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Challenges in Pancreatic Cancer by Borislav Vladimirov,Mila Kovacheva-Slavova Pdf
Pancreatic cancer is one of the most lethal solid organ tumors with a poor five-year survival rate despite current oncological advances. The early and proper diagnosis of pancreatic cancer is of great importance for the improvement of the overall prognosis. This book provides an overview of the current challenges and states of pancreatic cancer and pancreatic neuroendocrine tumors, including information on diagnostic tools, treatment strategies, and mechanisms of pancreatic cancer therapy resistance.
Management of Localized Pancreatic Cancer by Susan Tsai,Paul S. Ritch,Beth A. Erickson,Douglas B. Evans Pdf
This book is designed to present a comprehensive understanding for the rationale of neoadjuvant treatment sequencing for localized pancreatic cancer and to focus on accurate clinical staging and stage-specific treatment sequencing. Sections address important aspects of clinical management of localized pancreatic cancer from diagnosis to surgery. These areas include initial radiographic staging, management of obstructive jaundice, role of chemotherapy and chemoradiation in neoadjuvant therapy, assessment of treatment response, and operative considerations for complex vascular resections. A brief review of suggested readings addressing the particular topic follows in each section, as well as a summary of clinical “pearls”. Management of Localized Pancreatic Cancer: Current Treatment and Challenges provides a comprehensive resource which clearly defines the principles of neoadjuvant therapy as well as a clinical framework for successful therapy. It serves as a valuable guide to physicians of multiple disciplines who are interested in utilizing neoadjuvant therapy for localized pancreatic cancer.
Theranostic Approach for Pancreatic Cancer by Ganji Purnachandra Nagaraju,Sarfraz Ahmad Pdf
Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. This book discusses several topics related to pancreatic cancer such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy. Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer. Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancer Discusses treatment options available currently as well as prospective options for the future Focuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment
"Pancreatic Cancer: A Comprehensive Resource for Patients and Families" is an essential guide for anyone affected by this challenging disease. This meticulously crafted book offers an in-depth look into the world of pancreatic cancer, providing valuable insights and support for patients, their families, and caregivers.Structured into a number of thoughtfully organized chapters, this book covers a wide range of critical topics:Begin your journey with an understanding of Pancreatic Cancer, exploring its biology, types, and the risk factors involved.Learn about Symptoms and Early Detection to recognize signs and the importance of timely diagnosis.The Diagnosis of Pancreatic Cancer chapter navigates through the complex processes of imaging, biopsies, and the significance of staging.Delve into Treatment Options, discussing the nuances of surgery, radiation, chemotherapy, and newer therapies like immunotherapy.Managing Side Effects and Complications offers practical advice on dealing with treatment's physical and emotional impacts.Advanced and Metastatic Pancreatic Cancer addresses the challenges of more severe cases and focuses on palliative care.Stay informed about the latest advancements with a chapter on Clinical Trials and Research.The Role of Genetics in pancreatic cancer is demystified, providing insights into familial risks and genetic testing.Emphasize Prevention and healthy living through chapters on Lifestyle and Prevention.Find solace and support with our comprehensive guide on Support for Patients and Families, discussing emotional coping strategies and caregiver roles.Navigate the often-overlooked Legal and Financial Issues that arise with long-term illness.End-of-Life Care provides sensitive and practical advice for making difficult decisions.Survivors and Life After Treatment focuses on the challenges and triumphs post-treatment.Finally, look towards the Future of Pancreatic Cancer Treatment, exploring emerging therapies and the promise of personalized medicine."Packed with information and practical advice, 'Pancreatic Cancer: A Comprehensive Resource for Patients and Families' is more than just a book; it's a companion in your journey, offering hope, understanding, and guidance through every stage of this illness. This book is an invaluable tool for anyone touched by pancreatic cancer, whether you are a patient, a loved one, or a medical professional seeking to provide the best care and support."
Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy by Ganji Purnachandra Nagaraju Pdf
Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy edited by Dr. Nagaraju, PhD., DSc. focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy. Modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property by introducing new strategies and drugs Provides information about on-going research as well as clinical data on pancreatic cancer and detailed descriptions about therapeutic options for easy understanding Utilizes full color figures to help the understanding of the content and tables for easy comparison of information as well as quick access to it
Challenges in Pancreatic Pathology by Andrada Seicean Pdf
The assessment of the pancreas is a challenging problem because it has a profound location and it often presents difficulties in diagnosis and treatment. Despite many efforts in dealing with pancreatic diseases, the pathogenesis is not completely understood, the symptoms and imaging methods are unspecific, and the treatment possibilities are sometimes very limited. The major purpose of this book is to offer the reader a better understanding of the challenging aspects in pancreatic pathology, starting with anatomy and following with different pancreatic pathology. More space is allotted to pancreatic cancer, including surgical procedures, and to the management of the cystic lesions of the pancreas. This book is meant to provide a thorough guide for the best approaches in some of the difficult problems in pancreatology.
