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Author : Brian J. Nickoloff,Frank O. Nestle Publisher : Karger Medical and Scientific Publishers Page : 391 pages File Size : 50,6 Mb Release : 2008-01-01 Category : Medical ISBN : 9783805583916
Dermatologic Immunity by Brian J. Nickoloff,Frank O. Nestle Pdf
Nickeloff (skin cancer research, Cardinal Bernardin Cancer Center, Chicago) and Nestle (cutaneous medicine and immunotherapy, King's College, London School of Medicine at Guy's, UK) assemble 19 review articles on autoimmune disease processes that affect the skin, covering both humoral and cellular immunity. The etiology, cellular and molecular mechanisms, therapeutic strategies, and pathophysiology of diseases such as psoriasis, dermatitis, cutaneous lupus erythematosus, vitiligo, and scleroderma are discussed by individuals in dermatology, genetics, immunology, and pathology who are based around the world. The book is aimed at clinical researchers, students, allergists, immunologists, dermatologists, and internists.
Anthony A. Gaspari,Stephen K. Tyring,Daniel H. Kaplan
Author : Anthony A. Gaspari,Stephen K. Tyring,Daniel H. Kaplan Publisher : Springer Page : 895 pages File Size : 50,6 Mb Release : 2017-04-24 Category : Medical ISBN : 9783319297859
Clinical and Basic Immunodermatology by Anthony A. Gaspari,Stephen K. Tyring,Daniel H. Kaplan Pdf
This updated volume provides a “user-friendly” reference for dermatologists, dermatology residents and students, as well as for health care workers in related fields to better understand immune-mediated skin diseases and their therapies. The focus is on what is needed by the physician/resident or student for betting understanding the pathophysiology of the disease as well as the mechanisms of action of the therapies. The reader can easily read about groups of related diseases as well as groups of related therapies. The level of complexity of the book is such that it has practical applications on a daily basis but can also be used by the resident as a teaching tool and as a handy source of review for the boards. In addition, it can be used the practicing dermatologist to study for recertification. The scope of the book is immunology, immunogenetics, immunopathology and immunopharmacology as they relate to clinical dermatology.
This book reviews the role of each cell subset in the skin, providing the basics for understanding skin immunology and the mechanisms of skin diseases. The skin is one of the immune organs and is continually exposed to foreign antigens and external stimuli that must be monitored and characterized for possible elimination. Upon exposure to foreign antigens, the skin can elicit a variety of immune responses in harmony with skin components that include keratinocytes, dendritic cell subsets, mast cells, basophils, fibroblasts, macrophages, gamma-delta T cells, neutrophils, myeloid-derived suppressor cells, vascular and lymphatic cells, hair follicles, platelets, and adipose tissues, among others. In the past 10 years, knowledge of immunology has expanded drastically in areas such as innate immunity (Toll-like receptors, C-type lectins), and host defenses to bacteria and viruses, and this increased knowledge has led to the development of more effective treatment of psoriasis and other skin diseases. This book provides updates on the mechanisms of skin diseases including contact dermatitis, atopic dermatitis, psoriasis, urticaria, drug eruption, bullous diseases, anaphylaxis, graft-versus-host disease, rosacea, lymphoma, photodermatology, and collagen vascular diseases. Understanding the basics of skin immunology will help clinicians and dermatologists use new therapeutics such as biologics efficiently. Serving as an intermediary between basic science and clinical medicine, this book gives readers the opportunity to understand and marvel at the mystery and fascination of skin immunology.
