Decellularization Methods Of Tissue And Whole Organ In Tissue Engineering

Author : Abdol-Mohammad Kajbafzadeh
Publisher : Springer Nature
Page : 266 pages
File Size : 53,5 Mb
Release : 2021-09-28
Category : Medical
ISBN : 9783030827359

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Decellularization Methods of Tissue and Whole Organ in Tissue Engineering by Abdol-Mohammad Kajbafzadeh Pdf

This contributed volume is the first of a series that introduces safe, feasible, and practical decellularization and recellularization techniques for tissue and organ reconstruction. We have put special emphasis on the research areas most likely to develop well-engineered scaffolds for tissue and organ engineering, while presenting easily applicable bench-to-bedside approaches highlighting the latest technical innovations in the field. This book includes both a fundamental discussion for a broad understanding of the basis of tissue repair and substitution, as well as chapters written by world renowned specialists from 20 countries providing deeper discussions and analysis of related sub disciplines. Within these pages, the reader will find state-of-the-art protocols and current clinical challenges in cell and tissue biology, including accurate and comprehensive information on extracellular matrices, natural biomaterials, tissue dynamics, morphogenesis, stem cells, cellular fate progressions, cell and tissue properties for in-vitro and in-vivo applications. This comprehensive and carefully organized treatise provides a clear framework for graduate students and postdoctoral researchers new to the field, but also for researchers and practitioners looking to expand their knowledge on tissue and organ reconstruction.

Author : Kamal Hany Hussein,Sotirios Korossis,Laura Iop
Publisher : Frontiers Media SA
Page : 287 pages
File Size : 55,5 Mb
Release : 2023-05-02
Category : Science
ISBN : 9782832521830

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Tissue and organ decellularization strategies in regenerative medicine; recent advances, current translational challenges, and future directions by Kamal Hany Hussein,Sotirios Korossis,Laura Iop Pdf

Author : Xiaoming Li,Huiqi Xie
Publisher : Springer Nature
Page : 517 pages
File Size : 43,6 Mb
Release : 2021-04-28
Category : Medical
ISBN : 9789813369627

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Decellularized Materials by Xiaoming Li,Huiqi Xie Pdf

This book will consist of 8 chapters, in which important issues regarding decellularized materials (DMs) will be discussed. This book will provide special knowledge of materials for the persons with biomedical background, and special biomedical knowledge for the persons with the background of materials, which will hopefully become a valuable informative read for the researchers and students of biomedical engineering major.

Author : Jeffrey R. Morgan,Martin L. Yarmush
Publisher : Springer Science & Business Media
Page : 1215 pages
File Size : 41,8 Mb
Release : 1998-09-28
Category : Technology & Engineering
ISBN : 9780896035164

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Tissue Engineering Methods and Protocols by Jeffrey R. Morgan,Martin L. Yarmush Pdf

In recent years, the field of tissue engineering has begun, in part, to c- lesce around the important clinical goal of developing substitutes or repla- ments for defective tissues or organs. These efforts are focused on many tissues including skin, cartilage, liver, pancreas, bone, blood, muscle, the vascu- ture, and nerves. There is a staggering medical need for new and effective treatments for acquired as well as inherited defects of organs/tissues. Tissue engineering is at the interface of the life sciences, engineering, and clinical medicine and so draws upon advances in cell and molecular biology, mate- als sciences, and surgery, as well as chemical and mechanical engineering. Such an interdisciplinary field requires a broad knowledge base as well as the use of a wide assortment of methods and approaches. It is hoped that by bringing together these protocols, this book will help to form connections - tween the different disciplines and further stimulate the synergism underlying the foundation of the tissue engineering field.

Author : Anthony Atala,Robert Lanza
Publisher : Gulf Professional Publishing
Page : 580 pages
File Size : 42,8 Mb
Release : 2001-10-12
Category : Science
ISBN : 9780124366367

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Methods of Tissue Engineering by Anthony Atala,Robert Lanza Pdf

This reference book combines the tools, experimental protocols, detailed descriptions and know-how for the successful engineering of tissues and organs in one volume.

