Computer Aided Pharmaceutics And Drug Delivery

Author : Vikas Anand Saharan
Publisher : Springer Nature
Page : 767 pages
File Size : 45,7 Mb
Release : 2022-05-30
Category : Medical
ISBN : 9789811651809

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Computer Aided Pharmaceutics and Drug Delivery by Vikas Anand Saharan Pdf

This book examines the role of computer-assisted techniques for discovering, designing, optimizing and manufacturing new, effective, and safe pharmaceutical formulations and drug delivery systems. The book discusses computational approaches, statistical modeling and molecular modeling for the development and safe delivery of drugs in humans. The application of concepts of QbD (Quality by Design), DoE (Design of Experiments), artificial intelligence and in silico pharmacokinetic assessment/simulation have been made a lot easier with the help of commercial software and expert systems. This title provides in-depth knowledge of such useful software with illustrations from the latest researches. The book also fills in the gap between pharmaceutics and molecular modeling at micro, meso and maro scale by covering topics such as advancements in computer-aided Drug Design (CADD), drug-polymer interactions in drug delivery systems, molecular modeling of nanoparticles and pharmaceutics/bioinformatics. This book provides abundant applications of computers in formulation designing and characterization are provided as examples, case studies and illustrations. Short reviews of software, databases and expert systems have also been added to culminate the interest of readers for novel applications in formulation development and drug delivery. Computer-aided pharmaceutics and drug delivery is an authoritative reference source for all the latest scholarly update on emerging developments in computed assisted techniques for drug designing and development. The book is ideally designed for pharmacists, medical practitioners, students and researchers.

Author : Ahindra Nag,Baishakhi Dey
Publisher : McGraw Hill Professional
Page : 240 pages
File Size : 51,9 Mb
Release : 2010-10-06
Category : Technology & Engineering
ISBN : 9780071701259

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Computer-Aided Drug Design and Delivery Systems by Ahindra Nag,Baishakhi Dey Pdf

THE LATEST BREAKTHROUGHS IN COMPUTER-AIDED DRUG DESIGN AND DELIVERY This definitive text provides in-depth information on computer-assisted techniques for discovering, designing, and optimizing new, effective, and safe drugs. Computer-Aided Drug Design and Delivery Systems offers objective and quantitative data on the use and delivery of drugs in humans. Enabling technologies such as bioinformatics, pharmacokinetics, biosensors, robotics, and bioinstruments are thoroughly discussed in this innovative work. Coverage includes: Computer-aided drug design (CADD) Drug delivery systems Bioinformatics of drug molecules and databases Lipase- and esterase-mediated drugs and drug intermediates Pharmacokinetics and pharmacodynamics of drugs Biomarkers, biosensors, and robotics in medicine Biomedical instrumentation

Author : Dimitrios A. Lamprou
Publisher : MDPI
Page : 436 pages
File Size : 55,6 Mb
Release : 2020-07-01
Category : Medical
ISBN : 9783039364237

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3D Printing of Pharmaceuticals and Drug Delivery Devices by Dimitrios A. Lamprou Pdf

The 3D printing (3DP) process was patented in 1986; however, only in the last decade has it begun to be used for medical applications, as well as in the fields of prosthetics, bio-fabrication, and pharmaceutical printing. 3DP or additive manufacturing (AM) is a family of technologies that implement layer-by-layer processes in order to fabricate physical models based on a computer aided design (CAD) model. 3D printing permits the fabrication of high degrees of complexity with great reproducibility in a fast and cost-effective fashion. 3DP technology offers a new paradigm for the direct manufacture of individual dosage forms and has the potential to allow for variations in size and geometry as well as control dose and release behavior. Furthermore, the low cost and ease of use of 3DP systems means that the possibility of manufacturing medicines and medical devices at the point of dispensing or at the point of use could become a reality. 3DP thus offers the perfect innovative manufacturing route to address the critical capability gap that hinders the widespread exploitation of personalized medicines for molecules that are currently not easy to deliver. This Special Issue will address new developments in the area of 3D printing and bioprinting for drug delivery applications, covering the recent advantages and future directions of additive manufacturing for pharmaceutical products.

Author : Defang Ouyang,Sean C. Smith
Publisher : John Wiley & Sons
Page : 350 pages
File Size : 48,6 Mb
Release : 2015-07-20
Category : Science
ISBN : 9781118573990

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Computational Pharmaceutics by Defang Ouyang,Sean C. Smith Pdf

Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems. Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field. This book is included in the Advances in Pharmaceutical Technology book series.

