Conjugation And Deconjugation Of Ubiquitin Family Modifiers

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Conjugation and Deconjugation of Ubiquitin Family Modifiers

Marcus Groettrup
Conjugation and Deconjugation of Ubiquitin Family Modifiers Book PDF

Author : Marcus Groettrup
Publisher : Springer Science & Business Media
Page : 270 pages
File Size : 49,5 Mb
Release : 2011-01-11
Category : Science
ISBN : 9781441966766

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Conjugation and Deconjugation of Ubiquitin Family Modifiers by Marcus Groettrup Pdf

† 1 a a 4 † 17 10 15 ubiquitin; and of 16 VCP 17 18 20 33 34 34 36 p domain. 41 42 42 43 P U 42 47 binding. C. elegans 16 In 21 22 50 51 52 53 13 and UFD 4 10 of Cdc48. 18 30 of Ufd2. COFACTORS 47 23 13 47 47 47 72 15 15 and of Spt23 p90. Ufd2 and Cdc48. In C. elegans 74 16 75 75 76 76 Ufd2 25 54 54 7 56 p47 7 7 80 30 30 81 82 82 but and CD3 26 DUB COFACTORS 30 UFD3 OTU1 4 Cdc48 30 4 OLE1. 15 27 87 REFERENCES 30 REGULATION OF UBIQUITIN MONOUBIQUITINATION UBIQUITINATION 1 32 7 S) d 33 12 13 14 15 18 19 15 20 21 35 15 15 27 15 31 32 31 33 36 monoubiquitination of pol pol 34 37 34 monoubiquitination. 20 35 trans 3 15 REFERENCES by monoubiquitination. Mol Cell; 2009. UBIQUITIN LIGASE ACTIVITY BY Nedd 1 2 of 41 5 6 8 fold. 9 13 14 edd 43 18 18 K M and k 18 22 23 K M 24 25 K M 26 edd 45 18 27 K M K D 18 25 . 8 10 M 21 28 MECHANISM AND REGULATION OF CRLs 34 41 34 edd 47 48 S. pombe 49 51 p27 and I by SCF and SCF 57 58 59 60 CTD CTD CTD CTD in Cul5 CTD CTD CTD 60 18

Ubiquitin Family Modifiers and the Proteasome

R. Jürgen Dohmen,Martin Scheffner
Ubiquitin Family Modifiers and the Proteasome Book PDF

Author : R. Jürgen Dohmen,Martin Scheffner
Publisher : Humana Press
Page : 666 pages
File Size : 53,8 Mb
Release : 2012-02-14
Category : Science
ISBN : 1617794732

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Ubiquitin Family Modifiers and the Proteasome by R. Jürgen Dohmen,Martin Scheffner Pdf

The ubiquitin-proteasome system (UPS) and ubiquitin-related modifiers are not only involved in cellular protein quality control but also in the regulation of many fundamental cellular processes/pathways as well as in their disease-relevant aberrations. Ubiquitin Family Modifiers and Proteasome: Reviews and Protocols presents both novel developments in UPS research and important methods related to the main recent advances in the field of ubiquitin family modifiers. Divided into five convenient sections, this volume focuses on the enzymology and substrate identification of ubiquitin family modifiers, the recognition and chain formation of these modifiers, the analysis of proteasome biogenesis and function, protein quality control, and finally the use of small molecules and strategies to study or manipulate the function of the UPS and of ubiquitin family modifiers, respectively. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Ubiquitin Family Modifiers and Proteasome: Reviews and Protocols will be of great use to investigators and students engaged in both basic and applied research in life sciences.

DNA Replication Stress

Robert M. Brosh Jr.
DNA Replication Stress Book PDF

Author : Robert M. Brosh Jr.
Publisher : MDPI
Page : 368 pages
File Size : 55,9 Mb
Release : 2019-08-27
Category : Science
ISBN : 9783039213894

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DNA Replication Stress by Robert M. Brosh Jr. Pdf

This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS

International Review of Cell and Molecular Biology

Anonim
International Review of Cell and Molecular Biology Book PDF

Author : Anonim
Publisher : Academic Press
Page : 308 pages
File Size : 45,6 Mb
Release : 2019-02-01
Category : Science
ISBN : 9780128167045

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International Review of Cell and Molecular Biology by Anonim Pdf

International Review of Cell and Molecular Biology, Volume 343 reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. Sections in this new release include The Molecular and Cellular Regulation of Brassicaceae Self-Incompatibility and Self-Pollen Rejection, Regulation of Plant Immunity by the Proteasome, the Role of the Ubiquitin Proteasome System in Plant Response to Abiotic Stress, Glycosylation in Anticancer Immunity, Emerging Themes in PDZ Domain Signaling: Structure, Function and Inhibition, and more. Publishes invited review articles on selected topics as authored by established and active cell and molecular biologists whose work is drawn from international sources Offers a wide range of perspectives on specific subjects

