Crispr Genome Surgery In Stem Cells And Disease Tissues

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CRISPR Genome Surgery in Stem Cells and Disease Tissues

Stephen H. Tsang
CRISPR Genome Surgery in Stem Cells and Disease Tissues Book PDF

Author : Stephen H. Tsang
Publisher : Academic Press
Page : 138 pages
File Size : 43,6 Mb
Release : 2021-10-20
Category : Science
ISBN : 9780128178775

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CRISPR Genome Surgery in Stem Cells and Disease Tissues by Stephen H. Tsang Pdf

CRISPR Genome Surgery in Stem Cells and Disease Tissues focuses uniquely on the clinical applications of CRISPR/Cas9 based technology. Topics include the latest advances in gene editing and its translational applications to various diseases, including retinal degenerative disease, recessively inherited diseases, and dominantly inherited diseases, to name a few. The book's target audience includes researchers, students, clinicians and the general public. This space that is not currently served by any existing resource, so this publication fills a gap in current literature. Provides a thorough review of CRISPR-Cas9, from discovery to therapy Covers the latest advances in gene editing and its translational applications to various diseases Written by global leaders in the fields of gene editing and stem cell therapy

Precision Medicine, CRISPR, and Genome Engineering

Stephen H. Tsang
Precision Medicine CRISPR and Genome Engineering Book PDF

Author : Stephen H. Tsang
Publisher : Springer
Page : 178 pages
File Size : 48,9 Mb
Release : 2017-11-11
Category : Science
ISBN : 9783319639048

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Precision Medicine, CRISPR, and Genome Engineering by Stephen H. Tsang Pdf

This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine. Chapters feature contributions from leaders in stem cell therapy and biology, providing a comprehensive view of the application of gene therapy in numerous fields with an emphasis on ophthalmology, stem cells, and agriculture. The book also highlights recent major technological advances, including ZFN, TALEN, and CRISPR. Precision Medicine, CRISPR, and Genome Engineering is part of the highly successful Advances in Experimental Medicine and Biology series. It is an indispensable resource for researchers and students in genetics as well as clinicians.

Autologous and Cancer Stem Cell Gene Therapy

Roger Bertolotti,Keiya Ozawa
Autologous and Cancer Stem Cell Gene Therapy Book PDF

Author : Roger Bertolotti,Keiya Ozawa
Publisher : World Scientific
Page : 489 pages
File Size : 44,9 Mb
Release : 2008
Category : Medical
ISBN : 9789812775863

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Autologous and Cancer Stem Cell Gene Therapy by Roger Bertolotti,Keiya Ozawa Pdf

Stem cells provide for life-long cell replacement in tissues and organs, and have inherent homing abilities that are critical in therapeutic applications. Stem cells are also the driving force of cancer where genetic/epigenetic alterations culminate in tumorigenesis either in tissue stem cells or in some of their derivatives. As a rare subset of the tumor, cancer stem cells are the only drive of tumor initiation/propagation. Autologous and cancer stem cells are thus the key targets of 1) long-term and transient-regenerative/epigenetic gene therapy and 2) of recurrence-free anticancer therapy, respectively. While cancer stem cell gene therapy still needs time to accomplish, autologous stem cells have been instrumental in the first unequivocal successes for gene therapy whereby ex vivo retrovirally corrected hematopoietic stem cells have been returned to the patients.This timely book presents 1) the aforementioned stem cell gene therapy achievements that rely on random-integration of therapeutic transgenes into host chromosomes and 2) emerging experimental approaches aimed at eliminating random-integration oncogenic hazards through site-specific integration or gene targeting. Breakthrough endonuclease-boosted gene targeting for gene correction (inherited diseases) or targeted integration of therapeutic transgenes (other disorders) culminating in an efficiency compatible with clinical trials is one of the highlights of the book. Highlights also include the pioneering transplantation of adult pluripotent stem cells as a substitute for tissue-specific stem cells, thereby pinpointing the invaluable potential for stem cell gene therapy applications of autologous cells able to contribute to all three germ layers. Stem cell gene therapy is thus discussed in terms of 1) magnifying stem cell therapeutic homing through transient regenerative gene therapy and 2) of tackling most pathologies (including mitochondrial DNA diseases and ageing disorders) through stem cell repopulation dynamics into appropriate niches (long-term engraftment) and tissues (cell turn-over). Regarding cancer stem cell gene therapy, focus is on both the increasing number of identified tissue-specific cancer stem cells as the ultimate therapeutic targets and on the development of armed stem cells as tumor-homing vectors for targeted anticancer therapy.

