Drug Toxicity And Metabolism In Pediatrics

Author : Sam Kacew
Publisher : CRC Press
Page : 332 pages
File Size : 53,8 Mb
Release : 2018-01-18
Category : Medical
ISBN : 9781351079976

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Drug Toxicity and Metabolism in Pediatrics by Sam Kacew Pdf

The aim of this text is to examine the physiological development of the fetus. It allows the reader to study the unique pharmacokinetic and metabolic features of newborns and gives specific examples of drug metabolism in the newborn. The purpose of this book is to enhance the current knowledge of pharmacology of the newborn by observing the embryo and placenta in normal and abnormal development, placental transfer of drugs, metabolic pathways, and metabolism of specific drugs such as theophylline, benzodiazepines, and antibiotics. This is a useful book for those involved in pediatric research, pharmacology, toxicology, experimental therapeutics and biology.

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Pesticides in the Diets of Infants and Children
Publisher : National Academies Press
Page : 402 pages
File Size : 40,9 Mb
Release : 1993-02-01
Category : Science
ISBN : 9780309048750

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Pesticides in the Diets of Infants and Children by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Pesticides in the Diets of Infants and Children Pdf

Many of the pesticides applied to food crops in this country are present in foods and may pose risks to human health. Current regulations are intended to protect the health of the general population by controlling pesticide use. This book explores whether the present regulatory approaches adequately protect infants and children, who may differ from adults in susceptibility and in dietary exposures to pesticide residues. The committee focuses on four major areas: Susceptibility: Are children more susceptible or less susceptible than adults to the effects of dietary exposure to pesticides? Exposure: What foods do infants and children eat, and which pesticides and how much of them are present in those foods? Is the current information on consumption and residues adequate to estimate exposure? Toxicity: Are toxicity tests in laboratory animals adequate to predict toxicity in human infants and children? Do the extent and type of toxicity of some chemicals vary by species and by age? Assessing risk: How is dietary exposure to pesticide residues associated with response? How can laboratory data on lifetime exposures of animals be used to derive meaningful estimates of risk to children? Does risk accumulate more rapidly during the early years of life? This book will be of interest to policymakers, administrators of research in the public and private sectors, toxicologists, pediatricians and other health professionals, and the pesticide industry.

Author : Wen Xie
Publisher : Academic Press
Page : 294 pages
File Size : 52,9 Mb
Release : 2016-09-12
Category : Medical
ISBN : 9780128029633

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Drug Metabolism in Diseases by Wen Xie Pdf

Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic

Author : Lester F. Soyka,Geoffrey P. Redmond
Publisher : Raven Press (ID)
Page : 312 pages
File Size : 48,5 Mb
Release : 1981
Category : Biotransformation (Metabolism)
ISBN : UCAL:B5040145

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Drug Metabolism in the Immature Human by Lester F. Soyka,Geoffrey P. Redmond Pdf

Author : Andrew E. Mulberg,Dianne Murphy,Julia Dunne,Lisa L. Mathis
Publisher : John Wiley & Sons
Page : 782 pages
File Size : 40,7 Mb
Release : 2013-05-20
Category : Medical
ISBN : 9781118312056

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Pediatric Drug Development by Andrew E. Mulberg,Dianne Murphy,Julia Dunne,Lisa L. Mathis Pdf

Most medicines have never been adequately tested for safety and efficacy in pediatric populations and preterm, infants and children are particularly vulnerable to adverse drug reactions. Pediatric Drug Development: Concepts and Applications, Second Edition, addresses the unique challenges in conducting effective drug research and development in pediatric populations. This new edition covers the legal and ethical issues of consent and assent, the additional legal and safety protections for children, and the appropriate methods of surveillance and assessment for children of varying ages and maturity, particularly for patient reported outcomes. It includes new developments in biomarkers and surrogate endpoints, developmental pharmacology and other novel aspects of global pediatric drug development. It also encompasses the new regulatory initiatives across EU, US and ROW designed to encourage improved access to safe and effective medicines for children globally. From an international team of expert contributors Pediatric Drug Development: Concepts and Applications is the practical guide to all aspects of the research and development of safe and effective medicines for children.

