Chemical Biology Of Nucleic Acids

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The Chemical Biology of Nucleic Acids

Günter Mayer
The Chemical Biology of Nucleic Acids Book PDF

Author : Günter Mayer
Publisher : John Wiley & Sons
Page : 595 pages
File Size : 55,7 Mb
Release : 2011-06-17
Category : Science
ISBN : 9781119957263

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The Chemical Biology of Nucleic Acids by Günter Mayer Pdf

With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

Nucleic Acids in Chemistry and Biology

G Michael Blackburn,Michael J Gait,David Loakes,David M Williams
Nucleic Acids in Chemistry and Biology Book PDF

Author : G Michael Blackburn,Michael J Gait,David Loakes,David M Williams
Publisher : Royal Society of Chemistry
Page : 824 pages
File Size : 47,5 Mb
Release : 2015-11-09
Category : Science
ISBN : 9781782625773

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Nucleic Acids in Chemistry and Biology by G Michael Blackburn,Michael J Gait,David Loakes,David M Williams Pdf

The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

Chemical Biology of Nucleic Acids

Volker A. Erdmann,Wojciech T. Markiewicz,Jan Barciszewski
Chemical Biology of Nucleic Acids Book PDF

Author : Volker A. Erdmann,Wojciech T. Markiewicz,Jan Barciszewski
Publisher : Springer Science & Business
Page : 599 pages
File Size : 44,6 Mb
Release : 2014-04-22
Category : Science
ISBN : 9783642544521

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Chemical Biology of Nucleic Acids by Volker A. Erdmann,Wojciech T. Markiewicz,Jan Barciszewski Pdf

This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.

Nucleic Acids in Medicinal Chemistry and Chemical Biology

Lihe Zhang,Xinjing Tang,Zhen Xi,Jyoti Chattopadhyaya
Nucleic Acids in Medicinal Chemistry and Chemical Biology Book PDF

Author : Lihe Zhang,Xinjing Tang,Zhen Xi,Jyoti Chattopadhyaya
Publisher : John Wiley & Sons
Page : 564 pages
File Size : 42,5 Mb
Release : 2022-12-15
Category : Science
ISBN : 9781119692782

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Nucleic Acids in Medicinal Chemistry and Chemical Biology by Lihe Zhang,Xinjing Tang,Zhen Xi,Jyoti Chattopadhyaya Pdf

Nucleic Acids in Medicinal Chemistry and Chemical Biology An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field. Readers will also find: A thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistry Comprehensive explorations of the methods used to determine the development of nucleic acid drugs Practical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical libraries In-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistry Perfect for medicinal and nucleic acid chemists, Nucleic Acids in Medicinal Chemistry and Chemical Biology will also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.

Nucleic Acids in Chemistry and Biology

G. Michael Blackburn,Michael J. Gait
Nucleic Acids in Chemistry and Biology Book PDF

Author : G. Michael Blackburn,Michael J. Gait
Publisher : Irl Press
Page : 528 pages
File Size : 40,7 Mb
Release : 1996
Category : Science
ISBN : 0199635331

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Nucleic Acids in Chemistry and Biology by G. Michael Blackburn,Michael J. Gait Pdf

Since the discovery of the DNA double helix in 1953, nucleic acids have formed the central theme of much of contemporary molecular science. Nowhere is this more apparent than in the increasing efforts to determine the DNA sequence of the human genome and the development of new diagnostics of genetic disease. Recent sophistication of nucleic acids synthesis has been key to the establishment of the biotechnology industry and our improving knowledge of nucleic acid structures and interactions is noticeably influencing the design of novel drugs.This second and completely revised edition draws on the expertise of the same international group of authors to set the basics of the nucleic acids in the context of the expanding horizons set by modern structural biology, RNA enzymology, drug discovery and biotechnology.

Chemistry and Biology of Artificial Nucleic Acids

Martin Egli,Piet Herdewijn
Chemistry and Biology of Artificial Nucleic Acids Book PDF

Author : Martin Egli,Piet Herdewijn
Publisher : Wiley-VCH
Page : 0 pages
File Size : 53,8 Mb
Release : 2012-04-16
Category : Science
ISBN : 3906390675

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Chemistry and Biology of Artificial Nucleic Acids by Martin Egli,Piet Herdewijn Pdf

This is the first book to provide a comprehensive overview of the field of artificial nucleic acids. Covering a tremendous amount of literature on the chemistry, biology, and structure of artificial nucleic acids, it will constitute an invaluable source of information for the specialist and for young researchers interested in starting a career in this fascinating field of research alike. This book combines the contributions of many of the major players in this research field, and covers the synthesis of sugar-, base- and backbone-modified nucleic acids, their structural characteristics studied by X-ray crystallography, and NMR in solution as well as their chemical and biological properties.

