Cellular Immune Mechanisms And Tumor Dormancy

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Cellular Immune Mechanisms and Tumor Dormancy

T. H. M. Stewart,E. Frederick Wheelock
Cellular Immune Mechanisms and Tumor Dormancy Book PDF

Author : T. H. M. Stewart,E. Frederick Wheelock
Publisher : CRC Press
Page : 559 pages
File Size : 51,6 Mb
Release : 2017-07-28
Category : Medical
ISBN : 9781351367721

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Cellular Immune Mechanisms and Tumor Dormancy by T. H. M. Stewart,E. Frederick Wheelock Pdf

Cellular Immune Mechanisms and Tumor Dormancy features the work of internationally recognized experts from various disciplines as they discuss the phenomenon of tumor dormancy in humans. Animal models are described in which cellular and molecular components of the immune control of dormancy have been identified, and the relevance of these models to human cancer patients is recognized. Data derived from studies of organ transplantation, adjuvant chemotherapy, radiotherapy, anaesthesia, surgery, and whole blood transfusion is presented to show the vulnerability of cellular mechanisms maintaining dormancy. The potential for increasing the incidence of dormancy in micro metastases is also shown for non-small cell lung cancer, lymphoma, and leukemia. Cellular Immune Mechanisms and Tumor Dormancy is an important reference volume that will benefit researchers from many disciplines, including immunologists, pathologists, surgeons, and clinicians

Cellular Immune Mechanisms and Tumor Dormancy

T. H. M. Stewart,E. Frederick Wheelock
Cellular Immune Mechanisms and Tumor Dormancy Book PDF

Author : T. H. M. Stewart,E. Frederick Wheelock
Publisher : CRC Press
Page : 384 pages
File Size : 44,6 Mb
Release : 2017-07-13
Category : Electronic
ISBN : 113810499X

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Cellular Immune Mechanisms and Tumor Dormancy by T. H. M. Stewart,E. Frederick Wheelock Pdf

Cellular Immune Mechanisms and Tumor Dormancy features the work of internationally recognized experts from various disciplines as they discuss the phenomenon of tumor dormancy in humans. Animal models are described in which cellular and molecular components of the immune control of dormancy have been identified, and the relevance of these models to human cancer patients is recognized. Data derived from studies of organ transplantation, adjuvant chemotherapy, radiotherapy, anaesthesia, surgery, and whole blood transfusion is presented to show the vulnerability of cellular mechanisms maintaining dormancy. The potential for increasing the incidence of dormancy in micro metastases is also shown for non-small cell lung cancer, lymphoma, and leukemia. Cellular Immune Mechanisms and Tumor Dormancy is an important reference volume that will benefit researchers from many disciplines, including immunologists, pathologists, surgeons, and clinicians

Systems Biology of Tumor Dormancy

Heiko Enderling,Nava Almog,Lynn Hlatky
Systems Biology of Tumor Dormancy Book PDF

Author : Heiko Enderling,Nava Almog,Lynn Hlatky
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 44,5 Mb
Release : 2012-11-09
Category : Science
ISBN : 9781461414452

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Systems Biology of Tumor Dormancy by Heiko Enderling,Nava Almog,Lynn Hlatky Pdf

This volume is based on the Workshop on Systems Biology of Tumor Dormancy meeting, held July 25th to July 28th, 2011. The first annual CCSB workshop brought together biologists, clinicians, mathematicians, and computer scientists to discuss various aspects of tumor dormancy and develop novel mathematical/computational models with the keynote speakers. Specific topics included the angiogenic switch, immune system interactions, cancer stem cells and signaling.

