Clostridioides Difficile

Author : Henning Sommermeyer,Jacek Piątek
Publisher : Springer Nature
Page : 96 pages
File Size : 44,7 Mb
Release : 2021-09-27
Category : Medical
ISBN : 9783030811006

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Clostridioides difficile by Henning Sommermeyer,Jacek Piątek Pdf

The book provides a comprehensive overview of the current knowledge about Clostridioides (C.) difficile (formerly known as Clostridium difficile) and Clostridioides difficile infections (CDI). The diseases caused by C. difficile range from mild diarrhea to fulminant and in some cases fatal colitis. Historically, CDI was considered mainly as a hospital-acquired problem. Today, a significant portion of CDI is community acquired. Triggered by the introduction of new antibiotics, hypervirulent and multi-drug resistant strains of C. difficile (e.g., C. difficile ribotype R027) have emerged and spread across the globe. The volume covers the microbiology, pathophysiology, epidemiology, risk factors for CDI, diagnosis, clinical pictures, treatment and prophylaxis. It includes an extensive reference list that allows an easy navigation through the original research publications. Clostridioides difficile helps the reader gain a better understanding of C. difficile, the challenges that may arise and the available treatment options. Given its broad coverage and features, it will appeal to a wide readership, from gastroenterologists through general physicians, nurses, and other healthcare providers, to students.

Author : Paola Mastrantonio,Maja Rupnik
Publisher : Springer
Page : 261 pages
File Size : 44,8 Mb
Release : 2018-01-29
Category : Medical
ISBN : 9783319727998

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Updates on Clostridium difficile in Europe by Paola Mastrantonio,Maja Rupnik Pdf

This book outlines the currently available clinical, epidemiological and experimental data on Clostridium difficile infection (CDI) with special emphasis on studies and results achieved in Europe. The incidence and severity of CDI has increased significantly over the last decade, and the book explains why C. difficile, recently reclassified as Clostridioides difficile, remains a significant challenge, also from economic perspective, to health care systems all over the world. The different reservoirs of this ubiquitous microorganism are reviewed as well as the different factors contributing to its virulence, such as toxins and biofilm formation. The rapid evolution of antibiotic resistance is clearly a concern and in a specific way can influence the CDI epidemiology. Additionally, new emerging strains and comparative genomics studies are discussed for their relevance from epidemiological and evolutionary point of view. The book also gives an overview on diagnostics, therapy and surveillance, all of which are still challenging. Therefore, a closer look is taken on the effect of probiotics as an alternative to antibiotics, for prevention and treatment of CDI. Fecal transplantation from healthy donors, passive immunotherapies and vaccines for patients with recurrences are also discussed in dedicated chapters. The book closes with a summary of the history and the achievements of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Clostridium difficile (ESGCD) written by the current and past presidents of the Society. It is the aim of this book to raise awareness on CDI and to disseminate updated information on its prevention, diagnosis and treatment.

Author : Teena Chopra
Publisher : Springer Nature
Page : 80 pages
File Size : 52,9 Mb
Release : 2019-11-14
Category : Medical
ISBN : 9783030297725

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Clostridium Difficile Infection in Long-Term Care Facilities by Teena Chopra Pdf

This book aims to fill knowledge gap among healthcare workers about Clostridium difficile (also known as C.difficile and CDI) among aging patients, especially those in long-term care facilities (LTCFs). Written by experts in infectious diseases and geriatric medicine, this book provides comprehensive information on all aspects of CDI pertaining to LTCF settings, including epidemiology, diagnosis, prevention, management and the unique challenges faced by LTCFs with regards to the CDI problem. The book begins by introducing the topic as it relates to aging patients before delving into the various aspects of CDI management. Topics include infection control and prevention, treatment of CDI, and the establishment of antibiotic stewardship programs to reduce inappropriate antibiotic use and reduce CDI rates. The book also features a chapter on probiotics for the prevention of CDI and new strategies to monitor environmental cleaning practices of CDI patient rooms that do not appear in any other resource. Clostridium Difficile Infection in Long-Term Care Facilities is an excellent resource for geriatricians, infectious diseases specialists, long-term care administrators, nurses, pharmacists, researchers, and all clinicians working with infections in long-term care settings.

