Cullin Ring Ligases And Protein Neddylation

Author : Yi Sun,Wenyi Wei,Jianping Jin
Publisher : Springer Nature
Page : 372 pages
File Size : 47,6 Mb
Release : 2020-01-02
Category : Science
ISBN : 9789811510250

Get Book

Cullin-RING Ligases and Protein Neddylation by Yi Sun,Wenyi Wei,Jianping Jin Pdf

This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine.

Author : Matthew Summers
Publisher : BoD – Books on Demand
Page : 228 pages
File Size : 41,9 Mb
Release : 2019-06-19
Category : Science
ISBN : 9781838804909

Get Book

Ubiquitin Proteasome System by Matthew Summers Pdf

The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.

Author : Jiayang Li,Chuanyou Li,Steven M Smith
Publisher : Academic Press
Page : 616 pages
File Size : 52,9 Mb
Release : 2017-04-19
Category : Science
ISBN : 9780128115633

Get Book

Hormone Metabolism and Signaling in Plants by Jiayang Li,Chuanyou Li,Steven M Smith Pdf

Plant Hormones: Biosynthesis and Mechanisms of Action is based on research funded by the Chinese government’s National Natural Science Foundation of China (NSFC). This book brings a fresh understanding of hormone biology, particularly molecular mechanisms driving plant hormone actions. With growing understanding of hormone biology comes new outlooks on how mankind values and utilizes the built-in potential of plants for improvement of crops in an environmentally friendly and sustainable manner. This book is a comprehensive description of all major plant hormones: how they are synthesized and catabolized; how they are perceived by plant cells; how they trigger signal transduction; how they regulate gene expression; how they regulate plant growth, development and defense responses; and how we measure plant hormones. This is an exciting time for researchers interested in plant hormones. Plants rely on a diverse set of small molecule hormones to regulate every aspect of their biological processes including development, growth, and adaptation. Since the discovery of the first plant hormone auxin, hormones have always been the frontiers of plant biology. Although the physiological functions of most plant hormones have been studied for decades, the last 15 to 20 years have seen a dramatic progress in our understanding of the molecular mechanisms of hormone actions. The publication of the whole genome sequences of the model systems of Arabidopsis and rice, together with the advent of multidisciplinary approaches has opened the door to successful experimentation on plant hormone actions. Offers a comprehensive description of all major plant hormones including the recently discovered strigolactones and several peptide hormones Contains a chapter describing how plant hormones regulate stem cells Offers a fresh understanding of hormone biology, particularly molecular mechanisms driving plant hormone actions Discusses the built-in potential of plants for improvement of crops in an environmentally friendly and sustainable manner

Author : Wang-Shick Ryu
Publisher : Academic Press
Page : 440 pages
File Size : 43,9 Mb
Release : 2016-03-30
Category : Science
ISBN : 9780128009994

Get Book

Molecular Virology of Human Pathogenic Viruses by Wang-Shick Ryu Pdf

Molecular Virology of Human Pathogenic Viruses presents robust coverage of the key principles of molecular virology while emphasizing virus family structure and providing key context points for topical advances in the field. The book is organized in a logical manner to aid in student discoverability and comprehension and is based on the author’s more than 20 years of teaching experience. Each chapter will describe the viral life cycle covering the order of classification, virion and genome structure, viral proteins, life cycle, and the effect on host and an emphasis on virus-host interaction is conveyed throughout the text. Molecular Virology of Human Pathogenic Viruses provides essential information for students and professionals in virology, molecular biology, microbiology, infectious disease, and immunology and contains outstanding features such as study questions and recommended journal articles with perspectives at the end of each chapter to assist students with scientific inquiries and in reading primary literature. Presents viruses within their family structure Contains recommended journal articles with perspectives to put primary literature in context Includes integrated recommended reading references within each chapter Provides access to online ancillary package inclusive of annotated PowerPoint images, instructor’s manual, study guide, and test bank

Author : J. Robin Harris,Jon Marles-Wright
Publisher : Springer
Page : 0 pages
File Size : 49,7 Mb
Release : 2018-08-07
Category : Science
ISBN : 3319835300