Immunodermatology is a field covering the majority of skin diseases, including the most prevalent onesin the general population. The Second Edition of Skin Immune System (SIS) discusses immune-mediated skin diseases and disease groups in which the SIS plays a role. It covers major findings in immunophysiology and immunopathology that have occurred since the introduction of the First Edition in 1990. As the subtitle indicates, the Second Edition adds a new emphasis on cutaneous immunology, and also includes new information on immune-based therapeutic interventions and methods, such as phototherapy and the immunological therapy of skin cancer. The book contains Part I, with introductory chapters; Part II, with descriptions of the cellular elements; and Part III, which describes the humoral and molecular components of SIS. Part IV follows to integrate the facts described in Parts II and III into concepts of pathophysiology. It contains a number of concepts entitled "response patterns" that describe how the constitutional elements of SIS work together. New in this edition are the descriptions of immunodermatological diseases individually described in Part V. Part VI is also all new and summarizes principles of immunotherapy.
Practical Immunodermatology by Xing-Hua Gao,Hong-Duo Chen Pdf
This book discusses typical skin diseases from an immunological point of view, introducing the latest immunological techniques and practices. It begins with a brief overview of the human immune system, including the basic concepts and principles as well as the general symbols used in immunology. Part Two describes the human skin as an integral part of the immune system, explaining the immunological roles of major cellular and molecular composites in the skin. Part Three illustrates typical skin diseases that have immunological involvement (immunodermatological conditions). It describes 40 skin diseases, focusing on immunological causes, pathogenesis, pattern of reaction and treatment choices and responses. The final part discusses advanced immunodiagnostics and immunotherapy in dermatology, providing detailed descriptions of immune techniques for the diagnosis of skin diseases, their principles and background, indications, requirements for sampling, test protocols, interpretation of results and trouble shooting. This work offers insights into both the systemic immune system and the skin immune system, and integrates the information into discussions of clinical diseases, relevant immune techniques and immunological drugs. Presenting the latest advances in clinical immunology, it is an invaluable resource for dermatologists, residents and graduate students in dermatology.
Immunodermatology by I.N. Gigli,P.A. Miescher,H.J. Müller-Eberhard Pdf
Peter A. Miescher The skin has always been one of the major targets to clinicians interested in immunology. Initially, the main focus was centred on allergic conditions such as contact hypersensitivity and urticeria. Gradually, the spectrum of immunological conditions involving the skin increased, encompassing diseases such as Dermatitis Herpetiformis, Erythema Muitiforme, Cutaneous Bullous Disorders and Photo toxic Reactions. It has been the intention of the editors of Springer Seminars in Immu nopathology to cover the broad spectrum of immune phenomena encountered in dermatological diseases with special emphasis to newer developments in Immunopathology. Dr. 1. N. Gigli has managed to assemble a series of important contributions within two issues of the Journal which are of such an interest to dermatologists that we decided to publish this topic as a separate volume for all dermatologists who do not have access to Seminars in Immunopathology. 3 Immunologically Mediated Epidermal Cell Injury Richard D. Sontheimer* and James N. Gilliam Division of Dermatology, University of Texas Health Science Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235, USA Introduction The epidermis is a functional unit of different cell types that has the critical role of protecting man from his environment. The three major cell types that make up the epidermis (keratinocytes, melanocytes, and Langerhans cells) serve different protective functions. The vast majority of epidermal cells are keratinocytes (Fig. 1).
Top scientific authors contribute their expertise and put a wealth of complex information into perspective in Skin Immune System: Cutaneous Immunology & Clinical Immunodermatology, Third Edition. This edition provides an overview of the skin immune system (SIS), a totally updated section on immunodermatological diseases, and six new chapters. Part I presents historical and comparative information on immunodermatology and includes a new chapter on the immunogenetics of inflammatory skin disease, while Part II covers the cellular elements of SIS and highlights newly defined functional subclasses of cells. Part III describes the humoral elements of SIS and provides two new chapters which focus on defensins and cathelicidins, and on the chemokines of human skin. Part IV discusses how the cellular and humoral elements of SIS interact under different circumstances and includes a new chapter on signal transduction pathways in cutaneous immunology. Part V focuses on dermatological diseases with a significant immunological background with a new chapter on the immunology of cutaneous drug eruptions, followed by Part VI on immunotherapy in dermatology, which features a new chapter reflecting the recent wave of products from biotechnology. Since the publication of the previous editions, a great deal of significant information has become available in almost all areas of cutaneous immunology and clinical immunodermatology. This progress has now been reflected in a completely updated and expanded resource.
