Diagnostic Pathology Familial Cancer Syndromes

Author : Vania Nosé
Publisher : Elsevier Health Sciences
Page : 897 pages
File Size : 51,6 Mb
Release : 2020-02-14
Category : Medical
ISBN : 9780323712057

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Diagnostic Pathology: Familial Cancer Syndromes by Vania Nosé Pdf

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Physicians should have the knowledge derived from morphological findings to identify the likelihood of a cancer patient having an additional underlying familial syndrome— and to decide if that patient should undergo molecular genetic evaluation. This volume is specifically designed to help pathologists, oncologists, and other physicians who diagnose and treat cancer to recognize syndromes and syndrome- associated neoplasms and advise patients and their families on the possibility of a familial syndrome and their risk of developing other tumors. Diagnostic Pathology: Familial Cancer Syndromes, second edition, is an easy-to-use, one-stop reference for information on hereditary cancer syndromes, including differential diagnosis and management, that offers a templated, highly formatted design; concise, bulleted text; and superior color images throughout. Contains all the information necessary to determine whether a neoplasm typically encountered in daily practice is sporadic or related to a familial cancer syndrome Features a revised structure to keep you up to date: Part I includes more than 80 detailed chapters describing diagnoses associated with familial cancer syndromes; Part II contains more than 70 chapters with detailed descriptions of major syndromes (cross-referenced with diagnoses); and Part III features a molecular factors index that includes a complete description of each known gene associated with a familial cancer syndrome Contains updated chapters with newly classified GI, neurology, multiple organ, eye, endocrine, GYN, and kidney tumors, as well as more than 20 entirely new chapters covering recently recognized syndromes Incorporates up-to-date molecular findings and their significance for familial cancer syndromes; new techniques and technologies being used to discover gene mutations and other alterations; and details on personalized medicine targeted to specific genes Features more than 2,200 images throughout, including clinical and radiological images, algorithms, graphics, gross pathology, histology, and a wide range of special and immunohistochemical stains—all carefully annotated to highlight the most diagnostically significant factors Features time-saving bulleted text, key facts in each chapter, an extensive index, and numerous tables for quick reference and thorough understanding

Author : Vania Nos?
Publisher : Elsevier
Page : 1000 pages
File Size : 55,8 Mb
Release : 2020-02-03
Category : Electronic
ISBN : 0323712045

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Diagnostic Pathology: Familial Cancer Syndromes by Vania Nos? Pdf

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Physicians should have the knowledge derived from morphological findings to identify the likelihood of a cancer patient having an additional underlying familial syndrome- and to decide if that patient should undergo molecular genetic evaluation. This volume is specifically designed to help pathologists, oncologists, and other physicians who diagnose and treat cancer to recognize syndromes and syndrome- associated neoplasms and advise patients and their families on the possibility of a familial syndrome and their risk of developing other tumors. Diagnostic Pathology: Familial Cancer Syndromes, second edition, is an easy-to-use, one-stop reference for information on hereditary cancer syndromes, including differential diagnosis and management, that offers a templated, highly formatted design; concise, bulleted text; and superior color images throughout.

Author : Joel K. Greenson,Gladell P. Paner
Publisher : Lippincott Williams & Wilkins
Page : 0 pages
File Size : 46,8 Mb
Release : 2013-12
Category : Cancer
ISBN : 193188496X

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Familial Cancer Syndromes by Joel K. Greenson,Gladell P. Paner Pdf