Get Book

Macromolecular Protein Complexes by J. Robin Harris,Jon Marles-Wright Pdf

This volume of the established Subcellular Biochemistry series presents 20 chapters dealing with a broad range of interesting protein complexes. It will enable researchers to readily appreciate the major contribution from both X-ray crystallography and cryo-electron microscopy in this field of study. The biological significance of these structural studies is emphasised throughout the book. The diversity of the material included here indicates the breadth of this field and the tremendous progress that has been made in recent years. The book is directed primarily to advanced students and researchers in structural biology, and others in the biochemical sciences. It will be supplemented by other related books within the Subcellular Biochemistry series. One of the Editors (JM-W) is actively involved in structural biology and the other (JRH), as a retired academic and the Series Editor of Subcellular Biochemistry, has long experience at editing multi-author books./div

Author : Tim Raemaekers
Publisher : Leuven University Press
Page : 140 pages
File Size : 49,5 Mb
Release : 2003-09
Category : Science
ISBN : 9058673030

Get Book

NuSAP, a Novel Microtubule-Associated Protein Involved in Mitotic Spindle Organization by Tim Raemaekers Pdf

"Vitamin D and bone, Linking the fields of vitamin D and bone with those of the nucleus and mitotic spindle, Nucleus structure and dynamics, Organization of the nucleus, Microtubules and associated proteins, Mitosis and spindle assembly, Control and mechanism of spindle formation and dynamics, Materials and methods, NuSAP, and novel MAP involved in spindle organization, NuSAP expression in cultured osteoblasts: regulation during development and by 1,25-dihydroxyvitamin D3, Analysis of NuSAP gene expression at the tissue level and chromosomal localization of human and mouse NuSAP, Developmentally regulated expression of NuSAP in the rat testis and mouse embryo, Chromosomal localization of human and mouse Nusap, General discussion and perspectives."

Author : Michele Pagano
Publisher : Springer Science & Business Media
Page : 248 pages
File Size : 48,6 Mb
Release : 1998-06-08
Category : Medical
ISBN : 3540640312

Get Book

Cell Cycle Control by Michele Pagano Pdf

Addressing the regulation of the eukaryotic cell cycle, this book brings together experts to cover all aspects of the field, clearly and unambiguously, delineating what is commonly accepted in the field from the problems that remain unsolved. It will thus appeal to a large audience: basic and clinical scientists involved in the study of cell growth, differentiation, senescence, apoptosis, and cancer, as well as graduates and postgraduates.

Author : Rosa Barrio,James D. Sutherland,Manuel S. Rodriguez
Publisher : Springer Nature
Page : 350 pages
File Size : 40,5 Mb
Release : 2020-04-09
Category : Science
ISBN : 9783030382667

Get Book

Proteostasis and Disease by Rosa Barrio,James D. Sutherland,Manuel S. Rodriguez Pdf

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

Author : Huib Ovaa,Monique P. C. Mulder,Zhihao Zhuang,Benedikt M. Kessler,Lei Liu
Publisher : Frontiers Media SA
Page : 205 pages
File Size : 50,8 Mb
Release : 2020-12-11
Category : Science
ISBN : 9782889638253

Get Book

Probing the Ubiquitin Landscape by Huib Ovaa,Monique P. C. Mulder,Zhihao Zhuang,Benedikt M. Kessler,Lei Liu Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Hilmar Weinmann,Craig Crews
Publisher : Royal Society of Chemistry
Page : 382 pages
File Size : 41,8 Mb
Release : 2020-10-07
Category : Medical
ISBN : 9781839160776

Get Book

Protein Degradation with New Chemical Modalities by Hilmar Weinmann,Craig Crews Pdf

Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally ‘difficult to target’ proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.

