Cycloadditions In Bioorthogonal Chemistry

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Cycloadditions in Bioorthogonal Chemistry

Milan Vrabel,Thomas Carell
Cycloadditions in Bioorthogonal Chemistry Book PDF

Author : Milan Vrabel,Thomas Carell
Publisher : Springer
Page : 157 pages
File Size : 44,8 Mb
Release : 2016-05-28
Category : Science
ISBN : 9783319296869

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Cycloadditions in Bioorthogonal Chemistry by Milan Vrabel,Thomas Carell Pdf

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

Cycloadditions in Bioorthogonal Chemistry

John Paquette
Cycloadditions in Bioorthogonal Chemistry Book PDF

Author : John Paquette
Publisher : Createspace Independent Publishing Platform
Page : 300 pages
File Size : 44,7 Mb
Release : 2017-03-14
Category : Electronic
ISBN : 1981878025

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Cycloadditions in Bioorthogonal Chemistry by John Paquette Pdf

The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed.

Cycloaddition Reactions in Organic Synthesis

Shu Kobayashi,Karl Anker Jørgensen
Cycloaddition Reactions in Organic Synthesis Book PDF

Author : Shu Kobayashi,Karl Anker Jørgensen
Publisher : John Wiley & Sons
Page : 354 pages
File Size : 47,7 Mb
Release : 2002
Category : Science
ISBN : 3527301593

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Cycloaddition Reactions in Organic Synthesis by Shu Kobayashi,Karl Anker Jørgensen Pdf

During the miners' strike in the 1980s, a worker is killed in the striking coalfields of Wales. Some months later, a government minister thought to be connected with the death is also shot. Lewis Redfern—once a radical but now a political analyst and journalist—pursues the sniper, a lonely hunt that leads him through an imbroglio of civil service leaks to a secret organization: a source of insurrection far more powerful than anyone could have suspected known as the Volunteers. In this fast-paced narrative of espionage and intrigue, Redfern, through his obsessive pursuit of justice, finally encounters the truth about himself as the novel discusses the conflict between moral choice and political loyalty.

Modern Applications of Cycloaddition Chemistry

Paolo Quadrelli
Modern Applications of Cycloaddition Chemistry Book PDF

Author : Paolo Quadrelli
Publisher : Elsevier
Page : 352 pages
File Size : 48,8 Mb
Release : 2019-03-20
Category : Science
ISBN : 9780128152744

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Modern Applications of Cycloaddition Chemistry by Paolo Quadrelli Pdf

Modern Applications of Cycloaddition Chemistry examines this area of organic chemistry, with special attention paid to cycloadditions in synthetic and mechanistic applications in modern organic chemistry. While many books dedicated to cycloaddition reactions deal with the synthesis of heterocycles, general applications, specific applications in natural product synthesis, and the use of a class of organic compounds, this work sheds new light on pericyclic reactions by demonstrating how these valuable tools elegantly solve synthetic and mechanistic problems. The work examines how pericyclic reactions have been extensively applied to different chemistry areas, such as chemical biology, biological processes, catalyzed cycloaddition reactions, and more. This work will be useful for organic chemists who deal with organic chemistry, medicinal chemistry, agrochemistry and material chemistry. Provides details on the synthesis of antiviral and anticancer compounds, marking the key role of unconventional catalyzed cycloaddition reactions for preparing new derivatives in a unique reaction pathway that is scalable in industrial processes Contains the most up-to-date review of the use of pericyclic reactions in drug delivery Includes the enzyme-catalyzed processes involving cycloaddition reactions for different targets, demonstrating that cycloaddition is more common in nature than expected Features new applications for cycloadditions in material chemistry and provides a general view of the most recent results in the area

Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products, Volume 59

Albert Padwa,William H. Pearson
Synthetic Applications of 1 3 Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products Volume 59 Book PDF

Author : Albert Padwa,William H. Pearson
Publisher : John Wiley & Sons
Page : 962 pages
File Size : 42,9 Mb
Release : 2002-11-01
Category : Science
ISBN : 9780471280613

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Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products, Volume 59 by Albert Padwa,William H. Pearson Pdf

Dipolar cycloaddition reactions have found many useful applications in chemistry, particularly with respect to the synthesis of compounds with new chiral centers. Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products updates the popular 1984 edition, featuring the advances made over the past twenty years and focusing on synthetic applications.

Synthesis of Heterocycles via Cycloadditions I

Alfred Hassner
Synthesis of Heterocycles via Cycloadditions I Book PDF

Author : Alfred Hassner
Publisher : Springer
Page : 229 pages
File Size : 45,8 Mb
Release : 2008-04-10
Category : Science
ISBN : 9783540783718

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Synthesis of Heterocycles via Cycloadditions I by Alfred Hassner Pdf

Heterocyclic chemistry is the biggest branch of chemistry covering two-thirds of the chemical literature. This series covers hot topics of frontier research summarized by reputed scientists in the field.