Author : American Society for Pharmacology and Experimental Therapeutics
Publisher : Unknown
Page : 456 pages
File Size : 53,9 Mb
Release : 1984
Category : Medical
ISBN : UOM:39015006035144

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Drug Metabolism and Drug Toxicity by American Society for Pharmacology and Experimental Therapeutics Pdf

Author : Evelyne Jacqz-Aigrain,Imti Choonara
Publisher : CRC Press
Page : 830 pages
File Size : 53,5 Mb
Release : 2021-02-25
Category : Medical
ISBN : 9780849374449

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Paediatric Clinical Pharmacology by Evelyne Jacqz-Aigrain,Imti Choonara Pdf

The treatment of children with medicinal products is an important scientific area. It is recognized that many medicines that are used extensively in pediatric patients are either unlicensed or off-label. This textbook will help pediatric health professionals effectively treat children with the most appropriate medicine with minimal side effects.

Author : John F. Ryan
Publisher : Saunders
Page : 344 pages
File Size : 47,5 Mb
Release : 1986
Category : Medical
ISBN : UOM:39015009564835

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A Practice of Anesthesia for Infants and Children by John F. Ryan Pdf

Author : Anonim
Publisher : Academic Press
Page : 288 pages
File Size : 46,7 Mb
Release : 2019-07-13
Category : Medical
ISBN : 9780128173176

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Drug-Induced Liver Injury by Anonim Pdf

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Author : Albert P. Li
Publisher : John Wiley & Sons
Page : 530 pages
File Size : 48,6 Mb
Release : 2021-07-27
Category : Medical
ISBN : 9781119170846

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Transporters and Drug-Metabolizing Enzymes in Drug Toxicity by Albert P. Li Pdf

TRANSPORTERS AND DRUG-METABOLIZING ENZYMES IN DRUG TOXICITY Explore up-to-date coverage on the interaction between drug metabolism enzymes, transporters, and drug toxicity with this leading resources Transporters and Drug-Metabolizing Enzymes in Drug Toxicity delivers a comprehensive and updated review of the relationship between drug metabolism, transporters, and toxicity, providing insights into a major challenge in drug development – accurate assessment of human drug toxicity. Combining two disciplines frequently considered independently of one another, the book combines drug metabolism and toxicology with a focus on the role of biotransformation on drug toxicity and as a major factor for species and individual differences. Mechanism and species differences in drug metabolizing enzymes and transporters are discussed, as are the methods used to investigate the role of drug metabolizing enzymes and transporters in drug toxicity. Finally, the distinguished authors describe promising new experimental approaches to accurately assessing human drug toxicity via the consideration of human-specific drug metabolism in toxicity assays. In addition to topics as diverse as extended clearance models, experimental approaches for the estimation of DILI potential of drug candidates and roles of transporters in renal drug toxicity, readers will also enjoy the inclusion of such subjects as: A thorough overview of and introduction to drug metabolism and transporters and drug toxicity An exploration of drug metabolism enzymes and transporter activities as risk factors of marketed drugs associated with drug-induced fatalities A discussion of human-based in vitro experimental models for the evaluation of metabolism-dependent drug toxicity A treatment of mechanism-based experimental models for the evaluation of BSEP inhibition and DILI An examination of transporters and cochlea toxicity Perfect for scientists, students, and practitioners with interests in metabolism, toxicology, and drug development in the pharmaceutical industry, Transporters and Drug-Metabolizing Enzymes in Drug Toxicity will also earn a place in the libraries of medicinal chemists, pharmacologists, biochemists, toxicologists, and regulators in the pharmaceutical and health industries.

