Management Of Chemical And Biological Samples For Screening Applications

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Management of Chemical and Biological Samples for Screening Applications

Mark Wigglesworth,Terry Wood
Management of Chemical and Biological Samples for Screening Applications Book PDF

Author : Mark Wigglesworth,Terry Wood
Publisher : John Wiley & Sons
Page : 435 pages
File Size : 45,8 Mb
Release : 2012-04-30
Category : Medical
ISBN : 9783527328222

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Management of Chemical and Biological Samples for Screening Applications by Mark Wigglesworth,Terry Wood Pdf

Filling an obvious gap in the scientific literature, this practice-oriented reference is the first to tie together the working knowledge of large screening centers in the pharmaceutical and biotechnological field. It spans the entire fi eld of this emerging discipline, from compound acquisition to collection optimization for specific purposes, to technology and quality control. In so doing, it applies two decades of expertise gathered by several large pharmaceutical companies to current and future challenges in high-throughput screening. With its treatment of libraries of small molecules as well as biobanks containing biomolecules, microorganisms and tissue samples, this reference is universally applicable for any molecular scientist involved in a large screening program.

Chemical Biology

Natanya Civjan
Chemical Biology Book PDF

Author : Natanya Civjan
Publisher : John Wiley & Sons
Page : 657 pages
File Size : 49,8 Mb
Release : 2012-08-07
Category : Science
ISBN : 9781118434505

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Chemical Biology by Natanya Civjan Pdf

An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: The design, development, and optimization of drug candidates The pharmacokinetics and properties of drugs Drug transport and delivery Natural products and natural product models as pharmaceuticals Biological mechanisms underlying health and disease Treatment strategies for a range of diseases, from HIV to schizophrenia Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.

Analytical Characterization of Biotherapeutics

Jennie R. Lill,Wendy Sandoval
Analytical Characterization of Biotherapeutics Book PDF

Author : Jennie R. Lill,Wendy Sandoval
Publisher : John Wiley & Sons
Page : 378 pages
File Size : 53,5 Mb
Release : 2017-08-14
Category : Science
ISBN : 9781119053101

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Analytical Characterization of Biotherapeutics by Jennie R. Lill,Wendy Sandoval Pdf

The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting attention in the design and delivery of a therapeutic protein, exposes analytical challenges that may occur when characterizing these molecules, and presents a number of tested solutions. The first single-volume guide of its kind, Analytical Characterization of Biotherapeutics brings together contributions from scientists at the leading edge of biotherapeutics research and manufacturing. Key topics covered in-depth include the structural characterization of recombinant proteins and antibodies, antibody de novo sequencing, characterization of antibody drug conjugates, characterization of bi-specific or other hybrid molecules, characterization of manufacturing host-cell contaminant proteins, analytical tools for biologics molecular assessment, and more. Each chapter is written by a recognized expert or experts in their field who discuss current and cutting edge approaches to fully characterizing biotherapeutic proteins and antigen reagents Covers the full range of characterization strategies for large molecule based therapeutics Provides an up-to-date account of the latest approaches used for large molecule characterization Chapters cover the background needed to understand the challenges at hand, solutions to characterize these large molecules, and a summary of emerging options for analytical characterization Analytical Characterization of Biotherapeutics is an up-to-date resource for analytical scientists, biologists, and mass spectrometrists involved in the analysis of biomolecules, as well as scientists employed in the pharmaceuticals and biotechnology industries. Graduate students in biology and analytical science, and their instructors will find it to be fascinating and instructive supplementary reading.

Small Molecule Medicinal Chemistry

Werngard Czechtizky,Peter Hamley
Small Molecule Medicinal Chemistry Book PDF

Author : Werngard Czechtizky,Peter Hamley
Publisher : John Wiley & Sons
Page : 546 pages
File Size : 44,8 Mb
Release : 2015-11-02
Category : Science
ISBN : 9781118771600

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Small Molecule Medicinal Chemistry by Werngard Czechtizky,Peter Hamley Pdf

Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Chapters discuss benefits, challenges, case studies, and industry perspectives for improving drug discovery programs with respect to quality and costs. • Focuses on small molecules and their critical role in medicinal chemistry, reviewing chemical and economic advantages, challenges, and trends in the field from industry perspectives • Discusses novel approaches and key topics, like screening collection enhancement, risk sharing, HTS triage, new lead finding approaches, diversity-oriented synthesis, peptidomimetics, natural products, and high throughput medicinal chemistry approaches • Explains how to reduce design-make-test cycle times by integrating medicinal chemistry, physical chemistry, and ADME profiling techniques • Includes descriptive case studies, examples, and applications to illustrate new technologies and provide step-by-step explanations to enable them in a laboratory setting

Microbial Forensics

Bruce Budowle,Steven E. Schutzer,Stephen A. Morse
Microbial Forensics Book PDF

Author : Bruce Budowle,Steven E. Schutzer,Stephen A. Morse
Publisher : Academic Press
Page : 526 pages
File Size : 45,6 Mb
Release : 2019-11-30
Category : Law
ISBN : 9780128153802

