Targeted Cancer Treatment In Silico

Author : Natalia L. Komarova,Dominik Wodarz
Publisher : Springer Science & Business Media
Page : 235 pages
File Size : 46,7 Mb
Release : 2013-11-19
Category : Mathematics
ISBN : 9781461483014

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Targeted Cancer Treatment in Silico by Natalia L. Komarova,Dominik Wodarz Pdf

Countless medical researchers over the past century have been occupied by the search for a cure of cancer. So far, they have developed and implemented a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, small molecule inhibitors, and oncolytic viruses. However, patterns of these treatments' effectiveness remain largely unclear, and a better understanding of how cancer therapies work has become a key research goal. Cancer Treatment in Silico provides the first in-depth study of approaching this understanding by modeling cancer treatments, both mathematically and through computer simulations. The main goal of this book is to help expose students and researchers to in silico methods of studying cancer. It is intended for both the applied mathematics and experimental oncology communities, as mathematical models are playing an increasingly important role to supplement laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, the work will be a valuable resource for scientists and students alike.

Author : Kenneth K.W. To,William C.S. Cho
Publisher : Academic Press
Page : 460 pages
File Size : 47,9 Mb
Release : 2020-07-29
Category : Science
ISBN : 9780128199039

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Drug Repurposing in Cancer Therapy by Kenneth K.W. To,William C.S. Cho Pdf

Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Author : Rishabha Malviya,Sonali Sundram
Publisher : Springer Nature
Page : 949 pages
File Size : 54,8 Mb
Release : 2023-04-11
Category : Science
ISBN : 9789811997860

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Targeted Cancer Therapy in Biomedical Engineering by Rishabha Malviya,Sonali Sundram Pdf

This book highlights the role of Biomedical Engineering (BME) used in diagnosis (e.g., body scanners) and treatment (radiation therapy and minimal access surgery in order to prevent various diseases). In recent years, an important progress has been made in the expansion of biomedical microdevices which has a major role in diagnosis and therapy of cancer. When fighting cancer, efficacy and speed are of the utmost importance. A recently developed microfluidic chip has enabled a breakthrough in testing the efficacy of specialized cancer drugs. Effective cancer-targeting therapies will require both passive and active targeting strategies and a thorough understanding of physiologic barriers to targeted drug delivery. Targeted cancer treatments in development and the new combinatorial approaches show promise for improving targeted anticancer drug delivery and improving treatment outcomes. This book discusses the advancements and innovations in the field of BME that improve the diagnosis and treatment of cancer. This book is focused on bioengineering approaches to improve targeted delivery for cancer therapeutics, which include particles, targeting moieties, and stimuli-responsive drug release mechanisms. This book is a useful resource for students, researchers, and professionals in BME and medicine.

Author : Girish Kumar Gupta,Mohammad Hassan Baig
Publisher : Walter de Gruyter GmbH & Co KG
Page : 210 pages
File Size : 44,5 Mb
Release : 2022-05-09
Category : Science
ISBN : 9783110493955

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In Silico Chemistry and Biology by Girish Kumar Gupta,Mohammad Hassan Baig Pdf

In Silico Chemistry and Biology: Current and Future Prospects provides a compact overview on recent advances in this highly dynamic branch of chemistry. Various methods of protein modelling and computer-assisted drug design are presented, including fragment- and ligand-based approaches. Many successful practical applications of these techniques are demonstrated. The authors also look to the future and describe the main challenges of the field.

Author : Guido Bocci,Giulio Francia
Publisher : Springer
Page : 302 pages
File Size : 52,7 Mb
Release : 2014-09-04
Category : Medical
ISBN : 9783662436042

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Metronomic Chemotherapy by Guido Bocci,Giulio Francia Pdf

This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Author : Daniela Spano,Aniello Cerrato,George Mattheolabakis
Publisher : Frontiers Media SA
Page : 206 pages
File Size : 46,7 Mb
Release : 2022-03-03
Category : Science
ISBN : 9782889745708

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Combinatorial Approaches for Cancer Treatment: from Basic to Translational Research by Daniela Spano,Aniello Cerrato,George Mattheolabakis Pdf

Author : Chad Brenner
Publisher : MDPI
Page : 418 pages
File Size : 49,7 Mb
Release : 2019-11-20
Category : Medical
ISBN : 9783039217885

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Application of Bioinformatics in Cancers by Chad Brenner Pdf

This collection of 25 research papers comprised of 22 original articles and 3 reviews is brought together from international leaders in bioinformatics and biostatistics. The collection highlights recent computational advances that improve the ability to analyze highly complex data sets to identify factors critical to cancer biology. Novel deep learning algorithms represent an emerging and highly valuable approach for collecting, characterizing and predicting clinical outcomes data. The collection highlights several of these approaches that are likely to become the foundation of research and clinical practice in the future. In fact, many of these technologies reveal new insights about basic cancer mechanisms by integrating data sets and structures that were previously immiscible. Accordingly, the series presented here bring forward a wide range of artificial intelligence approaches and statistical methods that can be applied to imaging and genomics data sets to identify previously unrecognized features that are critical for cancer. Our hope is that these articles will serve as a foundation for future research as the field of cancer biology transitions to integrating electronic health record, imaging, genomics and other complex datasets in order to develop new strategies that improve the overall health of individual patients.

