Conn S Handbook Of Models For Human Aging

Author : Jeffrey L. Ram,P. Michael Conn
Publisher : Academic Press
Page : 1218 pages
File Size : 43,9 Mb
Release : 2018-04-05
Category : Medical
ISBN : 9780128113547

Get Book

Conn's Handbook of Models for Human Aging by Jeffrey L. Ram,P. Michael Conn Pdf

Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students. Combines both the methods of study for human aging and animal models Provides a historical overview and discussion of model availability, key methods and ethical issues Contains over 200 full color illustrations

Author : P. Michael Conn
Publisher : Elsevier
Page : 1075 pages
File Size : 47,5 Mb
Release : 2011-04-28
Category : Medical
ISBN : 0080460062

Get Book

Handbook of Models for Human Aging by P. Michael Conn Pdf

The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations

Author : Anonim
Publisher : Elsevier
Page : 829 pages
File Size : 51,8 Mb
Release : 2006-12-15
Category : Science
ISBN : 9780080469072

Get Book

The Mouse in Biomedical Research by Anonim Pdf

Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mouse’s normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.

Author : Anonim
Publisher : Academic Press
Page : 1656 pages
File Size : 45,5 Mb
Release : 2019-11-20
Category : Medical
ISBN : 9780128160763

Get Book

Encyclopedia of Biomedical Gerontology by Anonim Pdf

Encyclopedia of Biomedical Gerontology, Three Volume Set presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention. Provides a ‘one-stop’ resource to information written by world-leading scholars in the field of biomedical gerontology Fills a critical gap of information in a field that has seen significant progress in the last 10 years

Author : Colin R Martin,Vinood B. Patel,Victor R Preedy
Publisher : Elsevier
Page : 708 pages
File Size : 50,5 Mb
Release : 2022-11-29
Category : Medical
ISBN : 9780323898867

Get Book

Handbook of Animal Models in Neurological Disorders by Colin R Martin,Vinood B. Patel,Victor R Preedy Pdf

Handbook of Animal Models in Neurological Disorders will better readers’ understanding of a large variety of animal models and their applicability in studying a number of neurological disorders. Featuring sections on brain injury, stroke and neuroinflammation, this volume discusses in detail the utility, success and pitfalls of multiple models for each condition. Multiple disorders are covered, ranging from neurodegenerative diseases like Alzheimer’s, Parkinson’s, and ALS, to multiple sclerosis, headache, migraine, and others. With expert authors, this book has applicability for anyone pursuing neuroscience or biomedical research working to better understand, study and ultimately treat neurological dysfunction. Summarizes animal models for a variety of neurological conditions Contains chapter abstracts, key facts, a dictionary and a summary Covers both neurodegenerative diseases and other neurological conditions Compares and contrasts different models and experimental systems Includes sections on Alzheimer’s, Parkinson’s, brain injury, migraine, multiple sclerosis, and more

Author : Livia D'Angelo,Paolo de Girolamo
Publisher : Academic Press
Page : 476 pages
File Size : 42,7 Mb
Release : 2021-08-28
Category : Science
ISBN : 9780128212455

Get Book

Laboratory Fish in Biomedical Research by Livia D'Angelo,Paolo de Girolamo Pdf

Fish, and particularly zebrafish, have become the fastest-growing segment of the research population. They offer several advantages, in terms of biology and technologies to apply, and thus are employed in numerous research fields. Laboratory Fish in Biomedical Research: Biology, Husbandry and Research Applications for Zebrafish, Medaka, Killifish, Swordtail Fish, Cavefish, Stickleback, Goldfish and Danionella Translucida addresses the relevant and increasing need to collect cutting-edge knowledge on husbandry, maintenance, welfare and experimental protocols of the most common freshwater species under standard laboratory conditions. Provides husbandry and management protocols, devices and water systems Shows strength and weakness of breeding Explores potential scientific applications and experimental protocols. with regards to the most used freshwater fish used for scientific purposes

Author : Jennifer L. Bizon,Alisa Woods
Publisher : Springer Science & Business Media
Page : 215 pages
File Size : 54,5 Mb
Release : 2008-11-12
Category : Medical
ISBN : 9781597454223