Author : Mark H. Wilcox
Publisher : Elsevier Health Sciences
Page : 201 pages
File Size : 51,6 Mb
Release : 2015-04-07
Category : Medical
ISBN : 9780323356800

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Clostridium difficile Infection, An Issue of Infectious Disease Clinics of North America, by Mark H. Wilcox Pdf

This issue of Infectious Disease Clinics of North America, guest edited by Dr. Mark H. Wilcox, is devoted to Clostridium Difficile Infection. Articles in this issue include: Potential sources of C. difficile for human infection; Colonisation versus carriage of C. difficile; Diagnostic pitfalls in C. difficile infection; The epidemiology of C. difficile infection in and outside of healthcare institutions; What makes epidemic C. difficile strains epidemic?: Fact versus fiction; Environmental interventions to control C. difficile infection; The contribution of strains and hosts to outcomes in C. difficile infection; Treatment of C. difficile infection; Faecal microbiota transplantation for the management of C. difficile infection; The morbidity, mortality, and costs associated with C. difficile infection; The potential of probiotics to prevent C. difficile infection; The prospect for vaccines to prevent C. difficile infection; and Predictive value of models of C. difficile infection.

Author : Paola Mastrantonio,Maja Rupnik
Publisher : Springer Nature
Page : 368 pages
File Size : 52,8 Mb
Release : 2024-01-04
Category : Medical
ISBN : 9783031421082

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Updates on Clostridioides difficile in Europe by Paola Mastrantonio,Maja Rupnik Pdf

This fully updated second edition outlines the currently available clinical, epidemiological and experimental data on Clostridioides difficile infections(CDI) with special emphasis on studies and results achieved in Europe. The incidence and severity of CDI has increased significantly over the last decade, and the book explains why C. difficile, recently reclassified as Clostridioides difficile, remains a significant challenge, also from economic perspective, to health care systems all over the world. The different reservoirs of this ubiquitous microorganism are reviewed as well as the different factors contributing to its virulence, such as toxins and biofilm formation. The rapid evolution of antibiotic resistance is clearly a concern and in a specific way can influence the CDI epidemiology. Additionally, new emerging strains and comparative genomics studies are taken into consideration for their relevance from epidemiological and evolutionary point of view. The book also gives an overview on diagnostics, therapy and surveillance, all of which are still challenging. Therefore, a closer look is taken on the effect of probiotics as an alternative to antibiotics, for prevention and treatment of CDI. Fecal transplantation from healthy donors, passive immunotherapies and vaccines for patients with recurrences are also discussed in dedicated chapters. New topics included sporulation and membrane vesicles in C. difficile. The book closes with a summary of the history and the achievements of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Clostridium difficile (ESGCD) written by the current and past presidents of the Society. It is the aim of this book to raise awareness on CDI and to disseminate updated information on its prevention, diagnosis and treatment.

Author : K. Aktories,T.D. Wilkins
Publisher : Springer Science & Business Media
Page : 150 pages
File Size : 42,5 Mb
Release : 2013-04-17
Category : Science
ISBN : 9783662062722

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Clostridium difficile by K. Aktories,T.D. Wilkins Pdf

Clostridium difficile has been recognized as the cause of a broad spectrum of enteric disease ranging from mild antibiotic-associated diarrhea to pseudomembranous colitis. This volume gives new insights into the microbiology, diagnostics and epidemiology of Clostridium difficile and describes recent strategies in treatment of diseases caused by this agent. Main parts of the volume are devoted to Clostridium difficile toxins A and B which are the major virulence factors. The molecular biology, biochemistry, pharmacology and cell biology of these toxins which are the prototypes of a new family of large clostridial cytotoxins is described in great detail. Clostridium difficile toxins act as glucosyltransferases to inactivate small GTP-binding proteins of the Rho family which are involved in regulation of the actin cytoskeleton, cell adhesion and various signaling processes.

