Novel Approaches For Drug Delivery

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Novel Approaches for Drug Delivery

Author : Keservani, Raj K.,Sharma, Anil K.,Kesharwani, Rajesh Kumar
Publisher : IGI Global
Page : 515 pages
File Size : 55,6 Mb
Release : 2016-07-15
Category : Medical
ISBN : 9781522507529

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Novel Approaches for Drug Delivery by Keservani, Raj K.,Sharma, Anil K.,Kesharwani, Rajesh Kumar Pdf

Providing optimal care to patients is a primary concern in the healthcare field. By utilizing the latest resources and research in biomedical applications, the needs and expectations of patients can be successfully exceeded. Novel Approaches for Drug Delivery is an authoritative reference source for the latest scholarly research on emerging developments within the pharmaceutical industry, examining the current state and future directions of drug delivery systems. Highlighting therapeutic applications, predictive toxicology, and risk assessment perspectives, this book is ideally designed for medical practitioners, pharmacists, graduate-level students, scientists, and researchers.

Novel Drug Delivery Technologies

Author : Ambikanandan Misra,Aliasgar Shahiwala
Publisher : Springer Nature
Page : 448 pages
File Size : 51,6 Mb
Release : 2020-02-12
Category : Medical
ISBN : 9789811336423

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Novel Drug Delivery Technologies by Ambikanandan Misra,Aliasgar Shahiwala Pdf

The application of drug delivery is a valuable, cost-effective lifecycle management resource. By endowing drugs with new and innovative therapeutic benefits, drug delivery systems extend products’ profitable lifecycle, giving pharmaceutical companies competitive and financial advantages, and providing patients with improved medications. Formulation development is now being used to create new dosage forms for existing products, which not only reduces the time and expense involved in new drug development, but also helps with regard to patent protection and bypassing existing patents. Today’s culture demands convenience, a major factor determining adherence to drug therapy. Over the past few years, patient convenience-oriented research in the field of drug delivery has yielded a range of innovative drug-delivery options. As a result, various drug-delivery systems, including medicated chewing gums, oral dispersible tablets, medicated lozenges and lollipops, have now hit the market and are very popular. These dosage forms offer a highly convenient way to dose medications, not only for special population groups with swallowing difficulties, such as children and the elderly, but for the general populace as well. This book provides valuable insights into a number of formulation design approaches that are currently being used, or could be used, to provide new benefits from existing drug molecules.

Bioadhesive Drug Delivery Systems

Author : Edith Mathiowitz,Donald E. Chickering III,Claus-Michael Lehr
Publisher : CRC Press
Page : 704 pages
File Size : 43,7 Mb
Release : 1999-07-13
Category : Medical
ISBN : 1420001345

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Bioadhesive Drug Delivery Systems by Edith Mathiowitz,Donald E. Chickering III,Claus-Michael Lehr Pdf

This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake-offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs. Evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport! Written by over 50 international experts and reflecting broad knowledge of both traditional bioadhesive strategies and novel clinical applications, Bioadhesive Drug Delivery Systems discusses mechanical and chemical bonding, polymer-mucus interactions, the effect of surface energy in bioadhesion, polymer hydration, and mucus rheology analyzes biochemical properties of mucus and glycoproteins, cell adhesion molecules, and cellular interaction with two- and three-dimensional surfaces covers microbalances and magnetic force transducers, atomic force microscopy, direct measurements of molecular level adhesions, and methods to measure cell-cell interactions examines bioadhesive carriers, diffusion or penetration enhancers, and lectin-targeted vehicles describes vaginal, nasal, buccal, ocular, and transdermal drug delivery reviews bioadhesive interactions with the mucosal tissues of the eye and mouth, and those in the respiratory, urinary, and gastrointestinal tracts explores issues of product development, clinical testing, and production and more! Amply referenced with over 1400 bibliographic citations, and illustrated with more than 300 drawings, photographs, tables, and display equations, Bioadhesive Drug Delivery Systems serves as a sound basis for innovation in bioadhesive systems and an excellent introduction to the subject. This unique reference is ideal for pharmaceutical scientists and technologists; chemical, polymer, and plastics engineers; biochemists; physical, surface, and colloid chemists; biologists; and upper-level undergraduate and graduate students in these disciplines.

