Tumor Dormancy Quiescence And Senescence Volume 1

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Tumor Dormancy, Quiescence, and Senescence, Volume 1

M.A. Hayat
Tumor Dormancy Quiescence and Senescence Volume 1 Book PDF

Author : M.A. Hayat
Publisher : Springer Science & Business Media
Page : 332 pages
File Size : 47,7 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9789400759589

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Tumor Dormancy, Quiescence, and Senescence, Volume 1 by M.A. Hayat Pdf

With a particular emphasis on tumor dormancy in breast, lung, prostate, and liver cancers, as well as in melanoma, this first volume of a new Springer series focuses on the interrelationship between biological processes of aging and tumors—both dormant and quiescent. With detail supplied by numerous international researchers at the forefront of cancer research, the book examines a host of differing aspects of the topic. Featured contributions analyze the role of the quiescent state in regulating hematopoietic and muscle stem cells. They also explore the mediation, by the kinase, in the reversible quiescent state of a subset of ovarian, pancreatic, and colon cancers. The book includes key research on the molecular mechanisms underlying stress-induced cellular senescence, in addition to those governing the accumulation of reactive oxygen species, and the induction of premature senescence. It also provides information on suppressing cellular senescence in the most common, and most aggressive malignant primary brain tumor in humans, glioblastoma multiforme. With comprehensive and cutting-edge information on therapeutic interventions and on the correct diagnosis of relevant neoplasms, and with numerous color illustrations, this is the most up-to-date assessment of current medical knowledge in this crucial area of medical research.

Tumor Dormancy, Quiescence, and Senescence, Volume 2

M.A. Hayat
Tumor Dormancy Quiescence and Senescence Volume 2 Book PDF

Author : M.A. Hayat
Publisher : Springer Science & Business Media
Page : 336 pages
File Size : 55,9 Mb
Release : 2013-11-29
Category : Science
ISBN : 9789400777262

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Tumor Dormancy, Quiescence, and Senescence, Volume 2 by M.A. Hayat Pdf

In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases such as breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M. A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor. Taking a broad and varied perspective, this volume was written by 70 contributors representing 11 countries.

Tumor Dormancy, Quiescence, and Senescence, Vol. 3

M.A. Hayat
Tumor Dormancy Quiescence and Senescence Vol 3 Book PDF

Author : M.A. Hayat
Publisher : Springer
Page : 160 pages
File Size : 55,7 Mb
Release : 2014-09-12
Category : Science
ISBN : 9789401793254

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Tumor Dormancy, Quiescence, and Senescence, Vol. 3 by M.A. Hayat Pdf

This third volume in the series Tumor Dormancy, Quiescence, and Senescence discusses the role of tumor dormancy and senescence in a number of diseases, including breast cancer, ovarian cancer and leukemia. The contents are organized under five subheadings: General Applications, Role in Breast Cancer, Role in Ovarian Cancer, Role in Leukemia and Role in Cardiovascular Disease. The first section includes basic information on the definition of dormancy, how cells become senescent and what they do, along with an appraisal of the current state of research on dormancy. Section Two explores dormancy in breast cancer, including the progression of hormone-dependent mammary tumors after dormancy. Section Three details the resistance of Type II ovarian tumors, in which the resistant tumor cell population persists after chemotherapy in a state of dormancy, with recurrent tumors arising upon transformation of such dormant cells back to malignant growth. This section explains how lineage, histological subtypes and grade influence the differential response of ovarian cancer resistance to platinum drugs. The fourth section explores leukemia, discussing regulation of the promyelocytic leukemia protein and its role in premature senescence. The final section explores the role of senescence and autophagy in age-related cardiovascular diseases and the observation that autophagy seems to retard cardiac senescence. Like the two preceding volumes in the series, Volume 3 stands out for its comprehensive approach, its roster of some 26 expert contributors representing seven different countries and its up-to-date review of leading-edge technology and methods.

Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer

Michail Ignatiadis,Christos Sotiriou,Klaus Pantel
Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer Book PDF

Author : Michail Ignatiadis,Christos Sotiriou,Klaus Pantel
Publisher : Springer Science & Business Media
Page : 245 pages
File Size : 49,9 Mb
Release : 2012-04-23
Category : Medical
ISBN : 9783642281600

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Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer by Michail Ignatiadis,Christos Sotiriou,Klaus Pantel Pdf

This important book provides up-to-date information on a series of topical issues relating to the approach to minimal residual disease in breast cancer patients. It first explains how the study of minimal residual disease and circulating and disseminated tumor cells (CTCs/DTCs) can assist in the understanding of breast cancer metastasis. A series of chapters then discuss the various technologies available for the detection and characterization of CTCs and DTCs, pinpointing their merits and limitations. Detailed consideration is given to the relevance of CTCs and DTCs, and their detection, to clinical research and practice. The role of other blood-based biomarkers is also addressed, and the closing chapters debate the challenges facing drug and biomarker co-development and the use of CTCs for companion diagnostic development. This book will be of interest and assistance to all who are engaged in the modern management of breast cancer.

Translational Research in Muscular Dystrophy

Shin'ichi Takeda,Yuko Miyagoe-Suzuki,Madoka Mori-Yoshimura
Translational Research in Muscular Dystrophy Book PDF

Author : Shin'ichi Takeda,Yuko Miyagoe-Suzuki,Madoka Mori-Yoshimura
Publisher : Springer
Page : 199 pages
File Size : 54,5 Mb
Release : 2016-02-02
Category : Medical
ISBN : 9784431556787

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Translational Research in Muscular Dystrophy by Shin'ichi Takeda,Yuko Miyagoe-Suzuki,Madoka Mori-Yoshimura Pdf

This book presents recent advances in translational research on muscular dystrophy (MD) to physicians and researchers, including cutting-edge research on the disease such as regenerative medicine, next-generation DNA sequencing, and nucleic acid therapies. It also describes the current systems for clinical trials and MD patient databases, resources, which will support the early realization of clinical application and improve patients’ quality of life. MD is the one of the most widely known inherited neuromuscular diseases and is classified into diverse types by symptoms, age of onset, mode of inheritance, and clinical progression. With the development of molecular biology, the occurrence mechanisms of each type of MD are gradually being elucidated. Although there is no known permanent cure yet, the stage of treatment research has now advanced to clinical trials.

Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cells

Carlos Hermano J. Pinheiro,Lucas Guimarães-Ferreira
Frontiers in Skeletal Muscle Wasting Regeneration and Stem Cells Book PDF

Author : Carlos Hermano J. Pinheiro,Lucas Guimarães-Ferreira
Publisher : Frontiers Media SA
Page : 261 pages
File Size : 40,8 Mb
Release : 2016-05-25
Category : Electronic book
ISBN : 9782889198320

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Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cells by Carlos Hermano J. Pinheiro,Lucas Guimarães-Ferreira Pdf

The search for knowledge on cellular and molecular mechanisms involved in skeletal muscle mass homeostasis and regeneration is an exciting scientific area and extremely important to develop therapeutic strategies for neuromuscular disorders and conditions related to muscle wasting. The mechanisms involved in the regulation of skeletal muscle mass and regeneration consist of molecular signaling pathways modulating protein synthesis and degradation, bioenergetics alterations and preserved function of muscle stem cells. In the last years, different kinds of stem cells has been reported to be localized into skeletal muscle (satellite cells, mesoangioblasts, progenitor interstitial cells and others) or migrate from non-muscle sites, such as bone marrow, to muscle tissue in response to injury. In addition, myogenic progenitor cells are also activated in skeletal muscle wasting disorders. The goal of this research topic is to highlight the available knowledge regarding skeletal muscle and stem cell biology in the context of both physiological and pathological conditions. Our purpose herein is to facilitate better dissemination of research into skeletal muscle physiology field. Frontiers in Physiology is a journal indexed in: PubMed Central, Scopus, Google Scholar, DOAJ, CrossRef.