Pancreatic cancer is a challenging and complex disease characterized by a dense fibrotic stroma and an immunosuppressive tumor microenvironment. Until recently, there were no predictive biomarkers to personalize selection of targeted or biologic therapies as a part of standard of care treatment. Moreover, the regulatory immune population of cells creates a “cold”, non-immunogenic tumor that is resistant to immunotherapies including checkpoint inhibitors. However, in the last few years, there has been substantial progress in our understanding of the role mutations in the pathogenesis of disease leading to increased adoption of germline and next generation sequencing to identify mutations and fusions to optimize selection of therapies and select patients for clinical trials of targeted agents. This book provides a comprehensive, global overview on therapy for pancreatic cancer, exploring approved therapies and focusing on the “Next” in drug development including molecularly targeted therapy and efforts at “Drugging the Undruggable”: the KRAS mutation. It also addresses efforts at targeting the inhospitable stroma to improve drug delivery to the tumor cells, incorporating ct DNA (liquid biopsies) in the care of patients and recent advances in immunotherapy. Pancreatic Cancer: Current Therapeutics and Future Directions will illuminate these challenges, review existing therapeutics, and highlight current and future efforts to improve outcomes in this devastating disease. Useful to physicians, fellows, medical students, residents, physician assistants, nurse practitioners, pharmaceutical companies and researchers interested in pancreatic cancer, it will first explain management of localized disease including resectability and adjuvant and neoadjuvant therapies. Targeted therapies including molecular, immunotherapy, stroma and role of ctDNA or “liquid biopsies” will be addressed. Finally, the book will explore the important role of pain management, diet and exercise in improving outcomes in pancreatic cancer.
Translational Pancreatic Cancer Research by Christoph W. Michalski,Jonas Rosendahl,Patrick Michl,Jörg Kleeff Pdf
This book incorporates a multi-disciplinary approach to present how research results can be translated into clinical trials. The first part begins with a chapter on variants of pancreatic cancer, precursor lesions and groups of people at risk to developing the disease. There is a particular focus on intraductal papillary mucinous neoplasia as a large-scale clinical challenge in pancreatology. The next two parts focus on diagnosis, biomarkers and stratification that emphasize how various approaches to biomarker development are important as both prognostic and predictive tools. The final part consists of personalized treatment approaches that include preclinical models of pancreatic cancer and stromal, epigenetic and metabolism targeting as promising approaches to be translated into early phase clinical trials. Chapters within this part also deal with approaches that are close to being implemented in clinical practice or are already being tested in (early) clinical trials, such as those that targeting the immune systems and strategies to overcome immunotherapy resistance; phase 1 clinical trials and translational approaches in surgical treatment. Written by experts in their fields, Translational Pancreatic Cancer Research provides an outlook towards future directions by integrating information both from basic and clinical research and though demonstrating pathways to better understanding pancreatic cancer and current approaches to translating these into clinical practice.
INTRODUCTION TO PANCREATIC CANCER Pancreatic cancer is a sickness that affects hundreds of humans each year. It is regarded as one of the most deadly varieties of cancer, with a survival rate that is among the lowest of all cancers. Despite the severity of this ailment, there may be tons to be found out about its causes, symptoms, and capacity remedies. we can look at the outlook for pancreatic cancer and explore some state-of-the-art research and trends within the field. Whether or not this disorder has tormented you or a loved one or you're truly curious about learning more about it, this publication will provide precious insights into the present-day state of knowledge regarding pancreatic cancer. Pancreatic cancer is a growing concern in the clinical community, and for good reason. This type of cancer is notoriously tough to detect and deal with, and it has one of the lowest 5-year survival rates of all important cancers. Despite these challenges, there is reason to wish. Researchers and scientific professionals are operating tirelessly to better apprehend the disorder and broaden new treatments that may enhance its effects for sufferers. we can explore the outlook for pancreatic cancers and what the future may additionally hold for those laid low with this devastating disease. Pancreatic cancer is a subject that has been making headlines recently because of its increasing occurrence and devastating impact on people and their families. At the same time, as many may have heard of this sort of cancer, not everyone knows the overall outlook. we will explore the outlook of pancreatic cancer and offer treasured facts and insights for all people searching for a better understanding of this disease. Whether or not you're a person who has, in my view, been laid low with pancreatic cancer or genuinely interested in getting to know more about it, this article is for you. Pancreatic cancer is a disorder that has affected humans of all ages and backgrounds. It's a complex and devastating infection regularly presents challenges in its prognosis and treatment. Although there have been sizable strides in research and treatment alternatives, pancreatic cancer remains one of the most difficult cancers to control. This article will explore the outlook for pancreatic cancers and offer insights into modern-day developments within the discipline. Whether or not this ailment has impacted you or someone you realize, we hope this text will provide valuable statistics and assist in enhancing cognizance of this essential health difficulty. Pancreatic cancer is a subject that has been gaining greater interest in recent years due to its excessive mortality rate and increasing prevalence. It's a complex disorder that may be difficult to diagnose and treat, making it all the more important to understand and appreciate the early warning symptoms. we can discover the outlook of pancreatic cancer, discussing its occurrence, causes, and potential treatment alternatives. Whether or not you are genuinely curious about this disorder or have a personal connection to it, this will offer valuable insights into the current state of pancreatic cancer studies and remedies.
