Cellular Immunotherapy Of Cancer

Author : Armin Ghobadi,John F. DiPersio
Publisher : Springer Nature
Page : 371 pages
File Size : 42,9 Mb
Release : 2022-01-01
Category : Medical
ISBN : 9783030878498

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Gene and Cellular Immunotherapy for Cancer by Armin Ghobadi,John F. DiPersio Pdf

Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field.

Author : H. C. Stevenson
Publisher : CRC Press
Page : 272 pages
File Size : 49,8 Mb
Release : 1989-07-17
Category : Medical
ISBN : 0824781112

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Adoptive Cellular Immunotherapy of Cancer by H. C. Stevenson Pdf

This volume presents the most complicated and powerful cancer biotherapies developed. It provides an overview of human immune system function and the mechanisms by which adoptive cellular immunotherapies (ACI) harnesses the activity. The volume provides a vision on the developments in ACI.

Author : H. C. Stevenson
Publisher : CRC Press
Page : 261 pages
File Size : 46,6 Mb
Release : 2021-05-30
Category : Medical
ISBN : 9781000444582

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Adoptive Cellular Immunotherapy of Cancer by H. C. Stevenson Pdf

This volume presents the most complicated and powerful cancer biotherapies developed. It provides an overview of human immune system function and the mechanisms by which adoptive cellular immunotherapies (ACI) harnesses the activity. The volume provides a vision on the developments in ACI.

Author : Robert L. Truitt
Publisher : John Wiley & Sons
Page : 494 pages
File Size : 45,8 Mb
Release : 1987-09-01
Category : Electronic
ISBN : 0471635413

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Cellular Immunotherapy of Cancer by Robert L. Truitt Pdf

Author : Daniel W. Lee,Nirali N. Shah
Publisher : Elsevier Health Sciences
Page : 246 pages
File Size : 41,9 Mb
Release : 2019-11-30
Category : Medical
ISBN : 9780323755979

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Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book by Daniel W. Lee,Nirali N. Shah Pdf

From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.

Author : Robert E Hawkins
Publisher : World Scientific
Page : 212 pages
File Size : 51,8 Mb
Release : 2014-05-05
Category : Medical
ISBN : 9789814618533

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Cellular Therapy Of Cancer: Development Of Gene Therapy Based Approaches by Robert E Hawkins Pdf

Cancer research has progressed enormously in recent years. This review volume will address recent findings in the area of T-cell therapy for cancer, including use of tumour infiltrating lymphocytes (TILs) as a therapy for melanoma, choice of target antigens, advances in engineered receptors, methods of gene transfer to T cells, review of cell processing methods and clinical trial design. Written by leadings scientists in the field, this up-to-date review on cancer research will be an important reference source to the researchers and healthcare professionals in the field.

Author : Katy Rezvani,Rohtesh S. Mehta
Publisher : Frontiers Media SA
Page : 182 pages
File Size : 45,5 Mb
Release : 2020-01-16
Category : Electronic
ISBN : 9782889633784

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Cellular Therapies in Cancer by Katy Rezvani,Rohtesh S. Mehta Pdf

Author : Jeffrey Medin,Daniel Fowler
Publisher : Springer Science & Business Media
Page : 442 pages
File Size : 49,8 Mb
Release : 2010-12-03
Category : Medical
ISBN : 9781607619802

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Experimental and Applied Immunotherapy by Jeffrey Medin,Daniel Fowler Pdf

Immunotherapy is now recognized as an essential component of treatment for a wide variety of cancers. It is an interdisciplinary field that is critically dependent upon an improved understanding of a vast network of cross-regulatory cellular populations and a diversity of molecular effectors; it is a leading example of translational medicine with a favorable concept-to-clinical-trial timeframe of just a few years. There are many established immunotherapies already in existence, but there are exciting new cancer immunotherapies just on the horizon, which are likely to be more potent, less toxic and more cost effective than many therapies currently in use. Experimental and Applied Immunotherapy is a state-of-the-art text offering a roadmap leading to the creation of these future cancer-fighting immunotherapies. It includes essays by leading researchers that cover a wide variety of topics including T cell and non-T cell therapy, monoclonal antibody therapy, dendritic cell-based cancer vaccines, mesenchymal stromal cells, negative regulators in cancer immunology and immunotherapy, non-cellular aspects of cancer immunotherapy, the combining of cancer vaccines with conventional therapies, the combining of oncolytic viruses with cancer immunotherapy, transplantation, and more. The field of immunotherapy holds great promise that will soon come to fruition if creative investigators can bridge seemingly disparate disciplines, such as T cell therapy, gene therapy, and transplantation therapy. This text is a vital tool in the building of that bridge.

