Cellular And Molecular Toxicology Of Nanoparticles

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Cellular and Molecular Toxicology of Nanoparticles

Quaiser Saquib,Mohammad Faisal,Abdulaziz A. Al-Khedhairy,Abdulrahman A. Alatar
Cellular and Molecular Toxicology of Nanoparticles Book PDF

Author : Quaiser Saquib,Mohammad Faisal,Abdulaziz A. Al-Khedhairy,Abdulrahman A. Alatar
Publisher : Springer
Page : 346 pages
File Size : 44,9 Mb
Release : 2018-02-16
Category : Science
ISBN : 9783319720418

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Cellular and Molecular Toxicology of Nanoparticles by Quaiser Saquib,Mohammad Faisal,Abdulaziz A. Al-Khedhairy,Abdulrahman A. Alatar Pdf

This edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates. The varied selection of test models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs with cells and its organelles can induce toxicological consequences, including transcriptional and translational alterations, DNA damage, cytotoxicity, oxidative stress, mitochondrial dysfunction and cell death. NPs can get internalized in cells through phagocytosis, macropinocytosis, receptor-mediated endocytosis and passive penetration, which can affect varied cell types. Readers will be benefited with the compilations on basic and molecular facet of NPs toxicity. The chapters will provide a comprehensive information on the state-of-the-art methodologies. The application of toxicogenomic approaches, which is already established in nanotoxicology, has been given special consideration to unravel the toxicodynamics of nanomaterials. Among these approaches, the high-throughput RNA sequencing (RNA-Seq), which is able to build a complete map of transcriptome across different cell types and perturbations upon NPs exposure has been included. The readers are also introduced to the less studied topic on the adsorption of biomolecules (mainly proteins) on the NPs surface, constituting the so-called “biomolecular corona”. The book has been designed for scientists engaged in NPs toxicity research. Nonetheless, it should be of interest to a variety of scientific disciplines including marine biology, environmental pollution, genetics, pharmacology, medicine, drug and food material sciences, consumer products. Also, the compilations will be of interest to the environmental watchdogs, federal regulators, risk assessors and the policy makers.

Toxicology of Nanomaterials

Yuliang Zhao,Zhiyong Zhang,Weiyue Feng
Toxicology of Nanomaterials Book PDF

Author : Yuliang Zhao,Zhiyong Zhang,Weiyue Feng
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 44,9 Mb
Release : 2016-09-08
Category : Science
ISBN : 9783527689156

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Toxicology of Nanomaterials by Yuliang Zhao,Zhiyong Zhang,Weiyue Feng Pdf

This book provides the reader with a comprehensive view of analytical methods for nanotoxicology studies. After an introduction to nanomaterials and toxicological studies, the book discusses various characterization methods of nanomaterials and continues with the detection of nanoparticles in vivo as well as in vitro. A variety of techniques in molecular toxicology of nanomaterials is presented, followed by a detailed explanation of interaction between nanoparticles and biomacromolecules, including the structure-toxicity relationships of nanomaterials. Finally, the book concludes with the advantages and challenges of the analytical methods for nanotoxicology.

Biological Responses to Nanoscale Particles

Peter Gehr,Reinhard Zellner
Biological Responses to Nanoscale Particles Book PDF

Author : Peter Gehr,Reinhard Zellner
Publisher : Springer
Page : 344 pages
File Size : 47,9 Mb
Release : 2019-04-16
Category : Science
ISBN : 9783030124618

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Biological Responses to Nanoscale Particles by Peter Gehr,Reinhard Zellner Pdf

In this book the recent progress accumulated in studies of the interaction of engineered nanoparticles with cells and cellular constituents is presented. The focus is on manufacturing and characterization of nanosized materials, their interactions with biological molecules such as proteins, the mechanisms of transport across biological membranes as well as their effects on biological functions. Fundamental molecular and cellular aspects are in the foreground of the book. A further particularity is the interdisciplinary approach, including fields such as preparatory and analytical chemistry, biophysics and the physics of colloids, advanced microscopy and spectroscopy for in-situ detection of nanoparticles, cellular toxicology and nanomedicine. Nanoscale particles are known to exhibit novel and unprecedented properties that make them different from their corresponding bulk materials. As our ability to control these properties is further advanced, a huge potential to create materials with novel properties and applications emerges. Although the technological and economic benefits of nanomaterials are indisputable, concerns have also been raised that nanoscale structuring of materials might also induce negative health effects. Unfortunately, such negative health effects cannot be deduced from the known toxicity of the corresponding macroscopic material. As a result, there is a major gap in the knowledge necessary for assessing their risk to human health.

