Compound Solutions

Author : Susan Craddock
Publisher : U of Minnesota Press
Page : 246 pages
File Size : 40,7 Mb
Release : 2017-02-21
Category : Social Science
ISBN : 9781452953786

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Compound Solutions by Susan Craddock Pdf

Claiming 1.5 million lives in 2015, tuberculosis is the world’s most deadly infectious disease. Because of the population it overwhelmingly affects, however, pharmaceutical companies are uninterested in developing better drugs for the disease. Compound Solutions examines Product Development Partnerships (PDPs), which arose early in the twenty-first century to develop new drugs and vaccines for infectious diseases in low-income countries. Here, for the first time, is a sustained examination of PDPs: the work they do, the partnerships they form, their mission, and their underlying philosophy of addressing global health needs—with implications that extend well beyond tuberculosis. Focusing on two PDPs for tuberculosis—the Global Alliance for TB Drug Development (TB Alliance) and Aeras (a nonprofit focused on vaccine development)—Susan Craddock argues that PDPs do much more than product development. As innovative sites of humanitarian pharmaceutical production, they are contravening mainstream pharmaceutical production by tying drug and vaccine research to global health needs rather than shareholder demand. In largely untethering the profit incentive from pharmaceutical production, Craddock shows, PDPs exhibit more creative and efficient scientific practices, reshaping regulatory norms and implementing more ethical forms of clinical trials that enhance community engagement and capacity building. An unparalleled, interdisciplinary analysis of PDPs as politically, socially, scientifically, and economically innovative sites of pharmaceutical production, Compound Solutions is a must for readers in the fields of public health, science and technology studies, and medical social science.

Author : Anonim
Publisher : Jeffrey Frank Jones
Page : 128 pages
File Size : 40,8 Mb
Release : 2024-06-26
Category : Electronic
ISBN : 8210379456XXX

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Drug Compounding And Manufacturing by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 576 pages
File Size : 45,6 Mb
Release : 1995
Category : Drinking water
ISBN : UCR:31210024933705

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Methods for the Determination of Organic Compounds in Drinking Water by Anonim Pdf

Author : Paul A Bartlett,Michael Entzeroth
Publisher : Royal Society of Chemistry
Page : 444 pages
File Size : 41,7 Mb
Release : 2007-10-31
Category : Science
ISBN : 9781847552556

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Exploiting Chemical Diversity for Drug Discovery by Paul A Bartlett,Michael Entzeroth Pdf

Conceptual and technological advances in chemistry and biology have transformed the drug discovery process. Evolutionary pressure among the diverse scientific and engineering disciplines that contribute to the identification of biologically active compounds has resulted in synergistic improvements at every step in the process. Exploiting Chemical Diversity for Drug Discovery encompasses the many components of this transformation and presents the current state-of-the-art of this critical endeavour. From the theoretical and operational considerations in generating a collection of compounds to screen, to the design and implementation of high-capacity and high-quality assays that provide the most useful biological information, this book provides a comprehensive overview of modern approaches to lead identification. Beginning with an introductory overview, subsequent chapters address topics that include the design of chemical libraries and methods for optimizing their diversity; automated and accelerated chemistry; high throughput assay design and detection techniques; and strategies for data analysis and property optimization. Written by experts in the field, both academic and industrial, and illustrated in full colour, this book provides an excellent overview for current practitioners and will also serve as a stimulating resource for future generations. Researchers in organic and medicinal chemistry, the biological and pharmacological sciences, as well as those interested in allied computational and engineering disciplines will value the comprehensive and up-to-date coverage.

Author : LaRoux K. Gillespie
Publisher : Society of Manufacturing Engineers
Page : 433 pages
File Size : 49,5 Mb
Release : 1999
Category : Technology & Engineering
ISBN : 9780872635012

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Deburring and Edge Finishing Handbook by LaRoux K. Gillespie Pdf

Written by industry expert, LaRoux Gillespie, this handbook is the most comprehensive book on burr removal and the treatment of edges ever published. Armed with this in-depth guide to deburring technologies, any engineer involved with part manufacturing will quickly discover how to accurately identify and evaluate the most efficient and cost effective deburring option(s) for a specific application. This groundbreaking work details 100 internationally recognized deburring and edge finishing processes you can employ. It also offers you an extensive base of technical information on a vast array of tools, applications and procedures available. From burr prevention in the design phase to actual burr removal on the line, you will be better prepared to deal with burrs and edge defects and also determine what tolerance level is acceptable for quality production standards - before it becomes a shopfloor problem. Learn how to weigh aesthetic and functional justifications across a wide array of mechanical, thermal, chemical, electrical and manual techniques.