Cancer Models

Michael Breitenbach,Jens Hoffmann
Cancer Models Book PDF

Author : Michael Breitenbach,Jens Hoffmann
Publisher : Frontiers Media SA
Page : 176 pages
File Size : 48,6 Mb
Release : 2019-02-05
Category : Electronic
ISBN : 9782889457014

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Cancer Models by Michael Breitenbach,Jens Hoffmann Pdf

Cancer research, like research on other diseases, highly depends on representative and reliable model systems. In the Research Topic “Cancer Models”, we collected original papers and review articles addressing the topic of tumor modeling from molecular biology, biochemistry, microorganisms, cells and organoids, fishes, animals and xenografts, up to computational cancer models and patient data analysis. This representative eBook describes that there is not a single molecular defined tumor but rather a heterogenic and highly variable complex of different individual diseases. This is what makes research on cancer so difficult, expensive, and explains the broad number of models needed for research. Our authors describe new next-generation sequencing-based methods to analyze complex patterns of chromosomal aberrations in order to understand the molecular biology of tumorigenesis as well as the role of cellular senescence and dormancy in the aetiology of tumor formation and development of therapy resistance of tumors. The current developments on 3D cultures are thoroughly reviewed, as these models help to overcome the current limitations of cell cultures and allow a more accurate mimicry of the native cancer tissue, including cellular heterogeneity and restore specific biochemical and morphological. Reviews about tumor models in zebrafish, different transgenic mouse strains and pigs conclude the book. In the final two chapters of this volume, the authors discuss the theoretical and mathematical models developed in cancer research.

Human Cell Transformation

Johng S. Rhim,Anatoly Dritschilo,Richard Kremer
Human Cell Transformation Book PDF

Author : Johng S. Rhim,Anatoly Dritschilo,Richard Kremer
Publisher : Springer Nature
Page : 246 pages
File Size : 49,5 Mb
Release : 2019-10-01
Category : Science
ISBN : 9783030222543

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Human Cell Transformation by Johng S. Rhim,Anatoly Dritschilo,Richard Kremer Pdf

This book, part contributed volume, part proceedings, discusses state-of-the-art advances on human cell transformation in cell models for the study of cancer and aging. Several of the chapters are from the Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging conference that was held in June 2018 at McGill University. The authors represent international expertise on a wide variety of topics ranging from different types of cancer (prostate, bone, breast, etc.) to tumor microenvironment, tumor progression, homogeneity, and possible therapies and treatments.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

M. A. Hayat
Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging Book PDF

Author : M. A. Hayat
Publisher : Academic Press
Page : 360 pages
File Size : 44,7 Mb
Release : 2013-07-29
Category : Medical
ISBN : 9780124055353

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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by M. A. Hayat Pdf

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections. Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases, there is a great need to understanding its role. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological situations (conditions) mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood. Volumes in the Series

Autophagy and Senescence in Cancer Therapy

Anonim
Autophagy and Senescence in Cancer Therapy Book PDF

Author : Anonim
Publisher : Academic Press
Page : 384 pages
File Size : 55,9 Mb
Release : 2021-04-13
Category : Medical
ISBN : 9780128241592

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Autophagy and Senescence in Cancer Therapy by Anonim Pdf

Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more. Addresses the relationship between autophagy and senescence in cancer therapy Covers autophagy and senescence in tumor dormancy Explores autophagy and senescence in disease recurrence

Cellular Quiescence

H. Daniel Lacorazza
Cellular Quiescence Book PDF

Author : H. Daniel Lacorazza
Publisher : Humana Press
Page : 303 pages
File Size : 51,7 Mb
Release : 2017-10-18
Category : Science
ISBN : 1493973703

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Cellular Quiescence by H. Daniel Lacorazza Pdf

This detailed volume explores methods and protocols that aim to increase our understanding of how cells enter a quiescent state during homeostasis and how cells exit quiescence and re-enter differentiating cell divisions to restore damaged tissues, essential for developing new approaches in regenerative medicine in the future. The chapters in this book were designed to address cellular quiescence in prokaryote and eukaryote organisms, detection of quiescence (Hoechst/pyronin Y, FUCCI, CFSE, BrdU, H2B-GFP, CyTOF), quiescence in stem cells (skin, intestinal, neuronal, hematopoietic), genomic regulation (gene expression, transcription factors, lncRNA, RNA methylation), as well as analysis of the heterogeneity of quiescence by computer modeling. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cellular Quiescence: Methods and Protocols offers a broad view of basic and cutting-edge technology to inspire research in this emerging field of cell biology.

