Drug Delivery For The Retina And Posterior Segment Disease
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Drug Delivery for the Retina and Posterior Segment Disease by Jayvadan K. Patel,Vijaykumar Sutariya,Jagat Rakesh Kanwar,Yashwant V. Pathak Pdf
This book addresses the issues relating to a wide variety of ocular diseases from which millions of people suffer. Long-term challenges include visual impairment and ocular blindness. Certain ocular diseases are quite rare, whereas others, such as cataracts, age-related macular degeneration (AMD), and glaucoma, are very common, especially in the aging population. A rapid expansion of new technologies in ocular drug delivery and new drug candidates, including biologics, to treat these challenging diseases in the retina and posterior segments of the eye have recently emerged. These approaches are necessary because the eye has many unique barriers to drug delivery. Thus, this timely reference Drug Delivery for the Retina and Posterior Segment Disease compiles and analyzes recent advances in the research and development of drug delivery systems for retina and posterior segment diseases of the eye, with an emphasis on the use of implantable devices, iontophoresis as well as micro- and nanoparticles.
Ocular Drug Delivery: Advances, Challenges and Applications by Richard T. Addo Pdf
The eye is a computerized system that has been designed for self-defense, and these defense mechanisms create challenges in administration of medications to the eye. Therefore, ocular drug delivery has been a major challenge to drug delivery researchers. There are on-going studies, in search of treatment especially for the diseases affecting the posterior segment of the eye. This book gives and overview of the background of ocular drug delivery and is unique for pharmacists, medical practitioners, students and drug delivery researchers.
Drug Product Development for the Back of the Eye by Uday B. Kompella,Henry F. Edelhauser Pdf
This comprehensive volume discusses approaches for a systematic selection of delivery systems for various classes of therapeutic agents including small molecule, protein, and nucleic acid drugs. Specific topics covered in this book include: Solution, suspension, gel, nanoparticle, microparticle, and implant dosage forms Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Regulatory path to drug product development Clinical endpoints for drug product development Emerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering. Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Regulatory path to drug product development Clinical endpoints for drug product development Emerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering. Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Regulatory path to drug product development Clinical endpoints for drug product development Emerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering.
Ocular Drug Delivery Systems by Deepak Thassu,Gerald J. Chader Pdf
Drug discovery for ocular diseases has taken great strides in the last two decades. From cornea to choroid, new drugs have been formulated to address a great variety of ocular diseases. Yet without good drug delivery systems, these drugs are less effective than they might be or could even cause serious side effects. Ocular Drug Delivery Systems: Barriers and Application of Nanoparticulate Systems presents research on the development of currently marketed devices and recent trends in the topical delivery of drugs to the posterior of the eye. With contributions from leading pharmaceutical researchers and industry experts, eye researchers, surgeons, pharmacologists from academia, the National Eye Institute, and leading ophthalmic companies such as Pfizer, Allergan, and Novartis, the book presents the state of the art in the use of nanoparticles in ocular drug delivery systems and also sets the stage for future developments. This volume provides both a current evaluation and a future roadmap for developments in ocular drug delivery. The subjects range from biological needs to material challenges and finally to clinical applications for improving drug delivery for conditions where treatments already exist. It also explores areas where effective drugs may be currently available but yet need a safe, efficient, and efficacious delivery vehicle.
Treatise on Ocular Drug Delivery by Ashim K. Mitra Pdf
A multidisciplinary approach is increasingly being adapted by the Pharmaceutical industry to tackle several challenges in developing efficacious treatment solutions. The field of Ophthalmology is no less different. Treatise on Ocular Drug Delivery is a unique collection of information put together by various experts in the field. One of the major goals behind this volume is to link clinical information with the current strategies employed in ocular drug delivery. This monograph covers a range of topics on ocular pharmacology. Chapters in the e-book cover several aspects of drug delivery research such as the biochemical background of specific eye diseases, challenges for ocular drug delivery, the role of influx and efflux transporters, novel drug delivery systems, pharmacokinetics, regulatory aspects, and patenting opportunities for researchers. This E-Book would serve as a suitable reference for pharmacy graduates, medical students, professional scientists and ophthalmic clinicians in academic and industrial laboratories.
Intraocular Drug Delivery by Glenn J. Jaffe,Paul Ashton,P. Andrew Pearson Pdf
This reference studies the most recent advances in the development of ocular drug delivery systems. Covering methods to treat or prevent ocular inflammation, retinal vascular disease, retinal degeneration, and proliferative eye disease, this source covers breakthroughs in the management of endophthalmitis, uveitis, diabetic macular edema, and age-r
Ocular Transporters in Ophthalmic Diseases and Drug Delivery by Joyce Tombran-Tink,Colin J. Barnstable Pdf
In this exceptionally important new work, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium and nutrients across the retinal pigment epithelium.