Author : S.P. Borriello
Publisher : Springer Science & Business Media
Page : 180 pages
File Size : 47,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400956643

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Antibiotic Associated Diarrhoea and Colitis by S.P. Borriello Pdf

Antimicrobial-associated diarrhea is often caused by Clostridium difficile; this disease can best be diagnosed by detection of fecal cytotoxin in a tissue culture assay and, when therapy is indicated, can be effectively treated with orally administered vancomycin. The cause of disease in most cases of antimicrobial-associated diarrhea that do not involve C. difficile is not known; fortunately, this form of diarrhea 1S usually mild. Antimicrobial-associated diarrhea may also rarely involve s. aureus and certain enteric pathogens. 37 QHAPTER 4 Qf. TECTlON. ISOLATION Al:iQ. . . IQENTlFICATlON OF CLOSTRIDIUM PIFFICILE S.P. BORRIELLO and PAULINE HONOUR Introduction 38 Detection of Co dlfflcile in stools 38 Direct methods 38 Indirect methods 39 Isolation of Co djfficjle 40 Identification of Co difflcile 44 38 DETECTION ISOLATION AND IDENTIFICATION OF CLOSTRIDIUM DIFFICILE S.P. Borriello and Pauline Honour Introduction In view of the mounting evidence generated world wide in the last few years that firmly implicates £. difficile as the aetiological agent in both antibiotic and non-antibiotic associated pseudomembranous colitis (Larson ~ al., 1978, Bartlett ~ al., 1978a, George ~ al., 1978a), and also recent recognition of the fact that there may be a spectrum of gastrointestinal diseases associated with £. difficile infections (Borriello and Larson, 1981, Bolton ~ al., 1980, Brettle ~ al., 1982), an increasing number of laboratories are seeking to detect, isolate and identify £. difficile from clinical samples.

Author : Jean-Claude Rambaud,J.Thomas LaMont
Publisher : Springer Science & Business Media
Page : 143 pages
File Size : 41,5 Mb
Release : 2013-12-01
Category : Medical
ISBN : 9782817809243

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Ökosystem Darm Special by Jean-Claude Rambaud,J.Thomas LaMont Pdf

Jean-Claude Rambaud The place occupied today in basic and clinical research by intestinal disease related to Clostridium difficile is such that it is hard to remember that this range of disorders was completely identified only in 1977-1978, even though pieces of the puzzle had been identified much earlier. A brief historical review of the discovery of the enteropathogenicity of C. difficile in man might thus be useful. The bacterium was described in 1935 in the stools of infants, using the name Bacillus difficilis [7]. Until 1977, the microorganism, renamed C. difficile, considered to be of endogenous origin, was isolated only in rare cases of abscess or infection, most often unrelated to the digestive tract. Its role in genito-urinary infections [6] was not confirmed. However, the frequency of infant healthy carriers was recognized from the outset [7, 13]. Pseudo-membranous colitis (PMC) was described in 1883 following a gastroenterostomy. Many cases of this condition were published subsequently before the antibiotic era, describing various risk factors [4]. However the disease began to flourish only with the increasingly wide use of antibiotics. Antibiotic associated PMC was first described as an enterocolitis, though with little pathological evidence. It was principally related to the use of chloramphenicol and tetracyclines and attributed to proliferation of Staphylococcus au reus [ 11], a concept strengthened by the spectacular therapeutic action of vancomycin.

Author : American Academy of Pediatrics
Publisher : Unknown
Page : 440 pages
File Size : 42,6 Mb
Release : 2007
Category : Health & Fitness
ISBN : 158110247X

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Red Book Atlas of Pediatric Infectious Diseases by American Academy of Pediatrics Pdf

Based on key content from Red Book: 2006 Report of the Committee on Infectious Diseases, 27th Edition, the new Red Bookr Atlas is a useful quick reference tool for the clinical diagnosis and treatment of more than 75 of the most commonly seen pediatric infectious diseases. Includes more than 500 full-color images adjacent to concise diagnostic and treatment guidelines. Essential information on each condition is presented in the precise sequence needed in the clinical setting: Clinical manifestations, Etiology, Epidemiology, Incubation period, Diagnostic tests, Treatment

Author : Peter Mullany,Adam P. Roberts
Publisher : Methods in Molecular Biology
Page : 260 pages
File Size : 50,7 Mb
Release : 2010-06-08
Category : Medical
ISBN : STANFORD:36105211741256

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Clostridium Difficile by Peter Mullany,Adam P. Roberts Pdf

This book brings together the most recently developed methods for studying clostridium difficile, including techniques involving isolation, molecular typing, genomics, genetic manipulation, and the use of animal models.