Advances in Stem Cell Research

Hossein Baharvand,Nasser Aghdami
Advances in Stem Cell Research Book PDF

Author : Hossein Baharvand,Nasser Aghdami
Publisher : Springer Science & Business Media
Page : 398 pages
File Size : 44,7 Mb
Release : 2012-05-26
Category : Science
ISBN : 9781617799402

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Advances in Stem Cell Research by Hossein Baharvand,Nasser Aghdami Pdf

Advances in Stem Cell Research discusses recent advances in stem cell science, including therapeutic applications. This volume covers such topics as biomanufacturing iPS cells for therapeutic applications, techniques for controlling stem cell fate decisions, as well as current basic research in such areas as germ line stem cells, genomics and proteomics in stem cell research. It is a useful book for biology and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research. The editors hope that the new knowledge and research outlined in this book will help contribute to new therapies for a wide variety of diseases that presently afflict humanity.

Stem Cell Repair and Regeneration

Nagy A. Habib
Stem Cell Repair and Regeneration Book PDF

Author : Nagy A. Habib
Publisher : Imperial College Press
Page : 305 pages
File Size : 50,6 Mb
Release : 2005
Category : Science
ISBN : 9781860947117

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Stem Cell Repair and Regeneration by Nagy A. Habib Pdf

This second book in the Stem Cell Repair and Regeneration series provides a deeper exploration of the therapeutic potential of undifferentiated human stem cells.Regenerative medicine is an extremely fast-moving field which is evolving from the initial days of hype and excitement to a more realistic appraisal of the role of stem cells in the treatment of degenerative disorders. The series aims to keep abreast of these changes by combining new knowledge in stem cell biology and therapeutic applications.The current volume contains papers by the field's leading scientists and explores the current knowledge on cell therapy for different diseases and injured organs, including diabetes, liver and heart disease.

Genetic Engineering of Mesenchymal Stem Cells

Jan A. Nolta
Genetic Engineering of Mesenchymal Stem Cells Book PDF

Author : Jan A. Nolta
Publisher : Springer Science & Business Media
Page : 173 pages
File Size : 53,6 Mb
Release : 2006-08-29
Category : Science
ISBN : 9781402039591

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Genetic Engineering of Mesenchymal Stem Cells by Jan A. Nolta Pdf

MSC (mesenchymal stem cells) have been reported to initiate revascularization after injury, to facilitate engraftment of blood-forming stem cells, and to reduce the incidence of graft-vs. host disease through their immune-suppressive qualities. Finally, bone marrow-derived MSC have been reported to home to areas of solid tumor revascularization, and thus may be used as delivery vehicles to target ablative agents into dividing tumor cells. Recently the characteristics of human MSC from adipose (fat) tissue have also been identified. The possibility of repairing tissues, speeding stem cell engraftment, and targeting solid tumors for specific killing, using MSC easily harvested from bone marrow, or better yet, from unwanted fat tissue, holds broad appeal, and is an intriguing possibility that could have dramatic effect on health care. This book has information on how to isolate, grow, and characterize MSC from marrow and fat, and gives important insight into how these cells may be used for gene delivery and cellular therapies in the future. Updates on emerging clinical trials are given.

