Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 50,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Molecular Biology of The Cell
Bruce Alberts
Dna Damage And Double Strand Breaks
Dna Damage And Double Strand Breaks Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Dna Damage And Double Strand Breaks book. This book definitely worth reading, it is an incredibly well-written.
DNA Damage and Double Strand Breaks
Anonim
Author : Anonim
Publisher : Elsevier
Page : 166 pages
File Size : 43,7 Mb
Release : 2022-11-03
Category : Science
ISBN : 9780323994057
DNA Damage and Double Strand Breaks by Anonim Pdf
DNA Damage and Double Strand Breaks, Volume 51 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters that provide an update on female and male genital schistosomiasis and a call to integrate efforts to escalate diagnosis, treatment and awareness in endemic and non-endemic settings, vertebrates as uninfected disseminators of helminth eggs and larvae, and combatting anthelmintic resistance in ruminants. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series
DNA Repair and Mutagenesis
Errol C. Friedberg,Graham C. Walker,Wolfram Siede,Richard D. Wood
Author : Errol C. Friedberg,Graham C. Walker,Wolfram Siede,Richard D. Wood
Publisher : American Society for Microbiology Press
Page : 2587 pages
File Size : 51,8 Mb
Release : 2005-11-22
Category : Science
ISBN : 9781555813192
DNA Repair and Mutagenesis by Errol C. Friedberg,Graham C. Walker,Wolfram Siede,Richard D. Wood Pdf
An essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.
DNA
Payam Behzadi
Author : Payam Behzadi
Publisher : BoD – Books on Demand
Page : 235 pages
File Size : 55,8 Mb
Release : 2021-05-19
Category : Medical
ISBN : 9781838810931
DNA by Payam Behzadi Pdf
DNA is the most important biomolecule ever discovered. Indeed, this molecule bears genetic information from one generation to another. In this regard, DNA bases have a key role in transferring genetic information and data safely. However, there are cellular, genetic, and environmental factors that may damage the different parts of DNA molecules. These damages may result in mutations and cell death. As such, several DNA repair mechanisms have evolved. Over three sections, this book examines many of these mechanisms.
Silencing, Heterochromatin and DNA Double Strand Break Repair
Kevin D. Mills
Author : Kevin D. Mills
Publisher : Springer Science & Business Media
Page : 129 pages
File Size : 44,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461543619
Silencing, Heterochromatin and DNA Double Strand Break Repair by Kevin D. Mills Pdf
The field of DNA repair is vast and advancing rapidly. Recent investigations have begun to focus on the involvement of chromatin in the repair of broken DNA. Although I have no doubt that many breakthroughs in our understanding of chromatin, chromatin regulation, and DNA repair lie in our future, presently this is a new line in inquiry. As such there are many, many unanswered questions. Indeed, most of the correct questions have probably not even been asked yet. Here I have attempted to present a review of some of the current body of knowledge that may prove relevant to understanding the role of chromatin in DNA repair. Because the volume of research, and the relevant findings, come from a staggering array of labs, systems, and ideas I have focused primarily on findings developed from the study of the budding yeast Saccharomyces cerevisiae. Unfortunately, this means that I have left out a great deal of information. It is my hope, however, that the information I do detail, particularly in Chapter 1, will give a flavor for the scope of the problem and perhaps highlight some of the interesting directions this field is taking, or may one day take. I would also point out that the primary research that is presented herein is not in any way meant to represent the comprehensive scope of research being performed. To understand DNA repair will require investigation from innumerable labs, performed by innumerable researchers, moving in unexpected directions.
Human Radiosensitivity
Anonim
Author : Anonim
Publisher : Unknown
Page : 152 pages
File Size : 45,5 Mb
Release : 2013
Category : Ionizing radiation
ISBN : 0859517403
Human Radiosensitivity by Anonim Pdf
DNA Repair
Inna Kruman
Author : Inna Kruman
Publisher : BoD – Books on Demand
Page : 652 pages
File Size : 41,7 Mb
Release : 2011-11-07
Category : Medical
ISBN : 9789533076973
DNA Repair by Inna Kruman Pdf
The book consists of 31 chapters, divided into six parts. Each chapter is written by one or several experts in the corresponding area. The scope of the book varies from the DNA damage response and DNA repair mechanisms to evolutionary aspects of DNA repair, providing a snapshot of current understanding of the DNA repair processes. A collection of articles presented by active and laboratory-based investigators provides a clear understanding of the recent advances in the field of DNA repair.