Advances in Molecular Toxicology

James C. Fishbein
Advances in Molecular Toxicology Book PDF

Author : James C. Fishbein
Publisher : Elsevier
Page : 265 pages
File Size : 52,5 Mb
Release : 2011-06-27
Category : Medical
ISBN : 9780444538642

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Advances in Molecular Toxicology by James C. Fishbein Pdf

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed. Cutting-edge reviews by leading workers in the discipline In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Molecular Toxicology

Nick Plant
Molecular Toxicology Book PDF

Author : Nick Plant
Publisher : Taylor & Francis
Page : 164 pages
File Size : 51,9 Mb
Release : 2021-02-27
Category : Science
ISBN : 9781000107005

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Molecular Toxicology by Nick Plant Pdf

Molecular Toxicology is a concise introduction to the subject, taking the reader through the theoretical principles of toxicology followed by specific examples. In the first section, the concepts behind possible mechanisms of toxicity are described (e.g. the specific enzyme or receptor system) using examples where appropriate. Following this a series of examples are used to show the extension of concept into the real world, in an organ specific manner. The book concludes with a section outlining toxicity assessment methods, where the impact of molecular biology is having a considerable impact, including DNA microarrays, proteomics and bioinformatics.

Handbook of Materials for Nanomedicine

Vladimir Torchilin
Handbook of Materials for Nanomedicine Book PDF

Author : Vladimir Torchilin
Publisher : CRC Press
Page : 294 pages
File Size : 42,6 Mb
Release : 2020-03-16
Category : Technology & Engineering
ISBN : 9781000067132

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Handbook of Materials for Nanomedicine by Vladimir Torchilin Pdf

In the fast-developing field of nanomedicine, a broad variety of materials have been used for the development of advanced delivery systems for drugs, genes, and diagnostic agents. With the recent breakthroughs in the field, we are witnessing a new age of disease management, which is governed by precise regulation of dosage and delivery. This book presents the advances in the use of metal-based and other nanomaterials for medical imaging, diagnosis, theranostics, and drug delivery. It discusses silver, hybrid gold, and surface-modified magnetic nanoparticles, fluorescent quantum dots, lipid bubbles, and nanobubbles. It provides all available information about these materials and describes in detail their advantages and disadvantages and the areas where they could be utilized successfully. The text also covers topics such as improving bioactivity of poorly soluble actives, cellular and molecular toxicology of nanoparticles, and biofate of nanoemulsions.

Molecular and Cellular Mechanisms of Toxicity

Lewis L. Smith,Francesco De Matteis
Molecular and Cellular Mechanisms of Toxicity Book PDF

Author : Lewis L. Smith,Francesco De Matteis
Publisher : CRC Press
Page : 262 pages
File Size : 42,7 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9781000012828

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Molecular and Cellular Mechanisms of Toxicity by Lewis L. Smith,Francesco De Matteis Pdf

First Published in 1995: Written by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology. The first section considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen, fibers and aflatoxins. The second section discusses the interactions of carcinogens with DNA, and other targets, and their relevance to both molecular dosimetry of exposure and development of cancer. The final part is concerned with cellular and genetic aspects and includes coverage of some of the most recent and rapidly developing problems in toxicology.

Biochemical Toxicology

Muharrem Ince,Olcay Kaplan Ince,Gabrijel Ondrasek
Biochemical Toxicology Book PDF

Author : Muharrem Ince,Olcay Kaplan Ince,Gabrijel Ondrasek
Publisher : BoD – Books on Demand
Page : 232 pages
File Size : 47,6 Mb
Release : 2020-07-29
Category : Medical
ISBN : 9781789846966

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Biochemical Toxicology by Muharrem Ince,Olcay Kaplan Ince,Gabrijel Ondrasek Pdf

Biochemical Toxicology - Heavy Metals and Nanomaterials provides an overview of biochemical contamination, nanomaterials and toxic metals, and measurement techniques. It explains and clarifies important studies and compares and develops new and groundbreaking measurement techniques in the fields of organic and inorganic pollution and nanoscience. It is highly recommended for professionals and readers interested in the environment and human health.

