Cellular Quiescence

Author : H. Daniel Lacorazza
Publisher : Unknown
Page : 303 pages
File Size : 49,6 Mb
Release : 2018
Category : Cytology
ISBN : 1493973711

Get Book

Cellular Quiescence by H. Daniel Lacorazza Pdf

Author : H. Daniel Lacorazza
Publisher : Humana Press
Page : 303 pages
File Size : 49,6 Mb
Release : 2017-10-18
Category : Science
ISBN : 1493973703

Get Book

Cellular Quiescence by H. Daniel Lacorazza Pdf

This detailed volume explores methods and protocols that aim to increase our understanding of how cells enter a quiescent state during homeostasis and how cells exit quiescence and re-enter differentiating cell divisions to restore damaged tissues, essential for developing new approaches in regenerative medicine in the future. The chapters in this book were designed to address cellular quiescence in prokaryote and eukaryote organisms, detection of quiescence (Hoechst/pyronin Y, FUCCI, CFSE, BrdU, H2B-GFP, CyTOF), quiescence in stem cells (skin, intestinal, neuronal, hematopoietic), genomic regulation (gene expression, transcription factors, lncRNA, RNA methylation), as well as analysis of the heterogeneity of quiescence by computer modeling. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cellular Quiescence: Methods and Protocols offers a broad view of basic and cutting-edge technology to inspire research in this emerging field of cell biology.

Author : M.A. Hayat
Publisher : Springer Science & Business Media
Page : 332 pages
File Size : 49,8 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9789400759589

Get Book

Tumor Dormancy, Quiescence, and Senescence, Volume 1 by M.A. Hayat Pdf

With a particular emphasis on tumor dormancy in breast, lung, prostate, and liver cancers, as well as in melanoma, this first volume of a new Springer series focuses on the interrelationship between biological processes of aging and tumors—both dormant and quiescent. With detail supplied by numerous international researchers at the forefront of cancer research, the book examines a host of differing aspects of the topic. Featured contributions analyze the role of the quiescent state in regulating hematopoietic and muscle stem cells. They also explore the mediation, by the kinase, in the reversible quiescent state of a subset of ovarian, pancreatic, and colon cancers. The book includes key research on the molecular mechanisms underlying stress-induced cellular senescence, in addition to those governing the accumulation of reactive oxygen species, and the induction of premature senescence. It also provides information on suppressing cellular senescence in the most common, and most aggressive malignant primary brain tumor in humans, glioblastoma multiforme. With comprehensive and cutting-edge information on therapeutic interventions and on the correct diagnosis of relevant neoplasms, and with numerous color illustrations, this is the most up-to-date assessment of current medical knowledge in this crucial area of medical research.

Author : M.A. Hayat
Publisher : Springer Science & Business Media
Page : 336 pages
File Size : 52,6 Mb
Release : 2013-11-29
Category : Science
ISBN : 9789400777262

Get Book

Tumor Dormancy, Quiescence, and Senescence, Volume 2 by M.A. Hayat Pdf

In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases such as breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M. A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor. Taking a broad and varied perspective, this volume was written by 70 contributors representing 11 countries.

Author : Guang Yao,Alexis Ruth Barr,Jyotsna Dhawan
Publisher : Frontiers Media SA
Page : 183 pages
File Size : 41,8 Mb
Release : 2022-09-15
Category : Science
ISBN : 9782889769728

Get Book

Cellular Dormancy: State Determination and Plasticity by Guang Yao,Alexis Ruth Barr,Jyotsna Dhawan Pdf

Author : Gheorghita Isvoranu
Publisher : BoD – Books on Demand
Page : 194 pages
File Size : 53,6 Mb
Release : 2017-07-12
Category : Medical
ISBN : 9789535133438

Get Book

Lymphocyte Updates by Gheorghita Isvoranu Pdf

This book represents a synergic effort of an international team of specialists in immunology to expand the scientific achievements in the field of lymphocytes. It offers important and specific updated information to researchers, students, teachers, and medical professionals. Moreover, considering the remarkable dynamics of immunology and immunotherapy, this book "Lymphocyte Updates - Cancer, Autoimmunity, and Infection" aims to represent a significant source of concise scientific data and advancement of knowledge in this field. The chapters offer new insights into the latest scientific progress on lymphocyte roles in protective immunity, as well as their involvement in pathogenesis of various disorders.

