Download Full eBooks in PDF
Diagnostic Prognostic And Therapeutic Value Of Gene Signatures Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Diagnostic Prognostic And Therapeutic Value Of Gene Signatures book. This book definitely worth reading, it is an incredibly well-written.
Author : Anonim
Publisher : Unknown
Page : 196 pages
File Size : 42,5 Mb
Release : 2011-11-03
Category : Electronic
ISBN : 1617793590
Author : Antonio Russo,Stefano Iacobelli,Juan Iovanna
Publisher : Springer Science & Business Media
Page : 190 pages
File Size : 51,9 Mb
Release : 2011-11-03
Category : Medical
ISBN : 9781617793585
Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and medical oncologists.
Author : Yujin Hoshida
Publisher : Springer
Page : 366 pages
File Size : 40,9 Mb
Release : 2019-08-05
Category : Medical
ISBN : 9783030215408
This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.
Author : Aamir Ahmad
Publisher : Springer Science & Business Media
Page : 415 pages
File Size : 52,6 Mb
Release : 2012-11-08
Category : Medical
ISBN : 9781461456476
This volume comprehensively covers recent prrogress in breast cancer research. In an effort to successfully treat breast cancer, it is imperative to a) fully understand the disease with all its heterogeneity, b) understand the factors that influence the metastasis of breast cancer to distant organs making it lethal and c) understand the underlying processes that lead to the phenomenon of drug-resistance making the disease particularly incurable. The book explores all of these issues, including the phenomenon of epithelial-mesenchymal-transition, cancer stem cells as well as microRNAs in an attempt to better understand the disease in connection to its heterogeneity/metastasis/drug-resistance as well as to propose novel signaling pathways for therapeutic intervention. The profiling of tumors to molecularly classify breast cancers is also investigated so that customized targeted therapies can be developed.
Author : Hossain Shekhar,Xin Wang,Ismail Hosen,Florence Le Calvez-Kelm,Tianhui Chen,William C. Cho
Publisher : Frontiers Media SA
Page : 644 pages
File Size : 44,5 Mb
Release : 2023-06-05
Category : Science
ISBN : 9782832525128
Author : Colette Pameijer,Wen-Qing Li,Gagan Chhabra
Publisher : Frontiers Media SA
Page : 203 pages
File Size : 47,5 Mb
Release : 2023-06-05
Category : Medical
ISBN : 9782832524961
Author : Francesco Schettini,Daniele Generali
Publisher : Frontiers Media SA
Page : 364 pages
File Size : 48,5 Mb
Release : 2023-12-12
Category : Medical
ISBN : 9782832540725
In the last couple of decades, the study of the cancer genome and the progressive implementation of next-generation sequencing platforms have provided the Scientific and Oncology communities with a multitude of data, technologies, diagnostic, prognostic, and predictive tools that have been revolutionizing the way we can study, diagnose and treat cancer, including breast tumors. For example, genomic tests can now refine the prognosis of early-stage breast cancer patients beyond standard clinicopathological features and help guide escalated or de-escalated treatment choices. The identification of the molecular intrinsic subtypes might also be helpful in guiding treatment choices in advanced hormone receptor-positive disease. The identification of germline mutations in BRCA1 or BRCA2 has led to the development and introduction of PARP inhibitors for the treatment of advanced and early-stage breast cancer, along with personalized follow-up and prophylactic surgical procedures for patients with or without cancer, carrying such mutations.
Author : Israel Tojal Da Silva,Joel Correa Da Rosa,Liang Zhao,Rodrigo Drummond,Jianjiong Gao
Publisher : Frontiers Media SA
Page : 149 pages
File Size : 46,6 Mb
Release : 2022-09-21
Category : Science
ISBN : 9782832500200
Author : Pedro Borralho,Fernando Schmitt,Liang Wang,Umberto Malapelle
Publisher : Frontiers Media SA
Page : 279 pages
File Size : 52,8 Mb
Release : 2023-04-05
Category : Science
ISBN : 9782832518373
Author : Wei Wu,Hani Choudhry
Publisher : Springer Science & Business Media
Page : 383 pages
File Size : 48,7 Mb
Release : 2013-08-04
Category : Medical
ISBN : 9781461476450
This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology.This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. This volume will present true experimental results with concrete data processing pipelines, discuss the bottleneck of each platform for real project in cancer research. In additional, single cancer cell sequencing as the proof of concept will be introduced in this book, along with cutting-edge information provided will help the intended audience to develop a comprehensive understanding of the NGS technology and practical whole genome sequencing data analysis and rapidly translate into their own research, specifically in the field of cancer biology.
