Cellular Molecular Mechanisms In Epigenetic Evolutionary Biology

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Cellular-Molecular Mechanisms in Epigenetic Evolutionary Biology

John Torday,William Miller Jr.
Cellular Molecular Mechanisms in Epigenetic Evolutionary Biology Book PDF

Author : John Torday,William Miller Jr.
Publisher : Springer Nature
Page : 217 pages
File Size : 54,8 Mb
Release : 2020-02-13
Category : Science
ISBN : 9783030381332

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Cellular-Molecular Mechanisms in Epigenetic Evolutionary Biology by John Torday,William Miller Jr. Pdf

There has been no mechanistic explanation for evolutionary change consistent with phylogeny in the 150 years since the publication of ‘Origins’. As a result, progress in the field of evolutionary biology has stagnated, relying on descriptive observations and genetic associations rather testable scientific measures. This book illuminates the need for a larger evolutionary-based platform for biology. Like physics and chemistry, biology needs a central theory in order to frame the questions that arise, the way hypotheses are tested, and how to interpret the data in the context of a continuum.The reduction of biology to its self-referential, self-organized properties provides the opportunity to recognize the continuum from the Singularity/Big Bang to Consciousness based on cell-cell communication for homeostasis.

Epigenetic Inheritance and Evolution

Eva Jablonka,Marion J. Lamb
Epigenetic Inheritance and Evolution Book PDF

Author : Eva Jablonka,Marion J. Lamb
Publisher : Oxford University Press, USA
Page : 364 pages
File Size : 50,6 Mb
Release : 1995
Category : Language Arts & Disciplines
ISBN : 0198540620

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Epigenetic Inheritance and Evolution by Eva Jablonka,Marion J. Lamb Pdf

Does the inheritance of acquired characteristics play a significant role in evolution? In this book, Eva Jablonka and Marion J. Lamb attempt to answer that question with an original, provocative exploration of the nature and origin of hereditary variations. Starting with a historical account of Lamarck's ideas and the reasons they have fallen in disrepute, the authors go on to challenge the prevailing assumption that all heritable variation is random and the result of variation in DNA base sequences. They also detail recent breakthroughs in our understanding of the molecular mechanisms underlying inheritance--including several pathways not envisioned by classical population genetics--and argue that these advances need to be more fully incorporated into mainstream evolutionary theory. Throughout, the book offers a new look at the evidence for and against the hereditability of environmentally induced changes, and addresses timely questions about the importance of non-Mendelian inheritance. A glossary and extensive list of references round out the book. Urging a reconsideration of the present DNA-centric view prevalent in the field, Epigentic Inheritance and Evolution will make fascinating and important reading for students and researchers in evolution, genetics, ecology, molecular biology, developmental biology, and the history and philosophy of science.

Epigenetic Principles of Evolution

Nelson R. Cabej
Epigenetic Principles of Evolution Book PDF

Author : Nelson R. Cabej
Publisher : Elsevier
Page : 846 pages
File Size : 53,5 Mb
Release : 2011-11-22
Category : Science
ISBN : 9780124158511

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Epigenetic Principles of Evolution by Nelson R. Cabej Pdf

This is the first and only book, so far, to deal with the causal basis of evolution from an epigenetic view. By revealing the epigenetic "user" of the "genetic toolkit", this book demonstrates the primacy of epigenetic mechanisms and epigenetic information in generating evolutionary novelties. The author convincingly supports his theory with a host of examples from the most varied fields of biology, by emphasizing changes in developmental pathways as the basic source of evolutionary change in metazoans. Original and thought provoking--a radically new theory that overcomes the present difficulties of the theory of evolution Is the first and only theory that uses epigenetic mechanisms and principles for explaining evolution of metazoans Takes an integrative approach and shows a wide range of learning

Epigenetic Mechanisms of the Cambrian Explosion

Nelson R Cabej
Epigenetic Mechanisms of the Cambrian Explosion Book PDF

Author : Nelson R Cabej
Publisher : Academic Press
Page : 258 pages
File Size : 49,9 Mb
Release : 2019-10-12
Category : Science
ISBN : 9780128143124

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Epigenetic Mechanisms of the Cambrian Explosion by Nelson R Cabej Pdf

