Dopamine Receptor Agonists

Author : George Poste,Stanley T. Crooke
Publisher : Springer Science & Business Media
Page : 402 pages
File Size : 41,5 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781475703108

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Dopamine Receptor Agonists by George Poste,Stanley T. Crooke Pdf

Dopamine, in addition to its importance as a precursor of norepinephrine, is now known to be an important neurotransmitter in regulating functional activities in a number of major organ systems, including the central ner vous system. the cardiovascular system, the kidney, and the gut. Recent advances in our understanding of the functional role of dopamine, its mechanism of action and the pharmacology of dopaminergic agents have occurred on a broad front. The last few years have witnessed significant progress in the identification and classification of central and peripheral dopamine receptors and the factors that affect their responsiveness to inhibitory and stimulatory ligands. These advances have been paralleled by new insights into the contribution of alterations in dopaminergic reg ulation in causing disease and the utility of dopamine agonists and an tagonists as therapeutic modalities. This volume, the first in a series of publications arising from the annual Smith Kline and French Research Symposium on New Horizons in Therapeutics, provides a comprehensive survey of current research on peripheral dopamine receptors and the physiologic and therapeutic con sequences of stimulating pre-and postsynaptic dopamine receptors. Research in dopamine pharmacology mirrors the remarkable ad vances that are occurring in the field of pharmacology at large as a con sequence of the involvement of an ever-larger number of scientific dis ciplines in the study of drug action.

Author : Peter Jenner,R. Demirdamar
Publisher : IOS Press
Page : 200 pages
File Size : 42,7 Mb
Release : 1998
Category : Dopamine
ISBN : 9051992912

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Dopamine Receptor Subtypes by Peter Jenner,R. Demirdamar Pdf

Multiple subtypes of dopamine receptors exist in the brain. This volume reviews the characteristics of D-1, D-2, D-3 and D-4 receptors and describes the current concepts of their involvement in motor disorders and in the control of schizophrenia. Readers: the book will be of great interest to professionals in pharmacology, medicinal chemistry, neuroscience, cell biology and therapeutic applications in clinical medicine as antipsychotics, anti-Parkinson's disease and related areas.

Author : George Poste,Stanley T. Crooke
Publisher : Unknown
Page : 416 pages
File Size : 53,5 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 1475703112

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Dopamine Receptor Agonists by George Poste,Stanley T. Crooke Pdf

Author : George Breese
Publisher : Springer Science & Business Media
Page : 223 pages
File Size : 42,6 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781468451917

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Neurobiology of Central D1-Dopamine Receptors by George Breese Pdf

Our understanding of the functional mechanisms relating dopamine activity to normal and abnormal behavior has been turned "upside-down" by the recent developments described in the chapters of this volume. Heretofore, it was generally agreed that all of the pharmacological and behavioral properties ascribed to dopamine systems were mediated via activation or inhibition of the subtype of dopamine receptors termed D2. The properties of these receptors were first characterized in 1975 following their identification by receptor binding techniques utilizing 3H-butyrophenones, potent antipsychotic drugs, used in the treatment of schizophrenia. Although another subtype of dopamine receptor had already been identified a few years earlier, now termed the Dl receptor, its functional properties were unknow- other than the fact that it was associated with the activation of the enzyme adenylate cyclase. Our absence of knowledge of the behavioral functions of this receptor stemmed primarily from the lack of selective agonist and antagonists for DI receptors - drugs which did not also interact with D2 receptors. Selective agents for D2 receptors did exist and hence the behavioral roles of D2 receptors were easily ascribed. The work described in this text is primarily stimulated by the development of two selective Dl receptor drugs - the antagonist SCH 23390 and the agonist SKF 38393. The studies described herein clearly show that D1 receptors do indeed have many behavioral functions, on the surface often similar to those responses mediated by D2 receptors.

Author : Ian Creese,Claire M. Fraser
Publisher : Unknown
Page : 280 pages
File Size : 55,7 Mb
Release : 1987
Category : Dopamine
ISBN : UOM:39015012463470

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Dopamine Receptors by Ian Creese,Claire M. Fraser Pdf

"Dopamine Receptors" precisely chronicles the research being done on dopamine receptors, appraises the techniques and strategies being used, and provides thoughts on future trends. This volume is unique for its multidisciplinary coverage of dopamine receptors, with contributions ranging from physiological and behavioral studies to the biological characterization of dopamine receptors. Examines classifications of receptor subtypes based on ligand binding and adenylate cyclase studies, biochemical analysis, electrophysiological observations and autoradiography. This book also summarizes dopamine receptor involvement in a number of diseases and covers the role of autoreceptors in modulation of dopaminergic systems.

