Chronic Myeloid Leukemia

Author : Rüdiger Hehlmann
Publisher : Springer
Page : 255 pages
File Size : 44,6 Mb
Release : 2016-08-17
Category : Medical
ISBN : 9783319331980

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Chronic Myeloid Leukemia by Rüdiger Hehlmann Pdf

This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health. Among the management topics addressed are the choices, advantages, and pitfalls of first-, second-, and third-line treatments; the European LeukemiaNet recommendations; management of adverse effects of tyrosine kinase inhibitors (TKI); management of CML blast crisis; management of pregnancy in the context of CML; the role of hematopoietic cell transplantation; the current experience with TKI discontinuation; and the value of interferon α in improving the outcome of TKI treatment. Various aspects of relevance to treatment outcome are discussed, including prognostic scores, molecular monitoring (principles and interlaboratory standardization), and response-related predictors of survival. Furthermore, updates are provided on the increasing prevalence of CML and its implications and on the changing cost of care for CML, taking into account the forthcoming impact of availability of generic imatinib.

Author : Ronald Hoffman
Publisher : Unknown
Page : 2821 pages
File Size : 54,6 Mb
Release : 2005
Category : Blood
ISBN : 0443066280

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Hematology by Ronald Hoffman Pdf

Author : Stefan Faderl,Hagop Kantarjian
Publisher : John Wiley & Sons
Page : 460 pages
File Size : 52,9 Mb
Release : 2011-09-14
Category : Medical
ISBN : 9781444347814

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Leukemias by Stefan Faderl,Hagop Kantarjian Pdf

Edited by experts from one of the world’s largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials. Topics include: Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors) Ras inhibitors Epigenetic therapy (hypomethylaters and histone deacetylase inhibitors) Lenalidomide analogs New chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesine Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib) New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40) Thrombopoietic agents Leukemias: Principles and Practice of Therapy Includes practical information to guide you in challenging situations, such as treatment of elderly patients, pregnancy, relapsed and refractory disease Incorporates chapters on supportive care and pharmacologic information about the most frequently used drugs in this area

Author : Jorge Cortes,Michael Deininger
Publisher : CRC Press
Page : 174 pages
File Size : 43,7 Mb
Release : 2006-12-13
Category : Medical
ISBN : 9780849379567

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Chronic Myeloid Leukemia by Jorge Cortes,Michael Deininger Pdf

Chronic Myeloid Leukemia (CML) remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level and has been used by researchers to develop a variety of therapies and therapeutic assessment methods. This concise, readable guide assembles and synthesizes the latest developments and trends in the treatmen

Author : Tariq I. Mughal
Publisher : CRC Press
Page : 148 pages
File Size : 41,8 Mb
Release : 2013-04-25
Category : Medical
ISBN : 9781842145784

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Chronic Myeloid Leukemia by Tariq I. Mughal Pdf

Highly Commended, BMA Medical Book Awards 2014 Chronic myeloid leukemia is a clonal disease that results from an acquired genetic change in a single pluripotential hemopoietic stem cell. Efforts to confront this disease have been assisted by advances in cellular and molecular biology and the speed at which these findings have transformed the therapeutic algorithm. Nevertheless, there is some uncertainty with regards to how best to assess efficacy of treatment, especially with regards to the most appropriate surrogate markers for overall survival. From the standpoint of biology and clinical management, this handbook provides an authoritative state-of-the-art review of current and developing progress.

Author : Hillard M. Lazarus,Mary J. Laughlin
Publisher : Springer Science & Business Media
Page : 885 pages
File Size : 53,5 Mb
Release : 2010-03-02
Category : Medical
ISBN : 9781597454780

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Allogeneic Stem Cell Transplantation by Hillard M. Lazarus,Mary J. Laughlin Pdf

Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Author : Timothy P Hughes,David M Ross,Junia V Melo
Publisher : Springer
Page : 65 pages
File Size : 55,5 Mb
Release : 2014-11-06
Category : Medical
ISBN : 9783319083506

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Handbook of Chronic Myeloid Leukemia by Timothy P Hughes,David M Ross,Junia V Melo Pdf