Epigenetic Mechanisms of the Cambrian Explosion provides readers with a basic biological knowledge and epigenetic explanation of the biological puzzle of the Cambrian explosion, the unprecedented rapid diversification of animals that began 542 million years ago. During an evolutionarily instant of ~10 million years, which represents only 0.3% of the time of existence of life on Earth, or less than 2% of the time of existence of metazoans, all of the 30 extant body plans, major animal groups (phyla) and several extinct groups appeared. The work helps address this phenomena and tries to answer remaining questions for evolutionary biology, epigenetics, and scientific researchers. The book recognizes and presents objective representations of alternative theories for epigenetic evolution in this period, with the author drawing on his epigenetic theory of evolution to explain the causal basis of the Cambrian explosion. Both empirical evidence and theoretical arguments are presented in support of this thought-provoking epigenetic theory. Explains the Cambrian explosion from an entirely epigenetic view Takes a causal rather than descriptive approach to the phenomenon Allows for a broad readership, including those with only a basic biological knowledge, while maintaining scientific rigor

Epigenetic Mechanisms in Cellular Reprogramming

Alexander Meissner,Jörn Walter
Epigenetic Mechanisms in Cellular Reprogramming Book PDF

Author : Alexander Meissner,Jörn Walter
Publisher : Springer
Page : 230 pages
File Size : 54,9 Mb
Release : 2014-12-11
Category : Medical
ISBN : 9783642319747

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Epigenetic Mechanisms in Cellular Reprogramming by Alexander Meissner,Jörn Walter Pdf

The ability of a single genome to give rise to hundreds of functionally distinct cell type programs is in itself remarkable. Pioneering studies over the past few decades have demonstrated that this plasticity is retained throughout development, a phenomenon of epigenetic programming and reprogramming that remains one of the most fascinating areas of modern biology, with major relevance to human health and disease. This book presents the basic biology involved, including key mechanistic insights into this rapidly growing field.

Molecular mechanisms and physiology of disease

Nilanjana Maulik,Tom Karagiannis
Molecular mechanisms and physiology of disease Book PDF

Author : Nilanjana Maulik,Tom Karagiannis
Publisher : Springer
Page : 505 pages
File Size : 46,8 Mb
Release : 2014-05-31
Category : Medical
ISBN : 9781493907069

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Molecular mechanisms and physiology of disease by Nilanjana Maulik,Tom Karagiannis Pdf

In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.

Building the Most Complex Structure on Earth

Nelson R. Cabej
Building the Most Complex Structure on Earth Book PDF

Author : Nelson R. Cabej
Publisher : Newnes
Page : 308 pages
File Size : 47,5 Mb
Release : 2013-04-01
Category : Science
ISBN : 9780124017290

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Building the Most Complex Structure on Earth by Nelson R. Cabej Pdf

Building the Most Complex Structure on Earth provides readers with a basic biological education an easy and understandable introduction into a new epigenetic theory of development and evolution. This is a novel theory that describes the epigenetic mechanisms of the development and evolution of animals and explains the colossal evolution and diversification of animals from a new post-genetic perspective. Modern biology has demonstrated the existence of a common genetic toolkit in the animal kingdom, but neither the number of genes nor the evolution of new genes is responsible for the development and evolution of animals. The failure to understand how the same genetic toolkit is used to produce millions of widely different animal forms remains a perplexing conundrum in modern biology. The novel theory shows that the development and evolution of the animal kingdom are functions of epigenetic mechanisms, which are the competent users of the genetic toolkit. Provides a comprehensive view of the epigenetic aspects of reproduction, development, and evolution. Highly rigorous, but simple enough for readers with only a basic knowledge of biology.

Epigenetic Mechanisms of Gene Regulation

Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Epigenetic Mechanisms of Gene Regulation Book PDF

Author : Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Publisher : Unknown
Page : 716 pages
File Size : 51,8 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015047449171

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Epigenetic Mechanisms of Gene Regulation by Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs Pdf

Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.

Handbook of Epigenetics

Trygve Tollefsbol
Handbook of Epigenetics Book PDF

Author : Trygve Tollefsbol
Publisher : Academic Press
Page : 682 pages
File Size : 50,7 Mb
Release : 2017-07-10
Category : Science
ISBN : 9780128054772

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Handbook of Epigenetics by Trygve Tollefsbol Pdf

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials

DNA Replication, Recombination, and Repair

Fumio Hanaoka,Kaoru Sugasawa
DNA Replication Recombination and Repair Book PDF

Author : Fumio Hanaoka,Kaoru Sugasawa
Publisher : Springer
Page : 555 pages
File Size : 50,8 Mb
Release : 2016-01-22
Category : Science
ISBN : 9784431558736

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DNA Replication, Recombination, and Repair by Fumio Hanaoka,Kaoru Sugasawa Pdf

This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.

