Fast Facts Treatment Free Remission In Chronic Myeloid Leukemia

Author : S. Potluri
Publisher : Karger Medical and Scientific Publishers
Page : 54 pages
File Size : 42,9 Mb
Release : 2021-01-26
Category : Medical
ISBN : 9783318068344

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Fast Facts: Treatment-Free Remission in Chronic Myeloid Leukemia by S. Potluri Pdf

The tyrosine kinase inhibitor (TKI) imatinib was the first treatment to specifically target cancer cells, rather than the relatively indiscriminate effects of conventional chemotherapy on any rapidly dividing cells. This concept of targeted treatment in cancer is one of the important advances in modern medicine in the last 30 years. Indeed, treatment with TKIs has transformed chronic myeloid leukemia (CML) from a cancer with a poor prognosis to one in which many patients can expect a normal lifespan. Success with the TKIs has prompted the question of whether it is desirable – or feasible – for patients to remain on treatment for long periods. While the TKIs are targeted, they are associated with considerable toxicity, and long-term treatment has important economic implications for health services and patients. Thus, the concept of treatment-free remission (TFR) has emerged for patients in deep clinical remission. Clinical research over the last decade has focused on whether treatment can be stopped, how to best monitor patients while off treatment, and how to intervene before a clinical relapse. As this research progresses, the tantalizing prospect of a cure for some patients seems increasingly feasible. This new Fast Facts title outlines this trail-blazing approach to the long-term management of patients living with CML in remission. It explains the concepts of molecular and hematologic relapse, the highly sensitive technologies that allow disease monitoring, and how TFR is best managed in practice. It is a concise educational resource, ideal for any healthcare professional involved in the treatment of patients with CML who wants to understand TFR, particularly clinical nurse specialists and pharmacists who increasingly help clinicians to run CML clinics. Table of Contents: • The concept of treatment-free remission • Measurement of disease burden • Clinical practice • Future directions

Author : Rüdiger Hehlmann
Publisher : Springer
Page : 255 pages
File Size : 52,7 Mb
Release : 2016-08-17
Category : Medical
ISBN : 9783319331980

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Chronic Myeloid Leukemia by Rüdiger Hehlmann Pdf

This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health. Among the management topics addressed are the choices, advantages, and pitfalls of first-, second-, and third-line treatments; the European LeukemiaNet recommendations; management of adverse effects of tyrosine kinase inhibitors (TKI); management of CML blast crisis; management of pregnancy in the context of CML; the role of hematopoietic cell transplantation; the current experience with TKI discontinuation; and the value of interferon α in improving the outcome of TKI treatment. Various aspects of relevance to treatment outcome are discussed, including prognostic scores, molecular monitoring (principles and interlaboratory standardization), and response-related predictors of survival. Furthermore, updates are provided on the increasing prevalence of CML and its implications and on the changing cost of care for CML, taking into account the forthcoming impact of availability of generic imatinib.

Author : Hillard M. Lazarus,Mary J. Laughlin
Publisher : Springer Science & Business Media
Page : 881 pages
File Size : 55,7 Mb
Release : 2010-03-02
Category : Medical
ISBN : 9781597454780

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Allogeneic Stem Cell Transplantation by Hillard M. Lazarus,Mary J. Laughlin Pdf

Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Author : Stefan Faderl,Hagop Kantarjian
Publisher : John Wiley & Sons
Page : 460 pages
File Size : 47,6 Mb
Release : 2011-09-14
Category : Medical
ISBN : 9781444347814

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Leukemias by Stefan Faderl,Hagop Kantarjian Pdf

Edited by experts from one of the world’s largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials. Topics include: Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors) Ras inhibitors Epigenetic therapy (hypomethylaters and histone deacetylase inhibitors) Lenalidomide analogs New chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesine Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib) New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40) Thrombopoietic agents Leukemias: Principles and Practice of Therapy Includes practical information to guide you in challenging situations, such as treatment of elderly patients, pregnancy, relapsed and refractory disease Incorporates chapters on supportive care and pharmacologic information about the most frequently used drugs in this area

Author : Ajay Vora
Publisher : Springer
Page : 342 pages
File Size : 45,7 Mb
Release : 2017-04-21
Category : Medical
ISBN : 9783319397085

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Childhood Acute Lymphoblastic Leukemia by Ajay Vora Pdf