Chemoselective and Bioorthogonal Ligation Reactions

W. Russ Algar,Philip Dawson,Igor L. Medintz
Chemoselective and Bioorthogonal Ligation Reactions Book PDF

Author : W. Russ Algar,Philip Dawson,Igor L. Medintz
Publisher : John Wiley & Sons
Page : 430 pages
File Size : 53,7 Mb
Release : 2017-03-17
Category : Technology & Engineering
ISBN : 9783527683475

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Chemoselective and Bioorthogonal Ligation Reactions by W. Russ Algar,Philip Dawson,Igor L. Medintz Pdf

This timely, one-stop reference is the first on an emerging and interdisciplinary topic. Covering both established and recently developed ligation chemistries, the book is divided into two didactic parts: a section that focuses on the details of bioorthogonal and chemoselective ligation reactions at the level of fundamental organic chemistry, and a section that focuses on applications, particularly in the areas of chemical biology, biomaterials, and bioanalysis, highlighting the capabilities and benefits of the ligation reactions. With chapters authored by outstanding scientists who range from trailblazers in the field to young and emerging leaders, this book on a highly interdisciplinary topic will be of great interest for biochemists, biologists, materials scientists, pharmaceutical chemists, organic chemists, and many others.

Handbook of In Vivo Chemistry in Mice

Katsunori Tanaka,Kenward Vong
Handbook of In Vivo Chemistry in Mice Book PDF

Author : Katsunori Tanaka,Kenward Vong
Publisher : John Wiley & Sons
Page : 560 pages
File Size : 45,7 Mb
Release : 2020-04-27
Category : Science
ISBN : 9783527344321

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Handbook of In Vivo Chemistry in Mice by Katsunori Tanaka,Kenward Vong Pdf

Provides timely, comprehensive coverage of in vivo chemical reactions within live animals This handbook summarizes the interdisciplinary expertise of both chemists and biologists performing in vivo chemical reactions within live animals. By comparing and contrasting currently available chemical and biological techniques, it serves not just as a collection of the pioneering work done in animal-based studies, but also as a technical guide to help readers decide which tools are suitable and best for their experimental needs. The Handbook of In Vivo Chemistry in Mice: From Lab to Living System introduces readers to general information about live animal experiments and detection methods commonly used for these animal models. It focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release. Topics include: currently available mouse models; biocompatible fluorophores; radionuclides for radiodiagnosis/radiotherapy; live animal imaging techniques such as positron emission tomography (PET) imaging; magnetic resonance imaging (MRI); ultrasound imaging; hybrid imaging; biocompatible chemical reactions; ligand-directed nucleophilic substitution chemistry; biorthogonal prodrug release strategies; and various selective targeting strategies for live animals. -Completely covers current techniques of in vivo chemistry performed in live animals -Describes general information about commonly used live animal experiments and detection methods -Focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release -Places emphasis on material properties required for the development of appropriate compounds to be used for imaging and therapeutic purposes in preclinical applications Handbook of In Vivo Chemistry in Mice: From Lab to Living System will be of great interest to pharmaceutical chemists, life scientists, and organic chemists. It will also appeal to those working in the pharmaceutical and biotechnology industries.

Methods and Applications of Cycloaddition Reactions in Organic Syntheses

Nagatoshi Nishiwaki
Methods and Applications of Cycloaddition Reactions in Organic Syntheses Book PDF

Author : Nagatoshi Nishiwaki
Publisher : John Wiley & Sons
Page : 996 pages
File Size : 46,5 Mb
Release : 2013-12-17
Category : Science
ISBN : 9781118778203

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Methods and Applications of Cycloaddition Reactions in Organic Syntheses by Nagatoshi Nishiwaki Pdf

Advanced tools for developing new functional materials and applications in chemical research, pharmaceuticals, and materials science Cycloadditions are among the most useful tools for organic chemists, enabling them to build carbocyclic and heterocyclic structures. These structures can then be used to develop a broad range of functional materials, including pharmaceuticals, agrochemicals, dyes, and optics. With contributions from an international team of leading experts and pioneers in cycloaddition chemistry, this book brings together and reviews recent advances, trends, and emerging research in the field. Methods and Applications of Cycloaddition Reactions in Organic Syntheses focuses on two component cycloadditions, with chapters covering such topics as: N1 unit transfer reaction to C–C double bonds [3+2] Cycloaddition of α, β-unsaturated metal-carbene complexes Formal [3+3] cycloaddition approach to natural product synthesis Development of new methods for the construction of heterocycles based on cycloaddition reaction of 1,3-dipoles Cycloreversion approach for preparation of large π-conjugated compounds Transition metal-catalyzed or mediated [5+1] cycloadditions Readers will learn methods for seamlessly executing important reactions such as Diels-Alder and stereoselective dipolar reactions in order to fabricate heterocyclic compounds, natural products, and functional molecules. The book not only features cutting-edge topics, but also important background information, such as the contributors’ process for developing new methodologies, to help novices become fully adept in the field. References at the end of each chapter lead to original research papers and reviews for facilitating further investigation of individual topics. Covering the state of the science and technology, Methods and Applications of Cycloaddition Reactions in Organic Syntheses enables synthetic organic chemists to advance their research and develop new functional materials and applications in chemical research, pharmaceuticals, and materials science.

