are localized to the dilation region of a migrating neuron at points of matrix attachment. The absence of adhesion molecules at the cell rear led us to the hypothesis that endocytosis weakens adhesions in the dilation to allow the cell rear to move forward during migration. In support of this hypothesis, exposing SVZa explants to pharmacological inhibitors of either clathrin or dynamin prevents migration out of explants, and neurons that have migrated out have altered morphology and adhesion molecule distribution. Neurons exposed to a dynamin inhibitor tend to have "tails" of membrane at the rear, and these tails contain adhesion molecules. The presence of adhesion molecules at the rear of migrating neurons exposed to a dynamin inhibitor supports the idea that endocytosis plays a role in regulating adhesion disassembly. Endocytosis likely plays a critical role in general neuronal migration regardless of the specific neuronal subtype, migration mode, or substrate.

Author : Wieland B. Huttner
Publisher : John Wiley & Sons
Page : 821 pages
File Size : 48,6 Mb
Release : 2023-08-08
Category : Medical
ISBN : 9781119860822

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Neocortical Neurogenesis in Development and Evolution by Wieland B. Huttner Pdf

NEOCORTICAL NEUROGENESIS IN DEVELOPMENT AND EVOLUTION Understanding the development and evolution of the mammalian neocortex The development of the mammalian brain, including the human brain, is inextricably linked with its evolution. Of particular interest is the development of the neocortex, the youngest part of the cerebral cortex in evolutionary terms and the seat of such vital functions as sensory perception, generation of motor commands, and higher-order cognition. The process of neurogenesis is crucial to the formation and function of the neocortex, but this process is complex, based on species-specific adaptations of old and acquired new traits that subserve specific functions introduced during mammalian evolution. Neocortical Neurogenesis in Development and Evolution provides a groundbreaking and comprehensive overview of neurogenesis in the developing neocortex and its evolutionary implications. It covers the generation of neurons and their migration to their functional positions, neural patterning, cortical folding, and variations and malformations of cortical development. Readers will find: A comprehensive review of the evolution and development of the neocortex in mammals — the part of our brain involved in the higher cognitive functions A multitude of subject disciplines ranging from neuroscience, molecular biology, genetics, developmental biology, evolutionary biology and medicine to provide a holistic understanding of the evolutionary youngest part of the cerebral cortex Coverage of neurogenesis in the developing neocortex and how this contributes to our understanding of the evolutionary implications Neocortical Neurogenesis in Development and Evolution is essential for researchers and postgraduates in neuroscience, developmental biology, evolutionary biology, and medical research.