Author : P. Beart
Publisher : Springer
Page : 408 pages
File Size : 46,8 Mb
Release : 1988-06-18
Category : Medical
ISBN : 9781349100477

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Dopaminergic Neurons by P. Beart Pdf

The proceedings of the 1987 IUPHAR symposium held in Sydney, Australia are fully documented. Over 100 scientists from 16 countries attended the three-day conference, during which time 68 multi-disciplinary presentations concerning dopamine systems and their regulation were made.

Author : Anonim
Publisher : Springer Science & Business Media
Page : 62 pages
File Size : 46,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642738975

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The Role of Brain Dopamine by Anonim Pdf

As in other volumes in the series, this newest volume conveys up-to-date knowledge in a clear and straightforward manner. It begins with a survey of the neurobiological functions of the brain, with the emphasis on Parkinson's disease. This is followed by a presentation of the role of dopamine in the regulation of human anterior pituitary function. The final two chapters concentrate on the dopamine receptors: first, the binding sites are characterized and the biochemical and physiological consequences of dopamine-receptor stimulation are discussed and, finally, there is a report on the topology of a dopamine-receptor model that can account comprehensively for agonists and antagonists.

Author : Gaetano Di Chiara
Publisher : Springer Science & Business Media
Page : 355 pages
File Size : 42,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642560514

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Dopamine in the CNS I by Gaetano Di Chiara Pdf

With contributions by numerous experts

Author : János Fischer,Christian Klein,Wayne E. Childers
Publisher : John Wiley & Sons
Page : 317 pages
File Size : 40,9 Mb
Release : 2019-07-20
Category : Medical
ISBN : 9783527814718

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Successful Drug Discovery, Volume 4 by János Fischer,Christian Klein,Wayne E. Childers Pdf

Provides unique insider insight into the current drug development process, and what it takes to achieve success In this fourth volume in the series, inventors and primary developers of drugs that made it to the market continue telling the story of the drugs? discovery and development, and discuss the sometimes twisted route from the first drug candidate molecule to the final marketed one. Beginning with a general section addressing overarching topics for drug discovery, the book offers seven chapters that feature selected case studies describing recently introduced drugs or drug classes. These include small molecule drugs as well as biopharmaceuticals and range across different therapeutic fields. Together, they provide a representative cross-section of the present-day drug development effort. Successful Drug Discovery: Volume 4 covers trends in peptide-based drug discovery and the physicochemical properties of recently approved oral drugs. The section on drug class studies looks at antibody-drug conjugates and the discovery, evolution, and therapeutic potential of dopamine partial agonists. Featured case studies examine the discovery of Etelcalcetide for the treatment of secondary hyper-parathyroidism in patients with chronic kidney disease; the development of Lenvatinib Mesylate; the discovery and development of Venetoclax; and more. -Focuses on recently introduced drugs that have not been featured in any textbooks or general references, including Ocrelizumab, a new generation of anti-CD-20 mAb for the treatment of multiple sclerosis, and Venetoclax, a selective antagonist of BCL-2 -Features personal experiences of successful drug developers from industry and academia -Endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC) Successful Drug Discovery: Volume 4 provides a fascinating and informative look into the process of drug discovery and would be a great reference for those in the pharmaceutical industry, organic and pharmaceutical chemists, and lecturers in pharmacy.

Author : M. Kohsaka,T. Shohmori,Y. Tsukada
Publisher : Elsevier
Page : 438 pages
File Size : 41,6 Mb
Release : 2013-10-22
Category : Health & Fitness
ISBN : 9781483159317

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Advances in Dopamine Research by M. Kohsaka,T. Shohmori,Y. Tsukada Pdf

Advances in Dopamine Research documents the proceedings of a satellite symposium to the 8th International Congress of Pharmacology held in Okayama, Japan, July 1981. The importance of dopamine in brain function is reflected in this volume book by the chapters on the neurochemical, behavioral, neuroanatomical, and electrophysiological aspects of dopamine in the central nervous system. Dopamine receptor agonists and antagonists enjoy widespread use in the treatment of various brain disorders. A comprehensive account of research on the actions and mechanisms of action of drugs which affect central dopaminergic pathways is included in this volume. Also presented are accounts of the importance of dopamine and dopamine receptors in the periphery. It is hoped that this volume will be of interest to neuroscientists and pharmacologists, and indeed to all who are interested in clinical and scientific aspects of dopamine and other neurotransmitters.