Protecting the Code: DNA Double-Strand Break Repair Pathway Choice
David Maranon,Judit Jimenez Sainz,Sylvie M. Noordermeer,Matthias Altmeyer,Jenny Kaur Singh
Author : David Maranon,Judit Jimenez Sainz,Sylvie M. Noordermeer,Matthias Altmeyer,Jenny Kaur Singh
Publisher : Frontiers Media SA
Page : 258 pages
File Size : 44,8 Mb
Release : 2023-03-31
Category : Science
ISBN : 9782832500477
Protecting the Code: DNA Double-Strand Break Repair Pathway Choice by David Maranon,Judit Jimenez Sainz,Sylvie M. Noordermeer,Matthias Altmeyer,Jenny Kaur Singh Pdf
Regulation of DNA Double Strand Break Repair by Local Chromatin Architecture
Sérgio Fernandes de Almeida,Pablo Huertas,Gaelle Legube
Author : Sérgio Fernandes de Almeida,Pablo Huertas,Gaelle Legube
Publisher : Frontiers Media SA
Page : 117 pages
File Size : 45,6 Mb
Release : 2020-09-02
Category : Science
ISBN : 9782889639687
Regulation of DNA Double Strand Break Repair by Local Chromatin Architecture by Sérgio Fernandes de Almeida,Pablo Huertas,Gaelle Legube Pdf
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Grappling with the Multifaceted World of the DNA Damage Response
Antonio Porro
Author : Antonio Porro
Publisher : Frontiers Media SA
Page : 308 pages
File Size : 54,6 Mb
Release : 2017-01-10
Category : Electronic book
ISBN : 9782889450572
Grappling with the Multifaceted World of the DNA Damage Response by Antonio Porro Pdf
DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full double-strand breaks (DSBs). If DNA injuries are mis-repaired or unrepaired, they may ultimately result in mutations or wider-scale genome aberrations that threaten cell homeostasis. Consequently, the cells elicit an elaborate signalling network, known as DNA damage response (DDR), to detect and repair these cytotoxic lesions. This Research Topic was aimed at comprehensive investigations of basic and novel mechanisms that underlie the DNA damage response in eukaryotes.
In Situ Detection of DNA Damage
Vladimir V. Didenko
Author : Vladimir V. Didenko
Publisher : Springer Science & Business Media
Page : 314 pages
File Size : 50,8 Mb
Release : 2008-02-05
Category : Medical
ISBN : 9781592591794
In Situ Detection of DNA Damage by Vladimir V. Didenko Pdf
Detection and analysis of DNA damage is of critical importance in a variety of biological disciplines studying apoptosis, cell cycle and cell di- sion, carcinogenesis, tumor growth, embryogenesis and aging, neu- degenerative and heart diseases, anticancer drug development, environmental and radiobiological research, and others. Individual cells within the same tissue or in cell culture may vary in the extent of their DNA damage and, consequently, can display different re- tions to it. These differences between individual cells in the same cell popu- tion are detected using in situ approaches. In situ is a Latin term meaning “on site” or “in place.” It is used to denote the processes occurring or detected in their place of origin. In mole- lar and cell biology this usually refers to undisrupted mounted cells or tissue sections. In that meaning “in situ” is used as part of the terms “in situ PCR,” “in situ transcription,” “in situ hybridization,” “in situ end labeling,” and “in situ ligation.” Sometimes the “in situ” term is applied at the subcellular level to cells disrupted in the process of analysis, for example, in the detection of specific sequences in chromosomes using fluorescent in situ hybridization (FISH). Historically, the term was used primarily in methods dealing with nucleic acids.