Author : Lingqiang Zhang,Yu Rao,Cui Hua Liu,Daming Gao,Lixin Wan
Publisher : Frontiers Media SA
Page : 249 pages
File Size : 44,7 Mb
Release : 2021-12-30
Category : Science
ISBN : 9782889718993

Get Book

Ubiquitin Code: From Cell Biology to Translational Medicine by Lingqiang Zhang,Yu Rao,Cui Hua Liu,Daming Gao,Lixin Wan Pdf

Author : Marcus Groettrup
Publisher : Springer Science & Business Media
Page : 270 pages
File Size : 45,6 Mb
Release : 2011-01-11
Category : Science
ISBN : 9781441966766

Get Book

Conjugation and Deconjugation of Ubiquitin Family Modifiers by Marcus Groettrup Pdf

† 1 a a 4 † 17 10 15 ubiquitin; and of 16 VCP 17 18 20 33 34 34 36 p domain. 41 42 42 43 P U 42 47 binding. C. elegans 16 In 21 22 50 51 52 53 13 and UFD 4 10 of Cdc48. 18 30 of Ufd2. COFACTORS 47 23 13 47 47 47 72 15 15 and of Spt23 p90. Ufd2 and Cdc48. In C. elegans 74 16 75 75 76 76 Ufd2 25 54 54 7 56 p47 7 7 80 30 30 81 82 82 but and CD3 26 DUB COFACTORS 30 UFD3 OTU1 4 Cdc48 30 4 OLE1. 15 27 87 REFERENCES 30 REGULATION OF UBIQUITIN MONOUBIQUITINATION UBIQUITINATION 1 32 7 S) d 33 12 13 14 15 18 19 15 20 21 35 15 15 27 15 31 32 31 33 36 monoubiquitination of pol pol 34 37 34 monoubiquitination. 20 35 trans 3 15 REFERENCES by monoubiquitination. Mol Cell; 2009. UBIQUITIN LIGASE ACTIVITY BY Nedd 1 2 of 41 5 6 8 fold. 9 13 14 edd 43 18 18 K M and k 18 22 23 K M 24 25 K M 26 edd 45 18 27 K M K D 18 25 . 8 10 M 21 28 MECHANISM AND REGULATION OF CRLs 34 41 34 edd 47 48 S. pombe 49 51 p27 and I by SCF and SCF 57 58 59 60 CTD CTD CTD CTD in Cul5 CTD CTD CTD 60 18

Author : Tanveer Ali Dar,Laishram Rajendrakumar Singh
Publisher : Academic Press
Page : 0 pages
File Size : 42,8 Mb
Release : 2019-05-21
Category : Science
ISBN : 0128119136

Get Book

Protein Modificomics by Tanveer Ali Dar,Laishram Rajendrakumar Singh Pdf

Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes.

Author : John Wilson,Tim Hunt
Publisher : Garland Science
Page : 984 pages
File Size : 40,7 Mb
Release : 2014-11-21
Category : Science
ISBN : 9781317497271

Get Book

Molecular Biology of the Cell 6E - The Problems Book by John Wilson,Tim Hunt Pdf

The Problems Book helps students appreciate the ways in which experiments and simple calculations can lead to an understanding of how cells work by introducing the experimental foundation of cell and molecular biology. Each chapter reviews key terms, tests for understanding basic concepts, and poses research-based problems. The Problems Book has be

Author : Haleem J. Issaq
Publisher : Academic Press
Page : 489 pages
File Size : 46,7 Mb
Release : 2013-05-20
Category : Science
ISBN : 9780123947956

Get Book

Proteomic and Metabolomic Approaches to Biomarker Discovery by Haleem J. Issaq Pdf

Proteomic and Metabolomic Approaches to Biomarker Discovery demonstrates how to leverage biomarkers to improve accuracy and reduce errors in research. Disease biomarker discovery is one of the most vibrant and important areas of research today, as the identification of reliable biomarkers has an enormous impact on disease diagnosis, selection of treatment regimens, and therapeutic monitoring. Various techniques are used in the biomarker discovery process, including techniques used in proteomics, the study of the proteins that make up an organism, and metabolomics, the study of chemical fingerprints created from cellular processes. Proteomic and Metabolomic Approaches to Biomarker Discovery is the only publication that covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods, and presents a standard operating procedure for sample selection, preparation, and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. A vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals, and graduate students, Proteomic and Metabolomic Approaches to Biomarker Discovery provides the information needed to reduce clinical error in the execution of research. Describes the use of biomarkers to reduce clinical errors in research Includes techniques from a range of biomarker discoveries Covers all steps involved in biomarker discovery, from study design to study execution