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Author : Wendy N. Erber
Publisher : Unknown
Page : 350 pages
File Size : 53,5 Mb
Release : 2014-05-14
Category : Blood
ISBN : 0511918674
An integrative, comprehensive guide to the optimal utilization of laboratory techniques in diagnosing and monitoring hematological malignancies.
Author : Michal Witt,Malgorzata Dawidowska,Tomasz Szczepanski
Publisher : Springer Science & Business Media
Page : 468 pages
File Size : 51,7 Mb
Release : 2012-06-30
Category : Science
ISBN : 9783642294679
This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem cell transplantation, donor recipient matching, banking of biological material, analyses of post-transplant chimerism, and minimal residual disease monitoring. The volume concludes with an extensive section comprising thorough step-by-step protocols of molecular techniques in hematology, all of them validated in the authors’ own laboratories.
Author : Wendy N. Erber
Publisher : Cambridge University Press
Page : 349 pages
File Size : 49,6 Mb
Release : 2010-11-11
Category : Medical
ISBN : 9781139491730
The diagnosis and monitoring of hematological malignancies is complex and requires a systematic approach. Morphology, cell phenotyping, cytogenetics and molecular genetics are essential, and the results must be integrated. Diagnostic Techniques in Hematological Malignancies details the principles and applications of each of these test types in the diagnosis of hematological malignancies in blood and bone marrow. The first section describes the test modalities – including methodological principles, data interpretation and limitations – and is illustrated by clinical examples. The second section focuses on the clinical entities, detailing the most appropriate tests for diagnosis, staging and monitoring of different hematological malignancies and includes test utilization to identify prognostic markers and potential therapeutic targets. With contributions from multiple international experts, this illustrated book is an essential resource for qualified and trainee hematologists, oncologists, and pathologists. It's a practical and useful guide, providing a rational and structured approach to the laboratory assessment of hematological malignancies.
Author : Michal Witt,Malgorzata Dawidowska,Tomasz Szczepanski
Publisher : Springer
Page : 0 pages
File Size : 44,7 Mb
Release : 2015-06-26
Category : Science
ISBN : 3642445225
This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem cell transplantation, donor recipient matching, banking of biological material, analyses of post-transplant chimerism, and minimal residual disease monitoring. The volume concludes with an extensive section comprising thorough step-by-step protocols of molecular techniques in hematology, all of them validated in the authors’ own laboratories.
Author : Magdalena Czader
Publisher : Humana Press
Page : 304 pages
File Size : 55,8 Mb
Release : 2013-05-11
Category : Science
ISBN : 1627033580
Increased knowledge on the pathogenesis of hematologic diseases has been translated into diagnostic and prognostic applications. Hematopathology and laboratory hematology were among the first disciplines to embrace molecular diagnostics. Hematological Malignancies:Methods and Protocols, explores molecular-based assays frequently used in the routine diagnostic hematopathology and laboratory hematology. Many of these protocols were initially developed as research applications and were further refined as they transitioned to the diagnostic laboratory. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Hematological Malignancies: Methods and Protocols aids scientist in the continuing study of tests essential for contemporary laboratory diagnostics of hematological neoplasms.
Author : Torsten Haferlach,Claudia Haferlach,Wolfgang Kern,Susanne Schnittger
Publisher : Unknown
Page : 200 pages
File Size : 46,8 Mb
Release : 2012-04-15
Category : Blood
ISBN : 3540879625
This book reviews diagnostic techniques including cytomorphology, histomorphology, cytogenetics, FISH, flow cytometry and molecular genetics. Includes algorithms for diagnosis and follow-up scenarios.
Author : Martin S. Tallman,Leo I. Gordon
Publisher : Springer Science & Business Media
Page : 383 pages
File Size : 55,5 Mb
Release : 2007-11-23
Category : Medical
ISBN : 9780585385716
There is no field of medicine in which advances in therapy have been so closely linked to a better understanding of molecular medicine than in the area of hematologic malignancies. Diagnostic and Therapeutic Advances in Hematologic Malignancies will provide practitioners and academic clinicians with a better understanding of the constant evolving concepts in this area.
Author : Mina Luqing Xu,Alejandro Gru,Julia T. Geyer,Andrew G. Evans
Publisher : Frontiers Media SA
Page : 218 pages
File Size : 42,8 Mb
Release : 2022-03-15
Category : Medical
ISBN : 9782889747030
Author : Dieter Huhn
Publisher : Springer Science & Business Media
Page : 264 pages
File Size : 44,6 Mb
Release : 1998-09-18
Category : Medical
ISBN : 3540635785
Describing the latest methods of oncological and hematological diagnostics based on immunological, molecular, genetic, and histological models; this volume describes in detail, the comparative costs and effectiveness of these methods. At the end of the each chapter, detailed descriptions of the "how-to" aspects of the techniques are given.
