Disease And The Hippo Pathway

Author : Carsten Gram Hansen
Publisher : MDPI
Page : 226 pages
File Size : 41,7 Mb
Release : 2019-11-22
Category : Science
ISBN : 9783039217762

Get Book

Disease and the Hippo Pathway by Carsten Gram Hansen Pdf

The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies.

Author : Carsten Gram Hansen
Publisher : Unknown
Page : 226 pages
File Size : 43,5 Mb
Release : 2019
Category : Biology (General)
ISBN : 3039217771

Get Book

Disease and the Hippo Pathway: Cellular and Molecular Mechanisms by Carsten Gram Hansen Pdf

The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies.

Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Publisher : Springer
Page : 330 pages
File Size : 51,9 Mb
Release : 2015-10-13
Category : Science
ISBN : 9784431556510

Get Book

Innovative Medicine by Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto Pdf

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Author : Alexander Hergovich
Publisher : Humana Press
Page : 374 pages
File Size : 44,8 Mb
Release : 2019-02-04
Category : Science
ISBN : 149398909X

Get Book

The Hippo Pathway by Alexander Hergovich Pdf

This detailed book covers numerous expert methodologies to examine Hippo signaling on the structural, molecular, cellular, and organismal level. Beginning with a section on Drosophila genetics, the volume continues with parts exploring molecular and cell biological studies of the Hippo pathway, the use of structural biology and biochemistry, and a brief look at the Hippo pathway in mouse models. Written for the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, The Hippo Pathway: Methods and Protocols equips newcomers and specialists alike with key methodologies to accurately define the status of Hippo signaling in their experimental settings.

Author : Moshe Oren,Yael Aylon
Publisher : Unknown
Page : 362 pages
File Size : 42,9 Mb
Release : 2013-04-30
Category : Electronic
ISBN : 1461462215

Get Book

The Hippo Signaling Pathway and Cancer by Moshe Oren,Yael Aylon Pdf

Author : Mousumi Mutsuddi,Ashim Mukherjee
Publisher : Springer Nature
Page : 470 pages
File Size : 45,5 Mb
Release : 2019-12-05
Category : Medical
ISBN : 9789811322181

Get Book

Insights into Human Neurodegeneration: Lessons Learnt from Drosophila by Mousumi Mutsuddi,Ashim Mukherjee Pdf

This book is aimed at generating an updated reservoir of scientific endeavors undertaken to unravel the complicated yet intriguing topic of neurodegeneration. Scientists from Europe, USA and India who are experts in the field of neurodegenerative diseases have contributed to this book. This book will help readers gain insight into the recent knowledge obtained from Drosophila model, in understanding the molecular mechanisms underlying neurodegenerative disorders and also unravel novel scopes for therapeutic interventions. Different methodologies available to create humanized fly models that faithfully reflects the pathogenicities associated with particular disorders have been described here. It also includes information on the exciting area of neural stem cells. A brief discussion on neurofibrillary tangles, precedes the elaborate description of lessons learnt from Drosophila about Alzheimer's, Parkinson’s, Spinomuscular Atrophy, Huntington’s diseases, RNA expansion disorders and Hereditary Spastic Paraplegia. We have concluded the book with the use of Drosophila for identifying pharmacological therapies for neurodegenerative disorders. The wide range of topics covered here will not only be relevant for beginners who are new to the concept of the extensive utility of Drosophila as a model to study human disorders; but will also be an important contribution to the scientific community, with an insight into the paradigm shift in our understanding of neurodegenerative disorders. Completed with informative tables and communicative illustrations this book will keep the readers glued and intrigued. We have comprehensively anthologized the lessons learnt on neurodegeneration from Drosophila and have thus provided an insight into the multidimensional aspects of pathogenicities of majority of the neurodegenerative disorders.

Author : Moshe Oren,Yael Aylon
Publisher : Springer Science & Business Media
Page : 345 pages
File Size : 44,8 Mb
Release : 2013-03-19
Category : Medical
ISBN : 9781461462200

Get Book

The Hippo Signaling Pathway and Cancer by Moshe Oren,Yael Aylon Pdf

​​The Hippo signaling pathway is rapidly gaining recognition as an important player in organ size control and tumorigenesis, and many leading scientists are showing increased interest in this growing field and it's relation to cancer. The chapters in this volume cover virtually all aspects of tumor biology, because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few; Ras, Wnt, TGFbeta and p53. Moreover, Hippo signaling is not solely involved in regulating “classic” tumor characteristics such as cell proliferation, survival and growth, but is also diversely involved in cell-autonomous and non-cell-autonomous differentiation, migration and organ size control. The primary audience are researchers interested in basic science in the areas of tumor suppression, cell cycle and size regulation, development and differentiation.