Fragment-Based Drug Discovery

Steven Howard,Chris Abell
Fragment Based Drug Discovery Book PDF

Author : Steven Howard,Chris Abell
Publisher : Royal Society of Chemistry
Page : 314 pages
File Size : 46,7 Mb
Release : 2015-07-03
Category : Medical
ISBN : 9781849739085

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Fragment-Based Drug Discovery by Steven Howard,Chris Abell Pdf

Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.

Activity-Based Protein Profiling

Stephan A. Sieber
Activity Based Protein Profiling Book PDF

Author : Stephan A. Sieber
Publisher : Springer Science & Business Media
Page : 175 pages
File Size : 50,6 Mb
Release : 2012-02-21
Category : Science
ISBN : 9783642283789

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Activity-Based Protein Profiling by Stephan A. Sieber Pdf

ABPP Methodology: Introduction and Overview, by Matthew B. Nodwell und Stephan A. Sieber Activity-Based Protein Profiling for Natural Product Target Discovery, by Joanna Krysiak und Rolf Breinbauer Photoaffinity Labeling in Activity-Based Protein Profiling, by Paul P. Geurink, Laurette M. Prely, Gijs A. van der Marel, Rainer Bischoff und Herman S. Overkleeft Application of Activity-Based Protein Profiling to the Study of Microbial Pathogenesis, by William P. Heal und Edward W. Tate Functional Analysis of Protein Targets by Metabolomic Approaches, by Yun-Gon Kim und Alan Saghatelian

Synthesis of Heterocycles Via Cycloadditions II

Alfred Hassner
Synthesis of Heterocycles Via Cycloadditions II Book PDF

Author : Alfred Hassner
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 53,9 Mb
Release : 2008-07-21
Category : Science
ISBN : 9783540783725

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Synthesis of Heterocycles Via Cycloadditions II by Alfred Hassner Pdf

See Table of Contents (PMP)

Advances in Cycloaddition

Michael Harmata
Advances in Cycloaddition Book PDF

Author : Michael Harmata
Publisher : Elsevier
Page : 248 pages
File Size : 51,6 Mb
Release : 2000-01-21
Category : Science
ISBN : 0080546390

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Advances in Cycloaddition by Michael Harmata Pdf

This volume presents work from six different groups working on various aspects of cycloaddition chemistry. José Mascareñas gives us a very interesting account of the chemistry of &Bgr;-alkoxy-&ggr;-pyrones and related species. Al Padwa and Chris Staub discuss further advances in rhodium carbenoid chemistry and the unusual cycloaddition processes possible with these intermediates. Higher order cycloadditions mediated by transition metals highlight Jim Rigby's update on his group's efforts in this area. Lily Lee and John Snyder present us with a detailed account of the indole ring as a dienophile, challenging us to consider the untapped potential in this area. Brian Keay and Ian Hunt discuss the intramolecular Diels-Alder reactions of furan; a report that is both top-notch science, and what could be a great learning tool for students who need to see how fundamental chemical principles can and should be applied to synthetic problems. Finally, Kay Brummond introduces us to a new version of the Pauson-Khand reactions, one that will no doubt be further exploited in productive ways by her group well into the future.

Cycloaddition Reactions in Organic Synthesis

W. Carruthers
Cycloaddition Reactions in Organic Synthesis Book PDF

Author : W. Carruthers
Publisher : Pergamon
Page : 392 pages
File Size : 45,8 Mb
Release : 1990-10-02
Category : Science
ISBN : UCAL:B4339877

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Cycloaddition Reactions in Organic Synthesis by W. Carruthers Pdf

Demonstrates the wide scope of cycloaddition reactions, including the Diels-Alder reaction, the ene reaction, 1,3-dipolar cycloadditions and [2+2] cycloadditions in organic synthesis. The author, a leading exponent of the subject, illustrates the ways in which they can be employed in the synthesis of a wide range of carbocyclic and heterocyclic compounds, including a variety of natural products of various types. Special attention is given to intramolecular reactions, which often provide a rapid and efficient route to polycyclic compounds, and to the stereochemistry of the reactions, including recent and developing work on enantioselective synthesis.

The Nitrile Imine 1,3-Dipole

Craig Jamieson,Keith Livingstone
The Nitrile Imine 1 3 Dipole Book PDF

Author : Craig Jamieson,Keith Livingstone
Publisher : Springer Nature
Page : 159 pages
File Size : 51,5 Mb
Release : 2020-03-25
Category : Science
ISBN : 9783030434816

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The Nitrile Imine 1,3-Dipole by Craig Jamieson,Keith Livingstone Pdf

This book provides a comprehensive overview of the nitrilimine 1,3-dipole, from its initial discovery in 1959 to the most recent publications. Covering topics such as the core properties of the dipole and the various methods of synthesis available, it particularly highlights the diverse reactivity profile of the nitrilimine and its numerous applications in bioorthogonal and materials chemistry. The book is of interest to academic and industrial researchers working in this area and to those new to the field.