Bio-Targets and Drug Delivery Approaches

Author : Sabyasachi Maiti,Kalyan Kumar Sen
Publisher : CRC Press
Page : 611 pages
File Size : 49,7 Mb
Release : 2016-11-03
Category : Medical
ISBN : 9781498730006

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Bio-Targets and Drug Delivery Approaches by Sabyasachi Maiti,Kalyan Kumar Sen Pdf

The advances in drug delivery systems over recent years have resulted in a large number of novel delivery systems with the potential to revolutionize the treatment and prevention of diseases. Bio-Targets and Drug Delivery Approaches is an easy-to-read book for students, researchers and pharmaceutical scientists providing a comprehensive introduction to the principles of advanced drug delivery and targeting their current applications and potential future developments.

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies

Author : Manmohan Singh,Maya Salnikova
Publisher : Academic Press
Page : 520 pages
File Size : 52,8 Mb
Release : 2014-12-30
Category : Medical
ISBN : 9780124166615

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Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies by Manmohan Singh,Maya Salnikova Pdf

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies

Drug Delivery Approaches and Nanosystems, Volume 1

Author : Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani
Publisher : CRC Press
Page : 268 pages
File Size : 49,7 Mb
Release : 2017-11-15
Category : Medical
ISBN : 9781351846691

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Drug Delivery Approaches and Nanosystems, Volume 1 by Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani Pdf

This volume, the first of the two-volume Drug Delivery Approaches and Nanosystems series, presents a full picture of the state-of-the-art research and development in drug delivery systems using nanotechnology and its applications. It addresses the ever-expanding application of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques. Many methods of drug delivery systems have been used, but very few of them have been validated for medical use. A major reason for the above situation, the editors believe, is the gap between academia and research, and the gap between academic research and real-time clinical applications and needs. This volume addresses that gap. This volume presents 12 chapters that provide information about the preparation and characterization of nanocomposite materials used in drug delivery systems; advanced research of carbon nanotubes, nanocomposite materials, and polymer-clay, ceramics, and silicate glass-based nanocomposites; and the functionality of graphene nanocomposites. The book also provides detailed information on the application of nanotechnology in drug delivery systems in health care systems and medicine. The book describes how nanostructures are synthesized and draws attention to wide variety of nanostructures available for biological research and treatment applications. This valuable volume provides a wealth of information that will be valuable to scientists and researchers, faculty, and students. Volume 2 of the two-volume series is subtitled Drug Targeting Aspects of Nanotechnology. The volumes are available separately or as a set.

Nano Drug Delivery Strategies for the Treatment of Cancers

Author : Awesh K. Yadav,Umesh Gupta,Rajeev Sharma
Publisher : Academic Press
Page : 374 pages
File Size : 43,6 Mb
Release : 2020-09-03
Category : Science
ISBN : 9780128197943

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Nano Drug Delivery Strategies for the Treatment of Cancers by Awesh K. Yadav,Umesh Gupta,Rajeev Sharma Pdf

Nano Drug Delivery Strategies for the Treatment of Cancers discusses several current and promising approaches for the diagnosis and treatment of cancer by using the most recent developments in nanomedical technologies. The book presents introductory information about the biology of different types of cancer in order to provide the reader with knowledge on their specificities. In addition, it discusses various novel drug delivery systems, detailing their functionalities, expected outcomes and future developments in the field, focusing on brain, mouth and throat, breast, lung, liver, pancreas, stomach, colon, bool, skin and prostate cancers. The book is a valuable source for cancer researchers, oncologists, pharmacologists and nanotechnologists who are interested in novel drug delivery systems and devices for treatment of various types of cancer that take advantage of recent advances in this exciting field. Discusses a wide range of promising approaches for the diagnosis and treatment of cancer using the latest advancement in cutting-edge nanomedical technologies Provides foundational information on different types of cancer and their biology to help the reader choose the best nano drug delivery system for patients Presents novel drug delivery systems based on nanoparticles, microparticles, liposomes, self-assembling Micelles and block copolymer micelles

