Dermatotoxicology Methods

Author : Francis N. Marzulli,Howard I. Maibach
Publisher : CRC Press
Page : 390 pages
File Size : 43,6 Mb
Release : 2019-05-07
Category : Medical
ISBN : 9781439805879

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Dermatotoxicology Methods by Francis N. Marzulli,Howard I. Maibach Pdf

This work presents and evaluates methods employed to identify the potential of certain types of chemicals to adversely affect the skin. A variety of test methods are included such as tests for skin penetration, metabolism, irritation, the skin immune system, photo effects, skin cancer, and topical effects of retinoids and depigmenting chemicals. Tests for chemicals that affect the reproductive and nervous system are also included. Both animal and human tests that have been standardised and tests that are under development and employ animal alternatives are addressed in this book. Besides different testing methods, a rationale for accepting non-animal models and a review of some regulatory agency discussions about animal alternative tests are included.

Author : Taylor & Francis Group
Publisher : CRC Press
Page : 412 pages
File Size : 54,9 Mb
Release : 2020-09-30
Category : Electronic
ISBN : 1138416789

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Dermatotoxicology Methods by Taylor & Francis Group Pdf

This work presents and evaluates methods employed to identify the potential of certain types of chemicals to adversely affect the skin. A variety of test methods are included such as tests for skin penetration, metabolism, irritation, the skin immune system, photo effects, skin cancer, and topical effects of retinoids and depigmenting chemicals. Tests for chemicals that affect the reproductive and nervous system are also included. Both animal and human tests that have been standardised and tests that are under development and employ animal alternatives are addressed in this book. Besides different testing methods, a rationale for accepting non-animal models and a review of some regulatory agency discussions about animal alternative tests are included.

Author : Francis Nicholas Marzulli,Howard I. Maibach
Publisher : Taylor & Francis Group
Page : 390 pages
File Size : 48,8 Mb
Release : 1998-01-01
Category : Dermatotoxicology
ISBN : 1560326719

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Dermatotoxicology Methods by Francis Nicholas Marzulli,Howard I. Maibach Pdf

This work presents and evaluates methods employed to identify the potential of certain types of chemicals to adversely affect the skin. A variety of test methods are included such as tests for skin penetration, metabolism, irritation, the skin immune system, photo effects, skin cancer, and topical effects of retinoids and depigmenting chemicals. Tests for chemicals that affect the reproductive and nervous system are also included. Both animal and human tests that have been standardised and tests that are under development and employ animal alternatives are addressed in this book. Besides different testing methods, a rationale for accepting non-animal models and a review of some regulatory agency discussions about animal alternative tests are included.

Author : Francis N. Marzulli,Howard I. Maibach
Publisher : CRC Press
Page : 420 pages
File Size : 49,7 Mb
Release : 2019-05-07
Category : Medical
ISBN : 1439805873

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Dermatotoxicology Methods by Francis N. Marzulli,Howard I. Maibach Pdf

This work presents and evaluates methods employed to identify the potential of certain types of chemicals to adversely affect the skin. A variety of test methods are included such as tests for skin penetration, metabolism, irritation, the skin immune system, photo effects, skin cancer, and topical effects of retinoids and depigmenting chemicals. Tests for chemicals that affect the reproductive and nervous system are also included. Both animal and human tests that have been standardised and tests that are under development and employ animal alternatives are addressed in this book. Besides different testing methods, a rationale for accepting non-animal models and a review of some regulatory agency discussions about animal alternative tests are included.

