Nucleic Acids In Medicinal Chemistry And Chemical Biology

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Nucleic Acids in Medicinal Chemistry and Chemical Biology

Lihe Zhang,Xinjing Tang,Zhen Xi,Jyoti Chattopadhyaya
Nucleic Acids in Medicinal Chemistry and Chemical Biology Book PDF

Author : Lihe Zhang,Xinjing Tang,Zhen Xi,Jyoti Chattopadhyaya
Publisher : John Wiley & Sons
Page : 564 pages
File Size : 45,6 Mb
Release : 2023-01-05
Category : Science
ISBN : 9781119692744

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Nucleic Acids in Medicinal Chemistry and Chemical Biology by Lihe Zhang,Xinjing Tang,Zhen Xi,Jyoti Chattopadhyaya Pdf

Nucleic Acids in Medicinal Chemistry and Chemical Biology An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field. Readers will also find: A thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistry Comprehensive explorations of the methods used to determine the development of nucleic acid drugs Practical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical libraries In-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistry Perfect for medicinal and nucleic acid chemists, Nucleic Acids in Medicinal Chemistry and Chemical Biology will also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.

The Chemical Biology of Nucleic Acids

Günter Mayer
The Chemical Biology of Nucleic Acids Book PDF

Author : Günter Mayer
Publisher : John Wiley & Sons
Page : 595 pages
File Size : 41,9 Mb
Release : 2011-06-17
Category : Science
ISBN : 9781119957263

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The Chemical Biology of Nucleic Acids by Günter Mayer Pdf

With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

Medicinal Chemistry of Nucleic Acids

Lihe Zhang,Zhen Xi,Jyoti Chattopadhyaya
Medicinal Chemistry of Nucleic Acids Book PDF

Author : Lihe Zhang,Zhen Xi,Jyoti Chattopadhyaya
Publisher : John Wiley & Sons
Page : 477 pages
File Size : 42,8 Mb
Release : 2011-08-10
Category : Medical
ISBN : 9781118092811

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Medicinal Chemistry of Nucleic Acids by Lihe Zhang,Zhen Xi,Jyoti Chattopadhyaya Pdf

Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acid chemistry and biology Essential information on the use of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.

The Chemical Biology of Nucleic Acids

Günter Mayer
The Chemical Biology of Nucleic Acids Book PDF

Author : Günter Mayer
Publisher : Wiley
Page : 478 pages
File Size : 44,7 Mb
Release : 2010-07-13
Category : Science
ISBN : 0470519746

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The Chemical Biology of Nucleic Acids by Günter Mayer Pdf

With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

Chemical Biology of Nucleic Acids

Volker A. Erdmann,Wojciech T. Markiewicz,Jan Barciszewski
Chemical Biology of Nucleic Acids Book PDF

Author : Volker A. Erdmann,Wojciech T. Markiewicz,Jan Barciszewski
Publisher : Springer Science & Business
Page : 599 pages
File Size : 42,9 Mb
Release : 2014-04-22
Category : Science
ISBN : 9783642544521

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Chemical Biology of Nucleic Acids by Volker A. Erdmann,Wojciech T. Markiewicz,Jan Barciszewski Pdf

This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.

Nucleic Acids in Chemistry and Biology

G Michael Blackburn,Michael J Gait,David Loakes,David M Williams
Nucleic Acids in Chemistry and Biology Book PDF

Author : G Michael Blackburn,Michael J Gait,David Loakes,David M Williams
Publisher : Royal Society of Chemistry
Page : 824 pages
File Size : 50,9 Mb
Release : 2015-11-09
Category : Science
ISBN : 9781782625773

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Nucleic Acids in Chemistry and Biology by G Michael Blackburn,Michael J Gait,David Loakes,David M Williams Pdf

The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

New Frontiers in Chemical Biology

Mark E. Bunnage
New Frontiers in Chemical Biology Book PDF

Author : Mark E. Bunnage
Publisher : Royal Society of Chemistry
Page : 329 pages
File Size : 40,5 Mb
Release : 2011
Category : Medical
ISBN : 9781849731256

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New Frontiers in Chemical Biology by Mark E. Bunnage Pdf

This book highlights the new frontiers in chemical biology and describes their impact and future potential in drug discovery.