Proteostasis and Disease

Rosa Barrio,James D. Sutherland,Manuel S. Rodriguez
Proteostasis and Disease Book PDF

Author : Rosa Barrio,James D. Sutherland,Manuel S. Rodriguez
Publisher : Springer Nature
Page : 350 pages
File Size : 53,6 Mb
Release : 2020-04-09
Category : Science
ISBN : 9783030382667

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Proteostasis and Disease by Rosa Barrio,James D. Sutherland,Manuel S. Rodriguez Pdf

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

Cullin-RING Ligases and Protein Neddylation

Yi Sun,Wenyi Wei,Jianping Jin
Cullin RING Ligases and Protein Neddylation Book PDF

Author : Yi Sun,Wenyi Wei,Jianping Jin
Publisher : Springer Nature
Page : 372 pages
File Size : 41,8 Mb
Release : 2020-01-02
Category : Science
ISBN : 9789811510250

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Cullin-RING Ligases and Protein Neddylation by Yi Sun,Wenyi Wei,Jianping Jin Pdf

This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine.

Aging Research in Yeast

Michael Breitenbach,S. Michal Jazwinski,Peter Laun
Aging Research in Yeast Book PDF

Author : Michael Breitenbach,S. Michal Jazwinski,Peter Laun
Publisher : Springer Science & Business Media
Page : 373 pages
File Size : 40,8 Mb
Release : 2011-11-19
Category : Science
ISBN : 9789400725614

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Aging Research in Yeast by Michael Breitenbach,S. Michal Jazwinski,Peter Laun Pdf

This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.

Reprogramming Microbial Metabolic Pathways

Xiaoyuan Wang,Jian Chen,Peter Quinn
Reprogramming Microbial Metabolic Pathways Book PDF

Author : Xiaoyuan Wang,Jian Chen,Peter Quinn
Publisher : Springer Science & Business Media
Page : 445 pages
File Size : 46,7 Mb
Release : 2012-10-20
Category : Computers
ISBN : 9789400750548

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Reprogramming Microbial Metabolic Pathways by Xiaoyuan Wang,Jian Chen,Peter Quinn Pdf

Metabolic engineering has been developed over the past 20 years to become an important tool for rational engineering of microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of metabolites in microorganisms. The overall goal is to achieve a better understanding of metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production. This book brings together contributions from leading researchers at the cutting edge of these topics. The subject matter is divided into two sections. The first section deals with novel and emerging methods for redesigning microorganisms exploiting systems biology and gene regulation. The second discusses practical aspects of metabolic engineering for over production of a variety of valuable chemicals and materials by fermentation.

Water Soluble Vitamins

Olaf Stanger
Water Soluble Vitamins Book PDF

Author : Olaf Stanger
Publisher : Springer Science & Business Media
Page : 388 pages
File Size : 41,6 Mb
Release : 2011-11-27
Category : Medical
ISBN : 9789400721999

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Water Soluble Vitamins by Olaf Stanger Pdf

The discovery of vitamins in the early 1900s, their later chemical characterization and the clarification of pivotal metabolic functions are sequential aspects of a brilliant chapter in the history of modern nutritional sciences and medicine. The name, derived from “vital-amines”, indicates their elementary metabolic key functions in human metabolism. Vitamins are truly families of compounds, which include precursors and various free and bound forms, all with individual roles in metabolism and function. A more recent approach therefore searches for the components, the understanding of their roles in physiology and pathology as well as looking for novel pharmacological applications. When used properly, vitamins are, indeed, “magical” substances. Due to their efficacy, they should therefore be regarded as drugs with effects and side effects to be weighted against each other. Today, it is not the previously fatal deficiency-associated diseases that are in the focus of interest, but rather the relation of suboptimal vitamin bioavailability to chronic disease. This is complicated by genetic susceptibility, lifestyle, and the presence or absence of health-compromising habits, such as smoking. In turn, the development and application of new and more sensitive and specific assays further enable us to look more closely into the many functions of vitamins. Water soluble vitamins are complex molecular structures and even today, many areas in vitamin biochemistry are not yet fully understood. Novel effects and functions of vitamins remain and continue to be discovered. This book presents most recent research results and fascinating new knowledge on the role and effects of the water soluble vitamins in man. Some of the most distinguished chemists, biochemists, biologists and clinicians have contributed valuable chapters sharing unexpected novel insights into the biochemistry, (epi)genetics, metabolism, and function of water soluble vitamins, with their potential for clinical applications. Thus, physicians, clinicians, scientists, researchers, epidemiologists. nutritional specialists and health professionals alike will find stimulating and fascinating new insight in the many roles that water soluble vitamins play in human health and disease.

