Cerebral Signal Transduction

Author : Maarten E. A. Reith
Publisher : Springer Science & Business Media
Page : 423 pages
File Size : 40,5 Mb
Release : 2000-02-16
Category : Medical
ISBN : 9781592590193

Get Book

Cerebral Signal Transduction by Maarten E. A. Reith Pdf

Since the pioneering discovery of cyclic AMP four decades ago, a multitude of signaling pathways have been uncovered in which an extracellular signal (first messenger) impacts the cell surface, thereby triggering a cascade that ultimately acts on the cell nucleus. In each cascade the first messenger gives rise to the appearance of a second messenger such as cyclic AMP, cyclic GMP, or diacylglycerol, which in turn triggers a third messenger, a fourth messenger, and so forth. Many advances in elucidating such pathways have been made, including efforts to link messenger molecules to brain processes operative in health or disease. However, the latter type of information, relating signaling pathways to brain function, is scattered across a variety of publication media, which makes it difficult to integrate the multiple roles of different signaling cascades into our understanding of brain function in health and disease. The primary aim of Cerebral Signal Transduction: From First to Fourth Messengers, therefore, is to offer a comprehensive picture of the recent advances made in the signaling field as it relates to neuronal and cere bral function. The current state of progress provides an exciting opportunity for such a comprehensive focus because molecular tools have become available to selectively remove, reduce, or enhance spe cific components in the signaling pathways, e. g. , by interfering with the genes encoding key proteins. In addition, the increased awareness of crosstalk between different signaling cascades has revealed many possibilities for changes in gene expression underlying long-term changes in brain function.

Author : Masao Ito
Publisher : Elsevier
Page : 310 pages
File Size : 43,7 Mb
Release : 2012-12-02
Category : Self-Help
ISBN : 9780323156585

Get Book

Brain Signal Transduction and Memory by Masao Ito Pdf

Brain Signal Transduction and Memory is a compilation of the proceedings of the Fifth Takeda Science Foundation Symposium on Bioscience, held on November 28-30, 1988, in Kyoto, Japan. The symposium provided a forum for the discussion of a wide range of topics on brain signal transduction and its role in memory formation. Topics covered include the role of phosphoinositides in neural signaling; the homeostasis of calcium ions; the involvement of protein kinase C in brain signal transduction and memory formation; long-term potentiation in the hippocampus; synaptic plasticity and memory; and organization of neural tissues by plasticity. This book is comprised of 21 chapters and begins with an analysis of the phosphoinositide signaling system and how it might function within the nervous system, followed by a discussion on the molecular heterogeneity of the protein kinase C family and its implications for the regulation of neuronal cells. The formation and reorganization of synaptic contacts in the developing nervous system, as well as the factors that influence the plasticity of this process, are then explored. Other chapters focus on the biochemical mechanisms involved in the generation and maintenance of enhanced synaptic transmission; quantal release in the hippocampus; molecular mechanisms of long-term depression in the cerebellum; and cellular mechanisms for reorganization of synaptic inputs after early brain damage. This monograph will appeal to biologists, physiologists, bioscientists, and clinicians.

Author : Maarten E a Reith
Publisher : Unknown
Page : 444 pages
File Size : 53,6 Mb
Release : 2000-02-16
Category : Electronic
ISBN : 146849614X

Get Book

Cerebral Signal Transduction by Maarten E a Reith Pdf

Author : Mark P. Mattson
Publisher : Springer Science & Business Media
Page : 349 pages
File Size : 44,5 Mb
Release : 1997-10-10
Category : Medical
ISBN : 9781592594757

Get Book

Neuroprotective Signal Transduction by Mark P. Mattson Pdf

In Neuroprotective Signal Transduction prominent researchers and clinicians focus on how inter- and intracellular signaling mechanisms prevent the degeneration and death of neurons occurring in both acute and chronic neurodegenerative disorders. Authoritative contributions dissect the signaling pathways of an array of neuroprotective factors-ranging from neurotrophins (NGF, BDNF, NT-3, and NT-4/5), to growth factors (bFGF, IGF-1, GDNF), to cytokines (TNF, IL-1b, and TGFb), to secreted amyloid precursor proteins, to protease nexin-1. Also treated are cytoprotective signaling events that occur within injured neurons independently of intercellular signals. Neuroprotective Signal Transduction presents fundamental, cutting-edge treatment of the cellular and molecular signal transduction pathways found in human neurodegenerative conditions. The book's elucidation of the molecular cascades evolved by the nervous system to protect itself is now lead to effective strategies for preventing neuronal degeneration in such conditions as stroke, traumatic brain injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, and will form the basis for powerful new drug discovery and gene therapy strategies.