Author : Jelena Duris
Publisher : Elsevier
Page : 340 pages
File Size : 41,6 Mb
Release : 2023-09-18
Category : Medical
ISBN : 9780443186561

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Computer-Aided Applications in Pharmaceutical Technology by Jelena Duris Pdf

Computer-Aided Applications in Pharmaceutical Technology: Delivery Systems, Dosage Forms, and Pharmaceutical Unit Operations, Second Edition covers the fundamentals of experimental design application and interpretation in pharmaceutical technology, chemometric methods with an emphasis on their applications in process control, neural computing, data science, computer-aided biopharmaceutical characterization, as well as the application of computational fluid dynamics in pharmaceutical technology. Completely updated, the book introduces the theory and practice of computational tools through new case studies. Chapters cover Quality by Design in pharmaceutical development, overview data mining methodologies, present computer-aided formulation development, cover experimental design applications, and much more. Presents a comprehensive review of the current state of the art on various computer-aided applications in pharmaceutical technology Includes case studies to facilitate understanding of various concepts in computer-aided applications Covers applications such as the development of dosage forms and/or delivery systems, pharmaceutical unit operations, and relevant physiologically based pharmacokinetic simulations

Author : Rahul Shukla,Aleksey Kuznetsov,Akbar Ali
Publisher : BoD – Books on Demand
Page : 330 pages
File Size : 47,5 Mb
Release : 2023-06-07
Category : Medical
ISBN : 9781837684717

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Drug Formulation Design by Rahul Shukla,Aleksey Kuznetsov,Akbar Ali Pdf

This book discusses the theoretical and practical aspects required to formulate conventional drug dosage forms and advanced technology-based therapeutics. It is organized into four sections: “Preformulation”, “Formulation Design and Approaches”, “Characterization and Analysis”, and “Cocrystal Engineering”. The approaches discussed enhance the overall quality of treatment and overcome the side effects of available therapies. The book is a collection of scholarly literature relevant to pharmaceutical technology and existing pharmaceutical technologies. It is a useful reference for industrial personnel working on developing novel pharmaceutical dosage forms.

Author : Dr. Anamika Saxena, Mrs. Disha Dutta, Ms. Baljeet Kaur, Mr. Vikas Bhatt, Mrs. Ramsha Aslam
Publisher : Shashwat Publication
Page : 184 pages
File Size : 51,5 Mb
Release : 2024-06-10
Category : Medical
ISBN : 9789360872199

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Computer Aided Drug Development by Dr. Anamika Saxena, Mrs. Disha Dutta, Ms. Baljeet Kaur, Mr. Vikas Bhatt, Mrs. Ramsha Aslam Pdf

To introduce the book "Computer Aided Drug Development" brings me immense delight. The content of this book has been carefully crafted, adhering to the Pharmacy Council of India's mandated curriculum for Master of Pharmacy students. Research on the topic has attempted to use as simple a terminology as feasible in order to facilitate student understanding. Throughout the book, there are a lot of flowcharts and illustrations to aid students in understanding difficult ideas. It is the author's honest wish that students and academics alike may gain something from reading this book. This book Computer Aided Drug Development describes Computers in Pharmaceutical Research and Development, Quality-by-Design In Pharmaceutical Development, Computational Modeling Of Drug Disposition: Introduction, Modeling Techniques, Computer-aided formulation development, Computer-aided biopharmaceutical characterization, Computer Simulations in Pharmacokinetics and Pharmacodynamics, Artificial Intelligence (AI), Robotics and Computational fluid dynamics.

Author : Keservani, Raj K.,Sharma, Anil K.,Kesharwani, Rajesh Kumar
Publisher : IGI Global
Page : 515 pages
File Size : 41,5 Mb
Release : 2016-07-15
Category : Medical
ISBN : 9781522507529

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Novel Approaches for Drug Delivery by Keservani, Raj K.,Sharma, Anil K.,Kesharwani, Rajesh Kumar Pdf

Providing optimal care to patients is a primary concern in the healthcare field. By utilizing the latest resources and research in biomedical applications, the needs and expectations of patients can be successfully exceeded. Novel Approaches for Drug Delivery is an authoritative reference source for the latest scholarly research on emerging developments within the pharmaceutical industry, examining the current state and future directions of drug delivery systems. Highlighting therapeutic applications, predictive toxicology, and risk assessment perspectives, this book is ideally designed for medical practitioners, pharmacists, graduate-level students, scientists, and researchers.