Diagnostic Pathology: Familial Cancer Syndromes features a comprehensive review of the top 56 inherited tumor syndromes associated with neoplasms, which every surgical pathologists diagnoses in their daily sign-out practice. With over 175 chapters and written by well-known experts in the field, this book seeks to help surgical pathologists, clinicians, fellows, and residents understand the critical differences in diagnosing familial tumors and differentiating these from the sporadic counterpart. Besides the well-described pathology of these syndromes, the clinical implications on diagnosing these syndromes are also presented in detail. This book will guide pathologists and clinicians to master diagnostic criteria when diagnosing tumors associated with inherited tumor syndromes. The chapters are organized in 3 parts: The 1st part, "Overview of Syndromes" has the detailed description of the major syndromes within 56 chapters, genes involved, associated tumors, and diagnostic criteria. This part also contains tables that may be helpful in better classifying the diseases and the associated syndromes. Each syndrome described includes all benign and malignant tumors occurring in that specific syndrome including the differential diagnosis. The 2nd part, "Syndromes By Specific Diagnosis", discusses in detail, the diseases occurring within the syndromes described in part 1. The diagnoses are conveniently grouped according to the gland/organ/tissue involved. Distinct diseases are described by highlighting the characteristics of the tumors according to the different syndromes in which they occur. The book describes in detail some of the distinct characteristics of tumors found in inherited tumor syndromes that distinguishes these tumors from tumors in a sporadic setting. Each diagnosis includes definitions, terminology, etiology, pathogenesis, demographics, clinical presentations, therapy, prognosis, gross and microscopic pathology, differential diagnoses, and special studies including immunohistochemistry and molecular/genetics. Every diagnosis is discussed in concise, bulleted text that highlights the most diagnostically significant factors. The 3rd part is "Syndromes by Organ Location". This is also divided by organ/subspecialty and distributed among 40 chapters. This part has tables with "easy-to-find" possible syndromes by organ, with numerous tables including the differential diagnosis. Augmenting the text discussion are numerous gorgeous medical images, including clinical images, gross pathology, histology, and a wide range of special and immunohistochemical stains. Each image is carefully annotated to highlight the most diagnostically significant factors. Finally, this book features the classic benefits of all Amirsys® titles, including time-saving bulleted text, key facts in each chapter, stunning annotated images, extensive index, and Amirsys eBook Advantage(tm), an online version of the print book with larger images and fully searchable text. FEATURES: · Tables for easy reference and thorough understanding · 3 parts divided up for ease of understanding of familial syndromes as related to syndrome overviews, specific diagnoses, and organ location · Features the classic benefits of all Amirsys® titles, including time-saving bulleted text, Key Facts in each chapter, stunning annotated images, and an extensive index · Amirsys eBook Advantage(tm), an online version of the print book with fully searchable text

Author : Hansjakob Müller,R. J. Scott,Walter Weber
Publisher : S. Karger AG (Switzerland)
Page : 256 pages
File Size : 44,9 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015038151893

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Hereditary Cancer by Hansjakob Müller,R. J. Scott,Walter Weber Pdf

Molecular genetics has revolutionized our understanding of the susceptibility to and pathogenesis of cancer and is heralding the era of 'molecular oncology'. This progress is well illustrated by the gain in knowledge accumulated since the release of 'Familial Cancer' in 1985 - known among experts as the 'yellow book'. Cancer genes can now be identified, mapped and sequenced, and this technology has resulted in presymptomatic testing of persons at risk and the development of preventive therapeutic measures. This book provides an update of the latest advances by international experts in the field of hereditary cancer, with special emphasis on the needs of medical practice. The first part is devoted to a discussion of the mechanisms by which predispositions lead to breast and ovarian cancer, intestinal cancer, neoplasia of endocrine glands, and tumors in rare cancer syndromes. Attention is also given to epidemiological aspects of familial cancer occurrence. The second part covers genetic counseling and testing of members of high-risk families, as well as the prevention and treatment of hereditary cancer. Clearly written and well-organized, this book provides essential information not only for molecular geneticists and epidemiologists, but also for genetic counselors and oncologists.

Author : Joel K Greenson
Publisher : Elsevier Health Sciences
Page : 730 pages
File Size : 43,6 Mb
Release : 2015-07-24
Category : Medical
ISBN : 9780323400398

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Diagnostic Pathology: Gastrointestinal E-Book by Joel K Greenson Pdf

Part of the highly regarded Diagnostic Pathology series, this updated volume by Joel K. Greenson, MD, is a visually stunning, easy-to-use reference covering all aspects of gastrointestinal pathology. Outstanding images – including gross pathology, a wide range of pathology stains, and detailed medical illustrations – make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index. Packed with even more high-resolution images than the previous edition – more than 2,500 in all – depicting virtually any GI specimen you’re likely to see. Thoroughly updated content, including new information on drug-induced GI diseases such as olmesartan enteropathy, molecular testing in GI cancers, familial cancer syndromes in the GI tract, and the molecular biology of GI tract tumors as it relates to precision medicine and targeted therapy.