The Immune Functions of Epidermal Langerhans Cells by Heidrun Moll Pdf
This book is about the phenotypic and functional features of epidermal Langerhans cells in experimental models and in clinical medicine. Langerhans cells, members of the dendritic cell system in the skin, are critically involved in the regulation of cell-mediated immune responses and gain increasing attention in a wide spectrum of clinical areas such as allergy, autoimmunity, transplantation and resistance to tumors and infections. The book covers the latest, most timely developments in this rapidly advancing field. Leading researchers describe functional analyses at the cell and molecular level, elucidating processes related to antigen presentation and the role of cytokines, and discuss perspectives for a future use of Langerhans cells and other dendritic cells in the immunotherapy of various diseases.
First published in 1992. Dermal Immune System discusses the structural and functional characterizations of the dermal immune system, including dermal dendritic cells, monocyte/macrophages, microvascular endothelial cells, pericytes, veil cells, fibroblasts, mast cells, dermal T lymphocytes, and peripheral nerve endings. This information is invaluable for gaining an understanding of how multicellular complex networks interface within the dermis and between the exogenous environment and endogenous milieu. Specific examples are provided that document the involvement of the dermal immune system in the pathophysiology of several skin diseases that result from perturbation of normal cutaneous homeostasis. Dermal Immune System is an excellent reference volume that should always be close at hand for immunologists, cell biologists, investigative dermatologists, pathologists, and clinicians involved in the care of patients with skin disease.
Immunology of Vitiligo by Katia Boniface,Isabelle Caroline Le Poole,John E. Harris,Julien Seneschal,Thierry Passeron,Reinhart Speeckaert Pdf
Topic Editor Prof. John E. Harris is Scientific Founder of Villaris Therapeutics, Inc. Topic Editor Prof. Julien Seneschal received financial support from Sanofi Genzyme and Calypso Biotech. Topic Editor Prof. Caroline Le Poole is the CSO for Temprian Therapeutics, a company hoping to bring an HSP70iQ435A-based treatment to clinical trials for vitiligo. The approach for this treatment is different and separate from the proposed Research Topic. Please note that studies investigating HSP70iQ435A-based treatment thus fall out of the remit of this project. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Author : Danny W. Scott,William H. Miller Publisher : Elsevier Health Sciences Page : 552 pages File Size : 50,5 Mb Release : 2010-12-01 Category : Medical ISBN : 9781437709216
Equine Dermatology - E-Book by Danny W. Scott,William H. Miller Pdf
Diagnose, treat, and manage equine skin disorders with the most comprehensive reference available! With 900 full-color photos, Equine Dermatology covers skin diseases ranging from those that merely annoy the horse to others that interfere with the horse's ability to function in riding, working, or show. Thorough coverage includes essential basics and practical diagnostic methods, therapies, and specific abnormalities and defects. The book describes the structure and function of the skin, and discusses disorders including bacterial, fungal, parasitic, viral, protozoal, allergic, immune-mediated, endocrine, metabolic, and nutritional diseases. It also covers congenital and hereditary defects, pigmentation abnormalities, keratinization defects, environmental skin diseases, and skin tumors. Written by renowned equine dermatologists Danny Scott and Bill Miller, this all-inclusive resource covers the latest dermatologic topics and the newest therapies. Current, comprehensive coverage includes every known equine dermatosis. An emphasis on differential diagnosis includes key differentials and breed predilections for each disease, especially helpful when you have only a specimen and an incomplete history to work with. A consistent format makes it easy to locate information on each skin disorder, including a clinical description, its cause and pathogenesis, clinical features, clinical management, diagnosis, treatment, and any zoonotic aspects. Expert authors Danny W. Scott, DVM, and William H. Miller, Jr., VMD, offer years of knowledge, experience, and their vast image collections. Diagnostic tables in each chapter provide a quick reference for identifying lesions and disorders. An extensive list of references at the end of each chapter includes recommendations for further reading. New coverage of dermatologic conditions includes the latest topics and emerging disorders such as chronic progressive lymphedema, herpesvirus-2-associated dermatitis, salmonella-associated dermatoses, and nodular auricular chondropathy. Updated Diagnostic Methods chapter covers multiple methods of developing a differential diagnosis list based on breed, lesion type, patterns, and location. A focus on common clinical problems highlights the conditions most likely to be seen in practice. Almost 1,000 full-color photos of skin disorders make it easy to distinguish clinical characteristics and variations of normal and abnormal for accurate diagnosis and therapy.