Author : Jingzheng Ren,Weifeng Shen,Yi Man,Lichun Dong
Publisher : Elsevier
Page : 542 pages
File Size : 45,9 Mb
Release : 2021-06-05
Category : Technology & Engineering
ISBN : 9780128217436

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Applications of Artificial Intelligence in Process Systems Engineering by Jingzheng Ren,Weifeng Shen,Yi Man,Lichun Dong Pdf

Applications of Artificial Intelligence in Process Systems Engineering offers a broad perspective on the issues related to artificial intelligence technologies and their applications in chemical and process engineering. The book comprehensively introduces the methodology and applications of AI technologies in process systems engineering, making it an indispensable reference for researchers and students. As chemical processes and systems are usually non-linear and complex, thus making it challenging to apply AI methods and technologies, this book is an ideal resource on emerging areas such as cloud computing, big data, the industrial Internet of Things and deep learning. With process systems engineering's potential to become one of the driving forces for the development of AI technologies, this book covers all the right bases. Explains the concept of machine learning, deep learning and state-of-the-art intelligent algorithms Discusses AI-based applications in process modeling and simulation, process integration and optimization, process control, and fault detection and diagnosis Gives direction to future development trends of AI technologies in chemical and process engineering

Author : Defang Ouyang
Publisher : John Wiley & Sons
Page : 629 pages
File Size : 48,7 Mb
Release : 2024-06-21
Category : Science
ISBN : 9781119987253

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Exploring Computational Pharmaceutics by Defang Ouyang Pdf

Provides an extensive and up-to-date overview of the theory and application of computational pharmaceutics in the drug development process Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0 introduces a variety of current and emerging computational techniques for pharmaceutical research. Bringing together experts from academia, industry, and regulatory agencies, this edited volume also explores the current state, key challenges, and future outlook of computational pharmaceutics while encouraging development across all sectors of the field. Throughout the text, the authors discuss a wide range of essential topics, from molecular modeling and process simulation to intelligent manufacturing and quantitative pharmacology. Building upon Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0, this new edition provides a multi-scale perspective that reveals the physical, chemical, mathematical, and data-driven details of pre-formulation, formulation, process, and clinical studies, in addition to in vivo prediction in the human body and precision medicine in clinical settings. Detailed chapters address both conventional dosage forms and the application of computational technologies in advanced pharmaceutical research, such as dendrimer-based delivery systems, liposome and lipid membrane research, and inorganic nanoparticles. A major contribution to the development and promotion of computational pharmaceutics, this important resource: Discusses the development track, achievements, and prospects of computational pharmaceutics Presents multidisciplinary research to help physicists, chemists, mathematicians, and computer scientists locate problems in the field of drug delivery Covers a wide range of technologies, including complex formulations for water-insoluble drugs, protein/peptide formulations, nanomedicine, and gene delivery systems Focuses on the application of cutting-edge computational technologies and intelligent manufacturing of emerging pharmaceutical technologies Includes a systematic overview of computational pharmaceutics and Pharma 4.0 to assist non-specialist readers Covering introductory, advanced, and specialist topics, Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0 is an invaluable resource for computational chemists, computational analysts, pharmaceutical chemists, process engineers, process managers, and pharmacologists, as well as computer scientists, medicinal chemists, clinical pharmacists, material scientists, and nanotechnology specialists working in the field.

Author : Dimitrios A. Lamprou,Dennis Douroumis,Sheng Qi
Publisher : John Wiley & Sons
Page : 276 pages
File Size : 44,6 Mb
Release : 2024-05-15
Category : Science
ISBN : 9781119835981

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3D Printing of Pharmaceutical and Drug Delivery Devices by Dimitrios A. Lamprou,Dennis Douroumis,Sheng Qi Pdf

3D Printing of Pharmaceutical and Drug Delivery Devices 3D Printing of Pharmaceutical and Drug Delivery Devices Discover the latest, fast-developing technology to help move towards more cost-effective, small-batch, decentralized manufacturing of personalized systems 3D printing has revolutionized manufacturing. Its precision and flexibility have enabled the large-scale production of materials and devices too complex for conventional industrial manufacturing. This has been particularly revolutionary in the field of pharmaceutical production, where 3D printing is being integrated into the manufacture of both drugs and drug delivery devices. It has never been more important for industry professionals to understand this form of production. 3D Printing of Pharmaceuticals and Drug Delivery Devices: Progress from Bench to Bedside offers a comprehensive overview of 3D printing technology and its pharmaceutical applications. It introduces readers to a world in which bespoke drug delivery systems developed for specific users or conditions is rapidly becoming a reality. Its detailed coverage of strategies and industrial processes incorporates the latest research and real-world experience of production. 3D Printing of Pharmaceuticals and Drug Delivery Devices: Progress from Bench to Bedside readers will also find: A multi-disciplinary authorial team of industry leaders Discussion of common technical and regulatory barriers and their possible solutions Far-ranging discussion of pharmaceutical applications across all sectors 3D Printing of Pharmaceuticals and Drug Delivery Devices: Progress from Bench to Bedside is essential reading for pharmaceutical industry professionals and researchers looking to occupy the leading edge.