Evolution, the Logic of Biology

John S. Torday,Virender K. Rehan
Evolution the Logic of Biology Book PDF

Author : John S. Torday,Virender K. Rehan
Publisher : John Wiley & Sons
Page : 296 pages
File Size : 41,8 Mb
Release : 2017-06-08
Category : Science
ISBN : 9781118729281

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Evolution, the Logic of Biology by John S. Torday,Virender K. Rehan Pdf

By focusing on the cellular mechanisms that underlie ontogeny, phylogeny and regeneration of complex physiologic traits, Evolution, the Logic of Biology demonstrates the use of homeostasis, the fundamental principle of physiology and medicine, as the unifying mechanism for evolution as all of biology. The homeostasis principle can be used to understand how environmental stressors have affected physiologic mechanisms to generate condition-specific novelty through cellular mechanisms. Evolution, the Logic of Biology allows the reader to understand the vertebrate life-cycle as an intergenerational continuum in support of effective, on-going environmental adaptation. By understanding the principles of physiology from their fundamental unicellular origins, culminating in modern-day metazoans, the reader as student, researcher or practitioner will be encouraged to think in terms of the prevention of disease, rather than in the treatment of disease as the eradication of symptoms. By tracing the ontogeny and phylogeny of this and other phenotypic homologies, one can perceive and understand how complex physiologic traits have mechanistically evolved from their simpler ancestral and developmental origins as cellular structures and functions, providing a logic of biology for the first time. Evolution, the Logic of Biology will be an invaluable resource for graduate students and researchers studying evolutionary development, medicine and biology, anthropology, comparative and developmental biology, genetics and genomics, and physiology.

Epigenetics

Benedikt Hallgrimsson Ph.D.,Brian K. Hall Ph.D.
Epigenetics Book PDF

Author : Benedikt Hallgrimsson Ph.D.,Brian K. Hall Ph.D.
Publisher : Univ of California Press
Page : 469 pages
File Size : 48,9 Mb
Release : 2011-04-11
Category : Science
ISBN : 9780520948822

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Epigenetics by Benedikt Hallgrimsson Ph.D.,Brian K. Hall Ph.D. Pdf

Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in development, disease, and evolution. Chapters cover such topics as morphogenesis and organ formation, conceptual foundations, and cell differentiation, and together demonstrate that the integration of epigenetics into mainstream developmental biology is essential for answering fundamental questions about how phenotypic traits are produced.

Epigenetic Gene Expression and Regulation

Suming Huang,Michael D Litt,C. Ann Blakey
Epigenetic Gene Expression and Regulation Book PDF

Author : Suming Huang,Michael D Litt,C. Ann Blakey
Publisher : Academic Press
Page : 482 pages
File Size : 50,9 Mb
Release : 2015-10-19
Category : Science
ISBN : 9780128004715

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Epigenetic Gene Expression and Regulation by Suming Huang,Michael D Litt,C. Ann Blakey Pdf

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science

Epigenetics

C. David Allis,Thomas Jenuwein,Danny Reinberg,Marie-Laure Caparros
Epigenetics Book PDF

Author : C. David Allis,Thomas Jenuwein,Danny Reinberg,Marie-Laure Caparros
Publisher : CSHL Press
Page : 503 pages
File Size : 53,9 Mb
Release : 2007
Category : Epigenesis, Genetic
ISBN : 9780879697242

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Epigenetics by C. David Allis,Thomas Jenuwein,Danny Reinberg,Marie-Laure Caparros Pdf

The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

Cellular and Molecular Approaches in Fish Biology

Ignacio Fernandez,Jorge Fernandes
Cellular and Molecular Approaches in Fish Biology Book PDF

Author : Ignacio Fernandez,Jorge Fernandes
Publisher : Academic Press
Page : 438 pages
File Size : 40,7 Mb
Release : 2021-12-02
Category : Science
ISBN : 9780128222744

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Cellular and Molecular Approaches in Fish Biology by Ignacio Fernandez,Jorge Fernandes Pdf

Cellular and Molecular Approaches in Fish Biology is a highly interdisciplinary resource to bring industry professionals, students and researchers up-to-date with the latest developments and information on fish biology research combining a historical overview of the different research areas in fish biology and detailed descriptions of cellular and molecular approaches with explanations and recommendations for research. The book presents a global perspective of each research area with detailed analytical methodologies on the cellular and molecular mechanisms within fish biology for expermentation. The book provides different points of view on how researchers have addressed timely issues, while describing and dissecting some of the new experimental/analytical approaches used to answer the key questions at cellular and molecular levels, making this a valuable resource to those in industry and academia as well as those entering the field. Provides detailed descriptions of each research approach, highlighting the tricks of the trade for its effective and successful application Includes the latest developments in fish reproduction, fish development and nutrition, fish welfare, fish immunology, ecology and biomedics Presents hot topics of research such as genetics, transcriptomics and epigenetics