Chromatin Readers in Health and Disease

Olivier Binda
Chromatin Readers in Health and Disease Book PDF

Author : Olivier Binda
Publisher : Academic Press
Page : 422 pages
File Size : 55,5 Mb
Release : 2023-09-29
Category : Medical
ISBN : 9780323903141

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Chromatin Readers in Health and Disease by Olivier Binda Pdf

Chromatin Readers in Health and Disease, Volume 35, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chromatin readers regulate access to genetic information, and how their aberrant regulation can contribute to human pathologies. Chromatin readers discussed include 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR, BRCT, bromodomains and Kac readers, chromodomains and chromobarrel readers, citrullination readers, macrodomains and poly-ADP-ribose readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor and TTD, UDR and ubiquitin, WD40, YEATS (crotonyl reader), MBD, SRA, and Methyl-RNA readers.In the book, more than a dozen leaders in the field examine a range of protein readers, their relationship to human disease, and the early therapeutics that act as chromatin signaling factors to treat cancers and Huntington's disease, among other disorders. Enables researchers and clinicians to understand chromatin signaling mechanisms that regulate gene expression through chromatin readers Highlights the role of chromatin readers in a variety of human pathologies, as well as early therapeutics that act on chromatin signaling Includes chapter contributions from international leaders in the field

Systems Biology of Tumor Dormancy

Heiko Enderling,Nava Almog,Lynn Hlatky
Systems Biology of Tumor Dormancy Book PDF

Author : Heiko Enderling,Nava Almog,Lynn Hlatky
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 42,5 Mb
Release : 2012-11-09
Category : Science
ISBN : 9781461414452

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Systems Biology of Tumor Dormancy by Heiko Enderling,Nava Almog,Lynn Hlatky Pdf

This volume is based on the Workshop on Systems Biology of Tumor Dormancy meeting, held July 25th to July 28th, 2011. The first annual CCSB workshop brought together biologists, clinicians, mathematicians, and computer scientists to discuss various aspects of tumor dormancy and develop novel mathematical/computational models with the keynote speakers. Specific topics included the angiogenic switch, immune system interactions, cancer stem cells and signaling.

The Cancer Stem Cell Niche

Susie Nilsson
The Cancer Stem Cell Niche Book PDF

Author : Susie Nilsson
Publisher : Academic Press
Page : 246 pages
File Size : 50,9 Mb
Release : 2021-02-09
Category : Science
ISBN : 9780323853255

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The Cancer Stem Cell Niche by Susie Nilsson Pdf

The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche

Phospholipases in Physiology and Pathology

Sajal Chakraborti
Phospholipases in Physiology and Pathology Book PDF

Author : Sajal Chakraborti
Publisher : Elsevier
Page : 2974 pages
File Size : 50,6 Mb
Release : 2023-08-01
Category : Science
ISBN : 9780323956888

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Phospholipases in Physiology and Pathology by Sajal Chakraborti Pdf

Phospholipases in Physiology and Pathology presents a comprehensive overview on the physiology and pathology of phospholipases. This seven-volume set considers the biochemical and molecular mechanisms of normal and abnormal cell function upon dysregulation of phospholipases in different diseases. Volumes cover signal transduction mechanisms, implications in cancer, infectious diseases, neural diseases, cardiovascular diseases and other diseases, implications in inflammation, apoptosis, gene expression and non-coding RNAs, the role of natural and synthetic compounds, and stem cell therapies, nanotechnology-based therapies, and more. Together, these volumes give researchers critical insight on the mechanistic and therapeutic aspects of phospholipases. Discusses the biochemical and molecular mechanisms of normal and abnormal cell function in different disease processes Covers a wide range of basic and translational research appropriate for scientists engaged in studying the regulation of phospholipases from interdisciplinary perspectives Features state-of-the-art chapter contributions from international leaders in the field