Epigenetics: Development and Disease

Tapas Kumar Kundu
Epigenetics Development and Disease Book PDF

Author : Tapas Kumar Kundu
Publisher : Springer Science & Business Media
Page : 698 pages
File Size : 47,9 Mb
Release : 2012-11-13
Category : Medical
ISBN : 9789400745254

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Epigenetics: Development and Disease by Tapas Kumar Kundu Pdf

Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.

Purinergic Regulation of Respiratory Diseases

Maryse Picher,Richard C. Boucher
Purinergic Regulation of Respiratory Diseases Book PDF

Author : Maryse Picher,Richard C. Boucher
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 41,8 Mb
Release : 2011-05-11
Category : Medical
ISBN : 9789400712171

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Purinergic Regulation of Respiratory Diseases by Maryse Picher,Richard C. Boucher Pdf

We proudly present the first book to integrate all aspects of purinergic signaling in the respiratory system. The first chapters introduce basic notions of purinergic pharmacology and metabolism, which allows readers from all scientific backgrounds to fully grasp the importance of these signaling networks for airway defenses, including mucociliary clearance and inflammatory responses. Then, chapters are devoted to the groundbreaking discovery that chronic respiratory diseases, including asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD), present specific aberrances in purinergic signaling which essentially drive lung complications. The last chapters describe the animal models used to investigate purinergic signaling in respiratory diseases, and the therapeutic applications developed by the pharmaceutical industry based on receptor agonists/antagonists and metabolic correctors. This highly comprehensive manuscript constitutes an invaluable tool for beginners and experts to follow the rapidly evolving research field of purinergic signaling. Furthermore, the critical analysis of past clinical protocols should facilitate the identification of potent therapeutic targets, and provide a better understanding of the data acquired in current clinical trials.

Regulated Proteolysis in Microorganisms

David A. Dougan
Regulated Proteolysis in Microorganisms Book PDF

Author : David A. Dougan
Publisher : Springer Science & Business Media
Page : 338 pages
File Size : 46,9 Mb
Release : 2013-03-12
Category : Medical
ISBN : 9789400759404

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Regulated Proteolysis in Microorganisms by David A. Dougan Pdf

This book contains an extensive collection of critical reviews, from leading researchers in the field of regulated protein degradation. It covers the role of regulated proteolysis in a range of microorganisms (from Gram positive, Gram negative and pathogenic bacteria to Archaea and the Baker’s yeast Saccharomyces cerevisiae).

Peroxisomes and their Key Role in Cellular Signaling and Metabolism

Luis A. del Río
Peroxisomes and their Key Role in Cellular Signaling and Metabolism Book PDF

Author : Luis A. del Río
Publisher : Springer Science & Business Media
Page : 353 pages
File Size : 51,9 Mb
Release : 2013-07-03
Category : Medical
ISBN : 9789400768895

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Peroxisomes and their Key Role in Cellular Signaling and Metabolism by Luis A. del Río Pdf

Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism. In recent years it has become increasingly clear that peroxisomes are involved in a range of important cellular functions in almost all eukaryotic cells. In higher eukaryotes, including humans, peroxisomes catalyze ether phospholipids biosynthesis, fatty acid alpha-oxidation, glyoxylate detoxification, etc, and in humans peroxisomes are associated with several important genetic diseases. In plants, peroxisomes carry out the fatty acid beta-oxidation, photorespiration, metabolism of ROS, RNS and RSS, photomorphogenesis, biosynthesis of phytohormones, senescence, and defence against pathogens and herbivores. In recent years it has been postulated a possible contribution of peroxisomes to cellular signaling. In this volume an updated view of the capacity and function of peroxisomes from human, animal, fungal and plant origin as cell generators of different signal molecules involved in distinct processes of high physiological importance is presented.

Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications

Susan C. Frost,Robert McKenna
Carbonic Anhydrase Mechanism Regulation Links to Disease and Industrial Applications Book PDF

Author : Susan C. Frost,Robert McKenna
Publisher : Springer Science & Business Media
Page : 429 pages
File Size : 45,6 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9789400773592

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Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications by Susan C. Frost,Robert McKenna Pdf

The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation. With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity. We have designed the book to cover basic information of mechanism, structure, and function of the CA families. The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches.

Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism

Aparajita Dey
Cytochrome P450 2E1 Its Role in Disease and Drug Metabolism Book PDF

Author : Aparajita Dey
Publisher : Springer Science & Business Media
Page : 269 pages
File Size : 55,5 Mb
Release : 2013-02-12
Category : Medical
ISBN : 9789400758810

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Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism by Aparajita Dey Pdf

The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.