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Author : Paul Wrede,Gisbert Schneider
Publisher : Walter de Gruyter GmbH & Co KG
Page : 396 pages
File Size : 55,8 Mb
Release : 2020-10-12
Category : Science
ISBN : 9783110874242
No detailed description available for "Concepts in Protein Engineering and Design".
Author : Paul R. Carey
Publisher : Elsevier
Page : 361 pages
File Size : 47,6 Mb
Release : 1996-06-21
Category : Science
ISBN : 0080539971
The design and production of novel peptides and proteins occupy pivotal positions in science and technology and will continue to do so in the 21st century. Protein Engineering and Design outlines the rapid advances in computer-based modeling, protein engineering, and methods needed for protein and peptide preparation and characterization. This indispensable reference lays the groundwork for understanding this multidisciplinary activity while providing an introduction for researchers and students to the field of protein design. Introduces and defines the techniques involved in protein engineering and design Provides a concise overview of key technologies involved and demonstrates their contributions to the specialized design and production of novel proteins and peptides
Author : Jeffrey L. Cleland,Charles S. Craik
Publisher : Wiley-Liss
Page : 558 pages
File Size : 41,5 Mb
Release : 1996-02-07
Category : Science
ISBN : UOM:39015037309690
PROTEIN ENGINEERING Principles and Practice Edited by JEFFREY L. CLELAND CHARLES S. CRAIK Proteins are involved in every aspect of life-structure, motion, catalysis, recognition and regulation. Protein Engineering: Principles and Practice provides a basic framework for understanding both proteins and protein engineering. This comprehensive book covers general, yet essential knowledge required for successful protein engineering, including everything from the fundamentals to modifying existing proteins and developing new proteins. The book begins by introducing the main concepts of protein engineering, including: understanding protein conformation, comprehending the relationship between protein composition and structure, and potential methods for predicting a protein's conformation. Other major subjects addressed are: * Using different host cell expression systems to produce specific proteins * Protein folding * Structure and function of proteins in relation to drug design * Construction of synthetic metal binding sites in proteins * Manufacture of tissue plasminogen activator * Generation of therapeutic antibodies This broad range of topics provides a solid foundation in protein engineering and supplies readers with knowledge essential to the design and production of proteins. Of primary interest to protein scientists-both students and researchers, in academia as well as industry-Protein Engineering is also extremely useful to chemical engineers, protein chemists, biochemists, and pharmaceutical chemists.
Author : Kristian Müller,Katja Arndt
Publisher : Springer Science & Business Media
Page : 318 pages
File Size : 48,5 Mb
Release : 2007-10-26
Category : Science
ISBN : 9781597451871
Protein engineering is a fascinating mixture of molecular biology, protein structure analysis, computation, and biochemistry, with the goal of developing useful or valuable proteins. Protein Engineering Protocols will consider the two general, but not mutually exclusive, strategies for protein engineering. The first is known as rational design, in which the scientist uses detailed knowledge of the structure and function of the protein to make desired changes. The s- ond strategy is known as directed evolution. In this case, random mutagenesis is applied to a protein, and selection or screening is used to pick out variants that have the desired qualities. By several rounds of mutation and selection, this method mimics natural evolution. An additional technique known as DNA shuffling mixes and matches pieces of successful variants to produce better results. This process mimics recombination that occurs naturally during sexual reproduction. The first section of Protein Engineering Protocols describes rational p- tein design strategies, including computational methods, the use of non-natural amino acids to expand the biological alphabet, as well as impressive examples for the generation of proteins with novel characteristics. Although procedures for the introduction of mutations have become routine, predicting and und- standing the effects of these mutations can be very challenging and requires profound knowledge of the system as well as protein structures in general.
Author : Anonim
Publisher : Academic Press
Page : 520 pages
File Size : 40,5 Mb
Release : 2013-02-14
Category : Science
ISBN : 9780123946294
This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers methods in protein design and it has chapters on such topics as protein switch engineering by domain insertion, evolution based design of proteins, and computationally designed proteins. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers methods in protein design Contains chapters with such topics as protein switch engineering by domain insertion, evolution-based design of proteins, and computationally designed proteins
Author : Mallorie N. Sheehan
Publisher : Unknown
Page : 221 pages
File Size : 42,6 Mb
Release : 2013
Category : Protein engineering
ISBN : 1616686499
Author : Raphael Guerois,Manuela López de la Paz
Publisher : Springer Science & Business Media
Page : 303 pages
File Size : 53,8 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781597451161
Protein Design: Methods and Applications presents the most up-to-date protein design and engineering strategies so that readers can undertake their own projects with a maximum chance of success. The authors present integrated computational approaches that require various degrees of computational complexity, and the major accomplishments that have been achieved in the design and structural characterization of helical peptides and proteins.
