Cellular And Molecular Targets For Chemoprevention

Author : Vernon E. Steele,Gary D. Stoner,Gary J. Kelloff,Charles W. Boone
Publisher : CRC Press
Page : 400 pages
File Size : 50,5 Mb
Release : 1992-04-07
Category : Medical
ISBN : 0849345308

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Cellular and Molecular Targets for Chemoprevention by Vernon E. Steele,Gary D. Stoner,Gary J. Kelloff,Charles W. Boone Pdf

Cellular and Molecular Targets for Chemoprevention provides comprehensive coverage of target mechanisms that have proved valuable in chemoprevention research, in addition to mechanisms that may prove valuable in the near future. The book discusses such topics as growth factor receptor modulation, cell-to-cell communication, differentiation modulation, antisense olgonucleotides, tumor suppressor genes, free radical scavengers, and polyamine synthesis inhibition. Cellular and Molecular Targets for Chemoprevention will be welcomed by scientists in all areas of cancer/chemoprevention research, pharmaceutical researchers, and advanced students.

Author : John M. Pezzuto,Ole Vang
Publisher : Springer Nature
Page : 639 pages
File Size : 51,8 Mb
Release : 2020-04-03
Category : Medical
ISBN : 9783030398552

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Natural Products for Cancer Chemoprevention by John M. Pezzuto,Ole Vang Pdf

This book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research.

Author : Gary J. Kelloff,Ernest T. Hawk,Caroline C. Sigman
Publisher : Humana
Page : 0 pages
File Size : 45,9 Mb
Release : 2010-11-19
Category : Medical
ISBN : 1617373427

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Cancer Chemoprevention by Gary J. Kelloff,Ernest T. Hawk,Caroline C. Sigman Pdf

A comprehensive reference survey on the identification and development of promising cancer chemopreventive agents that will help stimulate further novel research and new approvable drugs. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal transduction modulators, antioxidants, vitamins, and minerals. The overall focus is on molecular targets and mechanisms. A second volume, Strategies in Chemoprevention, describes the exciting methodologies that will accelerate progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs.

Author : Malay Chatterjee
Publisher : Springer
Page : 0 pages
File Size : 41,9 Mb
Release : 2016-06-24
Category : Medical
ISBN : 3319312529

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Molecular Targets and Strategies in Cancer Prevention by Malay Chatterjee Pdf

The book focuses on the understanding of molecular pathways by which normal cell progress to the definable stage of cancer. The chapters explore microbiota and chronic inflammation, multiple myeloma chemoprevention, microRNAs, cancer regulation, liquid biopsies, and angiogenesis. Recent advances of molecular risk assessment, tumor microenvironment, microneoplasia, malignant gene expressions are highlighted to provide a means and design of future cancer prevention strategies and challenges thereupon. The volume also explores various receptor drugs that are in development process with the emphasis of inhibitors used to prevent malignant gene expression. The book bridges the gap between basic science and clinical application of current knowledge of cancer and emphasizes that tumor progression and cancer metastasis are not random - treatments and cure are logical and eventual. Expertly authored and drawing from a wealth of international perspectives, Molecular Targets and Strategies in Cancer Prevention is invaluable reading for clinicians and researchers in the fields of oncology and molecular biology.

Author : Dhyan Chandra
Publisher : Springer Science & Business Media
Page : 260 pages
File Size : 55,5 Mb
Release : 2013-12-11
Category : Science
ISBN : 9781461493266

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Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy by Dhyan Chandra Pdf

