Complex Systems In Biomedicine

Author : Thomas Deisboeck,J. Yasha Kresh
Publisher : Springer Science & Business Media
Page : 857 pages
File Size : 42,8 Mb
Release : 2007-06-13
Category : Medical
ISBN : 9780387335322

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Complex Systems Science in Biomedicine by Thomas Deisboeck,J. Yasha Kresh Pdf

Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure. The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science. Key Topics Include: • Historic Perspectives of General Systems Thinking • Fundamental Methods and Techniques for Studying Complex Dynamical Systems • Applications from Molecular Networks to Disease Processes • Enabling Technologies for Exploration of Systems in the Life Sciences Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field. About the Editors: Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging. J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.

Author : Thomas Deisboeck,J. Yasha Kresh
Publisher : Springer
Page : 864 pages
File Size : 48,7 Mb
Release : 2010-11-16
Category : Medical
ISBN : 0387510761

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Complex Systems Science in Biomedicine by Thomas Deisboeck,J. Yasha Kresh Pdf

Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure. The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science. Key Topics Include: • Historic Perspectives of General Systems Thinking • Fundamental Methods and Techniques for Studying Complex Dynamical Systems • Applications from Molecular Networks to Disease Processes • Enabling Technologies for Exploration of Systems in the Life Sciences Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field. About the Editors: Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging. J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.

Author : A. Quarteroni,L. Formaggia,A. Veneziani
Publisher : Springer Science & Business Media
Page : 299 pages
File Size : 49,5 Mb
Release : 2007-03-20
Category : Science
ISBN : 9788847003965

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Complex Systems in Biomedicine by A. Quarteroni,L. Formaggia,A. Veneziani Pdf

Mathematicalmodelingofhumanphysiopathologyisatremendouslyambitioustask. It encompasses the modeling of most diverse compartments such as the cardiovas- lar,respiratory,skeletalandnervoussystems,aswellasthemechanicalandbioch- ical interaction between blood ?ow and arterial walls, and electrocardiac processes and electric conduction in biological tissues. Mathematical models can be set up to simulate both vasculogenesis (the aggregation and organization of endothelial cells dispersed in a given environment) and angiogenesis (the formation of new vessels sprouting from an existing vessel) that are relevant to the formation of vascular networks, and in particular to the description of tumor growth. The integration of models aimed at simulating the cooperation and interrelation of different systems is an even more dif?cult task. It calls for the setting up of, for instance, interaction models for the integrated cardio-vascular system and the interplay between the central circulation and peripheral compartments, models for the mid-to-long range cardiovascular adjustments to pathological conditions (e.g., to account for surgical interventions, congenital malformations, or tumor growth), models for integration among circulation, tissue perfusion, biochemical and thermal regulation, models for parameter identi?cation and sensitivity analysis to parameter changes or data uncertainty – and many others.

Author : Edison T. Liu,Douglas A. Lauffenburger
Publisher : Academic Press
Page : 448 pages
File Size : 44,6 Mb
Release : 2009-09-17
Category : Science
ISBN : 0080919839

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Systems Biomedicine by Edison T. Liu,Douglas A. Lauffenburger Pdf

Systems biology is a critical emerging field that quantifies and annotates the complexity of biological systems in order to construct algorithmic models to predict outcomes from component input. Applications in medicine are revolutionizing our understanding of biological processes and systems. Systems Biomedicine is organized around foundations, computational modeling, network biology, and integrative biology, with the extension of examples from human biology and pharmacology, to focus on the applications of systems approaches to medical problems. An integrative approach to the underlying genomic, proteomic, and computational biology principles provides researchers with guidance in the use of qualitative systems and hypothesis generators. To reflect the highly interdisciplinary nature of the field, careful detail has been extended to ensure explanations of complex mathematical and biological principles are clear with minimum technical jargon. Organized to reflect the important distinguishing characteristics of systems strategies in experimental biology and medicine Provides precise and comprehensive measurement tools for constructing a model of the system and tools for defining complexity as an experimental dependent variable Includes a thorough discussion of the applications of quantitative principles to biomedical problems

Author : William B. Blesser
Publisher : Unknown
Page : 652 pages
File Size : 48,5 Mb
Release : 1969
Category : Technology & Engineering
ISBN : UOM:39015003215871

