Complex Systems Science In Biomedicine

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Complex Systems Science in Biomedicine

Thomas Deisboeck,J. Yasha Kresh
Complex Systems Science in Biomedicine Book PDF

Author : Thomas Deisboeck,J. Yasha Kresh
Publisher : Springer Science & Business Media
Page : 857 pages
File Size : 51,9 Mb
Release : 2007-06-13
Category : Medical
ISBN : 9780387335322

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Complex Systems Science in Biomedicine by Thomas Deisboeck,J. Yasha Kresh Pdf

Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure. The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science. Key Topics Include: • Historic Perspectives of General Systems Thinking • Fundamental Methods and Techniques for Studying Complex Dynamical Systems • Applications from Molecular Networks to Disease Processes • Enabling Technologies for Exploration of Systems in the Life Sciences Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field. About the Editors: Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging. J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.

Complex Systems Science in Biomedicine

Thomas Deisboeck,J. Yasha Kresh
Complex Systems Science in Biomedicine Book PDF

Author : Thomas Deisboeck,J. Yasha Kresh
Publisher : Springer
Page : 864 pages
File Size : 41,7 Mb
Release : 2010-11-16
Category : Medical
ISBN : 0387510761

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Complex Systems Science in Biomedicine by Thomas Deisboeck,J. Yasha Kresh Pdf

Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure. The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science. Key Topics Include: • Historic Perspectives of General Systems Thinking • Fundamental Methods and Techniques for Studying Complex Dynamical Systems • Applications from Molecular Networks to Disease Processes • Enabling Technologies for Exploration of Systems in the Life Sciences Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field. About the Editors: Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging. J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.

The Local Information Dynamics of Distributed Computation in Complex Systems

Joseph T. Lizier
The Local Information Dynamics of Distributed Computation in Complex Systems Book PDF

Author : Joseph T. Lizier
Publisher : Springer Science & Business Media
Page : 249 pages
File Size : 41,6 Mb
Release : 2012-11-06
Category : Technology & Engineering
ISBN : 9783642329524

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The Local Information Dynamics of Distributed Computation in Complex Systems by Joseph T. Lizier Pdf

The nature of distributed computation in complex systems has often been described in terms of memory, communication and processing. This thesis presents a complete information-theoretic framework to quantify these operations on information (i.e. information storage, transfer and modification), and in particular their dynamics in space and time. The framework is applied to cellular automata, and delivers important insights into the fundamental nature of distributed computation and the dynamics of complex systems (e.g. that gliders are dominant information transfer agents). Applications to several important network models, including random Boolean networks, suggest that the capability for information storage and coherent transfer are maximised near the critical regime in certain order-chaos phase transitions. Further applications to study and design information structure in the contexts of computational neuroscience and guided self-organisation underline the practical utility of the techniques presented here.

Introduction to Complexity and Complex Systems

Robert B. Northrop
Introduction to Complexity and Complex Systems Book PDF

Author : Robert B. Northrop
Publisher : CRC Press
Page : 551 pages
File Size : 40,9 Mb
Release : 2010-12-10
Category : Medical
ISBN : 9781439894989

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Introduction to Complexity and Complex Systems by Robert B. Northrop Pdf

The boundaries between simple and complicated, and complicated and complex system designations are fuzzy and debatable, even using quantitative measures of complexity. However, if you are a biomedical engineer, a biologist, physiologist, economist, politician, stock market speculator, or politician, you have encountered complex systems. Furthermore, your success depends on your ability to successfully interact with and manage a variety of complex systems. In order not to be blindsided by unexpected results, we need a systematic, comprehensive way of analyzing, modeling, and simulating complex systems to predict non-anticipated outcomes. In its engaging first chapters, the book introduces complex systems, Campbell's Law, and the Law of Unintended Consequences, and mathematics necessary for conversations in complex systems. Subsequent chapters illustrate concepts via commonly studied biological mechanisms. The final chapters focus on higher-level complexity problems, and introduce complexity in economic systems. Designed as a reference for biologists and biological engineers, Introduction to Complexity and Complex Systems lends itself to use in a classroom course to introduce advanced students studying biomedical engineering, biophysics, or physiology to complex systems. Engaging and illustrative, this book aids scientists and decision makers in managing biological complexity and complex systems.