Author : Klaus Peter Wilhelm,Hongbo Zhai,Howard I. Maibach
Publisher : CRC Press
Page : 518 pages
File Size : 41,8 Mb
Release : 2012-09-27
Category : Medical
ISBN : 9781841848570

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Dermatotoxicology, Eighth Edition by Klaus Peter Wilhelm,Hongbo Zhai,Howard I. Maibach Pdf

The foundational reference in dermal toxicology, this classic text has been completely revised to bring it up to date in the new Eighth Edition, with almost a third of its chapters being newly added. The structure of the text has also been reorganized to enable easier location of a topic of interest. With contributions from leading international experts, this continues the tradition of providing unsurpassed theoretical and practical guidance for all those working on research aspects, on practical clinical issues, and on the regulatory aspects of exposure to toxic substances. This new edition contains updates to each chapter and contributions from leading international experts, provides an in-depth summary of research and regulatory applications related to dermal toxicology and pharmacology, presents many new chapters that describe the latest advances in dermatotoxicology, and addresses various levels of expertise regarding the development and use of dermal exposure data. New chapters include those on safety terminology, pharmacogenetics and dermatology, ethnic differences in skin properties, and the principles and practice of percutaneous absorption.

Author : Hongbo Zhai,Howard I. Maibach
Publisher : CRC Press
Page : 1232 pages
File Size : 52,9 Mb
Release : 2004-02-25
Category : Medical
ISBN : 1134441991

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Dermatotoxicology, Sixth Edition by Hongbo Zhai,Howard I. Maibach Pdf

For twenty-five years, Dermatotoxicology has stood as the definitive reference book in the field. A generation of toxicologists and dermatologists has consulted this volume throughout their careers, finding within it a wealth of theoretical and practical guidance. Updated and expanded to reflect the latest developments in skin toxicology, Dermatotoxicology, Sixth Edition includes fundamental information on the mechanisms of action of toxic substances on the skin, as well as practical information on the various methods to evaluating dermal toxicity. It is unparalleled in its coverage, and this new edition broadens its scope to include chapters on: * Barrier Creams * Cosmetic Reactions * UV Radiation Exposure * Electron Paramagnetic Resonance * Powdered Human Stratum Corneum * Iontophoresis * Permeability of Skin for Metal Compounds * Current Trends in Skin Cancer Research * Tape Stripping Method v. Stratum Corneum * Hazardous Substances from Soil and Water * Isolated Perfused Porcine Skin Flap * Physiologically-based Pharmacokinetic Models This completely revised and reworked edition constitutes a major contribution to the field of dermatotoxicology. Presenting the most modern concepts and methods in use today, researchers and clinicians will find this an invaluable resource time and time again.

Author : Howard I. Maibach,Golara Honari
Publisher : Academic Press
Page : 150 pages
File Size : 54,9 Mb
Release : 2014-06-24
Category : Science
ISBN : 9780124201996

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Applied Dermatotoxicology by Howard I. Maibach,Golara Honari Pdf

Applied Dermatotoxicology: Clinical Aspects provides concise, systematic, and state-of-the-art information on the toxicological effects of substances on skin, and recent advances in dermal toxicity testing. This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its anatomy and physiology. Next it presents a variety of dermatotoxicological effects, as well at the toxic agents that cause them, with color photographs to illustrate these effects. Applied Dermatotoxicology: Clinical Aspects is an essential reference for toxicologists in industry, and for those medical professionals who encounter cases of dermal exposure to toxic agents. A concise, yet inclusive review of effects of chemical exposure Includes background on basic skin biology Provides vital clinical reference for toxicologists in non-clinical settings

Author : Klaus Peter Wilhelm,Hongbo Zhai,Howard I. Maibach
Publisher : CRC Press
Page : 0 pages
File Size : 40,9 Mb
Release : 2012-09-27
Category : Medical
ISBN : 1841848557

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Dermatotoxicology, Eighth Edition by Klaus Peter Wilhelm,Hongbo Zhai,Howard I. Maibach Pdf

The foundational reference in dermal toxicology, this classic text has been completely revised to bring it up to date in the new Eighth Edition, with almost a third of its chapters being newly added. The structure of the text has also been reorganized to enable easier location of a topic of interest. With contributions from leading international experts, this continues the tradition of providing unsurpassed theoretical and practical guidance for all those working on research aspects, on practical clinical issues, and on the regulatory aspects of exposure to toxic substances. This new edition contains updates to each chapter and contributions from leading international experts, provides an in-depth summary of research and regulatory applications related to dermal toxicology and pharmacology, presents many new chapters that describe the latest advances in dermatotoxicology, and addresses various levels of expertise regarding the development and use of dermal exposure data. New chapters include those on safety terminology, pharmacogenetics and dermatology, ethnic differences in skin properties, and the principles and practice of percutaneous absorption.