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A Systems Approach to Biomedicine by William B. Blesser Pdf

Author : Robert B. Northrop
Publisher : CRC Press
Page : 551 pages
File Size : 50,7 Mb
Release : 2010-12-10
Category : Medical
ISBN : 9781439894989

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Introduction to Complexity and Complex Systems by Robert B. Northrop Pdf

The boundaries between simple and complicated, and complicated and complex system designations are fuzzy and debatable, even using quantitative measures of complexity. However, if you are a biomedical engineer, a biologist, physiologist, economist, politician, stock market speculator, or politician, you have encountered complex systems. Furthermore, your success depends on your ability to successfully interact with and manage a variety of complex systems. In order not to be blindsided by unexpected results, we need a systematic, comprehensive way of analyzing, modeling, and simulating complex systems to predict non-anticipated outcomes. In its engaging first chapters, the book introduces complex systems, Campbell's Law, and the Law of Unintended Consequences, and mathematics necessary for conversations in complex systems. Subsequent chapters illustrate concepts via commonly studied biological mechanisms. The final chapters focus on higher-level complexity problems, and introduce complexity in economic systems. Designed as a reference for biologists and biological engineers, Introduction to Complexity and Complex Systems lends itself to use in a classroom course to introduce advanced students studying biomedical engineering, biophysics, or physiology to complex systems. Engaging and illustrative, this book aids scientists and decision makers in managing biological complexity and complex systems.

Author : David C. Aron
Publisher : Springer Nature
Page : 255 pages
File Size : 50,7 Mb
Release : 2019-08-30
Category : Medical
ISBN : 9783030245931

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Complex Systems in Medicine by David C. Aron Pdf

This unique title explores complex systems in clinical medicine and the subsequent implementation of that knowledge into practice. Written conversationally and as a reflection on the journey of learning about complex systems, the book explores how knowledge of these systems can be applied to four key roles in academic medicine: clinical practice, education, research, and administration. Further, this title emphasizes how gaining an understanding of complex systems can greatly help a physician deal with the many challenges found in academic medicine. Unlike other books on complexity in medicine, which tend to focus on only one aspect of the management of patients, Complex Systems in Medicine deals with the multifaceted roles of a physician. The approach in this book is uniquely qualitative rather than mathematical, and is written to make it not only of interest to physicians, trainees, and allied health providers, but also to make it more accessible to a non-medical audience. The inclusion of personal anecdotes by the author provides concrete examples of the application of knowledge of complex systems in academic medicine. A first-of-its-kind contribution to the literature, Complex Systems in Medicine: A Hedgehog’s Tale of Complexity in Clinical Practice, Research, Education, and Management is not only a novel reference for medical professionals, it is an accessible tool for the non-medical audience hoping to learn more about complex systems and their direct relevance to medicine, a field that deals with the infinite variety of humans and their ills. It illustrates the consequences of the interactive elements of patient care that make medicine both a science and an art.

Author : Pietro Lio,Enrico Capobianco
Publisher : Frontiers E-books
Page : 114 pages
File Size : 49,9 Mb
Release : 2014-12-03
Category : Genetics
ISBN : 9782889193745

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Comprehensive Systems Biomedicine by Pietro Lio,Enrico Capobianco Pdf

Systems Biomedicine is a field in perpetual development. By definition a translational discipline, it emphasizes the role of quantitative systems approaches in biomedicine and aims to offer solutions to many emerging problems characterized by levels and types of complexity and uncertainty unmet before. Many factors, including technological and societal ones, need to be considered. In particular, new technologies are providing researchers with the data deluge whose management and exploitation requires a reinvention of cross-disciplinary team efforts. The advent of “omics” and high-content imaging are examples of advances de facto establishing the necessity of systems approaches. Hypothesis-driven models and in silico validation tools in support to all the varieties of experimental applications call for a profound revision. The focus on phases like mining and assimilating the data has substantially increased so to allow for interpretable knowledge to be inferred. Notably, to be able to tackle the newly generated data dimensionality, heterogeneity and complexity, model-free and data-driven intensive applications are increasingly shaping the computational pipelines and architectures that quant specialists set aside of the high-throughput genomics, transcriptomics, proteomics platforms. As for the societal aspects, in many advanced societies health care needs now more than in the past to address the problem of managing ageing populations and their complex morbidity patterns. In parallel, there is a growing research interest on the impact that cross-disciplinary clinical, epidemiological and quantitative modelling studies can have in relation to outcomes potentially affecting the quality of life of many people. Complex systems, including those characterizing biomedicine, are assessed in both their functionality and stability, and also relatively to the capacity of generating information from diversity, variation, and complexity. Due to the combined interactions and effects, such systems embed prediction power available for instance in both target identification or marker discovery, or more generally for conducting inference about patients’ pathological states, i.e. normal versus disease, diagnostic or prognostic analysis, and preventive assessment (e.g., risk evaluation). The ultimate goal, personalized medicine, will be achieved based on the confluence of the system’s predictive power to patient-specific profiling.

