Chronic Myeloid Leukemia

Author : Rüdiger Hehlmann
Publisher : Springer
Page : 255 pages
File Size : 40,7 Mb
Release : 2016-08-17
Category : Medical
ISBN : 9783319331980

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Chronic Myeloid Leukemia by Rüdiger Hehlmann Pdf

This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health. Among the management topics addressed are the choices, advantages, and pitfalls of first-, second-, and third-line treatments; the European LeukemiaNet recommendations; management of adverse effects of tyrosine kinase inhibitors (TKI); management of CML blast crisis; management of pregnancy in the context of CML; the role of hematopoietic cell transplantation; the current experience with TKI discontinuation; and the value of interferon α in improving the outcome of TKI treatment. Various aspects of relevance to treatment outcome are discussed, including prognostic scores, molecular monitoring (principles and interlaboratory standardization), and response-related predictors of survival. Furthermore, updates are provided on the increasing prevalence of CML and its implications and on the changing cost of care for CML, taking into account the forthcoming impact of availability of generic imatinib.

Author : Stefan Faderl,Hagop Kantarjian
Publisher : John Wiley & Sons
Page : 460 pages
File Size : 54,7 Mb
Release : 2011-09-14
Category : Medical
ISBN : 9781444347814

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Leukemias by Stefan Faderl,Hagop Kantarjian Pdf

Edited by experts from one of the world’s largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials. Topics include: Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors) Ras inhibitors Epigenetic therapy (hypomethylaters and histone deacetylase inhibitors) Lenalidomide analogs New chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesine Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib) New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40) Thrombopoietic agents Leukemias: Principles and Practice of Therapy Includes practical information to guide you in challenging situations, such as treatment of elderly patients, pregnancy, relapsed and refractory disease Incorporates chapters on supportive care and pharmacologic information about the most frequently used drugs in this area

Author : Ronald Hoffman
Publisher : Unknown
Page : 2821 pages
File Size : 49,6 Mb
Release : 2005
Category : Blood
ISBN : 0443066280

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Hematology by Ronald Hoffman Pdf

Author : Jorge Cortes,Michael Deininger
Publisher : CRC Press
Page : 174 pages
File Size : 53,7 Mb
Release : 2006-12-13
Category : Medical
ISBN : 9780849379567

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Chronic Myeloid Leukemia by Jorge Cortes,Michael Deininger Pdf

Chronic Myeloid Leukemia (CML) remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level and has been used by researchers to develop a variety of therapies and therapeutic assessment methods. This concise, readable guide assembles and synthesizes the latest developments and trends in the treatmen

Author : Hillard M. Lazarus,Mary J. Laughlin
Publisher : Springer Science & Business Media
Page : 881 pages
File Size : 40,9 Mb
Release : 2010-03-02
Category : Medical
ISBN : 9781597454780

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Allogeneic Stem Cell Transplantation by Hillard M. Lazarus,Mary J. Laughlin Pdf

Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Author : Timothy P Hughes,David M Ross,Junia V Melo
Publisher : Springer
Page : 65 pages
File Size : 42,8 Mb
Release : 2014-11-06
Category : Medical
ISBN : 9783319083506

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Handbook of Chronic Myeloid Leukemia by Timothy P Hughes,David M Ross,Junia V Melo Pdf

This concise, clinically focused pocket handbook assembles and synthesizes the latest developments and trends in the diagnosis and treatment of CML and provides an authoritative and convenient summary of the latest progress in TKI trials, the molecular monitoring of CML responses, and the development of new therapies to overcome resistance and improve patient care. Chronic myeloid leukemia (CML) is a rare type of leukemia (1–2 per 100,000 people) but is the most common chronic myeloproliferative neoplasm. CML remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level; CML was the first cancer to be associated with a recurring chromosome abnormality, which generates the Philadelphia (Ph) chromosome and its associated fusion gene BCR-ABL1. The clinical outcome for patients with CML has changed dramatically in the past 15 years and this has been due to the development of tyrosine kinase inhibitors (TKIs), compounds that inhibit the activity of the oncogenic BCR-ABL1 protein. A number of first-, second- and third-generation TKIs are now available for the treatment of CML, although a number of treatment challenges remain, not least the development of treatment-resistant CML. Parallel to the development of specific drugs for treating CML, major advances have been made in the field of disease monitoring and standardization of response criteria.