Get Book

Animal Models of Human Cognitive Aging by Jennifer L. Bizon,Alisa Woods Pdf

Significant improvements in lifestyle and medical science are leading to an ever increasing elderly population in the United States and other developed nations. The U.S census bureau estimates that the number of people over 65 will nearly double by 2030, and that the elderly will comprise nearly one-fifth of the world’s entire population within the next 20 years. In Animal Models of Human Cognitive Aging, Jennifer Bizon, Alisa Woods, and a panel of international authorities comprehensively discuss the use of animal models as a tool for understanding cognitive changes associated with the aging process. The book provides substantive background on the newest and most widely used animal models in studies of cognition and aging, while detailing the normal and pathological processes of brain aging of humans in relation to those models. Additional chapters comprehensively review frontal cortical deficits and executive function in primates as related to humans, and the use of transgenic modulation in mice to model Alzheimer’s and other age-related diseases. Groundbreaking and authoritative, Animal Models of Human Cognitive Aging provides a valuable resource for Neuroscientists, Gerontological Scientists and all aging medicine researchers, while serving as a primer for understanding current brain aging studies.

Author : G. Casadesus
Publisher : IOS Press
Page : 352 pages
File Size : 43,7 Mb
Release : 2011-07-05
Category : Medical
ISBN : 9781607507338

Get Book

Handbook of Animal Models in Alzheimer’s Disease by G. Casadesus Pdf

Animals have been used to model diseases or test new treatments since around 300 BC, and undoubtedly our ability to model disease in animals – including transgenic animals – has provided major breakthroughs in all fields of biomedical research. Due to their complexity and plurality of pathology and symptomatology, the study of neurodegenerative diseases relies heavily on animal models. These models have been developed in many species in the attempt to undercover the complex nature of the disease mechanisms involved. The ultimate goal is to test promising therapies and to manage, prevent or cure neurodegenerative disease. But because most animal models in this area do not reproduce the full phenotypical disease spectrum and the etiology and clinical presentation of neurodegenerative diseases differ from one patient to the next, the testing of these diseases in animal models often translates poorly to indices of efficacy when applied to the clinical population. Written by experts in the field with these advances and challenges in mind, this handbook provides an updated overview of the animal models being developed and used to study complex disease dynamics. The first part of the book presents an overview of animal models of various species and includes a review of new invertebrate animal models to study neurodegeneration. The second section presents the use of animal models to pinpoint disease mechanisms, and the last part of the handbook examines the various therapeutic interventions being used in models of neurodegenerative disease.

Author : Matt Kaeberlein,George Martin
Publisher : Academic Press
Page : 576 pages
File Size : 44,7 Mb
Release : 2015-08-20
Category : Medical
ISBN : 9780124116207

Get Book

Handbook of the Biology of Aging by Matt Kaeberlein,George Martin Pdf

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Author : Deepak Kumar Kaushik,Khalil Sherali Rawji,Shalina Ousman
Publisher : Frontiers Media SA
Page : 187 pages
File Size : 44,7 Mb
Release : 2021-10-13
Category : Science
ISBN : 9782889714742

Get Book

Age-Related Neuroimmunology of Degeneration and Repair by Deepak Kumar Kaushik,Khalil Sherali Rawji,Shalina Ousman Pdf

Author : Colin R Martin,Victor R Preedy,Rajkumar Rajendram
Publisher : Academic Press
Page : 608 pages
File Size : 41,8 Mb
Release : 2021-06-01
Category : Medical
ISBN : 9780128180013

Get Book

Assessments, Treatments and Modeling in Aging and Neurological Disease by Colin R Martin,Victor R Preedy,Rajkumar Rajendram Pdf

Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. The book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain, including Alzheimer’s, stroke and multiple sclerosis. Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of aging Features sections on diagnosis and biomarkers of neurological aging, Alzheimer’s and stroke Contains an abstract, key facts, a mini dictionary of terms, and summary points in each chapter Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations Includes more than 500 illustrations and tables