Author : Anonim
Publisher : Academic Press
Page : 498 pages
File Size : 43,7 Mb
Release : 2017-02-22
Category : Science
ISBN : 9780128016244

Get Book

Protein Kinases in Development and Disease by Anonim Pdf

Protein Kinases in Development and Disease discusses and reviews important, but often neglected, kinases. A good representation of current model organisms from plants and C. elegans to mice are used as the basis to illustrate how we can use our understanding of normal development to learn about disease. Reviews kinases, the fundamental regulators of most biological processes that have key roles in the development of all organisms Includes a broad scope of topics that are addressed Allows researchers and newcomers to this research area to gain a thorough picture of the current knowledge

Author : Morteza Jalali,Francesca Yvonne Louise Saldanha,Mehdi Jalali
Publisher : Academic Press
Page : 382 pages
File Size : 52,5 Mb
Release : 2017-03-31
Category : Science
ISBN : 9780128030783

Get Book

Basic Science Methods for Clinical Researchers by Morteza Jalali,Francesca Yvonne Louise Saldanha,Mehdi Jalali Pdf

Basic Science Methods for Clinical Researchers addresses the specific challenges faced by clinicians without a conventional science background. The aim of the book is to introduce the reader to core experimental methods commonly used to answer questions in basic science research and to outline their relative strengths and limitations in generating conclusive data. This book will be a vital companion for clinicians undertaking laboratory-based science. It will support clinicians in the pursuit of their academic interests and in making an original contribution to their chosen field. In doing so, it will facilitate the development of tomorrow’s clinician scientists and future leaders in discovery science. Serves as a helpful guide for clinical researchers who lack a conventional science background Organized around research themes pertaining to key biological molecules, from genes, to proteins, cells, and model organisms Features protocols, techniques for troubleshooting common problems, and an explanation of the advantages and limitations of a technique in generating conclusive data Appendices provide resources for practical research methodology, including legal frameworks for using stem cells and animals in the laboratory, ethical considerations, and good laboratory practice (GLP)

Author : H.M. Pinedo,J. Verweij
Publisher : Springer Science & Business Media
Page : 143 pages
File Size : 46,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461317579

Get Book

Treatment of Soft Tissue Sarcomas by H.M. Pinedo,J. Verweij Pdf

One of the major advances of the last decade concerning the treatment of patients with soft tissue sarcomas is that an increased number of patients are being discussed in multidisciplinary teams prior to the initial treatment. The present volume on soft tissue sarcomas in the series Cancer Treatment and Research reflects the multidisciplinary approach with a focus on recent developments. The availability of new histopathologic techniques has reduced the number of unclassified sarcomas and has furhter increased the importance of the histo pathologist in providing estimates of the prognosis of the patient as well as data for the planning of treatment strategy. Further data for this strategy will be provided by diagnostic imaging. In this field, the role of magnetic reson ance imaging has been further defined. Of utmost importance is the recent trend toward consensus in staging. The modification of the staging system of the American Joint Commission for Cancer Staging and End Results Report ing brings the possibility of a single staging system within reach in the next decade. As surgery still provides the only chance for cure, the importance of being the most sparing as possible is obvious. For this reason, radiotherapy has been applied with success. The introduction of relatively new radiation tech niques is therefore being observed with interest.

Author : Antonietta G. Gravina,Fabiana Zingone
Publisher : Frontiers Media SA
Page : 120 pages
File Size : 41,8 Mb
Release : 2022-08-17
Category : Medical
ISBN : 9782889767717

Get Book

Challenges in Inflammatory Bowel Disease: Current, Future and Unmet Needs by Antonietta G. Gravina,Fabiana Zingone Pdf

Author : Jeffrey Raizer,Andrew Parsa
Publisher : Springer
Page : 184 pages
File Size : 43,6 Mb
Release : 2014-12-02
Category : Medical
ISBN : 9783319120485

Get Book

Current Understanding and Treatment of Gliomas by Jeffrey Raizer,Andrew Parsa Pdf

This book reviews the significant advances in our understanding of glioma biology that have been achieved during the past decade and describes in detail the resultant new approaches to treatment. Improvements in surgical techniques, radiation therapy, and chemotherapy are comprehensively covered, with discussion of their impact in decreasing patient morbidity and increasing survival. In addition, individual chapters are devoted specifically to current treatment for low-grade gliomas, anaplastic gliomas, and glioblastoma multiforme. Other topics addressed include treatment of the elderly patient, investigating emerging therapies from small molecules to immunotherapy and palliative care. This timely book will be a valuable source of up-to-date information for practitioners and will also be of interest to researchers.

Author : Nan-Shan Chang,Rongtuan Lin,Chun-I Sze,Rami I. Aqeilan
Publisher : Frontiers Media SA
Page : 138 pages
File Size : 42,6 Mb
Release : 2019-11-18
Category : Electronic
ISBN : 9782889631773

Get Book

WW Domain Proteins in Signaling, Cancer Growth, Neural Diseases, and Metabolic Disorders by Nan-Shan Chang,Rongtuan Lin,Chun-I Sze,Rami I. Aqeilan Pdf

Author : Zhaocai Zhou,Zengqiang Yuan,Wanjin Hong,Wenqi Wang
Publisher : Frontiers Media SA
Page : 106 pages
File Size : 46,9 Mb
Release : 2021-09-14
Category : Science
ISBN : 9782889713073

Get Book

A Hippo's View: From Molecular Basis to Translational Medicine by Zhaocai Zhou,Zengqiang Yuan,Wanjin Hong,Wenqi Wang Pdf

Author : Anthony S. Zannas,George P. Chrousos,Murray B. Stein
Publisher : Frontiers Media SA
Page : 142 pages
File Size : 44,7 Mb
Release : 2020-04-20
Category : Electronic
ISBN : 9782889636532

Get Book

Molecular Mechanisms in Stress and Trauma Related Disorders by Anthony S. Zannas,George P. Chrousos,Murray B. Stein Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.