Author : W. Mark Saltzman
Publisher : Oxford University Press
Page : 544 pages
File Size : 49,7 Mb
Release : 2004-07-15
Category : Medical
ISBN : 0198032404

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Tissue Engineering by W. Mark Saltzman Pdf

Tissue or organ transplantation are among the few options available for patients with excessive skin loss, heart or liver failure, and many common ailments, and the demand for replacement tissue greatly exceeds the supply, even before one considers the serious constraints of immunological tissue type matching to avoid immune rejection. Tissue engineering promises to help sidestep constraints on availability and overcome the scientific challenges, with huge medical benefits. This book lays out the principles of tissue engineering. It will be a useful reference work for those associated with this field and as a textbook for specialized courses in the subject. It is a companion volume to Saltzman's OUP book on drug delivery.

Author : C.W. Patrick,A.G. Mikos,L.V. McIntire
Publisher : Elsevier
Page : 700 pages
File Size : 52,6 Mb
Release : 1998-02-20
Category : Technology & Engineering
ISBN : 0080532055

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Frontiers in Tissue Engineering by C.W. Patrick,A.G. Mikos,L.V. McIntire Pdf

Frontiers in Tissue Engineering is a carefully edited compilation of state-of-the-art contributions from an international authorship of experts in the diverse subjects that make up tissue engineering. A broad representation of the medical, scientific, industrial and regulatory community is detailed in the book. The work is an authoritative and comprehensive reference source for scientists and clinicians working in this emerging field. The book is divided into three parts: fundamentals and methods of tissue engineering, tissue engineering applied to specialised tissues, and tissue engineering applied to organs. The text offers many novel approaches, including a detailed coverage of cell-tissue interactions at cellular and molecular levels; cell-tissue surface, biochemical, and mechanical environments; biomaterials; engineering design; tissue-organ function; new approaches to tissue-organ regeneration and replacement of function; ethical considerations of tissue engineering; and government regulation of tissue-engineered products.

Author : John P. Fisher,Antonios G. Mikos,Joseph D. Bronzino,Donald R. Peterson
Publisher : CRC Press
Page : 801 pages
File Size : 41,9 Mb
Release : 2012-12-11
Category : Medical
ISBN : 9781439874004

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Tissue Engineering by John P. Fisher,Antonios G. Mikos,Joseph D. Bronzino,Donald R. Peterson Pdf

Tissue engineering research continues to captivate the interest of researchers and the general public alike. Popular media outlets like The New York Times, Time, and Wired continue to engage a wide audience and foster excitement for the field as regenerative medicine inches toward becoming a clinical reality. Putting the numerous advances in the field into a broad context, Tissue Engineering: Principles and Practices explores current thoughts on the development of engineered tissues. With contributions from experts and pioneers, this book begins with coverage of the fundamentals, details the supporting technology, and then elucidates their applications in tissue engineering. It explores strategic directions, nanobiomaterials, biomimetics, gene therapy, cell engineering, and more. The chapters then explore the applications of these technologies in areas such as bone engineering, cartilage tissue, dental tissue, vascular engineering, and neural engineering. A comprehensive overview of major research topics in tissue engineering, the book: Examines the properties of stem cells, primary cells, growth factors, and extracellular matrix as well as their impact on the development of tissue-engineered devices Focuses upon those strategies typically incorporated into tissue-engineered devices or utilized in their development, including scaffolds, nanocomposites, bioreactors, drug delivery systems, and gene therapy techniques Presents synthetic tissues and organs that are currently under development for regenerative medicine applications The contributing authors are a diverse group with backgrounds in academia, clinical medicine, and industry. Furthermore, this book includes contributions from Europe, Asia, and North America, helping to broaden the views on the development and application of tissue-engineered devices. The book provides a useful reference for courses devoted to tissue engineering fundamentals and those laboratories developing tissue-engineered devices for regenerative medicine therapy.