Author : John W. Henson,Robert G Resta
Publisher : Academic Press
Page : 200 pages
File Size : 41,5 Mb
Release : 2021-06-15
Category : Medical
ISBN : 0323900291

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Diagnosis and Management of Hereditary Cancer by John W. Henson,Robert G Resta Pdf

There are a number of hereditary cancers whose formation can be ascribed to a single gene, which unlike most types of cancers can be used for cancer risk reduction and early detection. Diagnosis and Management of Hereditary Cancer summarizes these and presents for readers the field of brain cancer genetics in a series of 50 tables. These tables each organize known research from different initial observations, to help best diagnose. Clinicians can use symptoms to extrapolate to specific conditions and associated genes, or begin with genes to connect with common symptoms and disorders. Together these diagnostic methods when met in daily clinical practice will allow clinicians to identify the possibility of a hereditary condition. Information organized in this way is not presently available in a single reference until now. This volume will elevate the care of hereditary cancer patients with practice-enhancing information and enhance development of the field by stimulating better diagnosis, management, and treatment. Features a unique table-based presentation of 50 aspects of hereditary brain cancer Analyzes genetics, genetic testing, and clinical features of multiple cancers Reviews clinical features for multiple hereditary cancer syndromes Presents a landscape picture book-style layout for better view of tabular information Provides a table-based presentation to better access information

Author : Mahul B. Amin,Satish K. Tickoo
Publisher : Elsevier Health Sciences
Page : 1100 pages
File Size : 46,7 Mb
Release : 2022-07-22
Category : Medical
ISBN : 9780323763332

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Diagnostic Pathology: Genitourinary E-Book by Mahul B. Amin,Satish K. Tickoo Pdf

Offering complete, practical guidance on the evaluation of the surgical pathology specimen, the Manual of Surgical Pathology concentrates decades of experience from the faculty and staff of one of the busiest and most respected pathology departments in the world. From a specimen’s arrival in the department to preparation of the final report, you’ll find step-by-step instructions on specimen processing, tissue handling, gross dissection technique, histological examination, application of special stains, development of a differential diagnosis, and more. The fully revised 4th Edition is an invaluable reference for practicing pathologists, residents, and pathology assistants as a practical, everyday resource for learning and applying optimal specimen evaluation as well as an excellent guide for board review. Helps you find information quickly with a user-friendly design, concise paragraphs, numbered lists, and bulleted material throughout the text. Reflects the latest AJCC staging information, as well as updates throughout on reporting procedures, protocols, and safety. Offers detailed instructions on the dissection, description, and sampling of specimens, and explains the application of pathology reports to patient management. Provides procedures for new types of specimens including pulmonary image guided resections, endoscopic mucosal resection, endoscopic submucosal dissection, laparoscopic hysterectomy, or nephrectomy morcellation, vertical sleeve gastrectomy, and evaluation of breast implant capsules with a clinical suspicion of lymphoma Features dozens of illustrations that demonstrate the gross appearance of common pathologic lesions, and more than 150 tables that examine the interpretation of histochemical stains, immunohistochemical studies, electron microscopy findings, cytogenetic changes, and much more. Examines the specimens from every organ and system as well as bullets, medical devices, and foreign materials. Includes a new chapter on occupational hazards for pathologists ranging from visual and musculoskeletal problems to exposure and prevention of workplace acquired infection and cancer.