Author : Sumner J. Yaffe,Jacob V. Aranda
Publisher : Lippincott Williams & Wilkins
Page : 1072 pages
File Size : 40,5 Mb
Release : 2011
Category : Medical
ISBN : 9780781795388

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Neonatal and Pediatric Pharmacology by Sumner J. Yaffe,Jacob V. Aranda Pdf

"Neonatal and Pediatric Pharmacology offers guidelines for safe, effective, and rational drug therapy in newborns, children and adolescents. The book provides relevant and useful data on the molecular, physiologic, biochemical, and pharmacologic mechanisms of drug action and therapy in this population. The authors identify areas of innovative basic and translational research necessary for the continuing evaluation and development of drugs for the fetus, newborns, children and adolescents. Neonatal and Pediatric Pharmacology is is a valuable reference for all health care professionals who treat the fetus, newborns, children, and adolescents, including neonatologists, nurses, pediatricians, general practitioners, students, obstetricians, perinatologists, surgeons and allied health professionals. It will be useful anytime during the day and especially in the middle of the night when knowledge of appropriate indications, safe and effective use, dosage, and therapeutic regimen for a certain drug or molecular entity is immediately needed. The book is also directed to those involved in basic, clinical, and other academic pharmacological research, the pharmaceutical industry, and regulatory agencies dealing with drug and therapeutic developments for this population. Those teaching pharmacology and therapeutics will find this compilation of information extremely useful in preparing teaching materials"--Provided by publisher.

Author : Hannsjörg W. Seyberth,Anders Rane,Matthias Schwab
Publisher : Springer Science & Business Media
Page : 385 pages
File Size : 51,7 Mb
Release : 2011-09-01
Category : Medical
ISBN : 9783642201950

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Pediatric Clinical Pharmacology by Hannsjörg W. Seyberth,Anders Rane,Matthias Schwab Pdf

The objective of this volume is to give an overview of the present state of the art of pediatric clinical pharmacology including developmental physiology, pediatric-specific pathology, special tools and methods for development of drugs for children (assessment of efficacy, toxicity, long-term safety etc.) as well as regulatory and ethical knowledge and skills. In the future, structural and educational changes have to lead back to a closer cooperation and interaction of pediatrics with (clinical) pharmacology and pharmacy.

Author : Ernst Jucker
Publisher : Springer Science & Business Media
Page : 384 pages
File Size : 52,9 Mb
Release : 1998
Category : Drugs
ISBN : 3764358211

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Progress in drug research. 50.1998 by Ernst Jucker Pdf

Progress in Drug Research is a prestigious book series (founded in 1959) which provides extensive expert-written reviews on a wide spectrum of highly topical areas in current pharmaceutical and pharmalogical research. Each volume contains fully cross-referencing indexes which link the volumes together, forming a virtually encyclopaedic work. The series thus serves as an important, time-saving source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines. Volume 50 in the series includes: P.N. Kaul: Drug discovery: Past, present and future M. Rohmer: Isoprenoid biosynthesis via the mevalonate -- independent route, a novel target for antibacterial drugs G. Edwards and A.H. Weston: Endothelium, -derived hyperpolarizing factor -- a critical appraisal R.W. Rockhold: Glutamatic involvement in psychomotor stimulant action J.M. Colacino and K.A. Staschke: The identification and development of antiviral agents for the treatment of chronic hepatitis B virus infection T.D. Johnson: Polyamines and cerebral ischemia

Author : Frederick J. Suchy,Ronald J. Sokol,William F. Balistreri
Publisher : Cambridge University Press
Page : 995 pages
File Size : 55,7 Mb
Release : 2007-05-07
Category : Medical
ISBN : 9781139464031

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Liver Disease in Children by Frederick J. Suchy,Ronald J. Sokol,William F. Balistreri Pdf

Completely revised new edition of the premier reference on pediatric liver disease. Liver Disease in Children, 3rd Edition provides authoritative coverage of every aspect of liver disease affecting infants, children, and adolescents. The book offers an integrated approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. Chapters are written by international experts and address the unique pathophysiology, manifestations, and management of these disorders in the pediatric population. The third edition has been thoroughly updated and features new contributions on liver development, cholestatic and autoimmune disorders, fatty liver disease, and inborn errors of metabolism. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.

Author : Jennifer B. Dressman,Christos Reppas
Publisher : CRC Press
Page : 432 pages
File Size : 46,7 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781420077346

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Oral Drug Absorption by Jennifer B. Dressman,Christos Reppas Pdf

Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an