This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Author : Daniele Focosi
Publisher : Springer
Page : 0 pages
File Size : 50,9 Mb
Release : 2016-11-14
Category : Medical
ISBN : 3319460900

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Resistance to Tyrosine Kinase Inhibitors by Daniele Focosi Pdf

The volume will serve as a primer on tyrosine kinase signaling and its importance in cancer. The volume will first introduce the common denominators of small-molecule and antibody-derived inhibitors, as well as the general phenomenon of resistance. The volume will then detail resistance to the most commonly used classes of tyrosine kinase inhibitors, and will focus specific chapters on resistance to BCR-ABL1, FLT3, angiokinase family members, and ALK inhibitors.

Author : Daniel Vasella, M.D.,Robert Slater
Publisher : Harper Collins
Page : 274 pages
File Size : 52,7 Mb
Release : 2003-06-03
Category : Business & Economics
ISBN : 9780060010300

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Magic Cancer Bullet by Daniel Vasella, M.D.,Robert Slater Pdf

History of the breakthrough of the cancer pill "Gleevec."

Author : Anonim
Publisher : BoD – Books on Demand
Page : 302 pages
File Size : 46,5 Mb
Release : 2021-10-06
Category : Science
ISBN : 9781839688379

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Vitamin E in Health and Disease by Anonim Pdf

Vitamin E is a group of fat-soluble compounds found in a wide variety of foods. Daily requirements of vitamin E can be met with a balanced diet. High-dose supplementation may be hazardous rather than beneficial. Vitamin E serves as an antioxidant, participates in anti-inflammatory processes, inhibits platelet aggregation, and enhances immunity. Vitamin E supplementation can be beneficial against coronary artery disease, eye disorders, cognitive decline, cancer, and skin aging. This book will mainly focus on the diverse functions of vitamin E, importance of vitamin E status to provide a healthy lifespan, and the interaction between vitamin E and several pathological conditions. Readers will receive a general overview of the importance of vitamin E in health and different pathological conditions.

Author : Ronald Hoffman
Publisher : Unknown
Page : 2821 pages
File Size : 48,6 Mb
Release : 2005
Category : Blood
ISBN : 0443066280

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Hematology by Ronald Hoffman Pdf

Author : Anonim
Publisher : Unknown
Page : 330 pages
File Size : 54,9 Mb
Release : 1954
Category : Korea
ISBN : CUB:U183020107212

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Korean Survey by Anonim Pdf

Author : Raanani P Ed
Publisher : S. Karger AG (Switzerland)
Page : 0 pages
File Size : 45,7 Mb
Release : 2004
Category : Blood
ISBN : 3805577737

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Minimal Residual Disease in Hematologic Malignancies by Raanani P Ed Pdf

Detection of minimal residual disease (MRD) is increasingly used in the management of leukemia patients. A wide variety of methods have been developed and include technologies designed to detect residual malignant cells beyond the sensitivity of conventional approaches such as morphology and banding cytogenetics in leukemia. The choice of the best method depends on the biology of the individual malignancy, i.e. on the determination of specific markers which are useful to differentiate between leukemic cells and normal hematopoiesis in leukemic patients. These markers include leukocyte differentiation antigens, fusion transcripts, transcripts overexpressed by mutated or nonmutated genes, rearranged genes, and individual markers like polymorphic repetitive DNA sequences. The major technologies for MRD detection, their advantages and disadvantages and their clinical applications are discussed in this special issue - from 'bench to bedside'. Providing a comprehensive overview on the significance of MRD in the evaluation, treatment and follow-up of hematologic malignancies, it will be of great value to hematologists, researchers interested in leukemias and lymphomas as well as laboratory technicians.

Author : Daniel P. Stark,Gilles Vassal
Publisher : Karger Medical Scientific
Page : 0 pages
File Size : 54,9 Mb
Release : 2016
Category : Cancer in children
ISBN : 3318059110

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Tumors in Adolescents and Young Adults by Daniel P. Stark,Gilles Vassal Pdf

The field of adolescents and young adult (AYA) oncology is experiencing a very challenging time. This book is a guide to the key issues for any clinician and health professional managing AYA with cancer in Europe. Emphasis is on collaboration between adult and pediatric specialists. Authors present their perception of the current state of the most prominent primary issues in AYA oncology. Chapters cover cross-cutting issues such as disease epidemiology, systems of care, access to innovative therapy and late effects of treatment and survivorship for AYA-onset cancers. There are discussions of the latest developments and the most important cancer types for AYA, including the shared perspectives of adult and pediatric specialists. Throughout the book recurrent challenges to the AYA community are exposed and solutions proposed. Tumors in Adolescents and Young Adults is highly recommended to any oncologist or haematologist treating patients aged 15 to 39 diagnosed with cancer. It will also be of interest to other members of the multidisciplinary teams involved with this patient group.