Author : Anthony Killeen
Publisher : Springer Science & Business Media
Page : 347 pages
File Size : 41,7 Mb
Release : 2003-11-07
Category : Medical
ISBN : 9781592594313

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Principles of Molecular Pathology by Anthony Killeen Pdf

Anthony Killeen, MD, PhD, offers a comprehensive yet concise introduction to molecular pathology that encompasses both applied and theoretical knowledge. Writing in a very readable style, the author reviews the basic concepts of human molecular biology, explains the principles of the most commonly used analytical methods, and discusses the molecular principles that underlie both inherited diseases and acquired genetic abnormalities that lead to cancer. Using common viral infections as examples, the book applies these molecular methods to the detection of microbial pathogens. The growing importance of pharmacogenetics and identity testing in the clinical laboratory is also highlighted.

Author : Vania Nosé
Publisher : Elsevier Health Sciences
Page : 922 pages
File Size : 54,7 Mb
Release : 2022-08-27
Category : Medical
ISBN : 9780323847568

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Diagnostic Pathology: Endocrine by Vania Nosé Pdf

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of endocrine pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Endocrine is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource. Provides essential knowledge in all areas of endocrine pathology, including thyroid, parathyroid, pituitary, adrenal, paraganglia, pancreas, skin, neuroendocrine neoplasms, and inherited tumor syndromes—more than 150 diagnoses in all Offers a wealth of new information based on recently recognized and discovered endocrine diseases, as well as tumor types with important implications for patient care Includes new content on thyroid lesions and tumors now associated with DICER1 gene mutations; the correlation of newly characterized genetic abnormalities in endocrine tumors associated with responses to targeted therapies; and newly recognized syndromes, such as multiple endocrine neoplasia type 4 and type 5, glucagon cell hyperplasia and neoplasia, and others Meticulously edited by Dr. Vania Nosé with contributions from renowned pathologists to ensure that common/classic endocrine diagnoses as well as newly recognized diseases and unusual cases, are well covered Features nearly 2,200 high-quality images in print and online, including clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis Includes updated criteria, terminology, and classifications for a wide range of tumors according to the latest literature, including the 2022 WHO Endocrine and Neuroendocrine Tumors classification Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care

Author : Vania Nosé
Publisher : Elsevier Health Sciences
Page : 700 pages
File Size : 49,7 Mb
Release : 2019-04-09
Category : Medical
ISBN : 9780323554664

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Diagnostic Pathology: Endocrine E-Book by Vania Nosé Pdf

Part of the highly regarded Diagnostic Pathology series, this updated volume by Dr. Vania Nosé is a visually stunning, easy-to-use reference covering 125 of the most common endocrine pathology diagnoses. Outstanding images—more than 2,400 in all—make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. This second edition incorporates the most recent clinical, pathological, histological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Essential knowledge in all areas of endocrine pathology, including thyroid, parathyroid, pituitary, adrenal, pancreas, skin, and inherited tumor syndromes Unsurpassed visual coverage with more than 2,400 carefully annotated clinical images, gross pathology, histology, and special and immunohistochemical stains that provide clinically and diagnostically important information on typical and variant disease features Designed to help you identify crucial elements of each diagnosis along with associated differential diagnoses and pitfalls to more quickly resolve problems during routine sign out of cases Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index Thoroughly updated content throughout, reflecting new WHO classifications for endocrine diseases, recently discovered and newly described endocrine disease entities and genetic causes, and treatment changes of endocrine diseases New coverage of encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC), with a new chapter on the new entity NIFTP, new genetic discoveries in the development of pheochromocytoma and paragangliomas, new names that demonstrate the differentiation of certain tumors, and new information on immunoglobulin G4-related disease (IgG4-RD) involving thyroid

Author : Anonim
Publisher : Unknown
Page : 93 pages
File Size : 42,8 Mb
Release : 2008
Category : Cancer
ISBN : 0199558396

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Concise Handbook of Familial Cancer Susceptibility Syndromes by Anonim Pdf

Author : Peter M. Sadow
Publisher : Elsevier Health Sciences
Page : 145 pages
File Size : 42,6 Mb
Release : 2014-11-20
Category : Medical
ISBN : 9780323326858