Author : Guy B. Faguet
Publisher : Springer Science & Business Media
Page : 365 pages
File Size : 48,9 Mb
Release : 2008-02-02
Category : Medical
ISBN : 9781592590742
The aim of Hematologic Malignancies: Methods and Techniques is to review those methods most useful for the diagnosis and subsequent mana- ment of hematologic malignancies. The scope of coverage is intentionally broad, ranging from routine procedures to highly sophisticated methods not currently offered by most clinical laboratories. The latter methods were selected especially to bring into focus recent advances in molecular biology that, since they provide us with strong tools for assessing the outcome of upcoming therapeutic modalities intent on disease eradication, are expected to impact the future diagnosis and management of these diseases. Thus, the c- mon thread among all chapters is clinical relevance, whether sanctioned by past experience or by the expectation that seemingly esoteric research techniques of today will prove clinically valuable in the future. Hematologic Malignancies: Methods and Techniques is primarily a compilation of methods presented in sufficient detail—by authors with extensive expertise in their field—to serve not only as a reference for seasoned research and clinical laboratory pers- nel, but also as a guide for the less experienced. Moreover, the contributing authors also discuss the pathophysiologic bases and the diagnostic usefulness that underscore each method’s clinical relevance. Thus, this volume should be also valuable to clinicians—especially hematologists, oncologists, and path- ogists—often bewildered by an ever increasing flow of new scientific inf- mation, the practical application of which is often either not clearly disclosed or difficult to discern.
Author : Laurent Degos,David C. Linch,Bob Lowenberg
Publisher : CRC Press
Page : 1492 pages
File Size : 52,7 Mb
Release : 2004-12-14
Category : Medical
ISBN : 9781841841458
The Second Edition of this successful title has been fully revised and updated and now includes expanded sections on normal and malignant haematopoiesis, offering a thorough review of the molecular and cellular processes involved in malignancy, developments in diagnostic techniques and treatment, concluding with discussion of treatment of individual diseases, late effects of therapy and supportive care. Short Contents
Author : Ali Guermazi
Publisher : Springer Science & Business Media
Page : 584 pages
File Size : 55,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642188329
One of the first book’s to deal specifically with imaging of the entire spectrum of hematological malignancies. The use of the latest imaging modalities is well described, and an important aspect of the book is the role of imaging techniques in differentiating between manifestations of the underlying disease and complications of treatment. Each of the 28 chapters is written by an internationally recognized expert, making this book the most current and complete treatment of this subject available. Includes many high-quality radiological and histological illustrations. It should be of great interest to radiologists and hematologists.
Author : Georg Maschmeyer,Kenneth V.I. Rolston
Publisher : Springer
Page : 335 pages
File Size : 43,8 Mb
Release : 2014-12-13
Category : Medical
ISBN : 9783662440001
Infections are among the most frequent complications in patients with hematological malignancies and in those undergoing high-dose chemotherapy and autologous hematopoietic stem cell transplantation. A profound knowledge on the epidemiology, diagnostic approaches, treatment modalities and prophylactic strategies is essential for the clinical management of these complications in patients who are often severely immunocompromised owing to their underlying diseases and in particular, the intensive myelosuppressive chemo and immunotherapy. This textbook provides a clinically oriented, compact and up-to-date overview on infections in hematology patients and their management. The typical pathogens to be considered in different subgroups of patients are identified and further aspects of the microbiological background are explored. Clinical, imaging, and laboratory-based diagnostic techniques are discussed and therapeutic strategies appropriate to different situations are then presented, with due attention to the pitfalls, toxicities and interactions that can arise during antimicrobial treatment. Strategies to prevent infection are also outlined, encompassing antimicrobial prophylaxis, isolation procedures, hospital hygiene, protective immunization and the use of hematopoietic growth factors.
Author : Manorama Bhargava
Publisher : Springer Nature
Page : 246 pages
File Size : 44,5 Mb
Release : 2021-02-13
Category : Medical
ISBN : 9789813347991
This book is a compendium of case studies in hematologic malignancies such as acute leukemias, myelodysplastic and myeloproliferative neoplasms, chronic leukemias and multiple myeloma covering cytogenetics (karyotyping Fluorescence in sitn hybridization (FISH)) and molecular studies in detail. The first few chapters describe the methodology employed for karyotyping, FISH and Real Time PCR technology conducive to establishment of these labs if required. Each case study is described in detail by including the clinical history of the patient, findings of peripheral blood, bone marrow aspirate and bone biopsy morphological details. This is then followed by flowcytometric immunophenotyping, cytogenetic and molecular observations leading collectively to a final diagnosis, A discussion follows based on the relevance of this data in informing the prognosis, treatment response and survival in these patients. Additionally, this data serves as a key determinant for clinical decision making involving evidence based rational management of patients including targeted therapy. For better understanding, each case study is accompanied by black and white or colour images as appropriate. This book is a source of learning and a valuable read for clinical hematologists, hematopathologists, medical oncologists, residents, interns, DM Hematology students and DNB Hematology students as well.
Author : Anna Porwit,Marie Christine Béné
Publisher : Cambridge University Press
Page : 247 pages
File Size : 46,8 Mb
Release : 2018-01-25
Category : Medical
ISBN : 9781107503830
This practical manual offers an active understanding of how to implement flow-cytometry when facing complex, haematological diseases.