Author : Paulo J.G. Lisboa,Emmanuel C. Ifeachor,Piotr S. Szczepaniak
Publisher : Springer Science & Business Media
Page : 290 pages
File Size : 42,5 Mb
Release : 2012-12-06
Category : Computers
ISBN : 9781447104872

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Artificial Neural Networks in Biomedicine by Paulo J.G. Lisboa,Emmanuel C. Ifeachor,Piotr S. Szczepaniak Pdf

Following the intense research activIties of the last decade, artificial neural networks have emerged as one of the most promising new technologies for improving the quality of healthcare. Many successful applications of neural networks to biomedical problems have been reported which demonstrate, convincingly, the distinct benefits of neural networks, although many ofthese have only undergone a limited clinical evaluation. Healthcare providers and developers alike have discovered that medicine and healthcare are fertile areas for neural networks: the problems here require expertise and often involve non-trivial pattern recognition tasks - there are genuine difficulties with conventional methods, and data can be plentiful. The intense research activities in medical neural networks, and allied areas of artificial intelligence, have led to a substantial body of knowledge and the introduction of some neural systems into clinical practice. An aim of this book is to provide a coherent framework for some of the most experienced users and developers of medical neural networks in the world to share their knowledge and expertise with readers.

Author : Yacov Y. Haimes
Publisher : John Wiley & Sons
Page : 928 pages
File Size : 52,6 Mb
Release : 2018-09-04
Category : Technology & Engineering
ISBN : 9781119173694

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Modeling and Managing Interdependent Complex Systems of Systems by Yacov Y. Haimes Pdf

A comprehensive guide to the theory, methodology, and development for modeling systems of systems Modeling and Managing Interdependent Complex Systems of Systems examines the complexity of, and the risk to, emergent interconnected and interdependent complex systems of systems in the natural and the constructed environment, and in its critical infrastructures. For systems modelers, this book focuses on what constitutes complexity and how to understand, model and manage it.Previous modeling methods for complex systems of systems were aimed at developing theory and methodologies for uncoupling the interdependencies and interconnections that characterize them. In this book, the author extends the above by utilizing public- and private- sector case studies; identifies, explores, and exploits the core of interdependencies; and seeks to understand their essence via the states of the system, and their dominant contributions to the complexity of systems of systems. The book proposes a reevaluation of fundamental and practical systems engineering and risk analysis concepts on complex systems of systems developed over the past 40 years. This important resource: Updates and streamlines systems engineering theory, methodology, and practice as applied to complex systems of systems Introduces modeling methodology inspired by philosophical and conceptual thinking from the arts and sciences Models the complexity of emergent interdependent and interconnected complex systems of systems by analyzing their shared states, decisions, resources, and decisionmakers Written for systems engineers, industrial engineers, managers, planners, academics and other professionals in engineering systems and the environment,this text is the resource for understanding the fundamental principles of modeling and managing complex systems of systems, and the risk thereto.