Author : Robert L. Jarret,Kevin McCluskey
Publisher : CRC Press
Page : 260 pages
File Size : 55,9 Mb
Release : 2019-07-16
Category : Science
ISBN : 9781351587761

Get Book

The Biological Resources of Model Organisms by Robert L. Jarret,Kevin McCluskey Pdf

This book discusses 14 model organisms and are used by thousands of researchers, teachers, and students each year in laboratories and classrooms, around the globe. Though acknowledged in innumerable scientific journal articles, little is generally known about the origin of these collections, how the organisms contained within them have been acquired, and how they are maintained and distributed. While some collections such as Drosophila have long histories others, such as the collection of Brachionus, are relatively new. They vary greatly in size. Yet, all have contributed and are continuing to contribute to global research efforts in many areas of scientific research as diverse as tissue regeneration, skin cancer, evolution, water purity, gene function, and hundreds of others. In addition to providing the raw materials for national and international research programs, these collections also provide educational tools used by colleges and high schools. The chapters in this book attempt to provide a brief look at the individual organisms, how they came to be accepted as model organisms, the history of the individual collections, examples of how the organisms have been and are being used in scientific research, and a description of the facilities and procedures used to maintain them. Features: • Provides an in-depth look at the collections of 14 model organisms that have enabled innumerable scientific breakthroughs over decades, and that continue to do so. • Includes detailed descriptions of the operating procedures used for the maintenance of each model organism collection. • Discusses the holdings of the collections of model organisms and its relevance to past, current and future scientific research. • Written by the leaders in the field of the management of model organisms.

Author : Vivian de Buffrénil,Armand J. de Ricqlès,Louise Zylberberg,Kevin Padian
Publisher : CRC Press
Page : 838 pages
File Size : 53,7 Mb
Release : 2021-06-24
Category : Medical
ISBN : 9781351189583

Get Book

Vertebrate Skeletal Histology and Paleohistology by Vivian de Buffrénil,Armand J. de Ricqlès,Louise Zylberberg,Kevin Padian Pdf

Vertebrate Skeletal Histology and Paleohistology summarizes decades of research into the biology and biological meaning of hard tissues, in both living and extinct vertebrates. In addition to outlining anatomical diversity, it provides fundamental phylogenetic and evolutionary contexts for interpretation. An international team of leading authorities review the impact of ontogeny, mechanics, and environment in relation to bone and dental tissues. Synthesizing current advances in the biological problems of growth, metabolism, evolution, ecology, and behavior, this comprehensive and authoritative volume is built upon a foundation of concepts and technology generated over the past fifty years.

Author : Isabel Sá-Correia
Publisher : Springer
Page : 242 pages
File Size : 48,9 Mb
Release : 2019-03-25
Category : Science
ISBN : 9783030130350

Get Book

Yeasts in Biotechnology and Human Health by Isabel Sá-Correia Pdf

This book discusses genome-based strategies to provide a holistic understanding of yeasts in Human Health and as model organisms in basic research or industrial production. Using numerous Saccharomyces cerevisiae strains and various non-conventional yeast species isolated from diverse origins, it describes essential biological processes, the biotechnological exploitation of yeast and pathogenesis control. It also demonstrates how functional and comparative genomics and the development of genome engineering tools are used in modern yeast research. The use of yeasts as experimental eukaryotic models increasingly gained prominence when several Nobel Prizes in Physiology/Medicine and Chemistry were awarded for innovative research, using yeast strains to elucidate molecular mechanisms in a wide range of human physiological processes and diseases, such as autophagy, cell cycle regulation and telomerase activity. This book offers useful insights for scientists in yeast research, clinical scientists working with yeast infectious models and for industrial researchers using applied microbiology.

Author : Wei Guo,S. Reddy Palli,Fei Li,Zhongxia Wu
Publisher : Frontiers Media SA
Page : 293 pages
File Size : 48,8 Mb
Release : 2022-02-10
Category : Science
ISBN : 9782889743551

Get Book

Genetic and Epigenetic Regulation of Insect Development, Reproduction, and Phenotypic Plasticity by Wei Guo,S. Reddy Palli,Fei Li,Zhongxia Wu Pdf