Proceedings of the European Conference on Complex Systems 2012

Thomas Gilbert,Markus Kirkilionis,Gregoire Nicolis
Proceedings of the European Conference on Complex Systems 2012 Book PDF

Author : Thomas Gilbert,Markus Kirkilionis,Gregoire Nicolis
Publisher : Springer Science & Business Media
Page : 1096 pages
File Size : 42,7 Mb
Release : 2013-08-15
Category : Science
ISBN : 9783319003955

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Proceedings of the European Conference on Complex Systems 2012 by Thomas Gilbert,Markus Kirkilionis,Gregoire Nicolis Pdf

The European Conference on Complex Systems, held under the patronage of the Complex Systems Society, is an annual event that has become the leading European conference devoted to complexity science. ECCS'12, its ninth edition, took place in Brussels, during the first week of September 2012. It gathered about 650 scholars representing a wide range of topics relating to complex systems research, with emphasis on interdisciplinary approaches. More specifically, the following tracks were covered: 1. Foundations of Complex Systems 2. Complexity, Information and Computation 3. Prediction, Policy and Planning, Environment 4. Biological Complexity 5. Interacting Populations, Collective Behavior 6. Social Systems, Economics and Finance This book contains a selection of the contributions presented at the conference and its satellite meetings. Its contents reflect the extent, diversity and richness of research areas in the field, both fundamental and applied.

Emergent Behavior in Complex Systems Engineering

Saurabh Mittal,Saikou Diallo,Andreas Tolk
Emergent Behavior in Complex Systems Engineering Book PDF

Author : Saurabh Mittal,Saikou Diallo,Andreas Tolk
Publisher : John Wiley & Sons
Page : 416 pages
File Size : 53,6 Mb
Release : 2018-04-17
Category : Technology & Engineering
ISBN : 9781119378860

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Emergent Behavior in Complex Systems Engineering by Saurabh Mittal,Saikou Diallo,Andreas Tolk Pdf

A comprehensive text that reviews the methods and technologies that explore emergent behavior in complex systems engineering in multidisciplinary fields In Emergent Behavior in Complex Systems Engineering, the authors present the theoretical considerations and the tools required to enable the study of emergent behaviors in manmade systems. Information Technology is key to today’s modern world. Scientific theories introduced in the last five decades can now be realized with the latest computational infrastructure. Modeling and simulation, along with Big Data technologies are at the forefront of such exploration and investigation. The text offers a number of simulation-based methods, technologies, and approaches that are designed to encourage the reader to incorporate simulation technologies to further their understanding of emergent behavior in complex systems. The authors present a resource for those designing, developing, managing, operating, and maintaining systems, including system of systems. The guide is designed to help better detect, analyse, understand, and manage the emergent behaviour inherent in complex systems engineering in order to reap the benefits of innovations and avoid the dangers of unforeseen consequences. This vital resource: Presents coverage of a wide range of simulation technologies Explores the subject of emergence through the lens of Modeling and Simulation (M&S) Offers contributions from authors at the forefront of various related disciplines such as philosophy, science, engineering, sociology, and economics Contains information on the next generation of complex systems engineering Written for researchers, lecturers, and students, Emergent Behavior in Complex Systems Engineering provides an overview of the current discussions on complexity and emergence, and shows how systems engineering methods in general and simulation methods in particular can help in gaining new insights in complex systems engineering.

Modeling and Managing Interdependent Complex Systems of Systems

Yacov Y. Haimes
Modeling and Managing Interdependent Complex Systems of Systems Book PDF

Author : Yacov Y. Haimes
Publisher : John Wiley & Sons
Page : 928 pages
File Size : 41,7 Mb
Release : 2018-09-04
Category : Technology & Engineering
ISBN : 9781119173694

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Modeling and Managing Interdependent Complex Systems of Systems by Yacov Y. Haimes Pdf

A comprehensive guide to the theory, methodology, and development for modeling systems of systems Modeling and Managing Interdependent Complex Systems of Systems examines the complexity of, and the risk to, emergent interconnected and interdependent complex systems of systems in the natural and the constructed environment, and in its critical infrastructures. For systems modelers, this book focuses on what constitutes complexity and how to understand, model and manage it.Previous modeling methods for complex systems of systems were aimed at developing theory and methodologies for uncoupling the interdependencies and interconnections that characterize them. In this book, the author extends the above by utilizing public- and private- sector case studies; identifies, explores, and exploits the core of interdependencies; and seeks to understand their essence via the states of the system, and their dominant contributions to the complexity of systems of systems. The book proposes a reevaluation of fundamental and practical systems engineering and risk analysis concepts on complex systems of systems developed over the past 40 years. This important resource: Updates and streamlines systems engineering theory, methodology, and practice as applied to complex systems of systems Introduces modeling methodology inspired by philosophical and conceptual thinking from the arts and sciences Models the complexity of emergent interdependent and interconnected complex systems of systems by analyzing their shared states, decisions, resources, and decisionmakers Written for systems engineers, industrial engineers, managers, planners, academics and other professionals in engineering systems and the environment,this text is the resource for understanding the fundamental principles of modeling and managing complex systems of systems, and the risk thereto.