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

Anonim
Quadruplex Nucleic Acids As Targets For Medicinal Chemistry Book PDF

Author : Anonim
Publisher : Academic Press
Page : 564 pages
File Size : 47,8 Mb
Release : 2020-08-26
Category : Science
ISBN : 9780128210185

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Quadruplex Nucleic Acids As Targets For Medicinal Chemistry by Anonim Pdf

The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Annual Reports in Medicinal Chemistry series

Quadruplex Nucleic Acids

Stephen Neidle,Shankar Balasubramanian
Quadruplex Nucleic Acids Book PDF

Author : Stephen Neidle,Shankar Balasubramanian
Publisher : Royal Society of Chemistry
Page : 301 pages
File Size : 43,6 Mb
Release : 2007-10-31
Category : Science
ISBN : 9781847555298

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Quadruplex Nucleic Acids by Stephen Neidle,Shankar Balasubramanian Pdf

Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also been discovered. Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the role of cations in structure and stability. The biology of quadruplexes and G-rich genomic regions and G-quartets in supramolecular chemistry and nanoscience are also considered. Surveying the current state of knowledge, and with contributions from leading experts, this is the first comprehensive review of this rapidly growing area. Quadruplex Nucleic Acids is ideal for researchers interested in areas related to chemistry, chemical biology, medicinal chemistry, molecular pharmacology, and structural and molecular biology.

Therapeutic Applications of Quadruplex Nucleic Acids

Stephen Neidle
Therapeutic Applications of Quadruplex Nucleic Acids Book PDF

Author : Stephen Neidle
Publisher : Academic Press
Page : 210 pages
File Size : 42,6 Mb
Release : 2012
Category : Business & Economics
ISBN : 9780123751386

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Therapeutic Applications of Quadruplex Nucleic Acids by Stephen Neidle Pdf

"Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--P. [4] of cover.

Chemistry and Biology of Non-canonical Nucleic Acids

Naoki Sugimoto
Chemistry and Biology of Non canonical Nucleic Acids Book PDF

Author : Naoki Sugimoto
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 52,5 Mb
Release : 2021-03-16
Category : Science
ISBN : 9783527817887

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Chemistry and Biology of Non-canonical Nucleic Acids by Naoki Sugimoto Pdf

Discover the fundamentals and intricacies of a subject at the interface of chemistry and biology with this authoritative resource Chemistry and Biology of Non-canonical Nucleic Acids delivers a comprehensive treatment of the chemistry and biology of non-canonical nucleic acids, including their history, structures, stabilities, properties, and functions. You'll learn about the role of these vital compounds in transcription, translation, regulation, telomeres, helicases, cancers, neurodegenerative diseases, therapeutic applications, nanotechnology, and more. An ideal resource for graduate students, researchers in physical, organic, analytical, and inorganic chemistry will learn about uncommon nucleic acids, become the common non-canonical nucleic acids that fascinate and engage academics and professionals in private industry. Split into 15 chapters covering a wide range of aspects of non-canonical nucleic acids, the book explains why these compounds exist at the forefront of a new research revolution at the intersection of chemistry and biology. Chemistry and Biology of Non-canonical Nucleic Acids also covers a broad range of topics critical to understanding these versatile and omnipresent chemicals, including: * A discussion of the dynamic regulation of biosystems by nucleic acids with non-canonical structures * The role played by nucleic acid structures in neurodegenerative diseases and various cancers * An exploration of the future outlook for the chemistry and biology of non-canonical nucleic acids * An introduction to the history of canonical and non-canonical structures of nucleic acids * An analysis of the physicochemical properties of non-canonical nucleic acids Perfect for biochemists, materials scientists, and bioengineers, Chemistry and Biology of Non-canonical Nucleic Acids will also earn a place in the libraries of medicinal and pharmaceutical chemists who wish to improve their understanding of life processes and the role that non-canonical nucleic acids play in them.