Author : Antonius M. VanDongen
Publisher : CRC Press
Page : 350 pages
File Size : 54,8 Mb
Release : 2008-10-29
Category : Science
ISBN : 142004415X

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Biology of the NMDA Receptor by Antonius M. VanDongen Pdf

The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written by one of the world’s leading authorities on NMDA receptors, Biology of the NMDA Receptor brings together virtually all the players in this important field.

Author : Ruben Vardanyan,Victor Hruby
Publisher : Academic Press
Page : 868 pages
File Size : 53,5 Mb
Release : 2016-01-07
Category : Science
ISBN : 9780124115248

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Synthesis of Best-Seller Drugs by Ruben Vardanyan,Victor Hruby Pdf

Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation

Author : Nassir Ghaemi
Publisher : Oxford University Press, USA
Page : 601 pages
File Size : 44,8 Mb
Release : 2019-01-04
Category : Medical
ISBN : 9780199995486

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Clinical Psychopharmacology by Nassir Ghaemi Pdf

Clinical Psychopharmacology offers a comprehensive guide to clinical practice that explores two major aspects of the field: the clinical research that exists to guide clinical practice of psychopharmacology, and the application of that knowledge with attention to the individualized aspects of clinical practice. The text consists of 50 chapters, organized into 6 sections, focusing on disease-modifying effects, non-DSM diagnostic concepts, and essential facts about the most common drugs. This innovative book advocates a scientific and humanistic approach to practice and examines not only the benefits, but also the harms of drugs. Providing a solid foundation of knowledge and a great deal of practical information, this book is a valuable resource for practicing psychiatrists, psychiatric nurse practitioners, medical students and trainees in psychiatry, as well as pharmacists.

Author : A. Lieberman,X. Lataste
Publisher : Parthenon Publishing
Page : 126 pages
File Size : 50,6 Mb
Release : 1989
Category : Medical
ISBN : UCLA:L0054954672

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Parkinson's Disease by A. Lieberman,X. Lataste Pdf

Author : John L. Waddington
Publisher : Unknown
Page : 312 pages
File Size : 44,9 Mb
Release : 1993
Category : Medical
ISBN : UOM:39015028912643

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D1:D2 Dopamine Receptor Interactions by John L. Waddington Pdf

This volume presents up-to-date comprehensive reviews of neuroscience research and theory on the fundamental interactions between the D1 and D2 dopamine receptor subtypes at numerous levels of investigation-from molecular biology and neuroanatomy, through electrophysiology, to the psychopharmacology of multiple forms of behavior, putative clinical significance, and therapeutic potential. This volume seeks to stand as a reference source on the evolution of the concept of D1: D2 interactions, on their substrates and psychopharmacological roles and, in such a continually evolving field, to look to the future. The Neuroscience Perspectives series aims to provide an all-round view of a current topic of great interest in neuroscience from the biochemical, pharmacological, and physiological standpoints together with the potential therapeutic applications. * SPECIAL FEATURES: * This is the ninth in Neuroscience Perspectives. * A Volume in Neuroscience Perspectives following series aim of providing all-round view of a current topic of great interest in Neuroscience from the biochemical, pharmacological and physiological standpoints together with the potential therapeutic applications. * The brain dopamine receptor has been the subject of intense interest for the past ten years owing to its involvement in motor and psychotic conditions. It is the target for the development of potential new drugs for eg. Schizophrenia and Parkinsons Diseases. Two subtypes of receptor have been found (D1 and D2). This book, edited by a respected expert in the field, examines the history of the topic, biochemistry, molecular biology and mode of interaction of the subtypes, and the therapeutic potential of the scientific discoveries, in the format of Neuroscience Perspectives. An issue of Nature in October 1990 led with the reported discovery of a D3 receptor. The implications of this for future research will be discussed in the final chapter.