Author : Sandeep Potluri
Publisher : Karger Medical and Scientific Publishers
Page : 54 pages
File Size : 45,9 Mb
Release : 2021-01-26
Category : Medical
ISBN : 9783318068337

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Fast Facts: Treatment-Free Remission in Chronic Myeloid Leukemia by Sandeep Potluri Pdf

The tyrosine kinase inhibitor (TKI) imatinib was the first treatment to specifically target cancer cells, rather than the relatively indiscriminate effects of conventional chemotherapy on any rapidly dividing cells. This concept of targeted treatment in cancer is one of the important advances in modern medicine in the last 30 years. Indeed, treatment with TKIs has transformed chronic myeloid leukemia (CML) from a cancer with a poor prognosis to one in which many patients can expect a normal lifespan. Success with the TKIs has prompted the question of whether it is desirable – or feasible – for patients to remain on treatment for long periods. While the TKIs are targeted, they are associated with considerable toxicity, and long-term treatment has important economic implications for health services and patients. Thus, the concept of treatment-free remission (TFR) has emerged for patients in deep clinical remission. Clinical research over the last decade has focused on whether treatment can be stopped, how to best monitor patients while off treatment, and how to intervene before a clinical relapse. As this research progresses, the tantalizing prospect of a cure for some patients seems increasingly feasible. This new Fast Facts title outlines this trail-blazing approach to the long-term management of patients living with CML in remission. It explains the concepts of molecular and hematologic relapse, the highly sensitive technologies that allow disease monitoring, and how TFR is best managed in practice. It is a concise educational resource, ideal for any healthcare professional involved in the treatment of patients with CML who wants to understand TFR, particularly clinical nurse specialists and pharmacists who increasingly help clinicians to run CML clinics. Table of Contents: • The concept of treatment-free remission • Measurement of disease burden • Clinical practice • Future directions

Author : Drew Provan,Hillard M. Lazarus
Publisher : John Wiley & Sons
Page : 452 pages
File Size : 42,8 Mb
Release : 2024-03-05
Category : Medical
ISBN : 9781394180479

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Molecular Hematology by Drew Provan,Hillard M. Lazarus Pdf

Provides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more. Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, COVID, cancer cell biology, gene therapy and gene editing in clinical practice, as well as the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout. Covers the molecular biology of different blood diseases, their pathogeneses, and current molecular research and therapies Illustrates the impact of molecular research on hematologic investigations and therapeutics Discusses how progress in basic science and therapeutics has improved the diagnosis and care of patients with various hematologic disorders Surveys recent developments in cancer-cell biology, with an emphasis on leukemia and lymphoma Includes access to a companion Digital Edition providing search across the book, downloadable illustrations, and notation tools Molecular Hematology is a must-have resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.

Author : Anonim
Publisher : BoD – Books on Demand
Page : 302 pages
File Size : 48,8 Mb
Release : 2021-10-06
Category : Science
ISBN : 9781839688379

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Vitamin E in Health and Disease by Anonim Pdf

Vitamin E is a group of fat-soluble compounds found in a wide variety of foods. Daily requirements of vitamin E can be met with a balanced diet. High-dose supplementation may be hazardous rather than beneficial. Vitamin E serves as an antioxidant, participates in anti-inflammatory processes, inhibits platelet aggregation, and enhances immunity. Vitamin E supplementation can be beneficial against coronary artery disease, eye disorders, cognitive decline, cancer, and skin aging. This book will mainly focus on the diverse functions of vitamin E, importance of vitamin E status to provide a healthy lifespan, and the interaction between vitamin E and several pathological conditions. Readers will receive a general overview of the importance of vitamin E in health and different pathological conditions.