Nucleic Acids in Chemistry and Biology

G. Michael Blackburn,Michael J. Gait,Martin Egli,Jonathan K. Watts
Nucleic Acids in Chemistry and Biology Book PDF

Author : G. Michael Blackburn,Michael J. Gait,Martin Egli,Jonathan K. Watts
Publisher : Unknown
Page : 600 pages
File Size : 52,8 Mb
Release : 2021-10-14
Category : Electronic
ISBN : 1788019040

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Nucleic Acids in Chemistry and Biology by G. Michael Blackburn,Michael J. Gait,Martin Egli,Jonathan K. Watts Pdf

Revised, extended, updated and lavishly illustrated, this 4th Edition of Nucleic Acids in Chemistry and Biology is a long-awaited standard text for teaching and research in nucleic acids science.

Principles of Nucleic Acid Structure

Stephen Neidle,Mark Sanderson
Principles of Nucleic Acid Structure Book PDF

Author : Stephen Neidle,Mark Sanderson
Publisher : Elsevier
Page : 454 pages
File Size : 49,9 Mb
Release : 2021-10-14
Category : Science
ISBN : 9780128196779

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Principles of Nucleic Acid Structure by Stephen Neidle,Mark Sanderson Pdf

Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA). This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results. Completely updated, with an expanded section on protein-nucleic acid interactions that reflects major increases in our knowledge Defines technical terms for novices Includes a complete list of resources, including relevant online databases and software, as well as useful websites

DNA Conjugates and Sensors

Keith R Fox,Tom Brown
DNA Conjugates and Sensors Book PDF

Author : Keith R Fox,Tom Brown
Publisher : Royal Society of Chemistry
Page : 250 pages
File Size : 45,6 Mb
Release : 2012-11-30
Category : Science
ISBN : 9781849734936

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DNA Conjugates and Sensors by Keith R Fox,Tom Brown Pdf

Applications of nucleic acids have developed recently to provide solutions for biosensors, diagnostic tools and as platforms for the assembly of complex structures. These developments have been possible as their base sequence can be used to assemble precise structures following simple and predictable rules. Self-assembled DNA can then be amplified using polymerase chain reaction (PCR) and this ultimately enables the preparation of synthetic nucleic acids. Their use as molecular tools or DNA-conjugates has recently been enhanced by the addition of other groups including enzymes, fluorophores and small molecules. Written by leaders in the field, this volume describes the preparation and application of these DNA-conjugates. Several have been used as sensors (aptamers, riboswitches and nanostructures) based on the ability of nucleic acids to adopt specific structures in the presence of ligands, whilst others link reporter groups such as proteins or fluorophores to RNA or DNA for detection, single molecule studies, and increasing the sensitivity of PCR. The book is relevant to researchers in areas related to analytical chemistry, chemical biology, medicinal chemistry, molecular pharmacology, and structural and molecular biology.

Aminoglycoside Antibiotics

Dev P. Arya
Aminoglycoside Antibiotics Book PDF

Author : Dev P. Arya
Publisher : John Wiley & Sons
Page : 336 pages
File Size : 44,9 Mb
Release : 2007-09-17
Category : Science
ISBN : 0470149663

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Aminoglycoside Antibiotics by Dev P. Arya Pdf

Advances that open new avenues in developing aminoglycoside antibiotics During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention. This is the first book to provide a complete overview of recent advances in the field and explore their tremendous potential for drug discovery and rational drug design. With chapters written by one or more leading experts in their specialty areas, the book addresses the chemistry, biology, and toxicology of aminoglycosides. Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery is a great resource for academic and industrial researchers in drug design and mechanism studies and for researchers studying antibiotic resistance, antibiotic design and synthesis, and the discovery of novel pharmaceuticals. It is also a valuable reference for graduate students in pharmacy, pharmaceutical science, biophysics, medicinal chemistry, and chemical biology.