Author : Vijai Singh
Publisher : Springer Nature
Page : 365 pages
File Size : 49,7 Mb
Release : 2024-06-28
Category : Electronic
ISBN : 9789819984015

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Advances in Bioinformatics by Vijai Singh Pdf

Author : Anya Hillery,Kinam Park
Publisher : CRC Press
Page : 633 pages
File Size : 52,8 Mb
Release : 2016-09-15
Category : Medical
ISBN : 9781482217728

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Drug Delivery by Anya Hillery,Kinam Park Pdf

This book provides a comprehensive introduction to advanced drug delivery and targeting, covering their principles, current applications, and potential future developments. This edition has been updated to reflect significant trends and cutting-edge advances that have occurred since the first edition was published. All the original chapters have been retained, but the material therein has been updated. Eight new chapters have been added that deal with entirely new technologies and approaches. Features: Offers a comprehensive introduction to the fundamental concepts and underlying scientific principles of drug delivery and targeting Presents an in-depth analysis of the opportunities and obstacles afforded by the application of nanotechnologies for drug delivery and targeting Includes a revised and expanded section on the major epithelial routes of drug delivery currently under investigation Describes the most recent, emerging, and innovative technologies of drug delivery Provides real-life examples of the clinical translation of drug delivery technologies through the use of case studies Discusses the pertinent regulatory hurdles and safety issues of drug delivery and targeting systems—crucial considerations in order to achieve licensing approval for these new technologies

Author : Sanjeev Kumar Singh
Publisher : Springer Nature
Page : 334 pages
File Size : 52,9 Mb
Release : 2021-02-02
Category : Science
ISBN : 9789811589362

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Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design by Sanjeev Kumar Singh Pdf

This book presents various computer-aided drug discovery methods for the design and development of ligand and structure-based drug molecules. A wide variety of computational approaches are now being used in various stages of drug discovery and development, as well as in clinical studies. Yet, despite the rapid advances in computer software and hardware, combined with the exponential growth in the available biological information, there are many challenges that still need to be addressed, as this book shows. In turn, it shares valuable insights into receptor-ligand interactions in connection with various biological functions and human diseases. The book discusses a wide range of phylogenetic methods and highlights the applications of Molecular Dynamics Simulation in the drug discovery process. It also explores the application of quantum mechanics in order to provide better accuracy when calculating protein-ligand binding interactions and predicting binding affinities. In closing, the book provides illustrative descriptions of major challenges associated with computer-aided drug discovery for the development of therapeutic drugs. Given its scope, it offers a valuable asset for life sciences researchers, medicinal chemists and bioinformaticians looking for the latest information on computer-aided methodologies for drug development, together with their applications in drug discovery.

Author : Arbind Prasad,Ashwani Kumar,Manoj Gupta
Publisher : John Wiley & Sons
Page : 356 pages
File Size : 47,7 Mb
Release : 2023-12-12
Category : Science
ISBN : 9781394166961

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Advanced Materials and Manufacturing Techniques for Biomedical Applications by Arbind Prasad,Ashwani Kumar,Manoj Gupta Pdf

ADVANCED MATERIALS and MANUFACTURING TECHNIQUES for BIOMEDICAL APPLICATIONS The book provides essential knowledge for the synthesis of biomedical products, development, nanomaterial properties, fabrication processes, and design techniques for different applications, as well as process design and optimization. In origin, biomaterials can come from nature or be synthesized in the laboratory with a variety of approaches that use metals, polymers, ceramic, or composite materials. They are often used or adapted for various biomedical applications. Biomaterials are commonly used in scaffolds, orthopedic, wound healing, fracture fixation, surgical sutures, artificial organ developments, pins and screws to stabilize fractures, surgical mesh, breast implants, artificial ligaments and tendons, and drug delivery systems. The sixteen chapters in Advanced Materials and Manufacturing Techniques in Biomedical Applications cover the synthesis, processing, design, manufacturing, and characterization of advanced materials; self-healing, bioinspired, nature-resourced, nanobiomaterials for biomedical applications; and manufacturing techniques such as rapid prototyping, additive manufacturing, etc. Audience The book is for engineers, technologists, and researchers working in the area of biomedical engineering and manufacturing techniques. It is also appropriate for upper-level undergraduate and graduate students.