Retinal Pharmacotherapeutics by Q.D. Nguyen,E.B. Rodrigues,M.E. Farah,W.F. Mieler,D.V. Do Pdf
The use of pharmacotherapeutics in the management of retinal diseases is rapidly evolving, and a favorable therapy for the patient. Today anti-VEGF agents are used for a range of indications from inflammation-related choroidal neovascularization to macular edema secondary to retinal vein occlusion or diabetic retinopathy. Beyond VEGF, there is an array of target areas under investigation – not only for vascular pathologies such as age-related macular degeneration and diabetic eye disease, but also for degenerative, infectious and inflammatory retinal conditions. This publication discusses many aspects from basic research on the retina, to animal models for retinal drug delivery, retinal diseases that are amenable to pharmacotherapy and also drugs and mechanisms in retinal diseases. Anyone concerned with the management of retinal diseases - the general ophthalmologist and the retina specialist alike – will find this book indispensable reading.
Ophthalmic Drug Delivery Systems by Ashim K. Mitra Pdf
The second edition of this text assembles significant ophthalmic advances and encompasses breakthroughs in gene therapy, ocular microdialysis, vitreous drug disposition modelling, and receptor/transporter targeted drug delivery.
Focal Controlled Drug Delivery by Abraham J. Domb,Wahid Khan Pdf
The concept of focal controlled drug delivery has been applied for treating illnesses that are localized to a certain tissue or organ. These delivery systems are applied directly to the diseased site and deliver a desired dose for an extended time period while minimizing systemic distribution of toxic drug. Controlled drug delivery systems have been focused on oral extended release formulations and on systemic delivery of small drugs and peptides. Despite the upsurge of interest in focal targeted drug delivery, there is currently no single reference text on the subject. By comparison, there are numerous authored and edited books on oral, systemic and transdermal drug delivery or books on biodegradable polymers as drug carriers. Thus, the aim of Focal Drug Delivery is to bring together leading experts and researchers in the field to provide an authoritative account of the essential pharmaceutical, technological, physiological and biological sciences underpinning the topic. In addition, the book will review advances in treatment options for diseases localized at a certain tissue or organ.
Drug Delivery Challenges and Novel Therapeutic Approaches for Retinal Diseases by Christopher L. Cioffi Pdf
This book reviews the current state of ocular drug therapy and future therapeutic opportunities for a wide variety of conditions, including Age-related Macular Degeneration, Diabetic Retinopathy and Macular Edema, Glaucoma, and Inherited Retinal Diseases. Retinal diseases are major contributors to moderate or severe vision impairment in adults aged 50 years and older. The respective patient populations for many of these indications is expected to significantly increase as the world population continues to grow older. An improved understanding of the etiological underpinnings of ocular degenerative diseases over the past decade has significantly bolstered ophthalmic drug discovery. In this volume, contributions from leading experts explore the unique challenges faced for ocular drug discovery and delivery providing the reader with detailed information on ocular pharmacokinetics, in vitro, ex vivo and in vivo models for retinal disease pathology and emerging gene therapy treatments. The book is intended for all researchers and clinicians who wish to increase their knowledge on the latest findings in ocular drug therapy.
Role of Novel Drug Delivery Vehicles in Nanobiomedicine by Rajeev K. Tyagi,Neeraj Garg,Rahul Shukla,Prakash Singh Bisen Pdf
Medical Nanotechnology and Nanomedicine introduces non-experts to the world of nanomedicine and its evolving organizational infrastructure. Considering the fluid nature of nano breakthroughs and the delicate balance between benefits and consequences as they apply to medicine, readers at all levels will gain a practical, understandable base of information on these developments so that they may take the greatest advantage of them. This practical reference investigates the impact of nanotechnology on applications in medicine and biomedical sciences, and the broader societal and economic effects. Eschewing technological details, it focuses on enhancing awareness of the business, regulatory, and administrative aspects of medical applications. It gives readers a critical, balanced, and realistic evaluation of existing nanomedicine developments and future prospects and provides an ideal foundation upon which to plan and make decisions.
Author : Larry Alexander Publisher : McGraw Hill Professional Page : 687 pages File Size : 41,6 Mb Release : 2002-07-17 Category : Medical ISBN : 9780071705745
Primary Care of the Posterior Segment, Third Edition by Larry Alexander Pdf
This is an essential text and reference for optometrists treating patients with problems of the retina, vitreous body, and optic nerve. The Third Edition has been updated with new information on pathophysiology, clinical management guidelines, treatment algorithms, and front index of signs and symptoms.
Roots of the theory and practice of ocular pharmacology may be traced to the ancient Mesopotamian code of Hammurabi and then to several papyri reflecting the clinical interests of the Egyptians. The evolution of its art and science was irregularly paced until the nineteenth century when Kohler, in 1884, proved the anesthetic effect of cocaine on the cornea, and when Fraser, Laquer, Schmiedeberg, Meyer, and others studied the pharmacology of the autonomic nervous system by way of observations of the pupil. Advances in the past few decades have been nothing short of explosive. How can the student, physician, or basic research scientist stay in touch with these electrifying studies? To help with the answer to this question, the authors set as their goal the development of increased understanding so that the student, research scientist, and ophthalmologist can cope with the latest discoveries. The authors want to narrow what appears to be an ever-increasing gap between basic science and ophthalmology. The basic aspects of pharmacology have been presented in light of the natural physiology. In this regard, while distinctions among endogenous mechanisms, drug effects, and the pathogenesis of disease are to be separately recognized, appreciation must be given to the concept that both the desirable and unwanted manifestations or functions caused by either disease or drugs must very often represent a quantitative change in normal metabolic pathways.