Maintenance of Genome Integrity: DNA Damage Sensing, Signaling, Repair and Replication in Plants
Alma Balestrazzi,V. Mohan Murali Achary,Anca Macovei,Kaoru Okamoto Yoshiyama,Ayako N Sakamoto
Author : Alma Balestrazzi,V. Mohan Murali Achary,Anca Macovei,Kaoru Okamoto Yoshiyama,Ayako N Sakamoto
Publisher : Frontiers Media SA
Page : 131 pages
File Size : 43,5 Mb
Release : 2016-05-06
Category : Botany
ISBN : 9782889198207
Maintenance of Genome Integrity: DNA Damage Sensing, Signaling, Repair and Replication in Plants by Alma Balestrazzi,V. Mohan Murali Achary,Anca Macovei,Kaoru Okamoto Yoshiyama,Ayako N Sakamoto Pdf
Environmental stresses and metabolic by-products can severely affect the integrity of genetic information by inducing DNA damage and impairing genome stability. As a consequence, plant growth and productivity are irreversibly compromised. To overcome genotoxic injury, plants have evolved complex strategies relying on a highly efficient repair machinery that responds to sophisticated damage perception/signaling networks. The DNA damage signaling network contains several key components: DNA damage sensors, signal transducers, mediators, and effectors. Most of these components are common to other eukaryotes but some features are unique to the plant kingdom. ATM and ATR are well-conserved members of PIKK family, which amplify and transduce signals to downstream effectors. ATM primarily responds to DNA double strand breaks while ATR responds to various forms of DNA damage. The signals from the activated transducer kinases are transmitted to the downstream cell-cycle regulators, such as CHK1, CHK2, and p53 in many eukaryotes. However, plants have no homologue of CHK1, CHK2 nor p53. The finding of Arabidopsis transcription factor SOG1 that seems functionally but not structurally similar to p53 suggests that plants have developed unique cell cycle regulation mechanism. The double strand break repair, recombination repair, postreplication repair, and lesion bypass, have been investigated in several plants. The DNA double strand break, a most critical damage for organisms are repaired non-homologous end joining (NHEJ) or homologous recombination (HR) pathway. Damage on template DNA makes replication stall, which is processed by translesion synthesis (TLS) or error-free postreplication repair (PPR) pathway. Deletion of the error-prone TLS polymerase reduces mutation frequencies, suggesting PPR maintains the stalled replication fork when TLS is not available. Unveiling the regulation networks among these multiple pathways would be the next challenge to be completed. Some intriguing issues have been disclosed such as the cross-talk between DNA repair, senescence and pathogen response and the involvement of non-coding RNAs in global genome stability. Several studies have highlighted the essential contribution of chromatin remodeling in DNA repair DNA damage sensing, signaling and repair have been investigated in relation to environmental stresses, seed quality issues, mutation breeding in both model and crop plants and all these studies strengthen the idea that components of the plant response to genotoxic stress might represent tools to improve stress tolerance and field performance. This focus issue gives researchers the opportunity to gather and interact by providing Mini-Reviews, Commentaries, Opinions, Original Research and Method articles which describe the most recent advances and future perspectives in the field of DNA damage sensing, signaling and repair in plants. A comprehensive overview of the current progresses dealing with the genotoxic stress response in plants will be provided looking at cellular and molecular level with multidisciplinary approaches. This will hopefully bring together valuable information for both plant biotechnologists and breeders.
DNA Damage and Double Strand Breaks Part B
Anonim
Author : Anonim
Publisher : Academic Press
Page : 0 pages
File Size : 54,7 Mb
Release : 2022-11-17
Category : Science
ISBN : 0323993982
DNA Damage and Double Strand Breaks Part B by Anonim Pdf
Intersection of Iron and Lipid Metabolism, Volume 52 in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics relating to enzymes research.
The DNA Damage Response: Implications on Cancer Formation and Treatment
Kum Kum Khanna,Yosef Shiloh
Author : Kum Kum Khanna,Yosef Shiloh
Publisher : Springer Science & Business Media
Page : 450 pages
File Size : 54,5 Mb
Release : 2009-09-18
Category : Medical
ISBN : 9789048125616
The DNA Damage Response: Implications on Cancer Formation and Treatment by Kum Kum Khanna,Yosef Shiloh Pdf
The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving ?eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.
Selected Topics in DNA Repair
Clark Chen
Author : Clark Chen
Publisher : BoD – Books on Demand
Page : 586 pages
File Size : 53,5 Mb
Release : 2011-10-26
Category : Medical
ISBN : 9789533076065
Selected Topics in DNA Repair by Clark Chen Pdf
This book is intended for students and scientists working in the field of DNA repair, focusing on a number of topics ranging from DNA damaging agents and mechanistic insights to methods in DNA repair and insights into therapeutic strategies. These topics demonstrate how scientific ideas are developed, tested, dialogued, and matured as it is meant to discuss key concepts in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.