Author : Fouad Sabry
Publisher : One Billion Knowledgeable
Page : 405 pages
File Size : 54,6 Mb
Release : 2022-10-05
Category : Medical
ISBN : PKEY:6610000394159

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Tissue Engineering by Fouad Sabry Pdf

What Is Tissue Engineering Tissue engineering is a subfield of biomedical engineering that focuses on repairing, maintaining, enhancing, or replacing various kinds of biological tissues through the utilization of a variety of techniques, including cells, engineering, and material science, as well as appropriate biochemical and physicochemical factors. Tissue engineering is not limited to applications that involve cells and tissue scaffolds; rather, it typically involves placing cells on tissue scaffolds in order to form new viable tissue for a medical purpose. However, tissue engineering is not limited to applications involving cells and tissue scaffolds. As a result of its expanding breadth and significance, it is now possible to consider it to be an independent field, despite the fact that it was originally classified as a sub-field of biomaterials. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Tissue engineering Chapter 2: Artificial organ Chapter 3: Regenerative medicine Chapter 4: Organ printing Chapter 5: Knee cartilage replacement therapy Chapter 6: Cardiomyoplasty Chapter 7: Neural tissue engineering Chapter 8: Nerve guidance conduit Chapter 9: Autologous chondrocyte implantation Chapter 10: Nano-scaffold Chapter 11: Fibrin scaffold Chapter 12: Decellularization Chapter 13: 3D bioprinting Chapter 14: 3D cell culture Chapter 15: In vivo bioreactor Chapter 16: Bioartificial heart Chapter 17: Regeneration in humans Chapter 18: Bio-ink Chapter 19: Artificial cartilage Chapter 20: Tissue engineering of heart valves Chapter 21: Artificial ovary (II) Answering the public top questions about tissue engineering. (III) Real world examples for the usage of tissue engineering in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of tissue engineering' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of tissue engineering.

Author : Panagiotis Mallis
Publisher : MDPI
Page : 110 pages
File Size : 44,9 Mb
Release : 2019-10-04
Category : Science
ISBN : 9783039214976

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Stem Cell and Biologic Scaffold Engineering by Panagiotis Mallis Pdf

Tissue engineering and regenerative medicine is a rapidly evolving research field which effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular populations using several tissue engineering approaches, such as the decellularization method. Indeed, the decellularization method aims to develop a cell-free biologic scaffold while keeping the extracellular matrix (ECM) intact. Furthermore, biologic scaffolds have been investigated for their in vitro potential for whole organ development. Currently, clinical products composed of decellularized matrices, such as pericardium, urinary bladder, small intestine, heart valves, nerve conduits, trachea, and vessels, are being evaluated for use in human clinical trials. Tissue engineering strategies require the interaction of biologic scaffolds with cellular populations. Among them, stem cells are characterized by unlimited cell division, self-renewal, and differentiation potential, distinguishing themselves as a frontline source for the repopulation of decellularized matrices and scaffolds. Under this scheme, stem cells can be isolated from patients, expanded under good manufacturing practices (GMPs), used for the repopulation of biologic scaffolds and, finally, returned to the patient. The interaction between scaffolds and stem cells is thought to be crucial for their infiltration, adhesion, and differentiation into specific cell types. In addition, biomedical devices such as bioreactors contribute to the uniform repopulation of scaffolds. Until now, remarkable efforts have been made by the scientific society in order to establish the proper repopulation conditions of decellularized matrices and scaffolds. However, parameters such as stem cell number, in vitro cultivation conditions, and specific growth media composition need further evaluation. The ultimate goal is the development of “artificial” tissues similar to native ones, which is achieved by properly combining stem cells and biologic scaffolds and thus bringing them one step closer to personalized medicine. The original research articles and comprehensive reviews in this Special Issue deal with the use of stem cells and biologic scaffolds that utilize state-of-the-art tissue engineering and regenerative medicine approaches.

Author : Kursad Turksen
Publisher : Humana Press
Page : 128 pages
File Size : 46,8 Mb
Release : 2018-07-21
Category : Science
ISBN : 1493976559

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Decellularized Scaffolds and Organogenesis by Kursad Turksen Pdf

This practical, hands-on volume examines the use of decellularized tissues and organs as biologically-active scaffolds by providing numerous approaches from experts in the field. While knowledge of how to grow and differentiate cells in culture has dramatically improved over time, the book addresses the challenges of how to instruct particular cells of interest to recognize and respond to their environment so as to proliferate, differentiate, and function for restoration of original tissue and organ form and function. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Decellularized Scaffolds and Organogenesis: Methods and Protocols share novel approaches and insights that will provide new opportunities for those already in the field or moving to enter the field.