This book highlights the importance of phytochemicals and mitochondria in cancer prevention and therapy. Recent scientific discoveries have identified that naturally occurring biologically active compounds (i.e. phytochemicals) target multiple steps of tumorigenesis leading to the inhibition or delay in cancer progression. Mitochondria, organelles within a cell, are a critical target for phytochemicals in regulating the initiation, promotion, and progression of cancer. The book is divided into three parts to better communicate the important findings related to phytochemicals and mitochondria in cancer research. The first part describes updates on environmental and genetic factors causing cancer initiation and progression, the role of mitochondria function in regulating the process of tumorigenesis, and the role of mitochondria in regulating cell death such as apoptosis, autophagy, and necroptosis. The second part focuses on the elucidation of key target proteins that could be exploited for cancer prevention, an the role of phytochemicals in cancer prevention, updates on basic research related to phytochemicals action critical for cancer prevention, and updates on translational knowledge on cancer prevention by phytochemicals. The third part provides updates on phytochemicals targeting mitochondria for cancer therapy, an overview of action of phytochemicals on cancer stem cells, updates on the role of microRNA in phytochemicals-based therapy of cancer, and updates on phytochemicals-based translation research on therapy for metastatic cancer.

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 54,5 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia
Publisher : Springer Science & Business Media
Page : 502 pages
File Size : 55,9 Mb
Release : 2007-08-06
Category : Medical
ISBN : 9780387464015

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The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease by Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia Pdf

The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.

Author : Raymond C. Bergan
Publisher : Springer
Page : 0 pages
File Size : 45,5 Mb
Release : 2012-10-24
Category : Medical
ISBN : 1461356636

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Cancer Chemoprevention by Raymond C. Bergan Pdf

This volume offers a broad overview of topics related to cancer chemoprevention. It provides a review of topics ranging from basic research arenas to clinical trial design, implementation, and interpretation. It covers all key areas necessary for understanding the field of cancer chemoprevention for the interested reader, for individuals wishing to enter this area of investigation, and for individuals seeking guidance in particular areas of research, relating to agent identification, basic science investigations and clinical trials. The genesis of this book is based on the fact that cancer chemoprevention is a relatively new and rapidly evolving field spanning a wide array of disciplines, and forces researchers to address difficult and complex questions whose answers are not readily available. Cancer Chemoprevention provides a ready resource whose importance and intent lie in its ability to gather and solidify disparate data to explicitly outline areas of difficulty and to highlight future areas of important development. It provides broad outlines for current, ongoing and future directions in this area with various target organ sites, written by experts in their respective fields, whose primary research focuses upon that individual field.

Author : Fazlul H. Sarkar
Publisher : Springer Science & Business Media
Page : 383 pages
File Size : 53,6 Mb
Release : 2011-11-22
Category : Medical
ISBN : 9400726309

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Nutraceuticals and Cancer by Fazlul H. Sarkar Pdf

This book is about Nutraceuticals in cancer therapy, specifically targeted and Adjuvant therapy. It shows several approaches for possibly reducing systemic toxicity. This book illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in the prevention and/or treatment of human malignancies known to be mediated through alterations in multiple molecular targets. This book contains sixteen chapters which begin with historical perspective on the value of natural agents in the prevention of human malignancies followed by a series of current topics on multiple nutraceuticals targeting multiple cancers. This collection would likely be useful for bringing newer generations with broader perspectives in launching cutting-edge innovative molecular research, which would certainly help in designing targeted clinical trials in order to realize the dream of customize strategies for the prevention and/or treatment of human malignancies without causing any systemic toxicity. Moreover, the knowledge gained would allow novel utilization of nutraceuticals as adjunct to both conventional chemotherapy and radiation therapy in order to improve the overall quality of life and survival of patients diagnosed with cancers.

Author : Joseph C. Arcos,Mary F. Argus,Yin-tak Woo
Publisher : Springer Science & Business Media
Page : 712 pages
File Size : 45,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461240761

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Chemical Induction of Cancer by Joseph C. Arcos,Mary F. Argus,Yin-tak Woo Pdf