Institute of Medicine,Committee on Health Care for Homeless People
Author : Institute of Medicine,Committee on Health Care for Homeless People Publisher : National Academies Press Page : 257 pages File Size : 54,9 Mb Release : 1988-02-01 Category : Medical ISBN : 9780309038324
Homelessness, Health, and Human Needs by Institute of Medicine,Committee on Health Care for Homeless People Pdf
There have always been homeless people in the United States, but their plight has only recently stirred widespread public reaction and concern. Part of this new recognition stems from the problem's prevalence: the number of homeless individuals, while hard to pin down exactly, is rising. In light of this, Congress asked the Institute of Medicine to find out whether existing health care programs were ignoring the homeless or delivering care to them inefficiently. This book is the report prepared by a committee of experts who examined these problems through visits to city slums and impoverished rural areas, and through an analysis of papers written by leading scholars in the field.
Exploring Pancreatic Metabolism and Malignancy by Ganji Purnachandra Nagaraju,Aramati BM Reddy Pdf
This book comprehensively describes the association between metabolic syndrome and pancreatic cancer progression, and the mechanism of action and target definition with a view to drug discovery. Metabolic syndrome, which includes adnominal obesity, hypertension, dyslipidemia, and hyperglycemia, has recently been shown to play an important role in the etiology and progression of various cancers. Further, obesity and diabetes have been associated with an increased incidence of gastric cancers. The book reviews the key biological mechanisms underlying the association between metabolic dysregulation, including obesity-associated enhancement of growth factor signaling, inflammation, and perturbation in pancreatic cancer cell growth and metastasis. It also illustrates the role of the inflammatory signaling pathway in metabolic diseases as well as tumor growth and explores the potential of these pathways as the rational targets for pancreatic cancer therapy. Lastly, the book offers a comprehensive description of the challenges associated with diabetes and pancreatic cancer therapy.
Clinical Pancreatology for Practising Gastroenterologists and Surgeons by Juan Enrique Dominguez-Munoz Pdf
Clinical Pancreatology Since the book Clinical Pancreatology for Practising Gastroenterologists and Surgeons was first published sixteen years ago, the knowledge and clinical management of pancreatic diseases have developed markedly. Thanks to the development of the translational research and the from bench to bedside concept, much progress from the lab has been applied to clinical practice. In addition, several highly relevant clinical trials published over the last years have resulted in the update and optimisation of clinical guidelines. A new and validated classification of severity and complications of acute pancreatitis is firmly rooted in clinical practice and has been the basis for the development of minimally invasive approaches to pancreatic necrosis. The etiopathogenic knowledge of chronic pancreatitis and other pancreatopaties, like that associated with diabetes mellitus, has developed significantly. Especially important has been the development of the field of cystic pancreatic tumours, which has been reflected in the publication of several guidelines and consensus reports over the last few years. Most research efforts have focused on pancreatic cancer, which have led and will further lead to a significant increase in the therapeutic armamentarium against this devastating disease. Finally, many newly published studies have changed the concept, causes, clinical relevance, diagnosis and treatment of exocrine pancreatic insufficiency. This new edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons has enjoyed the collaboration of the world’s leading experts in each of the areas of clinical pancreatology with the aim of facilitating gastroenterologists, surgeons, oncologists, internists, nutritionists, diabetologists, paediatricians, radiologists, pathologists and other specialists in their decision making when facing patients with pancreatic diseases in their daily clinical practice. All in all, this book supplies an indispensable update of the relevant aspects of clinical pancreatology.
This book covers pancreatic cancer risk factors, treatment and clinical procedures. It provides an outline of pancreatic cancer genetic risk factors, biomarkers and systems biology for the better understanding of disease. As pancreatic cancer suffers from lack of early diagnosis or prognosis markers, this book encompasses stem cell and genetic makers to identify the disease in early stages. The book uncovers the rationale and effectiveness of monotherapy and combination therapy in combating the devastating disease. As immunotherapy is emerging as an attractive approach to cease pancreatic cancer progression, the present book covers various aspects of immunotherapy including innate, adaptive, active, passive and bacterial approaches. Management of anesthesia during surgery and pain after surgery has been discussed. Book also takes the reader through the role of endoscopy and fine needle guided biopsies in diagnosing and observing the disease progression.