Author : M.A. Hayat
Publisher : Springer
Page : 160 pages
File Size : 47,7 Mb
Release : 2014-09-12
Category : Science
ISBN : 9789401793254

Get Book

Tumor Dormancy, Quiescence, and Senescence, Vol. 3 by M.A. Hayat Pdf

This third volume in the series Tumor Dormancy, Quiescence, and Senescence discusses the role of tumor dormancy and senescence in a number of diseases, including breast cancer, ovarian cancer and leukemia. The contents are organized under five subheadings: General Applications, Role in Breast Cancer, Role in Ovarian Cancer, Role in Leukemia and Role in Cardiovascular Disease. The first section includes basic information on the definition of dormancy, how cells become senescent and what they do, along with an appraisal of the current state of research on dormancy. Section Two explores dormancy in breast cancer, including the progression of hormone-dependent mammary tumors after dormancy. Section Three details the resistance of Type II ovarian tumors, in which the resistant tumor cell population persists after chemotherapy in a state of dormancy, with recurrent tumors arising upon transformation of such dormant cells back to malignant growth. This section explains how lineage, histological subtypes and grade influence the differential response of ovarian cancer resistance to platinum drugs. The fourth section explores leukemia, discussing regulation of the promyelocytic leukemia protein and its role in premature senescence. The final section explores the role of senescence and autophagy in age-related cardiovascular diseases and the observation that autophagy seems to retard cardiac senescence. Like the two preceding volumes in the series, Volume 3 stands out for its comprehensive approach, its roster of some 26 expert contributors representing seven different countries and its up-to-date review of leading-edge technology and methods.

Author : Thomas C.G. Bosch
Publisher : Springer Science & Business Media
Page : 198 pages
File Size : 55,5 Mb
Release : 2008-04-03
Category : Science
ISBN : 9781402082740

Get Book

Stem Cells by Thomas C.G. Bosch Pdf

Much of our knowledge of stem cells has been inferred from studies of remarkable few species. The ability to manipulate stem cells in “model” organisms such as the mouse and a few other vertebrate species has driven our understanding of basic biology of stem cells. The power and efficiency of studying model organisms, however, comes at a cost since a few species, obviously, do not reflect nature ́s true diversity. Unfortunately, although all multicellular organisms seem to rely on stem cells, and although this seems to be a question of key importance for understanding the evolution of animal life, little is known about stem cells in early-branching taxa. “Stem Cells: From Hydra to Man” illustrates that there is more than human and mouse stem cells to learn from. Reflecting an enormous growth in the knowledge of stem cells in various organisms, the book presents the conceptual language and the nature of questions, as well as a summary of the advances in our understanding of stem cells from a comparative point of view that has resulted from the development of new technology and the development of novel model organisms over the past few decades. As such this book is largely a horizon analysis of a frontier rather than a retrospective. It presents an integrative approach to animal stem cells and covers the major contributions, tools and trends in a newly emerging field: comparative stem cell biology.

Author : Anonim
Publisher : ScholarlyEditions
Page : 1179 pages
File Size : 47,6 Mb
Release : 2013-05-01
Category : Science
ISBN : 9781490110066

Get Book

Issues in Life Sciences—Cellular Biology: 2013 Edition by Anonim Pdf

Issues in Life Sciences—Cellular Biology / 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Cells and Materials. The editors have built Issues in Life Sciences—Cellular Biology: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cells and Materials in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Life Sciences—Cellular Biology: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Alexander Birbrair
Publisher : Springer
Page : 270 pages
File Size : 42,9 Mb
Release : 2017-12-03
Category : Science
ISBN : 9783319691947

Get Book

Stem Cell Microenvironments and Beyond by Alexander Birbrair Pdf

This book discusses the main stem cell niches under distinct pathophysiological conditions. The role of tissue microenvironments in stem cell regulation, as well as modern methodologies and new techniques for the identification and characterization of stem cell niches, are discussed by leading experts in the field. Chapters describe the major components of various stem cell microenvironments, such as cellular components, soluble factors, cell-cell interactions, extra-cellular matrix proteins, and physical forces. Stem Cell Microenvironments and Beyond is part of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students and researchers in the field of stem cells or cell biology as well as clinicians.