Tumor Dormancy and Recurrence

Yuzhuo Wang,Francesco Crea
Tumor Dormancy and Recurrence Book PDF

Author : Yuzhuo Wang,Francesco Crea
Publisher : Humana Press
Page : 79 pages
File Size : 45,6 Mb
Release : 2017-08-31
Category : Medical
ISBN : 9783319592428

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Tumor Dormancy and Recurrence by Yuzhuo Wang,Francesco Crea Pdf

This volume will be the first to provide a comprehensive description of tumor dormancy. It will define the clinical and biological aspects of this phenomenon, as well as the cellular and molecular mechanisms associated with tumor dormancy. Chapters will be authored by world-renewed experts who are conducting cutting-edge research in the field. A unique feature will be a conclusive paragraph detailing future development and foreseeable clinical applications at the end of each chapter. The volume will serve as a fundamental instrument for every researcher and clinician interested in the field of tumor dormancy as well as a means of disseminating stimulating concepts and prompting the development of innovative technological solutions.

Interaction of Immune and Cancer Cells

Magdalena Klink
Interaction of Immune and Cancer Cells Book PDF

Author : Magdalena Klink
Publisher : Springer Science & Business Media
Page : 263 pages
File Size : 55,7 Mb
Release : 2013-11-26
Category : Medical
ISBN : 9783709113004

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Interaction of Immune and Cancer Cells by Magdalena Klink Pdf

The tumor environment is a dynamic network that includes cancer cells, immune cells, fibroblasts, endothelial cells, extracellular matrix, cytokines and receptors. The aim of this book is to summarize the role of these components, especially immune cells, in tumor suppression and/or progression and describe in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for scientists and medical doctors working and/or lecturing in the field of cancer research and immunology. ​

Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer

Michail Ignatiadis,Christos Sotiriou,Klaus Pantel
Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer Book PDF

Author : Michail Ignatiadis,Christos Sotiriou,Klaus Pantel
Publisher : Springer Science & Business Media
Page : 245 pages
File Size : 43,5 Mb
Release : 2012-04-23
Category : Medical
ISBN : 9783642281600

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Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer by Michail Ignatiadis,Christos Sotiriou,Klaus Pantel Pdf

This important book provides up-to-date information on a series of topical issues relating to the approach to minimal residual disease in breast cancer patients. It first explains how the study of minimal residual disease and circulating and disseminated tumor cells (CTCs/DTCs) can assist in the understanding of breast cancer metastasis. A series of chapters then discuss the various technologies available for the detection and characterization of CTCs and DTCs, pinpointing their merits and limitations. Detailed consideration is given to the relevance of CTCs and DTCs, and their detection, to clinical research and practice. The role of other blood-based biomarkers is also addressed, and the closing chapters debate the challenges facing drug and biomarker co-development and the use of CTCs for companion diagnostic development. This book will be of interest and assistance to all who are engaged in the modern management of breast cancer.

A Survey of Models for Tumor-Immune System Dynamics

John A. Adam,Nicola Bellomo
A Survey of Models for Tumor Immune System Dynamics Book PDF

Author : John A. Adam,Nicola Bellomo
Publisher : Springer Science & Business Media
Page : 357 pages
File Size : 49,7 Mb
Release : 2012-10-06
Category : Mathematics
ISBN : 9780817681197

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A Survey of Models for Tumor-Immune System Dynamics by John A. Adam,Nicola Bellomo Pdf

Mathematical Modeling and Immunology An enormous amount of human effort and economic resources has been directed in this century to the fight against cancer. The purpose, of course, has been to find strategies to overcome this hard, challenging and seemingly endless struggle. We can readily imagine that even greater efforts will be required in the next century. The hope is that ultimately humanity will be successful; success will have been achieved when it is possible to activate and control the immune system in its competition against neoplastic cells. Dealing with the above-mentioned problem requires the fullest pos sible cooperation among scientists working in different fields: biology, im munology, medicine, physics and, we believe, mathematics. Certainly, bi ologists and immunologists will make the greatest contribution to the re search. However, it is now increasingly recognized that mathematics and computer science may well able to make major contributions to such prob lems. We cannot expect mathematicians alone to solve fundamental prob lems in immunology and (in particular) cancer research, but valuable sup port, however modest, can be provided by mathematicians to the research aspirations of biologists and immunologists working in this field.