Drug Delivery

Author : Binghe Wang,Longqin Hu,Teruna J. Siahaan
Publisher : John Wiley & Sons
Page : 740 pages
File Size : 45,5 Mb
Release : 2016-04-18
Category : Science
ISBN : 9781118833360

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Drug Delivery by Binghe Wang,Longqin Hu,Teruna J. Siahaan Pdf

Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications • Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics • Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics • Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery

Novel Delivery Systems for Transdermal and Intradermal Drug Delivery

Author : Ryan F. Donnelly,Thakur Raghu Raj Singh
Publisher : John Wiley & Sons
Page : 290 pages
File Size : 53,9 Mb
Release : 2015-09-28
Category : Science
ISBN : 9781118734513

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Novel Delivery Systems for Transdermal and Intradermal Drug Delivery by Ryan F. Donnelly,Thakur Raghu Raj Singh Pdf

This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications. Furthermore, it presents in-depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle-free injections, nanoparticulate systems and peptide-carrier-type systems. It also covers conventional physical enhancement strategies, such as tape-stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation Discussions about the penetration of the stratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes of in vivoanimal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry.

Novel Drug Delivery Systems for Phytoconstituents

Author : Madhu Gupta,Durgesh Nandini Chauhan,Vikas Sharma,Nagendra Singh Chauhan
Publisher : CRC Press
Page : 375 pages
File Size : 54,9 Mb
Release : 2019-07-23
Category : Health & Fitness
ISBN : 9781351057615

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Novel Drug Delivery Systems for Phytoconstituents by Madhu Gupta,Durgesh Nandini Chauhan,Vikas Sharma,Nagendra Singh Chauhan Pdf

Novel Drug Delivery Systems for Phytoconstituents discusses general principles of drug targeting, construction material and technological concerns of different phytoconstituent in delivery systems. It focuses on the development of novel herbal formulations and summarizes their method of preparation, type of active ingredients, route of administration, biological activity and their applications. It dicusses therapeutic activities of plant derived chemicals, their limitations in clinical applications and novel drug delivery solutions to overcome them to provide better therapeutic effects with controlled and targeted drug delivery. Focus on drug delivery of phytomolecules Act as bridge between natural product scientist and clinical doctors Discusses mechanism of poor bioavailability of herbal molecules Increases awareness towards phytochemical efficacy Summarizes efficient novel delivery systems-based formulations. It extensively covers the applications of novel drug delivery systems including polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid capsules, liposomes, phytosomes, microsphere, transferosomes, and ethosomes. Some chapters are especially focused on anticancer phytodrugs, silymarin, andrographolide, berberine, and curcumin delivery with special emphasis on their application.

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents

Author : Manju Rawat Singh,Deependra Singh,Jagat Kanwar,Nagendra Singh Chauhan
Publisher : Academic Press
Page : 657 pages
File Size : 47,8 Mb
Release : 2020-04-07
Category : Business & Economics
ISBN : 9780128199183

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Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents by Manju Rawat Singh,Deependra Singh,Jagat Kanwar,Nagendra Singh Chauhan Pdf