Author : Chen Yi,Ryszard Pluta,Guan Wang,Liang Ouyang,Bo Liu
Publisher : Frontiers Media SA
Page : 158 pages
File Size : 49,5 Mb
Release : 2023-04-17
Category : Science
ISBN : 9782832515747

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Targeting autophagy in cancer therapy: Focus on small-molecule modulators and new strategies by Chen Yi,Ryszard Pluta,Guan Wang,Liang Ouyang,Bo Liu Pdf

Author : Debmalya Barh
Publisher : Springer
Page : 559 pages
File Size : 47,6 Mb
Release : 2014-10-13
Category : Medical
ISBN : 9788132208433

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Omics Approaches in Breast Cancer by Debmalya Barh Pdf

Breast cancer is the most common cancer in females that accounts for highest cancer specific deaths worldwide. In the last few decades research has proven that breast cancer can be treated if diagnosed at early stages and proper therapeutic strategy is adopted. Omics-based recent approaches have unveiled the molecular mechanism behind the breast tumorigenesis and aid in identification of next-generation molecular markers for early diagnosis, prognosis and even the effective targeted therapy. Significant development has taken place in the field of omics in breast cancer in the last decade. The most promising omics approaches and their outcomes in breast cancer have been presented in this book for the first time. The book covers omics technologies and budding fields such as breast cancer miRNA, lipidomics, epigenomics, proteomics, nutrigenomics, stem cell, pharmacogenomics and personalized medicine and many more along with conventional topics such as breast cancer management etc. It is a research-based reference book useful for clinician-scientists, researchers, geneticists and health care industries involved in various aspects of breast cancer. The book will also be useful for students of biomedicine, pathology and pharmacy.

Author : Sotiris Missailidis
Publisher : John Wiley & Sons
Page : 424 pages
File Size : 49,5 Mb
Release : 2008-10-13
Category : Science
ISBN : 9780470697030

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Anticancer Therapeutics by Sotiris Missailidis Pdf

Written by the winner of the 2008 Mike Price Fellowship "This volume provides a comprehensive overview of the wealth of information now available in this important and fast-moving subject." Anticancer Research, November - December 2008 This book provides a clear introduction to the area, with an overview of the various drug design and development approaches for cancer therapeutics and their progress in today’s multidisciplinary approach to cancer treatment. Clearly structured throughout, the book not only provides information on currently used molecular treatment approaches, but also describes the various agents that are currently at various stages of development and clinical trials, thus making them the drugs of tomorrow. The book goes on to present current therapeutic regimes including their indications and side effects, as well as their position in the international market in terms of sales and development costs. Furthermore, coverage of our advancement in the understanding of cancer biology and how this has driven the drug discovery process is clearly discussed. Modern drug discovery aspects, through genomic, proteomic and metabolomic approaches are referred to as well as combinatorial chemistry techniques and discovery of chemotherapeutic agents from plant extracts, re-use of old drugs and drugs from other indications, or de novo rational drug design. Including contributions from leading experts in the field, this book provides the reader with a complete overview of the various types of therapeutic agents, current and emerging, as well as other aspects associated with anticancer therapy, drug design, resistance and clinical trials in oncology.

Author : Mireille Alhouayek,Ester Pagano
Publisher : Frontiers Media SA
Page : 158 pages
File Size : 48,8 Mb
Release : 2022-08-31
Category : Science
ISBN : 9782889768752

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Colorectal Cancer: Targets, Treatment and Prevention by Mireille Alhouayek,Ester Pagano Pdf

Author : Sajal Chakraborti
Publisher : Elsevier
Page : 2974 pages
File Size : 45,6 Mb
Release : 2023-08-01
Category : Science
ISBN : 9780323956888

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Phospholipases in Physiology and Pathology by Sajal Chakraborti Pdf

Phospholipases in Physiology and Pathology presents a comprehensive overview on the physiology and pathology of phospholipases. This seven-volume set considers the biochemical and molecular mechanisms of normal and abnormal cell function upon dysregulation of phospholipases in different diseases. Volumes cover signal transduction mechanisms, implications in cancer, infectious diseases, neural diseases, cardiovascular diseases and other diseases, implications in inflammation, apoptosis, gene expression and non-coding RNAs, the role of natural and synthetic compounds, and stem cell therapies, nanotechnology-based therapies, and more. Together, these volumes give researchers critical insight on the mechanistic and therapeutic aspects of phospholipases. Discusses the biochemical and molecular mechanisms of normal and abnormal cell function in different disease processes Covers a wide range of basic and translational research appropriate for scientists engaged in studying the regulation of phospholipases from interdisciplinary perspectives Features state-of-the-art chapter contributions from international leaders in the field

Author : Zhe-Sheng Chen,Jian-ye Zhang,Yunkai Zhang,Yan-yan Yan
Publisher : Frontiers Media SA
Page : 1123 pages
File Size : 46,8 Mb
Release : 2020-07-22
Category : Electronic
ISBN : 9782889638840

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Targeted Cancer Therapies, From Small Molecules to Antibodies by Zhe-Sheng Chen,Jian-ye Zhang,Yunkai Zhang,Yan-yan Yan Pdf

Author : Fazlul H. Sarkar
Publisher : Springer Science & Business
Page : 349 pages
File Size : 43,9 Mb
Release : 2014-04-22
Category : Medical
ISBN : 9783319051345

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MicroRNA Targeted Cancer Therapy by Fazlul H. Sarkar Pdf

Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book “MicroRNA targeted Cancer therapy” and it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs.

Author : Anonim
Publisher : Elsevier
Page : 496 pages
File Size : 51,5 Mb
Release : 2024-06-30
Category : Electronic
ISBN : 9780443153136

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by Anonim Pdf