Author : Greg H. Enders
Publisher : Springer Science & Business Media
Page : 204 pages
File Size : 47,8 Mb
Release : 2010-03-10
Category : Medical
ISBN : 9781441917706

Get Book

Cell Cycle Deregulation in Cancer by Greg H. Enders Pdf

Cancer is fundamentally a disease of abnormal cell proliferation: Cancer cells multiply when and where they should not. This proliferation entails escape from normal bounds imposed by the tissue environment, the internal biology of the cell (DNA damage, chromosomal imbalances, disorganized mitotic spindles), and the proliferative history of the cell (normal generational times). Some of the key oncogenic events in cancer directly perturb proteins that regulate progression through the cell division cycle, others alter cell cycle progression indirectly, through effects on signaling pathway that impinge on the cell cycle. This biology is fundamentally important in cancer therapy. Many of the workhorse treatments for cancer rely on killing proliferating cells. Furthermore, there is growing recognition that stem cell-transit amplifying cell hierarchies may persist or be generated during tumorigenesis, generating important functional heterogeneity in cell cycle control among tumor cells, with far-reaching scientific and clinical implications. This volume outlines major cell cycle perturbations that drive tumorigenesis and considers the prospects for using such knowledge in cancer therapy.

Author : Natalia L. Komarova,Dominik Wodarz
Publisher : Springer Science & Business Media
Page : 235 pages
File Size : 54,8 Mb
Release : 2013-11-19
Category : Mathematics
ISBN : 9781461483014

Get Book

Targeted Cancer Treatment in Silico by Natalia L. Komarova,Dominik Wodarz Pdf

Countless medical researchers over the past century have been occupied by the search for a cure of cancer. So far, they have developed and implemented a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, small molecule inhibitors, and oncolytic viruses. However, patterns of these treatments' effectiveness remain largely unclear, and a better understanding of how cancer therapies work has become a key research goal. Cancer Treatment in Silico provides the first in-depth study of approaching this understanding by modeling cancer treatments, both mathematically and through computer simulations. The main goal of this book is to help expose students and researchers to in silico methods of studying cancer. It is intended for both the applied mathematics and experimental oncology communities, as mathematical models are playing an increasingly important role to supplement laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, the work will be a valuable resource for scientists and students alike.

Author : Society for Mathematical Biology. Conference
Publisher : American Mathematical Soc.
Page : 145 pages
File Size : 41,8 Mb
Release : 2010
Category : Mathematics
ISBN : 9780821848456

Get Book

New Perspectives in Mathematical Biology by Society for Mathematical Biology. Conference Pdf

Provides an overview of the distinct variety and diversity of current research in this field. In every chapter of this book, which covers themes ranging from cancer modelling to infectious diseases to orthopaedics and musculoskeletal tissue mechanics, there is clear evidence of the strong connections and interactions of mathematics with the biological and biomedical sciences that have spawned new models and novel insights.

Author : Mark A. LaBarge,William Curtis Hines,Derek Charles Radisky,Catherine Park
Publisher : Frontiers Media SA
Page : 201 pages
File Size : 46,8 Mb
Release : 2020-01-24
Category : Electronic
ISBN : 9782889634163

Get Book

Microenvironment in Disease and Aging by Mark A. LaBarge,William Curtis Hines,Derek Charles Radisky,Catherine Park Pdf

Author : Anthony Scimè,Mireille Khacho
Publisher : Frontiers Media SA
Page : 161 pages
File Size : 41,5 Mb
Release : 2022-01-21
Category : Science
ISBN : 9782889741342

Get Book

The Role of Metabolism in Stem Cell Fates by Anthony Scimè,Mireille Khacho Pdf