Encyclopedia of Complexity and Systems Science

Anonim
Encyclopedia of Complexity and Systems Science Book PDF

Author : Anonim
Publisher : Springer
Page : 10398 pages
File Size : 48,9 Mb
Release : 2009-07-24
Category : Science
ISBN : 0387695729

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Encyclopedia of Complexity and Systems Science by Anonim Pdf

This encyclopedia provides an authoritative single source for understanding and applying the concepts of complexity theory together with the tools and measures for analyzing complex systems in all fields of science and engineering. It links fundamental concepts of mathematics and computational sciences to applications in the physical sciences, engineering, biomedicine, economics and the social sciences.

Complex Adaptive Systems

Ted Carmichael,Andrew J. Collins,Mirsad Hadžikadić
Complex Adaptive Systems Book PDF

Author : Ted Carmichael,Andrew J. Collins,Mirsad Hadžikadić
Publisher : Springer
Page : 250 pages
File Size : 55,6 Mb
Release : 2019-06-14
Category : Technology & Engineering
ISBN : 9783030203092

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Complex Adaptive Systems by Ted Carmichael,Andrew J. Collins,Mirsad Hadžikadić Pdf

​This book emerged out of international conferences organized as part of the AAAI Fall Symposia series, and the Swarmfest 2017 conference. It brings together researchers from diverse fields studying these complex systems using CAS and agent-based modeling tools and techniques. In the past, the knowledge gained in each domain has largely remained exclusive to that domain. By bringing together scholars who study these phenomena, the book takes knowledge from one domain to provide insight into others. Most interesting phenomena in natural and social systems include constant transitions and oscillations among their various phases – wars, companies, societies, markets, and humans rarely stay in a stable, predictable state for long. Randomness, power laws, and human behavior ensure that the future is both unknown and challenging. How do events unfold? When do they take hold? Why do some initial events cause an avalanche while others do not? What characterizes these events? What are the thresholds that differentiate a sea change from a non-event? Complex adaptive systems (CAS) have proven to be a powerful tool for exploring these and other related phenomena. The authors characterize a general CAS model as having a large number of self-similar agents that: 1) utilize one or more levels of feedback; 2) exhibit emergent properties and self-organization; and 3) produce non-linear dynamic behavior. Advances in modeling and computing technology have led not only to a deeper understanding of complex systems in many areas, but they have also raised the possibility that similar fundamental principles may be at work across these systems, even though the underlying principles may manifest themselves differently.

The Role of Model Integration in Complex Systems Modelling

Manish Patel,Sylvia Nagl
The Role of Model Integration in Complex Systems Modelling Book PDF

Author : Manish Patel,Sylvia Nagl
Publisher : Springer
Page : 168 pages
File Size : 55,7 Mb
Release : 2010-10-02
Category : Technology & Engineering
ISBN : 9783642156038

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The Role of Model Integration in Complex Systems Modelling by Manish Patel,Sylvia Nagl Pdf

Model integration – the process by which different modelling efforts can be brought together to simulate the target system – is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale. A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules. The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value.

Encyclopedia of Complexity and Systems Science

Anonim
Encyclopedia of Complexity and Systems Science Book PDF

Author : Anonim
Publisher : Springer
Page : 10398 pages
File Size : 52,7 Mb
Release : 2009-06-26
Category : Science
ISBN : 0387758887

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Encyclopedia of Complexity and Systems Science by Anonim Pdf

This encyclopedia provides an authoritative single source for understanding and applying the concepts of complexity theory together with the tools and measures for analyzing complex systems in all fields of science and engineering. It links fundamental concepts of mathematics and computational sciences to applications in the physical sciences, engineering, biomedicine, economics and the social sciences.

Comprehending the Complexity of Countries

Hans Kuijper
Comprehending the Complexity of Countries Book PDF

Author : Hans Kuijper
Publisher : Springer Nature
Page : 413 pages
File Size : 46,6 Mb
Release : 2022-01-18
Category : Social Science
ISBN : 9789811647093

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Comprehending the Complexity of Countries by Hans Kuijper Pdf

This book argues for computer-aided collaborative country research based on the science of complex and dynamic systems. It provides an in-depth discussion of systems and computer science, concluding that proper understanding of a country is only possible if a genuinely interdisciplinary and truly international approach is taken; one that is based on complexity science and supported by computer science. Country studies should be carefully designed and collaboratively carried out, and a new generation of country students should pay more attention to the fast growing potential of digitized and electronically connected libraries. In this frenzied age of globalization, foreign policy makers may – to the benefit of a better world – profit from the radically new country studies pleaded for in the book. Its author emphasizes that reductionism and holism are not antagonistic but complementary, arguing that parts are always parts of a whole and a whole has always parts.