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Microbial Forensics by Bruce Budowle,Steven E. Schutzer,Stephen A. Morse Pdf

Microbial Forensics, Third Edition, serves as a complete reference on the discipline, describing the advances, challenges and opportunities that are integral in applying science to help solve future biocrimes. New chapters include: Microbial Source Tracking, Clinical Recognition, Bioinformatics, and Quality Assurance. This book is intended for a wide audience, but will be indispensable to forensic scientists and researchers interested in contributing to the growing field of microbial forensics. Biologists and microbiologists, the legal and judicial system, and the international community involved with Biological Weapons Treaties will also find this volume invaluable. Presents new and expanded content that includes a statistical analysis of forensic data, legal admissibility and standards of evidence Discusses actual cases of forensic bioterrorism Includes contributions from editors and authors who are leading experts in the field, with primary experience in the application of this fast-growing discipline

The Biological Resources of Model Organisms

Robert L. Jarret,Kevin McCluskey
The Biological Resources of Model Organisms Book PDF

Author : Robert L. Jarret,Kevin McCluskey
Publisher : CRC Press
Page : 260 pages
File Size : 54,6 Mb
Release : 2019-07-16
Category : Science
ISBN : 9781351587761

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The Biological Resources of Model Organisms by Robert L. Jarret,Kevin McCluskey Pdf

This book discusses 14 model organisms and are used by thousands of researchers, teachers, and students each year in laboratories and classrooms, around the globe. Though acknowledged in innumerable scientific journal articles, little is generally known about the origin of these collections, how the organisms contained within them have been acquired, and how they are maintained and distributed. While some collections such as Drosophila have long histories others, such as the collection of Brachionus, are relatively new. They vary greatly in size. Yet, all have contributed and are continuing to contribute to global research efforts in many areas of scientific research as diverse as tissue regeneration, skin cancer, evolution, water purity, gene function, and hundreds of others. In addition to providing the raw materials for national and international research programs, these collections also provide educational tools used by colleges and high schools. The chapters in this book attempt to provide a brief look at the individual organisms, how they came to be accepted as model organisms, the history of the individual collections, examples of how the organisms have been and are being used in scientific research, and a description of the facilities and procedures used to maintain them. Features: • Provides an in-depth look at the collections of 14 model organisms that have enabled innumerable scientific breakthroughs over decades, and that continue to do so. • Includes detailed descriptions of the operating procedures used for the maintenance of each model organism collection. • Discusses the holdings of the collections of model organisms and its relevance to past, current and future scientific research. • Written by the leaders in the field of the management of model organisms.

Comprehensive Biomarker Discovery and Validation for Clinical Application

Péter Horvatovich,Rainer Bischoff
Comprehensive Biomarker Discovery and Validation for Clinical Application Book PDF

Author : Péter Horvatovich,Rainer Bischoff
Publisher : Royal Society of Chemistry
Page : 320 pages
File Size : 42,7 Mb
Release : 2013-06-17
Category : Science
ISBN : 9781849734363

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Comprehensive Biomarker Discovery and Validation for Clinical Application by Péter Horvatovich,Rainer Bischoff Pdf

This book focuses on proteomics biomarker discovery and validation procedures from the clinical perspective. It provides an overview of current technology and the challenges encountered throughout the process. This covers all key stages, from biomarker discovery and validation, through to registration with the European and US regulatory authorities (FDA and EMEA). All the important elements (such as patient selection, sample handling, data processing, and statistical analysis) are described in detail and the reader is introduced to each topic with well-described examples or guidelines for best practice. Case studies are also included to demonstrate clinical applications. Individual chapters explain the best performing techniques for profiling complex body fluids and biomarker discovery. This includes the application of mass spectrometry imaging combined with chromatography in profiling platforms and the use of laser micro dissection and MALDI imaging to study tissues in their natural environment. Future developments needed to improve the success rate of translating biomarker discovery into useful clinical tests are also discussed. Common pitfalls and success stories are described as are the limitations of the various technologies involved. Broad and interdisciplinary in approach, this book provides an excellent source of information for industrial and academic researchers, and those managing biobanks.

Rapid Chemical and Biological Techniques for Water Monitoring

Catherine Gonzalez,Richard Greenwood,Philippe Quevauviller
Rapid Chemical and Biological Techniques for Water Monitoring Book PDF

Author : Catherine Gonzalez,Richard Greenwood,Philippe Quevauviller
Publisher : John Wiley & Sons
Page : 440 pages
File Size : 53,9 Mb
Release : 2009-03-30
Category : Science
ISBN : 0470745436

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Rapid Chemical and Biological Techniques for Water Monitoring by Catherine Gonzalez,Richard Greenwood,Philippe Quevauviller Pdf

Rapid Chemical and Biological Techniques for Water Monitoring presents in one volume the broad spectrum of monitoring tools, both available and under development, and provides an assessment of their potential for underpinning environmental management and legislation. The book explores screening methods in the context of water policies; chemical methods; biological methods; potential use of screening methods; quality assurance and validation methods; integration of screening methods in water monitoring strategies. The text provides a timely source of information for post-graduates, researchers, and professionals involved in water management at all levels.