Nanotoxicology in Humans and the Environment

Jamie R. Lead,Shareen H. Doak,Martin J.D. Clift
Nanotoxicology in Humans and the Environment Book PDF

Author : Jamie R. Lead,Shareen H. Doak,Martin J.D. Clift
Publisher : Springer Nature
Page : 263 pages
File Size : 42,8 Mb
Release : 2021-12-13
Category : Medical
ISBN : 9783030798086

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Nanotoxicology in Humans and the Environment by Jamie R. Lead,Shareen H. Doak,Martin J.D. Clift Pdf

The book covers the area of ‘Nanotoxicology’ but primarily from the point of view of nanotoxicology at the interface with other disciplines including human toxicology; environmental toxicology; characterization, dose and transformations; regulation; public and elite group perceptions; and interactions with innovation.Nanotoxicology in Humans and the Environment is written for researchers in nanotoxicology in academia, industry, government, and research students. Given the rapid development, the maturing of the discipline and its importance in current regulation and industry development (eg REACH, TSCA), the book is very timely.

Nanotoxicity

Joshua Reineke
Nanotoxicity Book PDF

Author : Joshua Reineke
Publisher : Humana Press
Page : 0 pages
File Size : 44,5 Mb
Release : 2012-09-14
Category : Medical
ISBN : 1627030018

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Nanotoxicity by Joshua Reineke Pdf

The field of nanotechnology has developed very rapidly over the past decade lending great promise to medical applications in drug delivery, therapeutics, and biological imaging. Due to the great promise, rapid development, and broad application of nanomaterials, it is imperative that researchers from development through application seek a thorough understanding of nanotoxicity. Nanotoxicity: Methods and Protocols address the special considerations when applying toxicity studies to nanomaterials and detail newly developed methods for the study of nanotoxicity. These diverse methods span in vitro cell culture, model tissues, in situ exposure, in vivo models, analysis in plants, and mathematical modeling, proving to be relevant to pharmaceutical scientists, material scientists, bioengineers, toxicologists, environmentalists, immunologists, and cellular and molecular biologists, to name a few. As part of the highly successful Methods in Molecular BiologyTM, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Nanotoxicity: Methods and Protocols aims to diversify the capabilities of current researchers involved in nanotoxicology and to enable researchers in related fields to expand their knowledge of how nanomaterials interface with the biological environment.

Toxicology of Nanoparticles: Insights from Drosophila

Namita Agrawal,Prasanna Shah
Toxicology of Nanoparticles Insights from Drosophila Book PDF

Author : Namita Agrawal,Prasanna Shah
Publisher : Springer Nature
Page : 128 pages
File Size : 47,6 Mb
Release : 2020-08-24
Category : Medical
ISBN : 9789811555220

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Toxicology of Nanoparticles: Insights from Drosophila by Namita Agrawal,Prasanna Shah Pdf

This book offers an unparalleled source of information on in vivo assessment of nanoparticle toxicity by using Drosophila as a model organism. Nanoparticles have emerged as an useful tool for wide variety of biomedical, cosmetics, and industrial applications. However, our understanding of nanomaterial-mediated toxicity under in vivo condition remains limited. The book begins with a chapter on synthesis and characterization of nanoparticles used for various biological, medical and commercial purposes. The rest of the chapters deal with the impact of nanoparticles on different biological aspects like behavior, physiology and metabolic homoeostasis using Drosophila as a model organism. Lastly, the book summarizes how proper characterization and evaluation of safe dosage of nanoparticles can be a boon if incorporated in consumer goods and for biomedical applications. Overall, the book pursues an interdisciplinary approach by connecting nanotechnology and biology from various angles using Drosophila as a model system, so as to develop more efficient, safe and effective use of nanoparticles for human beings.

Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology

Saura C. Sahu,Daniel A. Casciano
Handbook of Nanotoxicology Nanomedicine and Stem Cell Use in Toxicology Book PDF

Author : Saura C. Sahu,Daniel A. Casciano
Publisher : John Wiley & Sons
Page : 713 pages
File Size : 52,5 Mb
Release : 2014-04-22
Category : Science
ISBN : 9781118855867

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Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology by Saura C. Sahu,Daniel A. Casciano Pdf

The Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology provides an insight into the current trends and future directions of research in these rapidly developing scientific fields. Written by leading scientists and experts, the Handbook will be of interest to various scientific disciplines including toxicology, medicine, and pharmacology, as well as food, drug, and other regulatory sciences.

