Direct Construction Of D3 Methylated All Carbon Quaternary Stereocenters Through Carbene Catalyzed Desymmetrization

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Direct construction of d3-methylated all-carbon quaternary stereocenters through carbene-catalyzed desymmetrization

Jingcheng Guo,Ye Zhang,Xiaoxiang Zhang,Zhenqian Fu

Author : Jingcheng Guo,Ye Zhang,Xiaoxiang Zhang,Zhenqian Fu
Publisher : OAE Publishing Inc.
Page : 11 pages
File Size : 54,5 Mb
Release : 2023-07-19
Category : Science
ISBN : 8210379456XXX

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Direct construction of d3-methylated all-carbon quaternary stereocenters through carbene-catalyzed desymmetrization by Jingcheng Guo,Ye Zhang,Xiaoxiang Zhang,Zhenqian Fu Pdf

The construction of d3-methylated all-carbon quaternary stereocenters has been successfully developed via carbene-catalyzed desymmetrization of prochiral d3-methylated oxindolyl 1,3-diketones. Three new stereogenic centers were efficiently constructed with satisfactory outcomes. Diverse spiro-polycyclic molecules with a d3-methylated all-carbon quaternary stereocenter were generated in good to excellent yields with good to excellent diastereoselectivities and excellent enantioselectivities. This reaction features a broad substrate scope, good functional-group tolerance, and easy scale-up.

Total Synthesis of Natural Products

Jie Jack Li,E.J. Corey

Author : Jie Jack Li,E.J. Corey
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 53,8 Mb
Release : 2013-03-14
Category : Science
ISBN : 9783642340659

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Total Synthesis of Natural Products by Jie Jack Li,E.J. Corey Pdf

'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.

N-Heterocyclic Carbenes in Organocatalysis

Akkattu T. Biju

Author : Akkattu T. Biju
Publisher : John Wiley & Sons
Page : 407 pages
File Size : 50,6 Mb
Release : 2019-01-07
Category : Science
ISBN : 9783527809059

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N-Heterocyclic Carbenes in Organocatalysis by Akkattu T. Biju Pdf

Summarizing the emerging field of N-heterocyclic carbenes used in organocatalysis, this is an excellent overview of the synthesis and applications of NHCs focusing on carbon-carbon and carbon-heteroatom bond formation. Alongside comprehensive coverage of the synthesis, characteristics and applications, this handbook and ready reference also includes chapters on NHCs for polymerization reactions and natural product synthesis.

Catalytic Asymmetric Synthesis

Takahiko Akiyama,Iwao Ojima

Author : Takahiko Akiyama,Iwao Ojima
Publisher : John Wiley & Sons
Page : 798 pages
File Size : 52,5 Mb
Release : 2022-05-27
Category : Science
ISBN : 9781119736417

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Catalytic Asymmetric Synthesis by Takahiko Akiyama,Iwao Ojima Pdf

Catalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis C–H bond functionalization reactions Carbon–carbon bond formation reactions, carbon–halogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric synthesis, the 4th edition of Catalytic Asymmetric Synthesis serves as an excellent desktop reference and text for researchers and students, from upper-level undergraduates all the way to experienced professionals in industry or academia.

Applications of Transition Metal Catalysis in Drug Discovery and Development

Matthew L. Crawley,Barry M. Trost

Author : Matthew L. Crawley,Barry M. Trost
Publisher : John Wiley & Sons
Page : 386 pages
File Size : 47,6 Mb
Release : 2012-05-14
Category : Science
ISBN : 9781118309834

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Applications of Transition Metal Catalysis in Drug Discovery and Development by Matthew L. Crawley,Barry M. Trost Pdf

This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development – it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.

C-H Activation for Asymmetric Synthesis

Françoise Colobert,Joanna Wencel-Delord

Author : Françoise Colobert,Joanna Wencel-Delord
Publisher : John Wiley & Sons
Page : 294 pages
File Size : 41,9 Mb
Release : 2019-11-11
Category : Science
ISBN : 9783527343409

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C-H Activation for Asymmetric Synthesis by Françoise Colobert,Joanna Wencel-Delord Pdf

Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed. Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods. -Covers one of the most rapidly developing fields in organic synthesis and catalysis -Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds) -Edited by two leading experts in C-H activation in asymmetric synthesis CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry.

Advanced Organic Chemistry

Francis A. Carey,Richard J. Sundberg

Author : Francis A. Carey,Richard J. Sundberg
Publisher : Springer Science & Business Media
Page : 1199 pages
File Size : 55,6 Mb
Release : 2007-06-27
Category : Science
ISBN : 9780387448992

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Advanced Organic Chemistry by Francis A. Carey,Richard J. Sundberg Pdf

The two-part, fifth edition of Advanced Organic Chemistry has been substantially revised and reorganized for greater clarity. The material has been updated to reflect advances in the field since the previous edition, especially in computational chemistry. Part A covers fundamental structural topics and basic mechanistic types. It can stand-alone; together, with Part B: Reaction and Synthesis, the two volumes provide a comprehensive foundation for the study in organic chemistry. Companion websites provide digital models for study of structure, reaction and selectivity for students and exercise solutions for instructors.