This concise, clinically focused pocket handbook assembles and synthesizes the latest developments and trends in the diagnosis and treatment of CML and provides an authoritative and convenient summary of the latest progress in TKI trials, the molecular monitoring of CML responses, and the development of new therapies to overcome resistance and improve patient care. Chronic myeloid leukemia (CML) is a rare type of leukemia (1–2 per 100,000 people) but is the most common chronic myeloproliferative neoplasm. CML remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level; CML was the first cancer to be associated with a recurring chromosome abnormality, which generates the Philadelphia (Ph) chromosome and its associated fusion gene BCR-ABL1. The clinical outcome for patients with CML has changed dramatically in the past 15 years and this has been due to the development of tyrosine kinase inhibitors (TKIs), compounds that inhibit the activity of the oncogenic BCR-ABL1 protein. A number of first-, second- and third-generation TKIs are now available for the treatment of CML, although a number of treatment challenges remain, not least the development of treatment-resistant CML. Parallel to the development of specific drugs for treating CML, major advances have been made in the field of disease monitoring and standardization of response criteria.

Author : Anonim
Publisher : BoD – Books on Demand
Page : 302 pages
File Size : 42,6 Mb
Release : 2021-10-06
Category : Science
ISBN : 9781839688379

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Vitamin E in Health and Disease by Anonim Pdf

Vitamin E is a group of fat-soluble compounds found in a wide variety of foods. Daily requirements of vitamin E can be met with a balanced diet. High-dose supplementation may be hazardous rather than beneficial. Vitamin E serves as an antioxidant, participates in anti-inflammatory processes, inhibits platelet aggregation, and enhances immunity. Vitamin E supplementation can be beneficial against coronary artery disease, eye disorders, cognitive decline, cancer, and skin aging. This book will mainly focus on the diverse functions of vitamin E, importance of vitamin E status to provide a healthy lifespan, and the interaction between vitamin E and several pathological conditions. Readers will receive a general overview of the importance of vitamin E in health and different pathological conditions.

Author : Sandeep Potluri
Publisher : Karger Medical and Scientific Publishers
Page : 54 pages
File Size : 52,9 Mb
Release : 2021-01-26
Category : Medical
ISBN : 9783318068337

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Fast Facts: Treatment-Free Remission in Chronic Myeloid Leukemia by Sandeep Potluri Pdf

The tyrosine kinase inhibitor (TKI) imatinib was the first treatment to specifically target cancer cells, rather than the relatively indiscriminate effects of conventional chemotherapy on any rapidly dividing cells. This concept of targeted treatment in cancer is one of the important advances in modern medicine in the last 30 years. Indeed, treatment with TKIs has transformed chronic myeloid leukemia (CML) from a cancer with a poor prognosis to one in which many patients can expect a normal lifespan. Success with the TKIs has prompted the question of whether it is desirable – or feasible – for patients to remain on treatment for long periods. While the TKIs are targeted, they are associated with considerable toxicity, and long-term treatment has important economic implications for health services and patients. Thus, the concept of treatment-free remission (TFR) has emerged for patients in deep clinical remission. Clinical research over the last decade has focused on whether treatment can be stopped, how to best monitor patients while off treatment, and how to intervene before a clinical relapse. As this research progresses, the tantalizing prospect of a cure for some patients seems increasingly feasible. This new Fast Facts title outlines this trail-blazing approach to the long-term management of patients living with CML in remission. It explains the concepts of molecular and hematologic relapse, the highly sensitive technologies that allow disease monitoring, and how TFR is best managed in practice. It is a concise educational resource, ideal for any healthcare professional involved in the treatment of patients with CML who wants to understand TFR, particularly clinical nurse specialists and pharmacists who increasingly help clinicians to run CML clinics. Table of Contents: • The concept of treatment-free remission • Measurement of disease burden • Clinical practice • Future directions

Author : Drew Provan,Hillard M. Lazarus
Publisher : John Wiley & Sons
Page : 452 pages
File Size : 51,7 Mb
Release : 2024-03-05
Category : Medical
ISBN : 9781394180479

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Molecular Hematology by Drew Provan,Hillard M. Lazarus Pdf

Provides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more. Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, COVID, cancer cell biology, gene therapy and gene editing in clinical practice, as well as the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout. Covers the molecular biology of different blood diseases, their pathogeneses, and current molecular research and therapies Illustrates the impact of molecular research on hematologic investigations and therapeutics Discusses how progress in basic science and therapeutics has improved the diagnosis and care of patients with various hematologic disorders Surveys recent developments in cancer-cell biology, with an emphasis on leukemia and lymphoma Includes access to a companion Digital Edition providing search across the book, downloadable illustrations, and notation tools Molecular Hematology is a must-have resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.