Molecular, Clinical and Environmental Toxicology

Andreas Luch
Molecular Clinical and Environmental Toxicology Book PDF

Author : Andreas Luch
Publisher : Springer Science & Business Media
Page : 580 pages
File Size : 45,8 Mb
Release : 2012-06-07
Category : Medical
ISBN : 9783764383404

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Molecular, Clinical and Environmental Toxicology by Andreas Luch Pdf

Environmental Toxicology is the third volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health or engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.

Nanotoxicology in Safety Assessment of Nanomaterials

Henriqueta Louro,Maria João Silva
Nanotoxicology in Safety Assessment of Nanomaterials Book PDF

Author : Henriqueta Louro,Maria João Silva
Publisher : Springer Nature
Page : 439 pages
File Size : 55,6 Mb
Release : 2022-05-18
Category : Medical
ISBN : 9783030880712

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Nanotoxicology in Safety Assessment of Nanomaterials by Henriqueta Louro,Maria João Silva Pdf

Since its advent, nanotechnologies are considered key enabling technologies that take advantage of a wide array of nanomaterials (NMs) for biomedical and industrial applications generating significant societal and economic benefits. However, such innovation increases human exposure to these substances through inhalation, ingestion or dermal contact raising public health concerns. Furthermore, the NMs’ specific physicochemical properties, that confer them unique beneficial characteristics, can also elicit nano-bio interactions leading to toxicity and concerns for public health. In addition, such properties can be affected by the surrounding matrix, particularly when incorporated in complex matrices such as food products, leading to secondary features potentially more relevant than primary characteristics for determining their toxicological outcome. These nano specific issues raise the question of whether the NMs may produce adverse outcomes that are not accounted for when using conventional toxicological approaches to assess their safety. Such uncertainties about the safety of NMs for human health and the environment may hamper a faster and more widespread exploration of their potentials. In response, the NMs definition has evolved, and nanotoxicology has developed towards new and more integrative approach methods to support regulatory and policy actions. This book provides a perspective on recent developments in the synthesis, application, and characterization of NMs and the related nanotechnologies, focusing on nanotoxicology for their accurate safety assessment early in the product development stage. The use of complex in vitro models, including multicellular systems and organoids, and “omics-based” approaches, such as transcriptomics or epigenomics, have greatly contributed to an in-depth understanding of the cellular and molecular mechanisms behind some NMs toxicity. Such mechanistic knowledge is equally addressed in this book and has set the basis for a predictive nanotoxicology approach building on adverse outcome pathways. In addition, considering the knowledge provided by the above-mentioned approaches, insights into risk assessment, standardization, and regulation of NMs are also included. Incorporating adequate nanosafety assessment early in the life-cycle of NMs will allow the implementation of the safe and sustainable-by-design paradigm enabling safety to keep pace with innovation. Chapters 10 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Nanotoxicology in Caenorhabditis Elegans

Dayong Wang
Nanotoxicology in Caenorhabditis Elegans Book PDF

Author : Dayong Wang
Publisher : Unknown
Page : 128 pages
File Size : 50,6 Mb
Release : 2018
Category : Caenorhabditis elegans
ISBN : 9811302340

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Nanotoxicology in Caenorhabditis Elegans by Dayong Wang Pdf

This book focuses on the toxicity of engineered nanomaterials (ENMs) and their underlying physicochemical, cellular, physiological, and molecular mechanisms. Further, it covers ENMs' translocation and their targeted organ toxicology, and discusses chemical and pharmacological strategies used to combat nanotoxicity. Engineered nanomaterials (ENMs) are defined as materials with one or more dimensions of less than 100 nm, and have shown considerable promise in several areas of development. At the same time, the potential toxicity of ENMs for human health and environmental organisms is increasingly attracting attention. In addition to the typical properties of model animals, Caenorhabditis elegans is extremely sensitive to environmental toxicants, which makes it the ideal in vivo assay system for toxicological studies. C. elegans has been widely used in toxicity assessment and toxicological studies of environmental toxicants and stresses. This book provides a comprehensive summary of nanotoxicology research on C. elegans.