Author : Norbert Pallua,Christoph V. Suschek
Publisher : Springer Science & Business Media
Page : 632 pages
File Size : 55,8 Mb
Release : 2010-12-16
Category : Medical
ISBN : 9783642028243

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Tissue Engineering by Norbert Pallua,Christoph V. Suschek Pdf

Tissue engineering is a multidisciplinary field incorporating the principles of biology, chemistry, engineering, and medicine to create biological substitutes of native tissues for scientific research or clinical use. Specific applications of this technology include studies of tissue development and function, investigating drug response, and tissue repair and replacement. This area is rapidly becoming one of the most promising treatment options for patients suffering from tissue failure. This abundantly illustrated and well-structured guide serves as a reference for all clinicians and researchers dealing with tissue engineering issues in their daily practice.

Author : Shuji Miyagawa
Publisher : Unknown
Page : 0 pages
File Size : 55,9 Mb
Release : 2017
Category : Electronic
ISBN : 9535147412

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Xenotransplantation by Shuji Miyagawa Pdf

Author : Beat H. Walpoth,Helga Bergmeister,Gary L. Bowlin,Deling Kong,Joris I. Rotmans,Peter Zilla
Publisher : Springer
Page : 0 pages
File Size : 42,6 Mb
Release : 2020-08-21
Category : Science
ISBN : 3030053350

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Tissue-Engineered Vascular Grafts by Beat H. Walpoth,Helga Bergmeister,Gary L. Bowlin,Deling Kong,Joris I. Rotmans,Peter Zilla Pdf

Cardiovascular diseases are still the leading cause of death in developed countries. Revascularization procedures such as coronary artery and peripheral bypass grafts, as well as access surgery represent a 2$ billion market yearly for the US alone. Despite intense research over many decades, no clinically suitable, shelf-ready, synthetic, vascular, small-caliber graft exists. There is therefore still a quest for such a clinical vascular prosthesis for surgical revascularization procedures and access surgery. Many approaches have been tried and are currently under investigation with promising results. These range from acellular and cell-based, stable or bio-degradable, synthetic scaffolds to biological or decellularized grafts, not forgetting self-assembly technologies for in vitro or in vivo VTE. All these approaches can be further enhanced by functionalization, e.g. with growth factors and drug elution. This updatable book aims to cover all the relevant aspects of Vascular Tissue Engineering (VTE) and novel alternatives to develop vascular grafts for clinical applications. The chapters in this book cover different aspects of manufacturing scaffolds with various polymers, mechanical characteristics, degradation rates, decellularization techniques, cell sheet assembly, 3-D printing and autologous mandril-based VTE. All the necessary in vitro tests such as biocompatibility and thrombogenicity are reviewed. Pre-clinical assessment of in vivo experimental models include patency, compliance, intimal hyperplasia, inflammatory reaction, cellular ingrowth and remodeling. Finally, early clinical trials will be periodically updated regarding results, regulatory aspects and post-marketing quality assessment. Furthermore, the reader should get an insight into various approaches, technologies and methods to better understand the complexity of blood surface and cell interactions in VTE. Translational research has yielded early human applications clearly showing the enormous need of research in the field to provide better solutions for our patients and this continuously updated book will hopefully become a reference in the field for life sciences.

Author : William S. Pietrzak
Publisher : Springer Science & Business Media
Page : 649 pages
File Size : 41,9 Mb
Release : 2008-04-11
Category : Medical
ISBN : 9781597452397

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Musculoskeletal Tissue Regeneration by William S. Pietrzak Pdf

The repair of musculoskeletal tissue is a vital concern of all surgical specialties, orthopedics and related disciplines. Written by recognized experts, this book aims to provide both basic and advanced knowledge of the newer methodologies being developed and introduced to the clinical arena. A valuable resource for researchers, developers, and clinicians, the book presents a foundation to propel the technology and integration of the current state of knowledge into the 21st century.