Autophagy in Immune Response: Impact on Cancer Immunotherapy

Salem Chouaib
Autophagy in Immune Response Impact on Cancer Immunotherapy Book PDF

Author : Salem Chouaib
Publisher : Academic Press
Page : 242 pages
File Size : 53,5 Mb
Release : 2020-05-25
Category : Science
ISBN : 9780128196090

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Autophagy in Immune Response: Impact on Cancer Immunotherapy by Salem Chouaib Pdf

Autophagy in Immune Response: Impact on Cancer Immunotherapy focuses on the status and future directions of autophagy with respect to different aspects of its interaction with the immune system and immunotherapy. The book takes scientific research in autophagy a step further by presenting reputable information on the topic and offering integrated content with advancements in autophagy, from cell biology and biochemical research, to clinical treatments. This book is a valuable source for cancer researchers, oncologists, graduate students and several members of biomedical field who are interested in learning more on the relationship between autophagy and immunotherapies. Presents updated knowledge on autophagy at the basic level and its potential use in cancer treatment Offers the first book to cover autophagy at the interface of cell biology, immunology and tumor biology Provides a wealth of information on the topic in a coherent and comprehensive collection of contributions by world renowned scientists and investigators

Mechanisms of Tumor Escape from the Immune Response

A. Ochoa
Mechanisms of Tumor Escape from the Immune Response Book PDF

Author : A. Ochoa
Publisher : Unknown
Page : 288 pages
File Size : 53,8 Mb
Release : 2002
Category : MEDICAL
ISBN : 0367804700

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Mechanisms of Tumor Escape from the Immune Response by A. Ochoa Pdf

The progressive growth of a malignant tumor is accompanied by a decline in the immune response, through mechanisms that have, until recently, been poorly understood. The new era of biological therapies, including cytokines, adoptive transfer of TIL cells, gene therapy and others, brought forth the need to understand the impact of the tumor on the immune system. Moreover, the inability to achieve in humans the unequivocal success of immunotherapy in murine models suggests the possibility that cancer can impair the development of a therapeutic immune response.Scientific and technological advances in cellular and molecular biology during the last two decades have provided new tools with which to explore the dysfunctional immune system of patients with cancer. Novel immunology concepts have provided new insights into changes occurring in tumor cells and the immune system, providing a more cohesive understanding of the process, including:*diminished or absent expression of HLA antigens and co-stimulatory molecules*arrested maturation of dentritic cells*alterations in expression of some signal transduction proteins*increased apoptosis in T and NK cells*presence of suppressor CD+4 and CD25+ T cellsMechanisms of Tumor Escape from the Immune Response provides an introduction to this rapidly developing and, as yet, unsettled area of cancer research, and will be a valuable reference for clinicians and researchers working in the field of cancer immunotherapy.

MHC Class-I Loss and Cancer Immune Escape

Federico Garrido
MHC Class I Loss and Cancer Immune Escape Book PDF

Author : Federico Garrido
Publisher : Springer
Page : 101 pages
File Size : 49,7 Mb
Release : 2019-05-28
Category : Medical
ISBN : 9783030178642

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MHC Class-I Loss and Cancer Immune Escape by Federico Garrido Pdf

This book is about the escape strategies used by cancer cells to avoid the immune response of the host. The main characters of this story are the “Antigen Presenting Molecules” and the “T Lymphocytes”. The former are known as the Major Histocompatibility Complex (MHC): the H-2 and the HLA molecules. The latter are a subgroup of white cells travelling all over our body which are capable to distinguish between “self and non self”. Readers will know from the inside about the history of the HLA genetic system and will discover how T lymphocytes recognize and destroy cancer cells. One of the key important questions is: Why tumors arise, develop and metastasize? This book tries to answer this question and will explain how cancer cells become invisible to killer T lymphocytes. The loss of the HLA molecules is a major player in this tumor escape mechanism. Cancer immunotherapy is aimed at stimulating T lymphocytes to destroy tumor cells. However, the clinical response rate is not as high as expected. The molecular mechanisms responsible for MHC/HLA antigen loss play a crucial role in this resistance to immunotherapy. This immune escape mechanism will be discussed in different types of tumors: lung, prostate, bladder and breast...ect. as well as melanoma and lymphoma. This book will be useful to Oncologists, Pathologists and Immunologist that will enter this fascinating area of research. It will be also interesting for biologist, doctoral students and medical residents interested in “Tumor Immunology”.