Author : Rial D. Rolfe
Publisher : Elsevier
Page : 408 pages
File Size : 40,8 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483289052

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Clostridium Difficile by Rial D. Rolfe Pdf

Despite the tremendous progress made during the last few years in understanding the pathogenesis, epidemiology, diagnosis, and treatment of Clostridium difficile-associated intestinal disease, many extremely important and fundamental questions remain to be answered. The objectives of this book are to summarize the available information regarding Clostridium difficile and its role in intestinal disease and to serve as a basis for future investigations in this challenging area. Clostridium difficile: its role in Intestinal Disease. An excellent volume that should appeal not only to the devotee of C difficile but to all gastroenterologists and microbiologists, this will not languish on my library shelves like so many other books I have reviewed. It will be regularly thumbed. --R.H. George, consultant microbiologist, Children's Hospital, Birmingham Clostridium difficile: Its Role in Intestinal disease. The book is well written and informative; it has a vast amount of information packed in it...this book would be a welcome addition to the researchers and clinicians interested in C difficile-associated intestinal diseases. --Edward Balish, University of Wisconsin Medical School

Author : Hideaki Kato
Publisher : Nova Science Publishers
Page : 52 pages
File Size : 54,7 Mb
Release : 2010
Category : Clostridium difficile
ISBN : 1613244665

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Clostridum [sic] Difficile-associated Diarrhea by Hideaki Kato Pdf

Author : C. S. Pitchumoni,T. Dharmarajan
Publisher : Springer Science & Business Media
Page : 690 pages
File Size : 50,7 Mb
Release : 2012-07-26
Category : Medical
ISBN : 9781441916235

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Geriatric Gastroenterology by C. S. Pitchumoni,T. Dharmarajan Pdf

As aging trends in the United States and Europe in particular are strongly suggestive of increasingly older society, it would be prudent for health care providers to better prepare for such changes. By including physiology, disease, nutrition, pharmacology, pathology, radiology and other relevant associated topics, Geriatric Gastroenterology fills the void in the literature for a volume devoted specifically to gastrointestinal illness in the elderly. This unique volume includes provision of training for current and future generations of physicians to deal with the health problems of older adults. It will also serve as a comprehensive guide to practicing physicians for ease of reference. Relevant to the geriatric age group, the volume covers epidemiology, physiology of aging, gastrointestinal physiology, pharmacology, radiology, pathology, motility disorders, luminal disorders, hepato-biliary disease, systemic manifestations, neoplastic disorders, gastrointestinal bleeding, cancer and medication related interactions and adverse events, all extremely common in older adults; these are often hard to evaluate and judge, especially considering the complex aging physiology. All have become important components of modern medicine. Special emphasis is be given to nutrition and related disorders. Capsule endoscopy and its utility in the geriatric population is also covered. Presented in simple, easy to read style, the volume includes numerous tables, figures and key points enabling ease of understanding. Chapters on imaging and pathology are profusely illustrated. All chapters are written by specialists and include up to date scientific information. Geriatric Gastroenterology is of great utility to residents in internal medicine, fellows in gastroenterology and geriatric medicine as well as gastroenterologists, geriatricians and practicing physicians including primary care physicians caring for older adults.

Author : J. Thomas Lamont
Publisher : In 30 Minutes Guides
Page : 0 pages
File Size : 55,6 Mb
Release : 2022-06
Category : Clostridium difficile
ISBN : 1641880783

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C. Diff In 30 Minutes by J. Thomas Lamont Pdf

Revised and updated second edition! If you or a loved one has C. diff, C. Diff In 30 Minutes can be an invaluable and expert resource to understand and deal with the infection and symptoms. Author, doctor, and Harvard Medical School Professor J. Thomas Lamont, M.D. uses plain-English explanations and case studies to explain how C. diff can be successfully managed.

Author : Hideaki Kato,Haru Kato
Publisher : Nova Novinka
Page : 0 pages
File Size : 55,8 Mb
Release : 2010
Category : Clostridium difficile
ISBN : 1617282782

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Clostridum Difficile-Associated Diarrhea by Hideaki Kato,Haru Kato Pdf

Clostridium Difficile is a gram-positive anaerobic, spore-forming bacterium involved in antibiotic-associated diarrhea and colitis, which is developed after administration of antibiotics. C. difficile is nosocomially transmissible via hospital staff and contaminated environmental surface, as well between patients. C. difficile infection results in a broad spectrum of disease ranging from mild diarrhea to severe life-threatening condition. Colonic injury and inflammation are caused by the two types of toxins: toxin A and B produced by the bacteria. This book the occurrence of and treatment options for clostridium difficile among patients who develop this condition.