Author : Anonim
Publisher : Unknown
Page : 67 pages
File Size : 50,9 Mb
Release : 1994
Category : Electronic
ISBN : OCLC:35544075
Author : Raghupathy Sarma
Publisher : Elsevier
Page : 440 pages
File Size : 54,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323150309
Protein Engineering: Applications in Science, Medicine, and Industry deals with the scientific, medical, and industrial applications of protein engineering. Topics range from protein structure and design to mutant analysis and complex systems. Applications such as production of novel antibiotics, genetic transformation of plants, and genetic engineering of bioinsecticides are described. This book is comprised of 25 chapters and begins with an overview of trends and developments in protein chemistry and their relevance to protein engineering, followed by a discussion on protein sequence data banks. Subsequent chapters explore the design and construction of biologically active peptides, including hormones; structural and functional analysis of thermophile proteins; the conformation of diphtheria toxin; and applications of surface-simulation synthesis in protein molecular recognition. The use of oligonucleotide-directed site-specific mutagenesis in functional analysis of the signal peptide for protein secretion is also considered. The results of studies on the mechanism of membrane fusion are presented. This monograph will serve as a useful guide for those who are already working on protein engineering and those who are about to start research in this field.
Author : Caroline Koehrer,Uttam L. RajBhandary
Publisher : Springer Science & Business Media
Page : 347 pages
File Size : 41,7 Mb
Release : 2009-01-07
Category : Science
ISBN : 9783540709411
Site-specific mutagenesis of DNA, developed some thirty years ago, has proven to be one of the most important advances in biology. By allowing the site-specific replacement of any amino acid in a protein with one of the other nineteen amino acids, it ushered in the new era of "Protein Engineering". The field of protein engineering has, however, evolved rapidly since then and the last fifteen years have witnessed remarkable advances through the use of new chemical, biochemical and molecular biological tools towards the synthesis and manipulation of proteins. The chapters included in this book reflect the rapid evolution of protein engineering and its many applications in basic research, biotechnology, material sciences and therapy. This book will provide the reader with an introduction to state-of the-art concepts and methods and will be of use to anyone interested in the study of proteins, in academia as well as in industry.
Author : John Joseph Langone
Publisher : Gulf Professional Publishing
Page : 864 pages
File Size : 45,5 Mb
Release : 1991
Category : Antigen-antibody reactions
ISBN : 012182103X
Computer-based design and modeling, computational approaches, and instrumental methods for elucidating molecular mechanisms of protein folding and ligand-acceptor interactions are included in Volumes 202 and 203, as are genetic and chemical methods for the production of functional molecules including antibodies and antigens, enzymes, receptors, nucleic acids and polysaccharides, and drugs.
Author : Ruth Hogue Angeletti
Publisher : Elsevier
Page : 378 pages
File Size : 40,6 Mb
Release : 1998-09-14
Category : Science
ISBN : 9780080539997
Proteins: Analysis and Design focuses solely on individual experimental approaches, rather than on specific classes of proteins. The book provides insight into the important issues in protein science and how one can cope with them. These include all issues which explore the detailed relationship of protein structure to function. Provides problems and technical solutions Includes posttranslational modifications Uses synthetic peptides as biological models Details mutagenesis and protein engineering Covers design of protein structure and function
Author : Krishna Mohan Poluri,Khushboo Gulati
Publisher : Springer
Page : 134 pages
File Size : 49,7 Mb
Release : 2016-11-12
Category : Technology & Engineering
ISBN : 9789811027321
This brief provides a broad overview of protein-engineering research, offering a glimpse of the most common experimental methods. It also presents various computational programs with applications that are widely used in directed evolution, computational and de novo protein design. Further, it sheds light on the advantages and pitfalls of existing methodologies and future perspectives of protein engineering techniques.
Author : Valentin Köhler
Publisher : Humana
Page : 0 pages
File Size : 51,9 Mb
Release : 2016-09-17
Category : Science
ISBN : 1493944088
Protein Design: Method and Applications, Second Edition expands upon the previous edition with current, detailed ideas on how to approach a potential protein design project. With new chapters on metals as structure-forming elements and functional sites, the design and characterization of fluorinated proteins, top-down symmetric deconstruction and the design of protein libraries and novel or repurposed enzymes. Written in the highly successful Methods in Molecular Biologyseries format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and intuitive, Protein Design: Method and Applications, Second Edition provides a number of practical protocols and instructive reviews to aid in the creation of new experiments.
Author : Tairo Oshima,Morio Ikehara,Koiti Titani
Publisher : Springer
Page : 355 pages
File Size : 47,6 Mb
Release : 1990-09-18
Category : Science
ISBN : 3540528873
Protein Engineering summarizes important new findings and presents up-to-date and overall information on the present field of protein engineering.