Author : Harry Salem,Sidney A. Katz
Publisher : CRC Press
Page : 616 pages
File Size : 50,7 Mb
Release : 2003-03-26
Category : Medical
ISBN : 9780203008799

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Alternative Toxicological Methods by Harry Salem,Sidney A. Katz Pdf

Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist

Author : Francis Nicholas Marzulli,Howard I. Maibach
Publisher : Hemisphere Pub
Page : 604 pages
File Size : 46,7 Mb
Release : 1977
Category : Contact dermatitis
ISBN : UOM:39015003227629

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Dermatotoxicology and Pharmacology by Francis Nicholas Marzulli,Howard I. Maibach Pdf

Author : Philip Wexler
Publisher : Academic Press
Page : 953 pages
File Size : 48,6 Mb
Release : 2000
Category : Medical
ISBN : 9780127447704

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Information Resources in Toxicology by Philip Wexler Pdf

History: -- K.D. Watson, P. Wexler, and J. Everitt. -- Highlights in the History of Toxicology. -- Selected References in the History of Toxicology. -- A Historical Perspective of Toxicology Information Systems. -- Books and Special Documents: -- G.L. Kennedy, Jr., P. Wexler, N.S. Selzer, and L.A. Malley. -- General Texts. -- Analytical Toxicology. -- Animals in Research. -- Biomonitoring/Biomarkers. -- Biotechnology. -- Biotoxins. -- Cancer. -- Chemical Compendia. -- Chemical--Cosmetics and Other Consumer. -- Products. -- Chemical--Drugs. -- Chemical--Dust and Fibers. -- Chemical--Metals. -- Chemicals--Pesticides -- Chemicals--Solvents. -- Chemical--Selected Chemicals. -- Clinical Toxicology. -- Developmental and Reproductive Toxicology. -- Environmental Toxicology--General. -- Environmental Toxicology-- Aquatic. -- Environmental Toxicology--Atmospheric. -- Environmental Toxicology--Hazardous Waste. -- Environmental Toxicology--Terrestrial. -- Environmental Toxicology--Wildlife. -- Ep ...

Author : A. Wallace Hayes
Publisher : CRC Press
Page : 2296 pages
File Size : 44,8 Mb
Release : 2007-09-25
Category : Medical
ISBN : 9781420005424

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Principles and Methods of Toxicology by A. Wallace Hayes Pdf

Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanis

Author : Hongbo Zhai,Howard I. Maibach
Publisher : CRC Press
Page : 1232 pages
File Size : 46,9 Mb
Release : 2004-02-25
Category : Medical
ISBN : 9780203426272

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Dermatotoxicology by Hongbo Zhai,Howard I. Maibach Pdf

For twenty-five years, Dermatotoxicology has stood as the definitive reference book in the field. A generation of toxicologists and dermatologists has consulted this volume throughout their careers, finding within it a wealth of theoretical and practical guidance. Updated and expanded to reflect the latest developments in skin toxicology, De

Author : Howard I. Maibach
Publisher : CRC Press
Page : 573 pages
File Size : 52,9 Mb
Release : 2001-03-15
Category : Medical
ISBN : 9781420022728

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Toxicology of Skin by Howard I. Maibach Pdf

Toxic injury to the skin in the general population, and particularly in western populations, is on the increase. This is partly due to the expanding number of natural and man-made chemicals present in our everyday environment. The need for a thorough understanding of the skin, and the mechanisms of toxicity therein, has never been more pressing. Th

Author : A. Wallace Hayes,Tetyana Kobets
Publisher : CRC Press
Page : 2143 pages
File Size : 47,9 Mb
Release : 2023-07-03
Category : Medical
ISBN : 9781000875775

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Hayes' Principles and Methods of Toxicology by A. Wallace Hayes,Tetyana Kobets Pdf

Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.