Agent-Based Modelling of Socio-Technical Systems

Koen H. van Dam,Igor Nikolic,Zofia Lukszo
Agent Based Modelling of Socio Technical Systems Book PDF

Author : Koen H. van Dam,Igor Nikolic,Zofia Lukszo
Publisher : Springer Science & Business Media
Page : 268 pages
File Size : 53,6 Mb
Release : 2012-10-08
Category : Computers
ISBN : 9789400749337

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Agent-Based Modelling of Socio-Technical Systems by Koen H. van Dam,Igor Nikolic,Zofia Lukszo Pdf

Decision makers in large scale interconnected network systems require simulation models for decision support. The behaviour of these systems is determined by many actors, situated in a dynamic, multi-actor, multi-objective and multi-level environment. How can such systems be modelled and how can the socio-technical complexity be captured? Agent-based modelling is a proven approach to handle this challenge. This book provides a practical introduction to agent-based modelling of socio-technical systems, based on a methodology that has been developed at TU Delft and which has been deployed in a large number of case studies. The book consists of two parts: the first presents the background, theory and methodology as well as practical guidelines and procedures for building models. In the second part this theory is applied to a number of case studies, where for each model the development steps are presented extensively, preparing the reader for creating own models.

Complex Systems in Medicine

David C. Aron
Complex Systems in Medicine Book PDF

Author : David C. Aron
Publisher : Springer Nature
Page : 255 pages
File Size : 55,8 Mb
Release : 2019-08-30
Category : Medical
ISBN : 9783030245931

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Complex Systems in Medicine by David C. Aron Pdf

This unique title explores complex systems in clinical medicine and the subsequent implementation of that knowledge into practice. Written conversationally and as a reflection on the journey of learning about complex systems, the book explores how knowledge of these systems can be applied to four key roles in academic medicine: clinical practice, education, research, and administration. Further, this title emphasizes how gaining an understanding of complex systems can greatly help a physician deal with the many challenges found in academic medicine. Unlike other books on complexity in medicine, which tend to focus on only one aspect of the management of patients, Complex Systems in Medicine deals with the multifaceted roles of a physician. The approach in this book is uniquely qualitative rather than mathematical, and is written to make it not only of interest to physicians, trainees, and allied health providers, but also to make it more accessible to a non-medical audience. The inclusion of personal anecdotes by the author provides concrete examples of the application of knowledge of complex systems in academic medicine. A first-of-its-kind contribution to the literature, Complex Systems in Medicine: A Hedgehog’s Tale of Complexity in Clinical Practice, Research, Education, and Management is not only a novel reference for medical professionals, it is an accessible tool for the non-medical audience hoping to learn more about complex systems and their direct relevance to medicine, a field that deals with the infinite variety of humans and their ills. It illustrates the consequences of the interactive elements of patient care that make medicine both a science and an art.

Systems Biomedicine

Edison T. Liu,Douglas A. Lauffenburger
Systems Biomedicine Book PDF

Author : Edison T. Liu,Douglas A. Lauffenburger
Publisher : Academic Press
Page : 448 pages
File Size : 49,8 Mb
Release : 2009-09-17
Category : Science
ISBN : 0080919839

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Systems Biomedicine by Edison T. Liu,Douglas A. Lauffenburger Pdf

Systems biology is a critical emerging field that quantifies and annotates the complexity of biological systems in order to construct algorithmic models to predict outcomes from component input. Applications in medicine are revolutionizing our understanding of biological processes and systems. Systems Biomedicine is organized around foundations, computational modeling, network biology, and integrative biology, with the extension of examples from human biology and pharmacology, to focus on the applications of systems approaches to medical problems. An integrative approach to the underlying genomic, proteomic, and computational biology principles provides researchers with guidance in the use of qualitative systems and hypothesis generators. To reflect the highly interdisciplinary nature of the field, careful detail has been extended to ensure explanations of complex mathematical and biological principles are clear with minimum technical jargon. Organized to reflect the important distinguishing characteristics of systems strategies in experimental biology and medicine Provides precise and comprehensive measurement tools for constructing a model of the system and tools for defining complexity as an experimental dependent variable Includes a thorough discussion of the applications of quantitative principles to biomedical problems