Stem Cell and Gene-Based Therapy

Alexander Battler,Jonathan Leor
Stem Cell and Gene Based Therapy Book PDF

Author : Alexander Battler,Jonathan Leor
Publisher : Springer Science & Business Media
Page : 422 pages
File Size : 51,9 Mb
Release : 2006-03-14
Category : Medical
ISBN : 9781846281426

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Stem Cell and Gene-Based Therapy by Alexander Battler,Jonathan Leor Pdf

Regenerative medicine – stem cell and gene-based therapy – offers a new approach for restoring function of damaged organs and tissues. This is the first book to cover the major new aspects and field of regenerative medicine. This title is therefore a timely addition to the literature. It brings together the major approaches to regenerative medicine in one text, which ensures that techniques learnt in one discipline are disseminated across other areas of medicine.

Stem Cells and Cancer Stem Cells, Volume 1

M.A. Hayat
Stem Cells and Cancer Stem Cells Volume 1 Book PDF

Author : M.A. Hayat
Publisher : Springer Science & Business Media
Page : 200 pages
File Size : 42,7 Mb
Release : 2011-10-12
Category : Medical
ISBN : 9789400717091

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Stem Cells and Cancer Stem Cells, Volume 1 by M.A. Hayat Pdf

Difference between tissue specific stem cells and embryonic stem cells is explained. The advantages of the latter are included. The application of human pluripotent stem cells, mesenchymal stem cells, and hematopoietic stem cells in cancer therapy and tissue/organ regeneration is detailed. Role of neural cancer stem cells in brain tumors, including their role in brain tumor therapy and the role of CD133 stem cell antigen in glioma patients, is emphasized. Therapeutic role of bone marrow-derived stem cells in myocardial infarction and the role of mesenchymal stem cells in orthopedics are explained. Transplantation of umbilical cord hematopoietic stem cells and allogeneic hematopoietic stem cell transplantation followed by graft-versus-host disease are presented. Role of cancer stem cells specifically in glioblastoma and medulloblastoma is included. It is also emphasized that CD133 is an appropriate stem cell marker for gliomas. Targeting of cancer cells is also explained.

Stem Cells in Regenerative Medicine

Julie Audet,William L. Stanford
Stem Cells in Regenerative Medicine Book PDF

Author : Julie Audet,William L. Stanford
Publisher : Methods in Molecular Biology
Page : 472 pages
File Size : 40,5 Mb
Release : 2009
Category : Science
ISBN : UCSD:31822030258412

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Stem Cells in Regenerative Medicine by Julie Audet,William L. Stanford Pdf

Here, leading experts in the field provide an updated representation of the landscape of stem cell-based therapies in a wide spectrum of tissue systems and ontogenic stages, from the isolation and culture of stem cells to their actual use in vivo.

Gene Therapy in Reconstructive and Regenerative Surgery

Giorgio Giatsidis
Gene Therapy in Reconstructive and Regenerative Surgery Book PDF

Author : Giorgio Giatsidis
Publisher : Unknown
Page : 128 pages
File Size : 46,8 Mb
Release : 2018
Category : Gene therapy
ISBN : 3319789589

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Gene Therapy in Reconstructive and Regenerative Surgery by Giorgio Giatsidis Pdf

This book offers an updated overview of the most recent research advances in the field, a comparison of established techniques and methods, a discussion on current experimental and translational challenges, and a commentary on potential opportunities and future directions. Dedicated chapters address and review the preclinical and clinical state-of-the-art of gene therapies for the reconstructive and regenerative surgery of skin and wounds, pathological scars, cartilage, tendons, skeletal muscles, and bio-engineered flaps. A brief guide to developing gene therapy clinical trials in the context of reconstructive and regenerative surgery is also provided. Biomedical and technological innovations are transforming our capacity to use gene therapies to safely and effectively repair, reconstruct, and regenerate tissues that are deficient or have been damaged by trauma and diseases. The targeted and controlled modulation of gene expression in tissues represents a game-changing, next-generation therapeutic tool for the modern reconstructive surgeon, expanding the horizon of regenerative surgery and tissue engineering. Through gene therapies, surgeons can direct (stem) cell differentiation and cell function, modulate the release of growth/transcriptional factors, affect the biological properties of regenerative scaffolds, control tissue inflammation, or induce immune-suppression in composite tissue allotransplants and xenotransplants. Written by renowned reconstructive surgeons and leading experts in each of these fields - from top academic institutions around the globe, the book provides an initial practical guide for veteran and newcomer surgeons alike, as well as for researchers interested in exploring the latest gene-based therapeutic strategies for reconstructive and regenerative surgery.