Practical Synthetic Organic Chemistry

Stéphane Caron

Author : Stéphane Caron
Publisher : John Wiley & Sons
Page : 850 pages
File Size : 53,9 Mb
Release : 2020-02-05
Category : Science
ISBN : 9781119448853

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Practical Synthetic Organic Chemistry by Stéphane Caron Pdf

This book is a hands-on guide for the organic chemist. Focusing on the most reliable and useful reactions, the chapter authors provide the information necessary for a chemist to strategically plan a synthesis, as well as repeat the procedures in the laboratory. Consolidates all the key advances/concepts in one book, covering the most important reactions in organic chemistry, including substitutions, additions, eliminations, rearrangements, oxidations, reductions Highlights the most important reactions, addressing basic principles, advantages/disadvantages of the methodology, mechanism, and techniques for achieving laboratory success Features new content on recent advances in CH activation, photoredox and electrochemistry, continuous chemistry, and application of biocatalysis in synthesis Revamps chapters to include new and additional examples of chemistry that have been demonstrated at a practical scale

Asymmetric Organocatalysis Combined with Metal Catalysis

Bruce A. Arndtsen,Liu-Zhu Gong

Author : Bruce A. Arndtsen,Liu-Zhu Gong
Publisher : Springer Nature
Page : 211 pages
File Size : 45,9 Mb
Release : 2020-04-24
Category : Science
ISBN : 9783030438517

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Asymmetric Organocatalysis Combined with Metal Catalysis by Bruce A. Arndtsen,Liu-Zhu Gong Pdf

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.The chapter "Enamine/Transition Metal Combined Catalysis: Catalytic Transformations Involving Organometallic Electrophilic Intermediates" is available open access under a CC BY 4.0 License via link.springer.com.

Organocatalysis

Manfred Reetz,Benjamin List,Stefan Jaroch,Hilmar Weinmann

Author : Manfred Reetz,Benjamin List,Stefan Jaroch,Hilmar Weinmann
Publisher : Springer Science & Business Media
Page : 348 pages
File Size : 40,9 Mb
Release : 2008-05-27
Category : Science
ISBN : 9783540734956

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Organocatalysis by Manfred Reetz,Benjamin List,Stefan Jaroch,Hilmar Weinmann Pdf

This book provides an excellent overview on state-of-the-art of modern organocatalysis. It presents the contributions from leading experts, with backgrounds in academia and industry, to an Ernst Schering Research Foundation Symposium held in April 2007. It will be of interest to those who want a general overview of the topic, but also to those who want to learn more about the state-of-the-art, current trends and perspectives in this highly dynamic field of research.

Asymmetric Phase Transfer Catalysis

Keiji Maruoka

Author : Keiji Maruoka
Publisher : John Wiley & Sons
Page : 236 pages
File Size : 51,5 Mb
Release : 2008-03-31
Category : Science
ISBN : 3527318429

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Asymmetric Phase Transfer Catalysis by Keiji Maruoka Pdf

Edited by the leading expert on the topic, this is the first book to present the latest developments in this exciting field. Alongside the theoretical aspects, the top contributors provide practical protocols to give readers additional important information otherwise unavailable. A must for every synthetic chemist in academia and industry.

Progress in the Chemistry of Organic Natural Products 114

A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi,Yoshinori Asakawa,Ji-Kai Liu

Author : A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi,Yoshinori Asakawa,Ji-Kai Liu
Publisher : Springer Nature
Page : 341 pages
File Size : 53,7 Mb
Release : 2021-04-01
Category : Science
ISBN : 9783030594442

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Progress in the Chemistry of Organic Natural Products 114 by A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi,Yoshinori Asakawa,Ji-Kai Liu Pdf

This book describes current understandings and recent progress in four areas: in the first one, the cytochalasans, a group of fungal derived natural products characterized by a perhydro-isoindolone core fused with a macrocyclic ring are shown to exhibit high structural diversity and a broad spectrum of bioactivities. The second one is dedicated to a description of bioactive compounds from the medicinal plants of Myanmar, the third one is dedicated to new structure elucidation techniques in the field of sesquiterpenes. The last one discusses the endogenous natural products that are produced by human cells including endogenous amines, steroids, and fatty acid derived natural products. The co-metabolism and natural product production of the human microbiome is also described including tryptophan, bile acids, choline, and cysteine.