Author : S. Kito
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 55,8 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781475759716

Get Book

Neuroreceptors and Signal Transduction by S. Kito Pdf

Since the first Hiroshima Symposium of Neurotransmitter Receptors in 1983, there have been conspicuous advances in this field. For instance, our knowledge on transmembrane signalling mechanism has increased almost exponentially and this great stride has been linking areas of biology that had been previously considered of as being separate. The Second Hiroshima International Neurotransmitter Receptor Symposium was held on October 6 to 9 bringing together an outstanding group of neuroscientists from various disciplines to integrate these advances in the hope that their valuable contributions will make this meeting a tradition in this city. The original title of the Symposium was "Receptor Mechanism of Neurotransmitter and Neuropeptides". This volume is based on papers presented at this Second Hiroshima Symposium. Our aim editing this book is to discuss various neurotransmitter receptors in terms of their structural and biochemical properties, functions, ligands and related intracellular control mechanism, and to know the general denominators of all receptors. The editors believe that this book will provide a useful state-of-the-art summary of neuroreceptor fields at present and profit for those who could not participate in the Hiroshima Conference vicariously by reading the texts included in this volume. The editors acknowledge the help of many friends and colleagues in making this book possible. We are especially grateful to Dr. Shinobu Inagaki, former assistant professor of Third De-partment of Internal Medicine, Hiroshima University School of Medicine who made the Symposium successful as secretary-general through her devoted efforts. In 1988, Dr.

Author : Christer Alling,Ivan Diamond,Steven W. Leslie,Grace Y. Sun,W. Gibson Wood
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 51,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461524700

Get Book

Alcohol, Cell Membranes, and Signal Transduction in Brain by Christer Alling,Ivan Diamond,Steven W. Leslie,Grace Y. Sun,W. Gibson Wood Pdf

Alcohol abuse and alcoholism are international problems whose costs economical ly, psychologically and medically have been well documented. Alcohol is a unique drug in that the effects of excessive use can have a deleterious effect on most if not all organs of the body. The brain is one of the organs most affected by excessive alcohol consumption. Effects on the brain can be seen in cognitive function, brain structure and neurochemistry. Over the past few years, there have been significant advances made in understanding how alcohol affects brain neurochemistry. This book examines four major areas, i. e. , membrane lipids, receptors and ion channels, second messengers, and gene expression, where significant advancements have been made. The book is divided into four sections based on the four major areas. In each section, data are examined that cover a range of approaches from in vitro to in vivo studies. The section on membrane lipids includes recent developments in how ethanol affects membrane cholesterol domains, polyunsaturated fatty acids, the cause and consequences of phosphatidylethanol formation, and the modulation of membrane protein function by lipid-protein interaction. The second section comprises chapters on NMDA and 5-HT3 receptors, including new aspects on alcohol neurotoxicity and the molecular heterogeneity that may underlie differences in alcohol sensitivity as well as chapters on GABA-gated chloride flux, and calcium channels.

Author : Hiroki Ozawa,Toshikazu Saito,Naohiko Takahata
Publisher : Springer Science & Business Media
Page : 213 pages
File Size : 52,7 Mb
Release : 2012-12-06
Category : Psychology
ISBN : 9784431684794

Get Book

Signal Transduction in Affective Disorders by Hiroki Ozawa,Toshikazu Saito,Naohiko Takahata Pdf

Recent progress in brain science has been remarkable, especially with regard to advances in the area of neuroscience. Particularly in the past decade, there have been many important discoveries about signal transduction in the brain. With this background, biological research in affective disorders has become well developed in relation to neural signaling. However, this field is fairly hard to understand comprehensively, and there is relatively little integrative work with clinical psychiatry in spite of the involvement of a wide variety of scien tific disciplines. This monograph brings together up-to-date reviews from several young Japanese scientists who work in basic and clinical neuroscience. The intention is to explain in plain language the information that has evolved on signal transduction in terms of the biological abnormalities and mechanisms of anti depressants. The model shown on the cover (and on page 24) is intended to help the reader understand signal transduction in the brain and the patho physiology of affective disorders as well as the mechanisms of antidepressants.