Author : T. J. Tighe,B. E. Shepp
Publisher : Psychology Press
Page : 325 pages
File Size : 48,6 Mb
Release : 2019-01-22
Category : Family & Relationships
ISBN : 9781317738138

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Perception, Cognition, and Development by T. J. Tighe,B. E. Shepp Pdf

This volume is based on a conference held at Dartmouth College’s Minary Conference Center in Holdemess, New Hampshire, June 4 -7 , 1981. The conference brought together a number of investigators whose separate lines of inquiry bear in significant ways on the relationships among perception, cognition, and development. The purpose was to consider interactions among these basic processes not only as a critical facet of the research programs of the participants but also as a central conceptual problem for current theoretical psychology. First published in 1983. Routledge is an imprint of Taylor & Francis, an informa company.

Author : John S. Gero,Ashok K. Goel
Publisher : Springer Science & Business Media
Page : 734 pages
File Size : 43,7 Mb
Release : 2008-09-27
Category : Computers
ISBN : 9781402087288

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Design Computing and Cognition '08 by John S. Gero,Ashok K. Goel Pdf

The importance of research and education in design continues to grow. For example, government agencies are gradually increasing funding of design research, and increasing numbers of engineering schools are revising their curricula to emphasize design. This is because of an increasing realization that design is part of the wealth creation of a nation and needs to be better understood and taught. The continuing globalization of industry and trade has required nations to re-examine where their core contributions lie if not in production efficiency. Design is a precursor to manufacturing for phy- cal objects and is the precursor to implementation for virtual objects. At the same time, the need for sustainable development is requiring design of new products and processes, and feeding a movement towards design - novations and inventions. There are now three sources for design research: design computing, design cognition and human-centered information technology. The foun- tions for much of design computing remains artificial intelligence with its focus on ways of representation and on processes that support simulation and generation. Artificial intelligence continues to provide an environm- tally rich paradigm within which design research based on computational constructions can be carried out. Design cognition is founded on concepts from cognitive science, an even newer area than artificial intelligence. It provides tools and methods to study human designers in both laboratory and practice settings.

Author : Jie Jack Li,E. J. Corey
Publisher : John Wiley & Sons
Page : 595 pages
File Size : 50,8 Mb
Release : 2013-04-12
Category : Medical
ISBN : 9781118354476

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Drug Discovery by Jie Jack Li,E. J. Corey Pdf

Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validation Drug metabolism and pharmacokinetics Central nervous system drugs In vitro and in vivo assays Cardiovascular drugs Cancer drugs Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field. Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.

Author : N.S. Stoloff,V.K. Sikka
Publisher : Springer Science & Business Media
Page : 690 pages
File Size : 55,8 Mb
Release : 2012-12-06
Category : Technology & Engineering
ISBN : 9781461312154

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Physical Metallurgy and processing of Intermetallic Compounds by N.S. Stoloff,V.K. Sikka Pdf

The attractive physical and mechanical properties of ordered intermetallic alloys have been recognized since early in this century. However, periodic attempts to develop intermetallics for structural applications were unsuc cessful, due in major part to the twin handicaps of inadequate low-temper ature ductility or toughness, together with poor elevated-temperature creep strength. The discovery, in 1979, by Aoki and Izumi in Japan that small additions of boron caused a dramatic improvement in the ductility of Ni3Al was a major factor in launching a new wave of fundamental and applied research on intermetallics. Another important factor was the issuance in 1984 of a National Materials Advisory Board reported entitled "Structural Uses for Ductile Ordered Alloys," which identified numerous potential defense-related applications and proposed the launching of a coordinated development program to gather engineering property and processing data. A substantial research effort on titanium aluminides was already underway at the Air Force Materials Laboratory at Wright Patterson Air Force Base in Ohio and, with Air Force support, at several industrial and university laboratories. Smaller programs also were under way at Oak Ridge National Laboratory, under Department of Energy sponsorship. These research efforts were soon augmented in the United States by funding from Department of Defense agencies such as Office of Naval Research and Air Force Office of Scientific Research, and by the National Science Foundation.