Name Reactions in Heterocyclic Chemistry

Jie Jack Li

Author : Jie Jack Li
Publisher : John Wiley & Sons
Page : 579 pages
File Size : 46,6 Mb
Release : 2004-12-27
Category : Science
ISBN : 9780471704140

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Name Reactions in Heterocyclic Chemistry by Jie Jack Li Pdf

Covers important name reactions relevant to heterocyclic chemistry The field of heterocyclic chemistry has long presented a special challenge for chemists. Because of the enormous amount and variety of information, it is often a difficult topic to cover for undergraduate and graduate chemistry students, even in simplified form. Yet the chemistry of heterocyclic compounds and methods for their synthesis form the bedrock of modern medicinal chemical and pharmaceutical research. Thus there is a great need for high quality, up-to-date, and authoritative books on heterocyclic synthesis helpful to both the professional research chemist as well as the advanced student. Name Reactions in Heterocyclic Chemistry provides a one-stop repository for this important field of organic chemistry. The primary topics include three- and four-membered heterocycles, five-membered heterocycles including indoles, furans, thiophenes, and oxazoles, six-membered heterocycles including quinolines, isoquinolines, and pyrimidines, and other heterocycles. Each name reaction is summarized in seven sections: Description Historical perspective Mechanism Variations and improvements Synthetic utility Experimental References Authored by a team of world-renowned contributors - some of whom have discovered the very reactions they describe - Name Reactions in Heterocyclic Chemistry represents a state-of-the-art resource for students and researchers alike.

Modern Organonickel Chemistry

Yoshinao Tamaru

Author : Yoshinao Tamaru
Publisher : John Wiley & Sons
Page : 346 pages
File Size : 52,5 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527604234

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Modern Organonickel Chemistry by Yoshinao Tamaru Pdf

Organonickel chemistry plays an increasingly important role in organic chemistry, and interest in this topic is now just as keen as in organopalladium chemistry. While there are numerous, very successful books on the latter, a book specializing in organonickel chemistry is long overdue. Edited by one of the leading experts in the field, this volume covers the many discoveries made over the past 30 years, and previously scattered throughout the literature. Active researchers working at the forefront of organonickel chemistry provide a comprehensive review of the topic, including cross-coupling reactions, asymmetric synthesis and heterogeneous catalysis reaction types. A must-have for both organometallic chemists and synthetic organic chemists.

Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Bimal Krishna Banik

Author : Bimal Krishna Banik
Publisher : Elsevier
Page : 699 pages
File Size : 43,7 Mb
Release : 2024-05-31
Category : Science
ISBN : 9780443161674

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Green Approaches in Medicinal Chemistry for Sustainable Drug Design by Bimal Krishna Banik Pdf

Extensive experimentation and high failure rates are a well-recognized downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry 2e reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry, Second Edition encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work. This second volume of the second edition includes the development of nanoparticles and nanocomposites, as well as the application of ultrasound and microwave-induced methods; studies solventless synthesis; defines the role of steroids; studies reactions in aqueous solution; identifies enzyme-mediated reactions; investigates ionic liquids and deep eutectic solvents; explores natural products; investigates solid supports; realizes the effects of salts; focuses on combinatorial chemistry; develops one-pot methods; analyzes multi-component reactions; investigates dipole moment values; and examines computer-assisted methods. Highlights the need for adoption of sustainable and green chemistry pathways in drug development Reveals risk factors associated with the drug development process and the ways sustainable approaches can help address these Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability

Direct Construction Of D3 Methylated All Carbon Quaternary Stereocenters Through Carbene Catalyzed Desymmetrization

Direct construction of d3-methylated all-carbon quaternary stereocenters through carbene-catalyzed desymmetrization by Jingcheng Guo,Ye Zhang,Xiaoxiang Zhang,Zhenqian Fu Pdf

Total Synthesis of Natural Products by Jie Jack Li,E.J. Corey Pdf

N-Heterocyclic Carbenes in Organocatalysis by Akkattu T. Biju Pdf

Catalytic Asymmetric Synthesis by Takahiko Akiyama,Iwao Ojima Pdf

Applications of Transition Metal Catalysis in Drug Discovery and Development by Matthew L. Crawley,Barry M. Trost Pdf

C-H Activation for Asymmetric Synthesis by Françoise Colobert,Joanna Wencel-Delord Pdf

Advanced Organic Chemistry by Francis A. Carey,Richard J. Sundberg Pdf

Practical Synthetic Organic Chemistry by Stéphane Caron Pdf

Asymmetric Organocatalysis Combined with Metal Catalysis by Bruce A. Arndtsen,Liu-Zhu Gong Pdf

Organocatalysis by Manfred Reetz,Benjamin List,Stefan Jaroch,Hilmar Weinmann Pdf

Asymmetric Phase Transfer Catalysis by Keiji Maruoka Pdf

Progress in the Chemistry of Organic Natural Products 114 by A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi,Yoshinori Asakawa,Ji-Kai Liu Pdf

Name Reactions in Heterocyclic Chemistry by Jie Jack Li Pdf

Modern Organonickel Chemistry by Yoshinao Tamaru Pdf

Green Approaches in Medicinal Chemistry for Sustainable Drug Design by Bimal Krishna Banik Pdf

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