Author : Anonim
Publisher : ScholarlyEditions
Page : 183 pages
File Size : 55,8 Mb
Release : 2013-07-22
Category : Medical
ISBN : 9781481664042

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Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2013 Edition by Anonim Pdf

Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Genetics. The editors have built Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Genetics in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Anonim
Publisher : ScholarlyEditions
Page : 103 pages
File Size : 46,5 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464902406

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Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2011 Edition by Anonim Pdf

Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Chronic Myeloid Leukemia. The editors have built Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chronic Myeloid Leukemia in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Uday R. Popat
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 46,9 Mb
Release : 2014
Category : Chronic myeloid leukemia
ISBN : 1629489719

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Chronic Myeloid Leukemia by Uday R. Popat Pdf

Targeted therapy has revolutionised modern oncology practice and has completely changed the outcome of once universally fatal diseases like chronic myeloid leukaemia (CML). The last decade has witnessed significant advances in the management of CML, which has become more like a chronic disease. Written by experts in the field, this volume nicely describes the current knowledge of the pathophysiology, clinical features, and management of CML. It covers not only clinical topics but also the basic science underlying these practices. It will be of help to clinicians and basic scientists alike. In addition to the state of the art treatment of CML, this book also covers many uncommon but very important special topics like management of CML in pregnancy or with children, management of resistance to new tyrosine kinases and treatment of the advanced phase of the disease. Written to be easily digestible, patients will also be able to access important and universally useful information on CML (eg: diagnosis, symptoms and signs, and treatment). Some themes especially, including drug and food interactions of tyrosine kinase inhibitors (TKIs), CML treatment during pregnancy, advantages/disadvantages of the most commonly used TKIs, and bone marrow transplantation indications, will be of popular concern. This extensively referenced book therefore should be of great help to both novices and experts in the field.

Author : J.V. Melo,J. Goldman
Publisher : Springer
Page : 354 pages
File Size : 43,8 Mb
Release : 2006-11-27
Category : Medical
ISBN : 3540345051

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Myeloproliferative Disorders by J.V. Melo,J. Goldman Pdf

This book contains a series of contributions from internationally renowned academics with special expertise in one or other diseases which collectively are grouped under the heading myeloproliferative disorders. There have been many recent developments in understanding the pathophysiology and a number therapeutic innovations in this area. A feature of this book is the speed with which it has been produced – an important factor in this rapidly moving field.

Author : Tariq I. Mughal
Publisher : CRC Press
Page : 154 pages
File Size : 43,6 Mb
Release : 2013-04-25
Category : Medical
ISBN : 9781842145777

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Chronic Myeloid Leukemia by Tariq I. Mughal Pdf

Highly Commended, BMA Medical Book Awards 2014 Chronic myeloid leukemia is a clonal disease that results from an acquired genetic change in a single pluripotential hemopoietic stem cell. Efforts to confront this disease have been assisted by advances in cellular and molecular biology and the speed at which these findings have transformed the therapeutic algorithm. Nevertheless, there is some uncertainty with regards to how best to assess efficacy of treatment, especially with regards to the most appropriate surrogate markers for overall survival. From the standpoint of biology and clinical management, this handbook provides an authoritative state-of-the-art review of current and developing progress.

Author : Masahiro Kizaki
Publisher : Springer
Page : 193 pages
File Size : 44,8 Mb
Release : 2015-11-05
Category : Medical
ISBN : 9784431557142

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Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia by Masahiro Kizaki Pdf

Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia provides a comprehensive understanding of the recent molecular genetics of Chronic Myelogenous Leukemia (CML) and a characterization of the molecular targets for drug development. Included are therapeutic implications, diagnosis, and prognosis for understanding and facilitating daily practice in the management of patients with CML. Understanding of the pathogenesis and therapy of hematological malignancies such as CML has grown significantly in recent years. This development owe much to the progress in molecular biology and now makes a major contribution to diagnosis and to treatment that pharmacologically targets the molecular events of CML. Molecular targeting therapy with newly developed agents such as small molecules and antibodies for hematological malignancies are being discovered after years of research. Some of these, including tyrosine kinase inhibitors such as imatinib, nilotinib, and dasatinib, lead to increased survival rates and improved therapies. With the opinion leaders of basic and clinical research in the field as authors, this book reviews recent advances in the biology of CML.