Synthesis Of Best Seller Drugs

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Synthesis of Best-Seller Drugs

Ruben Vardanyan,Victor Hruby
Synthesis of Best Seller Drugs Book PDF

Author : Ruben Vardanyan,Victor Hruby
Publisher : Academic Press
Page : 868 pages
File Size : 44,5 Mb
Release : 2016-01-07
Category : Science
ISBN : 9780124115248

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Synthesis of Best-Seller Drugs by Ruben Vardanyan,Victor Hruby Pdf

Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation

The Art of Drug Synthesis

Douglas S. Johnson,Jie Jack Li
The Art of Drug Synthesis Book PDF

Author : Douglas S. Johnson,Jie Jack Li
Publisher : John Wiley & Sons
Page : 350 pages
File Size : 41,8 Mb
Release : 2013-02-26
Category : Science
ISBN : 9781118678466

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The Art of Drug Synthesis by Douglas S. Johnson,Jie Jack Li Pdf

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

Synthesis of Essential Drugs

Ruben Vardanyan,Victor Hruby
Synthesis of Essential Drugs Book PDF

Author : Ruben Vardanyan,Victor Hruby
Publisher : Elsevier
Page : 634 pages
File Size : 55,7 Mb
Release : 2006-03-10
Category : Medical
ISBN : 008046212X

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Synthesis of Essential Drugs by Ruben Vardanyan,Victor Hruby Pdf

Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO’s Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types * Includes synonyms * Includes over 2300 references

An Introduction to Drug Synthesis

Graham L. Patrick
An Introduction to Drug Synthesis Book PDF

Author : Graham L. Patrick
Publisher : Oxford University Press, USA
Page : 587 pages
File Size : 43,8 Mb
Release : 2015
Category : Science
ISBN : 9780198708438

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An Introduction to Drug Synthesis by Graham L. Patrick Pdf

'Introduction to Drug Synthesis' explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.

Top Drugs

John Saunders
Top Drugs Book PDF

Author : John Saunders
Publisher : Unknown
Page : 91 pages
File Size : 42,8 Mb
Release : 2011
Category : Synthetic drugs
ISBN : 0191848603

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Top Drugs by John Saunders Pdf

Many of today's best selling drugs are first made in the chemical laboratory on a very small scale many years before they enter the market place. During the intervening period, organic chemists investigate alternative methods both to improve the overall yield of the process and to ensure that it operates safely on a manufacturing scale. This book describes how each drug works and then reviews the most efficient routes to their synthesis.

Contemporary Drug Synthesis

Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth
Contemporary Drug Synthesis Book PDF

Author : Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth
Publisher : John Wiley & Sons
Page : 238 pages
File Size : 44,5 Mb
Release : 2004-12-27
Category : Science
ISBN : 9780471686736

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Contemporary Drug Synthesis by Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth Pdf

An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

Pharmaceutical Process Chemistry for Synthesis

Peter J. Harrington
Pharmaceutical Process Chemistry for Synthesis Book PDF

Author : Peter J. Harrington
Publisher : John Wiley & Sons
Page : 815 pages
File Size : 42,9 Mb
Release : 2011-02-23
Category : Science
ISBN : 9780470922866

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Pharmaceutical Process Chemistry for Synthesis by Peter J. Harrington Pdf

There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

Fluorine In Pharmaceutical And Medicinal Chemistry: From Biophysical Aspects To Clinical Applications

Gouverneur Veronique,Muller Klaus
Fluorine In Pharmaceutical And Medicinal Chemistry From Biophysical Aspects To Clinical Applications Book PDF

Author : Gouverneur Veronique,Muller Klaus
Publisher : World Scientific
Page : 572 pages
File Size : 51,6 Mb
Release : 2012-04-26
Category : Science
ISBN : 9781908977892

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Fluorine In Pharmaceutical And Medicinal Chemistry: From Biophysical Aspects To Clinical Applications by Gouverneur Veronique,Muller Klaus Pdf

Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging.This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For examples, the reader will discover how fluorine has found its place as a key element improving drug efficacy, with reference to some of the best-selling drugs on the market. Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging./a

An Introduction to Drug Synthesis

Graham L. Patrick
An Introduction to Drug Synthesis Book PDF

Author : Graham L. Patrick
Publisher : Unknown
Page : 128 pages
File Size : 41,7 Mb
Release : 2015
Category : Drugs
ISBN : 0191073474

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An Introduction to Drug Synthesis by Graham L. Patrick Pdf

An Introduction to Drug Synthesis explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.