Author : Eric J. Nestler,Steven E. Hyman,Robert Malenka
Publisher : McGraw Hill Professional
Page : 570 pages
File Size : 47,9 Mb
Release : 2001-03-28
Category : Medical
ISBN : 0838563791

Get Book

Molecular Basis of Neuropharmacology : A Foundation for Clinical Neuroscience by Eric J. Nestler,Steven E. Hyman,Robert Malenka Pdf

* The most up-to-date and comprehensive coverage of the relationship of brain function and neuroactive chemicals * Authors are world-known leaders in the field * Molecular Neuropharmacology is the hot topic in medicine

Author : Gunnar Tiger
Publisher : Unknown
Page : 52 pages
File Size : 50,7 Mb
Release : 1990
Category : Cellular signal transduction
ISBN : 9171745041

Get Book

Signal Transduction in the Brain by Gunnar Tiger Pdf

Author : Fredrik Lennmyr
Publisher : Unknown
Page : 55 pages
File Size : 45,7 Mb
Release : 2002
Category : Electronic
ISBN : 9155452671

Get Book

Signal transduction in focal cerebral ischemia by Fredrik Lennmyr Pdf

Author : Stanislav Tregub
Publisher : STANISLAV TREGUB
Page : 184 pages
File Size : 49,8 Mb
Release : 2020-08-08
Category : Science
ISBN : 9785604473948

Get Book

Algorithm of the Mind by Stanislav Tregub Pdf

Based on a clear physical definition of the Mind given in the previous volume of the “Symphony of Matter and Mind” series, the author begins to formulate a unified concept of the Brain and Mind which will be developed in this and subsequent volumes. All mental phenomena, from basic sensory-motor to higher abstract-verbal, are the result of neural encoding of the external world signals and internal bodily signals into representations constituting the model of reality for the purpose of controlling the body and adapting to this reality. Thus, any theory of the brain faces the question of the nature of the neural code which could explain the observed speed and efficiency, scope and complexity of the computational process that we call the Mind. The mainstream theories of neuroscience that consider neural activity as trains of discrete identical spikes (various firing rate coding and temporal coding models) contradict the reality of the information density of neural computing. That is why, despite huge efforts by generations of researchers, this approach did not lead to deciphering the neural code. We know the details of the neural processes down to the molecular level but the brain remains a ‘black box’ that we cannot read. It is the outcome of the wrong theoretical assumption that should be revised. The author creates the concept of a neural code that overcomes the shortcomings of old models. There is another problem that cannot be avoided by any theory of consciousness. It is not enough to say that the brain creates the psyche as this leaves an explanatory gap. We need to show how this physiological system generates mental phenomena physically. The Mind is a technological process that works according to a certain algorithm based on physical laws. The author’s theory offers a fundamentally new approach to the nervous system that bridges physiology and psychology by illuminating the algorithm and the physics of the Mind from the intracellular to the system-wide level.

Author : Jennifer N. Meyers
Publisher : Nova Publishers
Page : 270 pages
File Size : 43,6 Mb
Release : 2007
Category : Cell interaction
ISBN : 1600213758

Get Book

Trends in Signal Transduction Research by Jennifer N. Meyers Pdf

Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.

Author : Emmanuel Valjent
Publisher : Frontiers E-books
Page : 216 pages
File Size : 54,8 Mb
Release : 2024-07-03
Category : Electronic
ISBN : 9782889190706

Get Book

Striatal Signaling: Two Decades of Progress by Emmanuel Valjent Pdf

This Research Topic aims to highlight and cover recent understanding on striatal signaling pathways, which are activated by a variety of therapeutic agents or drugs of abuse in physiological and pathological context. The recent development of different mouse models allowing the identification of specific cell types and neuronal circuits in which a given signaling pathway is activated in various physiological and pathological conditions provides essential information and allowed to untangle the complexity of study signal transduction in the brain in vivo.

Author : Oliver von Bohlen und Halbach,Rolf Dermietzel
Publisher : John Wiley & Sons
Page : 402 pages
File Size : 48,9 Mb
Release : 2006-12-13
Category : Medical
ISBN : 9783527609079

Get Book

Neurotransmitters and Neuromodulators by Oliver von Bohlen und Halbach,Rolf Dermietzel Pdf

A complete update of the highly acclaimed handbook with data on all neurotransmitters and the majority of neuromodulators. The coverage is now even more comprehensive, with 15% more entries on neuropeptides, "classic" neurotransmitters and related substances in a clear, alphabetical format. The methodological section has been expanded by 50% and now includes color figures, plus new chapters on genomics, proteomics, databases, microarrays, MALDI-TOF, neutrophins, FGF, endocannabinoids and neuroimaging. The text provides clearly structured information on the biosynthesis and degradation, localization, receptors, signal transduction pathways, and biological effects in the central nervous system, with all substances uniformly treated for an easy comparison of data. Furthermore, introductory chapters on receptors, transporters, and the blood-brain barrier make this an indispensable tool for researchers, teachers, and advanced students, as well as a must-have for every neuroscientist.

Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 74 pages
File Size : 50,8 Mb
Release : 2011-08-05
Category : Medical
ISBN : 9780309212212

Get Book

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System by Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.