Sensor Technologies

Michael J. McGrath,Cliodhna Ni Scanaill,Dawn Nafus
Sensor Technologies Book PDF

Author : Michael J. McGrath,Cliodhna Ni Scanaill,Dawn Nafus
Publisher : Apress
Page : 321 pages
File Size : 45,8 Mb
Release : 2014-01-23
Category : Computers
ISBN : 9781430260141

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Sensor Technologies by Michael J. McGrath,Cliodhna Ni Scanaill,Dawn Nafus Pdf

Sensor Technologies: Healthcare, Wellness and Environmental Applications explores the key aspects of sensor technologies, covering wired, wireless, and discrete sensors for the specific application domains of healthcare, wellness and environmental sensing. It discusses the social, regulatory, and design considerations specific to these domains. The book provides an application-based approach using real-world examples to illustrate the application of sensor technologies in a practical and experiential manner. The book guides the reader from the formulation of the research question, through the design and validation process, to the deployment and management phase of sensor applications. The processes and examples used in the book are primarily based on research carried out by Intel or joint academic research programs. “Sensor Technologies: Healthcare, Wellness and Environmental Applications provides an extensive overview of sensing technologies and their applications in healthcare, wellness, and environmental monitoring. From sensor hardware to system applications and case studies, this book gives readers an in-depth understanding of the technologies and how they can be applied. I would highly recommend it to students or researchers who are interested in wireless sensing technologies and the associated applications.” Dr. Benny Lo Lecturer, The Hamlyn Centre, Imperial College of London “This timely addition to the literature on sensors covers the broad complexity of sensing, sensor types, and the vast range of existing and emerging applications in a very clearly written and accessible manner. It is particularly good at capturing the exciting possibilities that will occur as sensor networks merge with cloud-based ‘big data’ analytics to provide a host of new applications that will impact directly on the individual in ways we cannot fully predict at present. It really brings this home through the use of carefully chosen case studies that bring the overwhelming concept of 'big data' down to the personal level of individual life and health.” Dermot Diamond Director, National Centre for Sensor Research, Principal Investigator, CLARITY Centre for Sensor Web Technologies, Dublin City University "Sensor Technologies: Healthcare, Wellness and Environmental Applications takes the reader on an end-to-end journey of sensor technologies, covering the fundamentals from an engineering perspective, introducing how the data gleaned can be both processed and visualized, in addition to offering exemplar case studies in a number of application domains. It is a must-read for those studying any undergraduate course that involves sensor technologies. It also provides a thorough foundation for those involved in the research and development of applied sensor systems. I highly recommend it to any engineer who wishes to broaden their knowledge in this area!" Chris Nugent Professor of Biomedical Engineering, University of Ulster

Industrial Processes and Waste Stream Management

Howard H. Guyer
Industrial Processes and Waste Stream Management Book PDF

Author : Howard H. Guyer
Publisher : John Wiley & Sons
Page : 616 pages
File Size : 53,7 Mb
Release : 1998-11-13
Category : Technology & Engineering
ISBN : 0471299847

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Industrial Processes and Waste Stream Management by Howard H. Guyer Pdf

INDUSTRIAL PROCESSES and WASTE STREAM MANAGEMENT This book provides environmental technology students with a quick, enjoyable way to master the knowledge and skills needed to develop and implement successful, cost-effective industrial pollution control programs, especially when used in coordination with the Industrial Processes and Waste Stream Management video series produced by INTELECOM Intelligent Telecommunications. The first section of the book lays the conceptual foundations with a detailed overview of waste stream management tools and regulations and the four EPA-approved treatment methods: physical, chemical, thermal, and biological. The following 20 chapters are organized by industry, and provide a fascinating case-by-case exploration of industrial processes and how the waste streams they generate are managed in all major industries, including petroleum, chemicals, mining, metals, paint, textiles, agriculture, paper, printing, nuclear, medical, and more. Features that make Industrial Processes and Waste Stream Management an ideal introduction to the subject for environmental technology students, include: * Acclaimed, user-friendly, modular format found in all the books in the Preserving the Legacy series * Basic anatomy, physiology, and chemistry concepts that help clarify how toxins interact with living tissue * Proven, rapid-learning modular format--each chapter features learning objectives, topic summaries, chapter-end reviews, and practice questions * Helpful sidebars that highlight critical concepts * More than 175 high-quality line drawings, photographs, diagrams, charts, and tables * Numerous easy-to-perform, skill-building classroom activities * A glossary of more than 1,000 essential terms * Extensive bibliography of recommended readings in all key subject areas Industrial Processes and Waste Stream Management is also an excellent refresher/quick-reference guide for practicing environmental technicians.