Author : Donald K. Routh
Publisher : Routledge
Page : 462 pages
File Size : 42,6 Mb
Release : 2017-07-05
Category : Psychology
ISBN : 9781351483063

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The Experimental Psychology of Mental Retardation by Donald K. Routh Pdf

The renaissance in the field of mental retardation since World War II has been expressed both in research and in renewed practical concern for the plight of the retarded. The 1958 monograph by Masland, Sarason, and Gladwin entitled Mental Subnormality: Biological, Psychological, and Cultural Factors was one spur, if not the only one, to much of the behavioral research which emerged in the late 1950's. Similarly, the Handbook of Mental Deficiency, edited by Norman Ellis and published in 1963, gave theoretical direction to many studies in the years following its appearance.The present book and the symposium on which it is based are an attempt to continue this tradition by presenting theory-based, programmatic research in mental retardation, aimed at the scientific understanding of the psychological processes involved. The final chapter attempts to draw some of the implications of this research for the practical assessment and remediation of retardation.The experimental work reported in this book generally uses rather traditional laboratory tasks, for example, classical conditioning or discrimination learning. But the interest is in underlying processes rather than in such apparent trivia as whether the child blinks his eyelid or which of two stimulus objects he selects. Thus, this book is oriented around the psychological processes of interest, namely learning, attention, memory, language, thinking, and emotion, and concludes with a section on the relationship between these processes and the biological aspects of retardation.

Author : Anonim
Publisher : Ardent Media
Page : 24 pages
File Size : 41,5 Mb
Release : 2024-06-26
Category : Electronic
ISBN : 8210379456XXX

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The Role of Affective Processes in Learning and Motivation by Anonim Pdf

Author : Matthew A. Cooper
Publisher : Cambridge University Press
Page : 305 pages
File Size : 49,9 Mb
Release : 2009-02-02
Category : Science
ISBN : 9781139476782

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Label-Free Biosensors by Matthew A. Cooper Pdf

Label-free biosensors are devices that use biological or chemical receptors to detect analytes (molecules) in a sample. They give detailed information on the selectivity, affinity, and, in many cases, also the binding kinetics and thermodynamics of an interaction. Although they can be powerful tools in the hands of a skilled user, there is often a lack of knowledge of the best methods for using label-free assays to screen for biologically active molecules and accurately and precisely characterize molecular recognition events. This book reviews both established and newer label-free techniques giving both the expert user and the general reader interested in the technologies and applications behind label-free an insight into the field from expert opinion leaders and practitioners of the technologies. Most importantly, chapters contain worked examples from leaders in the field that take the reader through the basics of experimental design, setup, assay development, and data analysis.

Author : Manuela Veloso,Agnar Aamodt
Publisher : Springer Science & Business Media
Page : 596 pages
File Size : 49,8 Mb
Release : 1995-10-16
Category : Computers
ISBN : 3540605983

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Case-Based Reasoning Research and Development by Manuela Veloso,Agnar Aamodt Pdf

This book constitutes the refereed proceedings of the First International Conference on Case-Based Reasoning, ICCBR-95, held in Sesimbra, Portugal, in October 1995. The 52 revised papers included are classified as scientific papers , application papers , and posters . All current aspects of research and development aiming at industrial applications in CBR are addressed. Among the topical sections are case and knowledge representation, case retrieval, nearest neighbour methods, case adaption and learning, cognitive modelling, integrated reasoning methods, and application-oriented methods: planning, decision making, diagnosis, interpretation, design, etc.

Author : Mark Wigglesworth,Terry Wood
Publisher : John Wiley & Sons
Page : 435 pages
File Size : 52,8 Mb
Release : 2012-12-05
Category : Medical
ISBN : 9783527645268

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Management of Chemical and Biological Samples for Screening Applications by Mark Wigglesworth,Terry Wood Pdf

Filling an obvious gap in the scientific literature, this practice-oriented reference is the first to tie together the working knowledge of large screening centers in the pharmaceutical and biotechnological field. It spans the entire fi eld of this emerging discipline, from compound acquisition to collection optimization for specific purposes, to technology and quality control. In so doing, it applies two decades of expertise gathered by several large pharmaceutical companies to current and future challenges in high-throughput screening. With its treatment of libraries of small molecules as well as biobanks containing biomolecules, microorganisms and tissue samples, this reference is universally applicable for any molecular scientist involved in a large screening program.

Author : Ramakrishna Seethala,Litao Zhang
Publisher : CRC Press
Page : 504 pages
File Size : 41,9 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781420061697

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Handbook of Drug Screening by Ramakrishna Seethala,Litao Zhang Pdf

Building upon the foundation of basics discussed in the previous edition, the Second Edition provides a more in-depth look at the latest methods and technologies of advanced drug screening, an essential function of drug discovery. With extensively updated content and 21 new chapters, this text examines:quality and efficiency of drug target validati