Chiral Drugs

Guo-Qiang Lin,Qi-Dong You,Jie-Fei Cheng
Chiral Drugs Book PDF

Author : Guo-Qiang Lin,Qi-Dong You,Jie-Fei Cheng
Publisher : John Wiley & Sons
Page : 469 pages
File Size : 41,5 Mb
Release : 2011-08-08
Category : Science
ISBN : 9781118075630

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Chiral Drugs by Guo-Qiang Lin,Qi-Dong You,Jie-Fei Cheng Pdf

An integrated view of chiral drugs from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies asymmetric synthesis, biocatalytic process, and chiral resolution to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective and safer drugs.

Top Drugs

Jie Jack Li
Top Drugs Book PDF

Author : Jie Jack Li
Publisher : Oxford University Press
Page : 240 pages
File Size : 51,7 Mb
Release : 2015-07-31
Category : Medical
ISBN : 9780199362592

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Top Drugs by Jie Jack Li Pdf

Drugs like Lipitor, Plavix, Taxol, and Zoloft are integral in today's medicinal world. These widely used products save lives and improve the quality of lives, playing a crucial role in everything from cholesterol management to cancer treatment. These advances in medicine were brought into existence after nuanced process of creation, featuring a wide range of chemical and pharmacological experimentation and discovery. Top Drugs: Their History, Pharmacology, and Synthesis provides an in-depth study on ten prominent drugs, outlining the chemistry behind each one's creation. Jie Jack Li, a medicinal chemist and an expert on drug discovery, offers a thorough analysis of the landscape of current drug development. The comprehensive text is divided by health issues, including cardiovascular, cancer, metabolic diseases, and infectious diseases. Each section features individual chapters on significant drugs, outlining the chemistry and history of the drug's discovery. Li begins each chapter with the product's history, providing necessary context. Li then proceeds to describe the mechanism of action, structure-activity relationship (SAR), bioavailability, metabolism, toxicology, the discovery route, and the process route. Top Drugs: Their History, Pharmacology, and Synthesis will acclimate students, scientists, and interested laypersons to the world of chemistry and drug discovery.

Molecules and Medicine

E. J. Corey,Barbara Czakó,László Kürti
Molecules and Medicine Book PDF

Author : E. J. Corey,Barbara Czakó,László Kürti
Publisher : John Wiley & Sons
Page : 272 pages
File Size : 49,6 Mb
Release : 2012-02-28
Category : Science
ISBN : 9781118361733

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Molecules and Medicine by E. J. Corey,Barbara Czakó,László Kürti Pdf

Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas.

The Role of Natural Products in Drug Discovery

J. Mulzer,R. Bohlmann
The Role of Natural Products in Drug Discovery Book PDF

Author : J. Mulzer,R. Bohlmann
Publisher : Springer Science & Business Media
Page : 363 pages
File Size : 40,6 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9783662040423

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The Role of Natural Products in Drug Discovery by J. Mulzer,R. Bohlmann Pdf

Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.

Strategies for Organic Drug Synthesis and Design

Daniel Lednicer
Strategies for Organic Drug Synthesis and Design Book PDF

Author : Daniel Lednicer
Publisher : John Wiley & Sons
Page : 700 pages
File Size : 40,6 Mb
Release : 2009-03-04
Category : Science
ISBN : 0470399597

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Strategies for Organic Drug Synthesis and Design by Daniel Lednicer Pdf

This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.

Lead Optimization for Medicinal Chemists

Florencio Zaragoza Dörwald
Lead Optimization for Medicinal Chemists Book PDF

Author : Florencio Zaragoza Dörwald
Publisher : John Wiley & Sons
Page : 627 pages
File Size : 42,8 Mb
Release : 2013-02-04
Category : Science
ISBN : 9783527645657

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Lead Optimization for Medicinal Chemists by Florencio Zaragoza Dörwald Pdf

Small structural modifications can significantly affect the pharmacokinetic properties of drug candidates. This book, written by a medicinal chemist for medicinal chemists, is a comprehensive guide to the pharmacokinetic impact of functional groups, the pharmacokinetic optimization of drug leads, and an exhaustive collection of pharmacokinetic data, arranged according to the structure of the drug, not its target or indication. The historical origins of most drug classes and general aspects of modern drug discovery and development are also discussed. The index contains all the drug names and synonyms to facilitate the location of any drug or functional group in the book. This compact working guide provides a wealth of information on the ways small structural modifications affect the pharmacokinetic properties of organic compounds, and offers plentiful, fact-based inspiration for the development of new drugs. This book is mainly aimed at medicinal chemists, but may also be of interest to graduate students in chemical or pharmaceutical sciences, preparing themselves for a job in the pharmaceutical industry, and to healthcare professionals in need of pharmacokinetic data.