In the approach to the analysis of disease, including, of course, cancer, two major thrusts may be distinguished. These may be referred to, in shorthand, as agents and processes: the causative agents (chemical, microbial, physical, environmental, and psychosocial) and the organismic processes, initiated and furthered by the agents, culminating in observable pathology (at the macromolecular, cytological, histological, organ function, locomotor, and behavioral levels). The past 25 years, since the appearance of the first volume of the predecessor series (1) authored by the Editors of this present volume, have seen an impressive number of studies on chemicals (and other agents) as etiologic factors in the induction of cancer. The major emphasis has been on the discovery of many chemical carcinogens of widely different structures, their metabolism by various tissues and cells, and, in turn, their molecular-biochemical effects on the cells. This rapidly expanded body of information, as effectively covered in the predecessor volumes, is an excellent entree to the second half of the overall problem of chemical carcinogenesis, the processes. The active agents trigger a large array of molecular-biochemical alterations to which the target cells, target tissues, and target organisms respond in many select and common ways. This second major aspect of the induction of cancer by chemicals (and by other agents)- the sequence of cellular and tissue changes clearly relevant to cancer-remains the challenge for the future.

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 666 pages
File Size : 46,9 Mb
Release : 1992
Category : Medicine
ISBN : UOM:39015074107643

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Current Catalog by National Library of Medicine (U.S.) Pdf

First multi-year cumulation covers six years: 1965-70.

Author : Anonim
Publisher : Unknown
Page : 476 pages
File Size : 52,9 Mb
Release : 1993
Category : Environmental health
ISBN : MINN:31951P00657233L

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Environmental Health Perspectives by Anonim Pdf

Author : Sandeep Singh,Anjana Munshi,Jitender Bariwal,Rajkumar S. Kalra
Publisher : Frontiers Media SA
Page : 200 pages
File Size : 47,8 Mb
Release : 2023-01-30
Category : Science
ISBN : 9782832512876

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Biological aspects of targeted drug discovery: Development of novel targets and/or chemotherapies, and drug repurposing by Sandeep Singh,Anjana Munshi,Jitender Bariwal,Rajkumar S. Kalra Pdf

Author : Manish Kumar,Ashita Sharma,Praveen Kumar
Publisher : Springer Nature
Page : 344 pages
File Size : 52,6 Mb
Release : 2020-07-20
Category : Medical
ISBN : 9789811559990

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Pharmacotherapeutic Botanicals for Cancer Chemoprevention by Manish Kumar,Ashita Sharma,Praveen Kumar Pdf

The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.

Author : Bharat B. Aggarwal,Ajaikumar B. Kunnumakkara
Publisher : World Scientific
Page : 457 pages
File Size : 43,8 Mb
Release : 2009
Category : Technology & Engineering
ISBN : 9789812837905

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Molecular Targets and Therapeutic Uses of Spices by Bharat B. Aggarwal,Ajaikumar B. Kunnumakkara Pdf

Traditional uses of spices : an overview / Ajaikumar B. Kunnumakkara ... [et al.] -- Black pepper (Piper nigrum) and its bioactive compound, piperine / Krishnapura Srinivasan -- Cardamom (Elettaria cardamomum) and its active constituent, 1,8-cineole / Archana Sengupta and Shamee Bhattacharjee -- Molecular targets and health benefits of cinnamon / Kiran Panickar ... [et al.] -- Cloves (eugenol) / Yoshinori Kadoma ... [et al.] -- Coriander / Sanjeev Shukla and Sanjay Gupta -- Fenugreek (diosgenin) / Jayadev Raju and Chinthalapally V. Rao -- Diallyl sulfide from garlic / Girija Kuttan and Punathil Thejass -- Ginger (6-gingerol) / Nidhi Nigam, Jasmine George, and Yogeshwer Shukla -- Kalonji (thymoquinone) / Ahmed O. Kaseb and Abdel-Hafez A. Selim -- Kokum (garcinol) / Manoj K. Pandey, Ajaikumar B. Kunnumakkara, and Bharat B. Aggarwal -- Capsaicin : a hot spice in the chemoprevention of cancer / Joydeb Kumar Kundu and Young-Joon Surh -- Rosemary (rosmarinic acid) / Jongsung Lee ... [et al.] -- Mint and its constituents / Ajaikumar B. Kunnumakkara ... [et al.] -- Turmeric (curcumin) / Jen-Kun Lin and Shoei-Yn Lin Shiau.