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Cellular Dynamics of the Neuron by Samuel H. Barondes Pdf
Cellular Dynamics of the Neuron covers advances in the study of the cellular dynamics of the neuron. The book discusses the synthesis and transport of the neuroplasm, as well as the synthesis, transport, and action of neurotransmitters. The text also describes the functional implications of synaptic ultrastructure and the morphological and biochemical correlates of neuronal plasticity. Cell biologists, neurobiologists, cell pathologists, molecular biologists, and physiologists will find the book invaluable.
Stephen W. Kuffler,John G. Nicholls,A. Robert Martin
Author : Stephen W. Kuffler,John G. Nicholls,A. Robert Martin Publisher : Sinauer Associates, Incorporated Page : 680 pages File Size : 48,7 Mb Release : 1984 Category : Medical ISBN : UOM:39015004470582
National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development
Author : National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development Publisher : National Academies Press Page : 610 pages File Size : 55,7 Mb Release : 2000-11-13 Category : Social Science ISBN : 9780309069885
From Neurons to Neighborhoods by National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development Pdf
How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.
This detailed volume gathers together a broad variety of methods essential to the investigation of the biology of astrocytes and their multifaceted roles in both healthy and diseased brains. Beginning with some overviews of the subject, the book continues by covering techniques for the isolation of astrocytes from animal models, the investigation of astrocyte morphology and function, as well as for understanding astrocyte pathologies in the central nervous system. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Astrocytes: Methods and Protocols serves as an ideal guide for both experienced and beginner scientists working toward unraveling the novel, fascinating roles of these versatile cells.
The Orexin System. Basic Science and Role in Sleep Pathology by M.A. Steiner,M. Yanagisawa,M. Clozel Pdf
The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer’s disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.
In Vivo Optical Imaging of Brain Function, Second Edition by Ron D. Frostig Pdf
These are exciting times for the field of optical imaging of brain function. Rapid developments in theory and technology continue to considerably advance understanding of brain function. Reflecting changes in the field during the past five years, the second edition of In Vivo Optical Imaging of Brain Function describes state-of-the-art techniques and their applications for the growing field of functional imaging in the live brain using optical imaging techniques. New in the Second Edition: Voltage-sensitive dyes imaging in awake behaving animals Imaging based on genetically encoded probes Imaging of mitochondrial auto-fluorescence as a tool for cortical mapping Using pH-sensitive dyes for functional mapping Modulated imaging Calcium imaging of neuronal activity using 2-photon microscopy Fourier approach to optical imaging Fully updated chapters from the first edition Leading Authorities Explore the Latest Techniques Updated to reflect continuous development in this emerging research area, this new edition, as with the original, reaches across disciplines to review a variety of non-invasive optical techniques used to study activity in the living brain. Leading authorities from such diverse areas as biophysics, neuroscience, and cognitive science present a host of perspectives that range from a single neuron to large assemblies of millions of neurons, captured at various temporal and spatial resolutions. Introducing techniques that were not available just a few years ago, the authors describe the theory, setup, analytical methods, and examples that highlight the advantages of each particular method.
Russian Cognitive Neuroscience by Chris Forsythe,Mikhail Zotov,Gabriel Radvansky,Larisa Tsvetkova Pdf
The editors have compiled an unprecedented collection of chapters by renowned Russian cognitive scientists and neuroscientists, placing research in a historical and cultural context.
Michael E. Selzer,Stephanie Clarke,Leonardo G. Cohen,Gert Kwakkel (Professor),Robert H. Miller (Professor)
Author : Michael E. Selzer,Stephanie Clarke,Leonardo G. Cohen,Gert Kwakkel (Professor),Robert H. Miller (Professor) Publisher : Cambridge University Press Page : 693 pages File Size : 41,6 Mb Release : 2014 Category : Nervous system ISBN : 9781107011670
Textbook of Neural Repair and Rehabilitation by Michael E. Selzer,Stephanie Clarke,Leonardo G. Cohen,Gert Kwakkel (Professor),Robert H. Miller (Professor) Pdf
In two freestanding volumes, the Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. Revised throughout, bringing the book fully up to date, this volume, Neural Repair and Plasticity, covers the basic sciences relevant to recovery of function following injury to the nervous system, reviewing anatomical and physiological plasticity in the normal central nervous system, mechanisms of neuronal death, axonal regeneration, stem cell biology, and research strategies targeted at axon regeneration and neuron replacement. New chapters have been added covering pathophysiology and plasticity in cerebral palsy, stem cell therapies for brain disorders and neurotrophin repair of spinal cord damage, along with numerous others. Edited and written by leading international authorities, it is an essential resource for neuroscientists and provides a foundation for the work of clinical rehabilitation professionals.
A comprehensive review of current research on synaptic plasticity. The traditional model of synapses as fixed structures has been replaced by a dynamic one in which synapses are constantly being deleted and replaced. This book, written by a leading researcher on the neurochemistry of schizophrenia, integrates material from neuroscience and cell biology to provide a comprehensive account of our current knowledge of the neurochemical basis of synaptic plasticity. The book presents the evidence for synaptic plasticity, an account of the dendritic spine and the glutamate synapse with a focus on redox mechanisms, and the biochemical basis of the Hebbian synapse. It discusses the role of endocytosis, special proteins, and local protein synthesis. Additional topics include volume transmission, arachidonic acid signaling, hormonal modulation, and psychological stress. Finally, the book considers pharmacological and clinical implications of current research, particularly with reference to schizophrenia and Alzheimer's disease.
Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.
Single Neuron Computation by Thomas M. McKenna,Joel L. Davis,Steven F. Zornetzer Pdf
This book contains twenty-two original contributions that provide a comprehensive overview of computational approaches to understanding a single neuron structure. The focus on cellular-level processes is twofold. From a computational neuroscience perspective, a thorough understanding of the information processing performed by single neurons leads to an understanding of circuit- and systems-level activity. From the standpoint of artificial neural networks (ANNs), a single real neuron is as complex an operational unit as an entire ANN, and formalizing the complex computations performed by real neurons is essential to the design of enhanced processor elements for use in the next generation of ANNs. The book covers computation in dendrites and spines, computational aspects of ion channels, synapses, patterned discharge and multistate neurons, and stochastic models of neuron dynamics. It is the most up-to-date presentation of biophysical and computational methods.
Micro-, Meso- and Macro-Connectomics of the Brain by Henry Kennedy,David C. Van Essen,Yves Christen Pdf
This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.