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Endocrine Pathology, An Issue of Surgical Pathology Clinics, by Peter M. Sadow Pdf

Early identification and diagnosis by type and stage is the key to high survival rates with thyroid cancer. To present the pathologist with current clinical information on diagnosis, differential diagnosis, staging, and prognosis of thyroid cancers, topics presented are: Poorly differentiated thyroid carcinoma; Paraganglimoa; Immunohistochemical markers for evaluation and prognosis in thyroid carcinoma; Familial endocrine syndromes; Parathyroid enoplasia; Inflammatory lesions of the thyroid associated with cancer; Assessing biological aggression in adrenal cortical neoplasia; Pituitary neoplasia; and Pancreatic endocrine neoplasia. Peter Sadow, whose clinical practice and research involve studying the mechanisms of endocrine carcinogenesis through translational studies involving the proteomics and genomics of endocrine neoplasms, primarily of the thyroid and adrenal glands, leads this issue.

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 846 pages
File Size : 43,6 Mb
Release : 2023-10-27
Category : Science
ISBN : 9780128229934

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Diagnostic Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease. Includes new material on mass spectrometry for infectious diseases, microbiome, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more Provides insights on the value of the molecular test in comparison to traditional methods, which include speed, precision, sensitivity and clinical impacts for the patient Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for the prognostication of disease

Author : Karen H. Lu
Publisher : CRC Press
Page : 0 pages
File Size : 40,9 Mb
Release : 2008-08-26
Category : Medical
ISBN : 142005287X

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Hereditary Gynecologic Cancer by Karen H. Lu Pdf

Hereditary Gynecologic Cancer: Risk, Prevention and Management fills the need that exists for a book addressing highly relevant clinical issues associated with the new field of hereditary gynecologic cancers. Written with the clinician in mind, the authors will cover a broad range of topics, beginning with an overview discussing clinical relevance of hereditary ovarian and hereditary endometrial cancers. Succeeding sections will provide in-depth analyses of Hereditary Breast Ovarian Cancer Syndrome, Lynch Syndrome, and other syndromes with gynecologic cancer components, and genetic risk assessment. Hereditary Gynecologic Cancer: Risk, Prevention and Management: is the first clinically focused reference detailing gynecologic patient management issues of BRCA1 and BRCA2 mutation carriers includes a practical section on genetic risk assessment and genetic testing examines case studies to demonstrate management techniques and decision-making provides detailed discussion of ovarian cancer screening, prevention and risk reducing surgery

Author : B.K. Kleinschmidt-DeMasters, MD,Fausto Rodriguez, MD,Tarik Tihan, MD, PhD
Publisher : Elsevier Health Sciences
Page : 860 pages
File Size : 44,6 Mb
Release : 2016-02-10
Category : Medical
ISBN : 9780323445924

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Diagnostic Pathology: Neuropathology by B.K. Kleinschmidt-DeMasters, MD,Fausto Rodriguez, MD,Tarik Tihan, MD, PhD Pdf

Part of the highly regarded Diagnostic Pathology series, Diagnostic Pathology: Neuropathology is a visually stunning, easy-to-use reference covering all aspects of neuropathology. Nearly 1,700 outstanding images, including a wide variety of pathology stains and high-quality medical illustrations, make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. This second edition incorporates the most recent clinical, pathological, histological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Expert Consult eBook version included, which allows you to search all of the text, figures, and references from the book on a variety of devices. Thoroughly updated content throughout includes new biomarkers and genetic markers; new diagnostic, therapeutic, and prognostic techniques; new entities and antibodies; new immunohistochemical markers; the new "integrated" diagnosis schema; and much more. Features exclusive images not found in the 2016 updated WHO Classification system of CNS neoplasms. Presents complete information on lesions of the brain, sellar region, and peripheral nerves, as well as benign cysts and selected infectious, inflammatory, reactive, vascular, and cortical dysplastic lesions. High-quality, carefully annotated color images (both common and rare) depict classic pathological features as well as variant patterns that are prone to creating diagnostic problems. Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index.