Tissue Engineering, Stem Cells, and Gene Therapies

Y. Murat Elçin
Tissue Engineering Stem Cells and Gene Therapies Book PDF

Author : Y. Murat Elçin
Publisher : Springer
Page : 340 pages
File Size : 44,7 Mb
Release : 2024-06-30
Category : Technology & Engineering
ISBN : 1461500648

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Tissue Engineering, Stem Cells, and Gene Therapies by Y. Murat Elçin Pdf

Recent years have seen an upsurge of significant interest in cell-based technologies. A range of productive and lively debate have taken place relating to tissue engineering, namely the construction of tissues and whole organs using molecularly-designed resorbable biomaterials to create tissue de novo, the potential use of human embryonic stem cells for transplantation and regenerative medicine, with similar potential for adult-derived stem cells, and gene therapy, in relation to cell transplantation. New findings in biomimetic materials, cell signalling pathways, extracellular matrix receptors and ligands, growth factors, and the human genome project, all present particularly motivating sources for the development of research in the evergrowing biomedical field. The purpose of this book is to stimulate further the work in biomedicine and to make the issues of related scientific disciplines accessible to a wider readership by characterising the current state of research in the biomedical field. The lectures and a selection of the presentations from BlOMED 200- th The 9 International Symposium on Biomedical Science and Technology, held in September 2002 in Turkey- constitute the basis for the volume. Tissue engineering, stem cells, cell and gene therapies were the major topics presented and discussed in the symposium. This book is intended to serve as an up-to-date synopsis of the major developments of our area through the work reflected in BlOMED 2002, though not covering all aspects of the topics, due to the natural restrictions within a volume of this kind.

Tissue Stem Cells

Andrew G. Renehan,Christopher S Potten,Robert B Clarke,James Wilson,Senior Research Fellow Department of Surgery Andrew G Renehan
Tissue Stem Cells Book PDF

Author : Andrew G. Renehan,Christopher S Potten,Robert B Clarke,James Wilson,Senior Research Fellow Department of Surgery Andrew G Renehan
Publisher : CRC Press
Page : 424 pages
File Size : 50,8 Mb
Release : 2019-08-30
Category : Electronic
ISBN : 0367390922

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Tissue Stem Cells by Andrew G. Renehan,Christopher S Potten,Robert B Clarke,James Wilson,Senior Research Fellow Department of Surgery Andrew G Renehan Pdf

Tissue stem cells and their medical applications have become a major focus of research over the past decade. With 16 full-color illustrations, this reference provides a thorough and up-to-date overview of the current and emerging technologies for stem cell research and transplantation. Divided into three sections covering general issues, adult stem cells within specific tissues, and clinical applications, this source studies advances in bone marrow transplantation, cancer development modeling, tumor analysis, and gene therapy.

Human Genome Editing

National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Human Genome Editing Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Publisher : National Academies Press
Page : 329 pages
File Size : 47,5 Mb
Release : 2017-08-13
Category : Medical
ISBN : 9780309452885

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Human Genome Editing by National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations Pdf

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Heritable Human Genome Editing

The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Heritable Human Genome Editing Book PDF

Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publisher : National Academies Press
Page : 239 pages
File Size : 45,7 Mb
Release : 2021-01-16
Category : Medical
ISBN : 9780309671132

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Heritable Human Genome Editing by The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing Pdf

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

CRISPR-Cas Systems

Rodolphe Barrangou,John van der Oost
CRISPR Cas Systems Book PDF

Author : Rodolphe Barrangou,John van der Oost
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 44,5 Mb
Release : 2012-12-13
Category : Science
ISBN : 9783642346576

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CRISPR-Cas Systems by Rodolphe Barrangou,John van der Oost Pdf

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.