Nucleic Acids in Medicinal Chemistry and Chemical Biology

Lihe Zhang,Xinjing Tang,Zhen Xi,Jyoti Chattopadhyaya
Nucleic Acids in Medicinal Chemistry and Chemical Biology Book PDF

Author : Lihe Zhang,Xinjing Tang,Zhen Xi,Jyoti Chattopadhyaya
Publisher : John Wiley & Sons
Page : 564 pages
File Size : 51,8 Mb
Release : 2023-01-05
Category : Science
ISBN : 9781119692744

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Nucleic Acids in Medicinal Chemistry and Chemical Biology by Lihe Zhang,Xinjing Tang,Zhen Xi,Jyoti Chattopadhyaya Pdf

Nucleic Acids in Medicinal Chemistry and Chemical Biology An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field. Readers will also find: A thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistry Comprehensive explorations of the methods used to determine the development of nucleic acid drugs Practical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical libraries In-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistry Perfect for medicinal and nucleic acid chemists, Nucleic Acids in Medicinal Chemistry and Chemical Biology will also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.

Nucleic Acids in Chemistry and Biology

G Michael Blackburn,Martin Egli,Michael J Gait,Jonathan K Watts
Nucleic Acids in Chemistry and Biology Book PDF

Author : G Michael Blackburn,Martin Egli,Michael J Gait,Jonathan K Watts
Publisher : Royal Society of Chemistry
Page : 774 pages
File Size : 45,6 Mb
Release : 2022-06-24
Category : Science
ISBN : 9781839163241

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Nucleic Acids in Chemistry and Biology by G Michael Blackburn,Martin Egli,Michael J Gait,Jonathan K Watts Pdf

The structure, function and reactions of nucleic acids are central to molecular biology and medicine and are crucial for understanding of the ever-expanding range of complex biological processes involved which are central to life. Revised, extended, updated and lavishly illustrated, this 4th Edition of Nucleic Acids in Chemistry and Biology is a long-awaited standard text for teaching and research in nucleic acids science. It maintains the close integration of chemistry and biology that characterised the earlier editions and contains a major expansion largely focused on the burgeoning growth of RNA science. Written by an international team of leading experts, all with extensive teaching experience, this 4th Edition provides up-to-date and extended coverage of the reactions and interactions of RNA and DNA with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecule-based introduction to the structure and biological roles of DNA and RNA and the basics of Genes and Genomes. New key chapters are devoted to non-coding RNA, nucleic acids sequencing, nucleic acid therapeutics, in vitro evolution and aptamers, and protein-RNA interactions. The text is linked to an extensive list of references to make it a definitive reference source. This authoritative volume presents topics in an integrated manner and readable style with full colour illustrations throughout. It is ideal for graduate and undergraduate students of chemistry and biochemistry, biophysics and biotechnology, and molecular biology and medicine. It will be a guidebook for new researchers to the field of nucleic acids science.

Chemistry and Biology of Non-canonical Nucleic Acids

Naoki Sugimoto
Chemistry and Biology of Non canonical Nucleic Acids Book PDF

Author : Naoki Sugimoto
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 51,7 Mb
Release : 2021-06-01
Category : Science
ISBN : 9783527345212

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Chemistry and Biology of Non-canonical Nucleic Acids by Naoki Sugimoto Pdf

Discover the fundamentals and intricacies of a subject at the interface of chemistry and biology with this authoritative resource Chemistry and Biology of Non-canonical Nucleic Acids delivers a comprehensive treatment of the chemistry and biology of non-canonical nucleic acids, including their history, structures, stabilities, properties, and functions. You'll learn about the role of these vital compounds in transcription, translation, regulation, telomeres, helicases, cancers, neurodegenerative diseases, therapeutic applications, nanotechnology, and more. An ideal resource for graduate students, researchers in physical, organic, analytical, and inorganic chemistry will learn about uncommon nucleic acids, become the common non-canonical nucleic acids that fascinate and engage academics and professionals in private industry. Split into 15 chapters covering a wide range of aspects of non-canonical nucleic acids, the book explains why these compounds exist at the forefront of a new research revolution at the intersection of chemistry and biology. Chemistry and Biology of Non-canonical Nucleic Acids also covers a broad range of topics critical to understanding these versatile and omnipresent chemicals, including: * A discussion of the dynamic regulation of biosystems by nucleic acids with non-canonical structures * The role played by nucleic acid structures in neurodegenerative diseases and various cancers * An exploration of the future outlook for the chemistry and biology of non-canonical nucleic acids * An introduction to the history of canonical and non-canonical structures of nucleic acids * An analysis of the physicochemical properties of non-canonical nucleic acids Perfect for biochemists, materials scientists, and bioengineers, Chemistry and Biology of Non-canonical Nucleic Acids will also earn a place in the libraries of medicinal and pharmaceutical chemists who wish to improve their understanding of life processes and the role that non-canonical nucleic acids play in them.