Author : José Luis García-Giménez
Publisher : Academic Press
Page : 696 pages
File Size : 45,7 Mb
Release : 2015-12-07
Category : Science
ISBN : 9780128019214
Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies
Author : Umberto Malapelle,Etienne Giroux Leprieur,Christian Rolfo,Paul Takam Kamga,Marius Tresor Chiasseu
Publisher : Frontiers Media SA
Page : 208 pages
File Size : 44,7 Mb
Release : 2021-06-28
Category : Medical
ISBN : 9782889669158
Author : Manfred Dietel
Publisher : Springer Science & Business Media
Page : 263 pages
File Size : 51,5 Mb
Release : 2007-06-10
Category : Medical
ISBN : 9783540460916
From its introduction, oncological chemotherapy has been encumbered by poor selectivity because antiproliferative drugs are often toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. Modern targeted therapies interact with defined molecules present on cancer cells, adding increased selectivity to their toxic effects. This book presents an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.
Author : George Peter Canellos,Thomas Andrew Lister,Bryan D. Young
Publisher : Saunders
Page : 794 pages
File Size : 47,5 Mb
Release : 2006
Category : Medical
ISBN : UOM:39015064128898
Edited and written by world authorities, this text encompasses all aspects of Hodgkin's disease, non-Hodgkin's lymphomas, and related disorders. Designed to be the "Bible" for both clinicians and scientists who deal with lymphoma, the book is packed with useful summary tables and abundant illustrations and translates cutting-edge discoveries into state-of-the-art management guidelines. The preeminent names in research and practice bring together today's entire spectrum of knowledge--from epidemiology, classification and prognosis through diagnosis and therapy, including the latest scientific advances, such as the impact of molecular biologic and genetic discoveries and new biologic markers. Covers molecular biology bone marrow transplantationlymphoma in AIDS and Hodgkins disease. Provides in-depth coverage of the underlying biology of the disease as well as etiology, pathology, diagnosis, and treatment. Discusses advances in the treatment of diseases including radiotherapy, radiolabeled monoclonal antibodies, treatment of cutaneous lymphoma, and metastatic disease. Contains precise clinical how-tos for managing bone marrow transplantation and diseases that resemble lymphomas. . Includes the recently codified new WHO classification of all lymphoid entities. . Offers new and updated information on the biology and recategorization (morphologic, clinical, genotypic/immunophenotypic) of distinct lymphoma entities.
Author : Anonim
Publisher : Academic Press
Page : 669 pages
File Size : 50,8 Mb
Release : 2008-11-11
Category : Science
ISBN : 9780080919034
This two-volume set — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — provides an in-depth look at one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease. The inclusion of the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and more presents this book as an essential tool for both students and specialists across many biological and medical disciplines, including human genetics and genomics, oncology, neuroscience, cardiology, infectious disease, molecular medicine, and biomedical science, as well as health policy disciplines focusing on ethical, legal, regulatory and economic aspects of genomics and medicine.Volume One Includes:Principles, Methodology and Translational Approaches, takes readers on the journey from principles of human genomics to technology, informatic and computational platforms for genomic medicine, as well as strategies for translating genomic discoveries into advances in personalized clinical care.Volume Two Includes:Genome Discoveries and Clinical Applications presents the latest developments in disease-based genomic and personalized medicine. With chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, this work provides the most comprehensive guide to the principles and practice of genomic and personalized medicine. Highly Commended 2013 BMA Medical Book Award for Medicine Contributions from leaders in the field provide unparalleled insight into current technologies and applications in clinical medicine. Full colour throughout enhances the utility of this work as the only available comprehensive reference for genomic and personalized medicine. Discusses scientific foundations and practical applications of new discoveries, as well as ethical, legal/regulatory, and social issues related to the practice of genomic medicine.