Author : Nava Dayan,Philip W. Wertz Publisher : John Wiley & Sons Page : 372 pages File Size : 40,8 Mb Release : 2011-06-09 Category : Medical ISBN : 9781118025321
Innate Immune System of Skin and Oral Mucosa by Nava Dayan,Philip W. Wertz Pdf
An in-depth look at cutting-edge research on the body's innate immune system Innate immunity is the body's first line of protection against potential microbial, viral, and environmental attacks, and the skin and oral mucosa are two of the most powerful barriers that which we rely on to stay well. The definitive book on the subject, Innate Immune System of Skin and Oral Mucosa: Properties and Impact in Pharmaceutics, Cosmetics, and Personal Care Products provides a comprehensive overview of these systems, including coverage of antimicrobial peptides and lipids and microbial challenges and stressors that can influence innate immunity. Designed to help experts and newcomers alike in fields like dermatology, oral pathology, cosmetics, personal care, and pharmaceuticals, the book is filled with suggestions to assist research and development. Looking at the many challenges facing the innate immune system, including the impact of topically applied skin products and medications, Innate Immune System of Skin and Oral Mucosa paves the way for next generation treatment avenues, preventative approaches, and drug development.
Strategies for Immunointerventions in Dermatology by Günter Burg,Reinhard G. Dummer Pdf
Recent progress in the fields of pharmacology and immunology has provided us with new possibilities for treating dermatological diseases. This book reviews the most important immunosuppressive and immunostimulatory drugs and gives helpful, practical information on the treatment of various dermatoses, including autoimmundiseases, atopic dermatitis, psoriasis, vasculitis, contact dermatitis, pyoderma gangrenosum, infectious diseases, and neoplasms of the skin - in particular, malignant melanoma.
Small Animal Dermatology - E-Book by Keith A. Hnilica Pdf
Designed with busy practitioners and students in mind, Small Animal Dermatology: A Color Atlas and Therapeutic Guide provides concise, thorough coverage of over 250 skin diseases affecting small animals. More than 1,000 high-quality images help to ensure accurate diagnoses, with coverage including clinical features, top differentials, treatment, and prognosis for each disorder. In this edition, author Keith A. Hnilica streamlines content for practical, everyday use in the clinic. The differential diagnosis chapter is updated for added clarity and easier use, and for quick access, chapters now list diseases based upon the frequency of their occurrence in the pet population. A user-friendly organization allows for quick and easy access to information on specific diseases. Vivid, full-color images facilitate accurate diagnosis of each disorder. A comprehensive drug appendix includes information about dosage, adverse reactions, indications, and contraindications. A new section on skin diseases of birds and exotic pets covers the management of rabbits, ferrets, hamsters, guinea pigs, gerbils, chinchillas, turtles, snakes, and lizards. Hundreds of new, full-color images clearly demonstrate the clinical appearance of skin lesions for accurate diagnosis and treatment. Expanded coverage includes multiple methods of developing a differential diagnosis list based on patterns, breed, lesion type, and lesion location. Coverage of the zoonotic potential of animal skin diseases includes information on preventing the spread of disease from animal to human. Content is streamlined to focus on the more common and likely to be seen clinical problems. A completely updated drug formulary outlines the most effective treatment of dermatological conditions.