Author : Anonim
Publisher : ScholarlyEditions
Page : 183 pages
File Size : 53,5 Mb
Release : 2013-07-22
Category : Medical
ISBN : 9781481664042

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Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2013 Edition by Anonim Pdf

Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Genetics. The editors have built Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Genetics in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Zhan He Wu
Publisher : BoD – Books on Demand
Page : 250 pages
File Size : 40,5 Mb
Release : 2020-03-25
Category : Medical
ISBN : 9781838800239

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Rare Diseases by Zhan He Wu Pdf

Rare diseases are a group of genetic disorders occurring in a small percentage of the population with the conditions being chronic but incurable. Approximately 7000 to 8000 different types have been identified and about 350 million people globally are affected in childhood and adulthood, resulting in enormous physical, mental, and psychological suffering and financial burden. It is imperative for medical scientists, clinicians, communities, and societies to ensure appropriate care is applied to ease the suffering of such patients. The extraordinary and unprecedented hallmark in the field of rare diseases has revolutionized modern human medicine with exciting and advancing developments of the genomic era over the last two decades. Patients with rare diseases have been receiving increasing benefits in care and life quality improvements than ever before. This book intends to share and exchange the advancing knowledge and experiences from the authors, who have the necessary expertise within the various topics and subjects in the research, diagnosis, and management of rare diseases. It is hoped they are able to provide further benefits to patients and families with the development of early and accurate diagnosis and effective therapies.

Author : J.V. Melo,J. Goldman
Publisher : Springer
Page : 354 pages
File Size : 54,5 Mb
Release : 2006-11-27
Category : Medical
ISBN : 3540345051

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Myeloproliferative Disorders by J.V. Melo,J. Goldman Pdf

This book contains a series of contributions from internationally renowned academics with special expertise in one or other diseases which collectively are grouped under the heading myeloproliferative disorders. There have been many recent developments in understanding the pathophysiology and a number therapeutic innovations in this area. A feature of this book is the speed with which it has been produced – an important factor in this rapidly moving field.

Author : Celalettin Ustun
Publisher : Unknown
Page : 318 pages
File Size : 46,5 Mb
Release : 2014
Category : Blood
ISBN : 1629489921

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Chronic Myeloid Leukemia by Celalettin Ustun Pdf

An international team of accomplished researchers has been assembled to define the role that antioxidants and pro-oxidants play in cancer. Increasing scientific evidence points to the importance of antioxidants and pro-oxidants in both the etiology of cancer development and in cancer treatments. This book should prove useful for research scientists wanting a comprehensive review of the latest accomplishment in this area and for health care-providers who advise patients and the general public about dietary antioxidants and the safety and appropriate use of antioxidant supplements. Endogenous antioxidants systems that play key roles in modulating the in vivo effects of reactive oxygen species (ROS) are reviewed in detailed. Many exogenous antioxidants such as vitamin E (tocopherols and tocotrienols), vitamin C, green tea polyphenols, beta-carotene and curcumin are individually discussed as well as their potential roles in alternative and complementary medicine approaches to cancer prevention and treatment. For public health professionals the question of whether or not antioxidants have a safe chemopreventive role is central: it is clearly much more effective to prevent cancer than deal with its consequences including the damaging side effects of many chemotherapeutics.

Author : Anonim
Publisher : ScholarlyEditions
Page : 103 pages
File Size : 52,7 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464902406

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Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2011 Edition by Anonim Pdf

Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Chronic Myeloid Leukemia. The editors have built Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chronic Myeloid Leukemia in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.