Author : Alberto D'Onofrio,Paola Cerrai,Alberto Gandolfi
Publisher : Springer Science & Business Media
Page : 398 pages
File Size : 44,9 Mb
Release : 2013-01-25
Category : Mathematics
ISBN : 9788847025714

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New Challenges for Cancer Systems Biomedicine by Alberto D'Onofrio,Paola Cerrai,Alberto Gandolfi Pdf

The future of oncology seems to lie in Molecular Medicine (MM). MM is a new science based on three pillars. Two of them are evident in its very name and are well known: medical science and molecular biology. However, there is a general unawareness that MM is firmly based on a third, and equally important, pillar: Systems Biomedicine. Currently, this term denotes multilevel, hierarchical models integrating key factors at the molecular, cellular, tissue, through phenotype levels, analyzed to reveal the global behavior of the biological process under consideration. It becomes increasingly evident that the tools to construct such complex models include, not only bioinformatics and modern applied statistics, as is unanimously agreed, but also other interdisciplinary fields of science, notably, Mathematical Oncology, Systems Biology and Theoretical Biophysics.

Author : Anonim
Publisher : Elsevier
Page : 952 pages
File Size : 55,9 Mb
Release : 2011-05-23
Category : Philosophy
ISBN : 0080931227

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Philosophy of Complex Systems by Anonim Pdf

The domain of nonlinear dynamical systems and its mathematical underpinnings has been developing exponentially for a century, the last 35 years seeing an outpouring of new ideas and applications and a concomitant confluence with ideas of complex systems and their applications from irreversible thermodynamics. A few examples are in meteorology, ecological dynamics, and social and economic dynamics. These new ideas have profound implications for our understanding and practice in domains involving complexity, predictability and determinism, equilibrium, control, planning, individuality, responsibility and so on. Our intention is to draw together in this volume, we believe for the first time, a comprehensive picture of the manifold philosophically interesting impacts of recent developments in understanding nonlinear systems and the unique aspects of their complexity. The book will focus specifically on the philosophical concepts, principles, judgments and problems distinctly raised by work in the domain of complex nonlinear dynamical systems, especially in recent years. -Comprehensive coverage of all main theories in the philosophy of Complex Systems -Clearly written expositions of fundamental ideas and concepts -Definitive discussions by leading researchers in the field -Summaries of leading-edge research in related fields are also included

Author : Anonim
Publisher : Springer
Page : 10398 pages
File Size : 48,5 Mb
Release : 2009-06-26
Category : Science
ISBN : 0387758887

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Encyclopedia of Complexity and Systems Science by Anonim Pdf

This encyclopedia provides an authoritative single source for understanding and applying the concepts of complexity theory together with the tools and measures for analyzing complex systems in all fields of science and engineering. It links fundamental concepts of mathematics and computational sciences to applications in the physical sciences, engineering, biomedicine, economics and the social sciences.

Author : Joachim P Sturmberg,Carmel Martin
Publisher : Springer Science & Business Media
Page : 941 pages
File Size : 49,5 Mb
Release : 2013-01-09
Category : Medical
ISBN : 9781461449980

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Handbook of Systems and Complexity in Health by Joachim P Sturmberg,Carmel Martin Pdf

This book is an introduction to health care as a complex adaptive system, a system that feeds back on itself. The first section introduces systems and complexity theory from a science, historical, epistemological, and technical perspective, describing the principles and mathematics. Subsequent sections build on the health applications of systems science theory, from human physiology to medical decision making, population health and health services research. The aim of the book is to introduce and expand on important population health issues from a systems and complexity perspective, highlight current research developments and their implications for health care delivery, consider their ethical implications, and to suggest directions for and potential pitfalls in the future.

Author : Paulo J.G. Lisboa,Emmanuel C. Ifeachor,Piotr S. Szczepaniak
Publisher : Springer Science & Business Media
Page : 314 pages
File Size : 40,8 Mb
Release : 2000-02-02
Category : Computers
ISBN : 1852330058

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Artificial Neural Networks in Biomedicine by Paulo J.G. Lisboa,Emmanuel C. Ifeachor,Piotr S. Szczepaniak Pdf

This volume provides a state-of-the-art survey of artificial neural network applications in biomedical diagnosis, laboratory data analysis and related practical areas. It looks at biomedical applications which involve customising neural network technology to resolve specific difficulties with data processing, and deals with applications relating to particular aspects of clinical practice and laboratory or medically-related analysis. Each chapter is self-contained with regard to the technology used, covering important technical points and implementation issues like the design of user interfaces and hardware/software platforms. Artificial Neural Networks in Biomedicine will be of interest to computer scientists and neural network practitioners who want to extend their knowledge of issues relevant to biomedical applications, developers of clinical computer systems, and medical researchers looking for new methods and computational tools.