Author : Anonim
Publisher : Elsevier
Page : 418 pages
File Size : 47,9 Mb
Release : 2024-03-27
Category : Science
ISBN : 9780443139963

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Cell-based Cancer Immunotherapy by Anonim Pdf

Cell-based Cancer Immunotherapy, Volume 183 provides the latest progress concerning research on anticancer cellular immunotherapies and their immunological, translation, or clinical aspects. Topics covered in this volume include Methods behind clinical DC vaccine products against glioblastoma, Fully closed and automated isolation of natural blood dendritic cells for cancer immunotherapy, Methods behind Oncolytic virus-based DC vaccines in cancer: towards a multiphase combined treatment strategy for Glioblastoma (GBM) patients, Identification of TCR repertoire patterns linked with anti-cancer immunotherapy, Training of epitope-TCR prediction models with healthy donor-derived cancer-specific T cells, Methods behind neoantigen predictions for anticancer vaccines, Methods behind CD137L-DC-EBV-VAX anticancer vaccine, and much more. Additional sections cover Gold Standard Assessment of Immunogenic Cell Death Induced by Photodynamic Therapy: From In Vitro to Tumor Mouse Models and Anti-Cancer Vaccination Strategies, Methods behind TCR analyses for colorectal cancer-associated TILs, The use of xCELLigence, Incucyte, and/or Cr/LDH/maker-release assays, Humanized mouse models for anti-cancer therapy, In vitro re-challenge of CAR T cells, Methods behind adoptively transferred tumor draining lymphocytes? for anticancer immunotherapy, and A murine glioblastoma platform to test cellular therapies with the standard of care. Provides comprehensive method articles from front-line experts on the topic of anticancer cellular immunotherapies Provides useful schematic material and cutting-edge discussions Presents the latest insights and future perspectives on the covered topics, along with their implications for immuno-oncology, as well as clinical perspectives

Author : Asha B. Pillai,Rizwan Romee
Publisher : Frontiers Media SA
Page : 132 pages
File Size : 46,5 Mb
Release : 2023-09-13
Category : Science
ISBN : 9782832534908

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Innate Immune Cell Therapy of Cancer by Asha B. Pillai,Rizwan Romee Pdf

Adoptive cellular immunotherapy of cancer, particularly chimeric antigen receptor-transduced T cell (CAR-T) therapies, have enjoyed an explosion of clinical trials and translational and basic research in the past decade. The concept and design of the CAR, though originally intended to optimize targeting of innate natural killer cells (NK cells) to tumor-specific antigens, was laterally applied in the past decade to conventional autologous and later third-party allogeneic T cells with first-in-kind successes in leukemia immunotherapy in both adults and children. This approach also spawned the development of an entire industry focused on cancer immunotherapy, laying the foundation for the current paradigm shifts away from toxic chemo/radiotherapy to immune targeting. Aside from cytokine-release toxicities, specific obstacles plaguing existing CAR-T cell therapies include suboptimal killing by fatigued or senescent autologous patient-derived T cells derived, acquisition of tumor resistance to T-cell based immune therapies, and graft-versus-host disease (GVHD) associated with allogeneic conventional T cell therapies.

Author : George Morstyn,William Sheridan
Publisher : Cambridge University Press
Page : 656 pages
File Size : 40,9 Mb
Release : 1996-03-29
Category : Medical
ISBN : 0521473152

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Cell Therapy by George Morstyn,William Sheridan Pdf

Cell therapy is a rapidly developing area, drawing on cell biology, molecular biology, virology, immunology, cell quantitation techniques and biomedical engineering. It has potential in many clinical settings, in the treatment of cancer and other diseases. This volume in the series Cancer: Clinical Science in Practice examines the current state and future prospects of cell therapy, which seems likely to have an even more profound impact on health care than did the production of proteins by recombinant DNA technology. The coverage is broad, including the scientific principles of haematopoietic cell therapy, the technology of cell collection and preparation, current and likely future clinical applications of cell therapy, and the principles and practice of cellular immunotherapy. Up-to-date and authoritative, volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the applications of biomedical science to the understanding and management of cancer.

Author : Paolo A. Ascierto,David F. Stroncek,Ena Wang
Publisher : Humana Press
Page : 305 pages
File Size : 48,8 Mb
Release : 2015-11-26
Category : Medical
ISBN : 9783319211671

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Developments in T Cell Based Cancer Immunotherapies by Paolo A. Ascierto,David F. Stroncek,Ena Wang Pdf

This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification or reprogramming to increase their ability to survive and expand when adoptively transferred back to the patients. Specific attention is devoted to the genetic manipulation of T cells through the introduction of re-directed T cell receptors, chimeric antibody receptors, and other genetic manipulation aimed at improving their effectiveness as anti-cancer agents. Furthermore, the revolutionary role of checkpoint inhibitors and their potential in combination with other immunotherapeutic approaches or with standard chemo and radiation therapy are extensively discussed.

Author : Robert L. Truitt,Robert Peter Gale,Mortimer M. Bortin
Publisher : Unknown
Page : 473 pages
File Size : 47,7 Mb
Release : 1987
Category : Cancer
ISBN : 0845150944

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Cellular Immunotherapy of Cancer by Robert L. Truitt,Robert Peter Gale,Mortimer M. Bortin Pdf

Author : Robert L. Truitt,Robert Peter Gale,Mortimer M. Bortin
Publisher : Unknown
Page : 514 pages
File Size : 42,5 Mb
Release : 1987
Category : Medical
ISBN : UOM:39015012459544

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Cellular Immunotherapy of Cancer by Robert L. Truitt,Robert Peter Gale,Mortimer M. Bortin Pdf

Author : Mary L. Disis
Publisher : Springer Science & Business Media
Page : 516 pages
File Size : 52,9 Mb
Release : 2007-10-28
Category : Medical
ISBN : 9781597450119

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Immunotherapy of Cancer by Mary L. Disis Pdf

Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.