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of biological and plant-based drugs and describes challenges faced in all aspects offering indispensable strategies to use in the development of bioactive medicines. Bioactive based medications are commonly used throughout the world and have been recognized by physicians and patients for their therapeutic efficacy. Bioactive formulations, including their subordinates and analogs, address 50% of all medicines in clinical practice. Novel bioactive medicine transporters can cure many disorders by both spatial and transitory approaches and have various justifications in medicinal potential. This book presents information on the utility of natural, plant, animal and bioengineered bioactive materials. It is a fundamental source of information and data for pharmacognosists, pharmaceutical analysts, drug transport scientists and pharmacologists working in bioactive medications. Advances information on various bioactive based medications, their sources, clinical consequences and transport strategies Illustrates diverse transport systems for bioactives and derivatives, novel techniques for formulations, targeting strategies and fundamental qualities of developed bioactive carriers, and their safety concerns and standardization Discusses distinctive transport systems, stability, upgraded dissolvability, and enhanced bioavailability of bioactives

Drug Targeting and Stimuli Sensitive Drug Delivery Systems

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Page : 836 pages
File Size : 41,9 Mb
Release : 2018-05-21
Category : Science
ISBN : 9780128136904

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Drug Targeting and Stimuli Sensitive Drug Delivery Systems by Alexandru Mihai Grumezescu Pdf

Drug Targeting and Stimuli Sensitive Drug Delivery Systems covers recent advances in the area of stimuli sensitive drug delivery systems, providing an up-to-date overview of the physical, chemical, biological and multistimuli-responsive nanosystems. In addition, the book presents an analysis of clinical status for different types of nanoplatforms. Written by an internationally diverse group of researchers, it is an important reference resource for both biomaterials scientists and those working in the pharmaceutical industry who are looking to help create more effective drug delivery systems. Shows how the use of nanomaterials can help target a drug to specific tissues and cells Explores the development of stimuli-responsive drug delivery systems Includes case studies to showcase how stimuli responsive nanosystems are used in a variety of therapies, including camptothecin delivery, diabetes and cancer therapy

Drug Delivery

Author : Monika Schäfer-Korting
Publisher : Springer Science & Business Media
Page : 506 pages
File Size : 49,9 Mb
Release : 2010-03-10
Category : Medical
ISBN : 9783642004773

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Drug Delivery by Monika Schäfer-Korting Pdf

In the view of most experts pharmacology is on drugs, targets, and actions. In the context the drug as a rule is seen as an active pharmaceutical ingredient and not as a complex mixture of chemical entities of a well defined structure. Today, we are becoming more and more aware of the fact that delivery of the active compound to the target site is a key. The present volume gives a topical overview on various modern approaches to drug targeting covering today’s options for specific carrier systems allowing successful drug treatment at various sites of the body difficult to address and allowing to increase the benefit-risk-ratio to the optimum possible.

In-Vitro and In-Vivo Tools in Drug Delivery Research for Optimum Clinical Outcomes

Author : Ambikanandan Misra,Aliasgar Shahiwala
Publisher : CRC Press
Page : 332 pages
File Size : 43,8 Mb
Release : 2018-06-22
Category : Medical
ISBN : 9781351368728

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In-Vitro and In-Vivo Tools in Drug Delivery Research for Optimum Clinical Outcomes by Ambikanandan Misra,Aliasgar Shahiwala Pdf

This book covers the essentials of drug delivery research and provides a unique forum for scientific experimental methods that are exclusively focused by the in-vitro, ex-vivo, and in-vivo methodologies of drug delivery research and felicitates translational research. The book includes recent and novel approaches in evaluation methods of transdermal, nasal, ocular, oral and intraoral, gastro-retentive, colon-targeted, and brain-targeted drug delivery systems. Providing up to date and comprehensive information, this text is invaluable to students, teachers, scientists, and others employed in the field of drug delivery.

Drug Delivery to the Brain

Author : Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lange,Robert G. Thorne
Publisher : Springer Science & Business Media
Page : 737 pages
File Size : 52,9 Mb
Release : 2013-12-03
Category : Medical
ISBN : 9781461491057

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Drug Delivery to the Brain by Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lange,Robert G. Thorne Pdf

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications. ​