Advanced Organic Chemistry of Nucleic Acids

Zoe A. Shabarova,Alexey A. Bogdanov
Advanced Organic Chemistry of Nucleic Acids Book PDF

Author : Zoe A. Shabarova,Alexey A. Bogdanov
Publisher : John Wiley & Sons
Page : 603 pages
File Size : 50,6 Mb
Release : 2008-07-11
Category : Science
ISBN : 9783527615926

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Advanced Organic Chemistry of Nucleic Acids by Zoe A. Shabarova,Alexey A. Bogdanov Pdf

Sequencing, cloning, transcription - these are but a few key techniques behind the current breathtaking advances in molecular biology and biochemistry. As these methods continuosly diversify, biochemists need a sound chemical understanding to keep the pace. Chemists beginning working in the molecular biology lab need an introduction to this field from their point of view. This book serves both: it describes most of the known chemical reactions of nucleosides, nucleotides, and nucleic acids in sufficient detail to provide the desired background, and additionally, the fundamental relations between sequence, structure and functionality of nucleic acids are presented. The first edition of this book, which was published in Russian, has immediately become a recognized standard reference. This second, thoroughly revised and updated edition, now published in English, is likely to achieve a similar position in the international scientific community.

Organic Chemistry of Nucleic Acids

N. Kochetkov
Organic Chemistry of Nucleic Acids Book PDF

Author : N. Kochetkov
Publisher : Springer Science & Business Media
Page : 382 pages
File Size : 41,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468429732

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Organic Chemistry of Nucleic Acids by N. Kochetkov Pdf

The study of nucleic acids is one of the most rapidly developing fields in modern science. The exceptionally important role of the nucleic acids as a key to the understanding of the nature of life is reflected in the enormous number of published works on the subject, including many outstanding monographs and surveys. The pathways of syn thesis and metabolism of nucleic acid,s and the many and varied biological functions of these biopolymers are examined with the utmost detail in the literature. Nearly as much attention has been paid to the macromolecular chemistry of the nucleic acids: elucidation of the size and shape of their molecules, the study of the physicochemical properties of their solutions, and the appropriate methods to be used in such research. The surveys of the chemistry of nucleic acids which have been published so far deal almost entirely with their synthesis and, in particular, with the synthetic chemistry of monomers (nucleosides and nucleotides) ; less attention has been paid to the synthesis of poly nucleotides. There is yet another highly important aspect of the chemistry of nucleic acids which is still in the formative stage, the study of the reactivity of nucleic acid macromolecules and their components. This can make an important contribution to the deter mination of the structure of these remarkable biopolymers and to the correct understanding of their biological functions.

The Chemical Biology of Nucleic Acids

Günter Mayer
The Chemical Biology of Nucleic Acids Book PDF

Author : Günter Mayer
Publisher : Wiley
Page : 478 pages
File Size : 42,9 Mb
Release : 2010-07-13
Category : Science
ISBN : 0470519746

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The Chemical Biology of Nucleic Acids by Günter Mayer Pdf

With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

Bioorganic Chemistry: Nucleic Acids

Sidney M. Hecht
Bioorganic Chemistry Nucleic Acids Book PDF

Author : Sidney M. Hecht
Publisher : OUP USA
Page : 516 pages
File Size : 55,6 Mb
Release : 1996-07-11
Category : Science
ISBN : 0195084675

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Bioorganic Chemistry: Nucleic Acids by Sidney M. Hecht Pdf

This book provides an overview of DNA and RNA including coverage of biosynthesis, stucture, and their functions in information storage and transmission. A review of fundamental material is presented in the first half of each chapter followed by a fairly detailed research example selected by the chapter author from current research.

Computational Tools for Chemical Biology

Sonsoles Martín-Santamaría
Computational Tools for Chemical Biology Book PDF

Author : Sonsoles Martín-Santamaría
Publisher : Royal Society of Chemistry
Page : 392 pages
File Size : 53,7 Mb
Release : 2017-11-01
Category : Science
ISBN : 9781782627005

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Computational Tools for Chemical Biology by Sonsoles Martín-Santamaría Pdf

This book offers a fresh perspective on how computational tools can aid the chemical biology research community and drive new research.

Nucleic Acids

Victor A. Bloomfield,Donald M. Crothers,Ignacio Tinoco
Nucleic Acids Book PDF

Author : Victor A. Bloomfield,Donald M. Crothers,Ignacio Tinoco
Publisher : Sterling Publishing Company
Page : 854 pages
File Size : 41,9 Mb
Release : 2000-04-17
Category : Science
ISBN : 0935702490

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Nucleic Acids by Victor A. Bloomfield,Donald M. Crothers,Ignacio Tinoco Pdf

Providing a comprehensive account of the structures and physical chemistry properties of nucleic acids, with special emphasis on biological function, this text has been organized to meet the needs of those who have only a basic understanding of physical chemistry and molecular biology.