Inflammation and Cancer

Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Inflammation and Cancer Book PDF

Author : Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Publisher : Springer
Page : 490 pages
File Size : 40,9 Mb
Release : 2014-05-12
Category : Medical
ISBN : 9783034808378

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Inflammation and Cancer by Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta Pdf

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Janeway's Immunobiology

Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Janeway s Immunobiology Book PDF

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 53,9 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Mesenchymal Stromal Cells as Tumor Stromal Modulators

Marcela Bolontrade,Mariana García
Mesenchymal Stromal Cells as Tumor Stromal Modulators Book PDF

Author : Marcela Bolontrade,Mariana García
Publisher : Academic Press
Page : 642 pages
File Size : 47,6 Mb
Release : 2016-10-24
Category : Medical
ISBN : 9780128031032

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Mesenchymal Stromal Cells as Tumor Stromal Modulators by Marcela Bolontrade,Mariana García Pdf

Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function Discusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue types Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges

Systems Biology of Cancer

Sam Thiagalingam
Systems Biology of Cancer Book PDF

Author : Sam Thiagalingam
Publisher : Cambridge University Press
Page : 597 pages
File Size : 54,5 Mb
Release : 2015-04-09
Category : Mathematics
ISBN : 9780521493390

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Systems Biology of Cancer by Sam Thiagalingam Pdf

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Revisiting Seed and Soil: A New Approach to Target Hibernating Dormant Tumor Cells, 2nd edition

Dalit Barkan,Ann F. Chambers,Angélica Santiago-Gomez
Revisiting Seed and Soil A New Approach to Target Hibernating Dormant Tumor Cells 2nd edition Book PDF

Author : Dalit Barkan,Ann F. Chambers,Angélica Santiago-Gomez
Publisher : Frontiers Media SA
Page : 158 pages
File Size : 44,9 Mb
Release : 2023-03-07
Category : Medical
ISBN : 9782832512548

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Revisiting Seed and Soil: A New Approach to Target Hibernating Dormant Tumor Cells, 2nd edition by Dalit Barkan,Ann F. Chambers,Angélica Santiago-Gomez Pdf

Metastasis is the major cause of mortality in cancer patients. Metastases can be present at the time of diagnosis or can occur years or decades after the removal of the primary tumor and treatment. This long latency in the manifestation of recurrent metastatic disease is explained clinically by the persistence of quiescent tumor cells that disseminated early in the course of the disease from the primary tumor to select distant organs. These residing disseminated tumor cells (DTCs) at distant organs lay dormant and asymptomatic until reawakened to form overt metastases. Importantly, the quiescent nature of these “hibernating” DTCs facilitates their resistance to conventional therapies that target actively dividing tumor cells. Therefore, unraveling the biology of dormancy and reactivation of the residing DTCs to life-threatening lesions is of utmost importance in order to develop new therapeutic strategies to prevent the recurrent metastatic disease from ever emerging or to better treat these recurrent cancers. The mechanisms underlying the biology of tumor dormancy and their reactivation to overt metastases are just beginning to emerge thanks to a growing appreciation of the potentially chronic nature of some cancers and the development of experimental model systems for their study. In this Research Topic, we will follow the journey of circulating tumor cells (CTCs) dispatching from the primary site until their successful lodging into a new and foreign site to become DTCs. We will explore the intrinsic mechanisms along with microenvironmental cues and niches that they encounter during their journey that may dictate their fate.