Author : Timothy Graubert,James R. Cook,Laura Scheuttpelz,Donald M. Arnold,Adam Cuker,Cindy Neunert,Keith R. McCrae,Margaret Ragni,Sarah O'Brien,Murat Arcasoy,Gary Lyman,Marc J. Kahn,Lawrence A. Solberg,Jecko Thachil,Timothy James Littlewood,Sioban Keel,Charles T. Quinn,Charles H. Packman,Stephan Moll,David Garcia,David P. Steensma,Anjali Sharathkumar,Jorge Di Paola,Amy D. Shapiro,A. Koneti Rao,Charles Eby,Jacob Rand,John Frater,Karen Quillen,Suzanne Bakdash,Dan S. Kaufman,David T. Scadden,Jerald Radich,Sergio Giralt,Geoffrey L. Uy,Inderjeet Dokal,Ross Levine,Ramon V. Tiu,Phillip Scheinberg,Lillian Sung,B. Douglas Smith,Daniel J. DeAngelo,Ching-Hon Pui,Kristie A. Blum,Ann LaCasce,Kerry Joanne Savage,Brad S. Kahl,Grzegorz S. Nowakowski,Vicki A. Morrison,Irene Ghobrial,Martha Lacy
Publisher : Unknown
Page : 637 pages
File Size : 50,7 Mb
Release : 2013-06-04
Category : Hematology
ISBN : 0982843518

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American Society of Hematology Self-Assessment Program by Timothy Graubert,James R. Cook,Laura Scheuttpelz,Donald M. Arnold,Adam Cuker,Cindy Neunert,Keith R. McCrae,Margaret Ragni,Sarah O'Brien,Murat Arcasoy,Gary Lyman,Marc J. Kahn,Lawrence A. Solberg,Jecko Thachil,Timothy James Littlewood,Sioban Keel,Charles T. Quinn,Charles H. Packman,Stephan Moll,David Garcia,David P. Steensma,Anjali Sharathkumar,Jorge Di Paola,Amy D. Shapiro,A. Koneti Rao,Charles Eby,Jacob Rand,John Frater,Karen Quillen,Suzanne Bakdash,Dan S. Kaufman,David T. Scadden,Jerald Radich,Sergio Giralt,Geoffrey L. Uy,Inderjeet Dokal,Ross Levine,Ramon V. Tiu,Phillip Scheinberg,Lillian Sung,B. Douglas Smith,Daniel J. DeAngelo,Ching-Hon Pui,Kristie A. Blum,Ann LaCasce,Kerry Joanne Savage,Brad S. Kahl,Grzegorz S. Nowakowski,Vicki A. Morrison,Irene Ghobrial,Martha Lacy Pdf

Hematologists and others working in hematology-related fields need to stay current with the latest advances in the rapidly evolving disciplines of adult and pediatric hematology. The American Society of Hematology Self-Assessment Program (ASH-SAP) is the only complete, comprehensive, educational resource available that fulfills this need, while also providing thorough board and recertification preparation, as well as AMA PRA Category 1 Credit'.

Author : Marie Bakitas Whedon,Debra Wujcik
Publisher : Jones & Bartlett Learning
Page : 616 pages
File Size : 48,7 Mb
Release : 1997
Category : Bone marrow
ISBN : 0763703567

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Blood and Marrow Stem Cell Transplantation by Marie Bakitas Whedon,Debra Wujcik Pdf

Nursing

Author : Jessica Wapner
Publisher : The Experiment, LLC
Page : 345 pages
File Size : 52,6 Mb
Release : 2014-04-08
Category : Health & Fitness
ISBN : 9781615191659

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The Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Lifesaving Treatment by Jessica Wapner Pdf

One of The Wall Street Journal’s 10 Best Nonfiction Books of the Year Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same. Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute—with extensive original reporting, including more than thirty-five interviews—to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it. The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.