Drug Metabolism In Diseases

Author : Wen Xie
Publisher : Academic Press
Page : 294 pages
File Size : 51,9 Mb
Release : 2016-09-12
Category : Medical
ISBN : 9780128029633

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Drug Metabolism in Diseases by Wen Xie Pdf

Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic

Author : James Paxton
Publisher : BoD – Books on Demand
Page : 310 pages
File Size : 47,7 Mb
Release : 2012-02-22
Category : Medical
ISBN : 9789535100997

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Topics on Drug Metabolism by James Paxton Pdf

In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.

Author : Gian Maria Pacifici,Olavi Pelkonen
Publisher : CRC Press
Page : 560 pages
File Size : 41,7 Mb
Release : 2001-05-24
Category : Medical
ISBN : 0748408649

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Interindividual Variability in Human Drug Metabolism by Gian Maria Pacifici,Olavi Pelkonen Pdf

The book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans. Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as sources of variability. Six chapters address variability of drug metabolism in vivo: variability of psychotropic drugs, antiepileptic drugs, the dopamine precursor levodopa, cardiovascular active drugs and anti HIV drugs. Seven chapters address the interindividual variability of the main drug metabolizing enzymes: CYP-450s, acetyltransferases, glucuronosyl transferase, methyl transferases, sulfotransferases and glutathione transferases in human liver and extrahepatic tissues. A separate chapter discusses the prediction of drug interaction. Comprehensive in coverage, and with contributions from the leading international experts, this book is essential reading for researchers from both academia and the pharmaceutical industry. Advanced undergraduates and postgraduates in pharmacology, clinical pharmacology, toxicology, biochemistry and epidemiology who are interested in drug metabolism will also find this an indispensable resource.

Author : Institute of Medicine,Division of Health Sciences Policy,Roundtable on Research and Development of Drugs, Biologics, and Medical Devices,Jonathan R. Davis,Sarah Pitluck,Peter Bouxsein,Ronald W. Estabrook
Publisher : National Academies Press
Page : 135 pages
File Size : 55,6 Mb
Release : 2000-04-07
Category : Medical
ISBN : 9780309183642

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Rational Therapeutics for Infants and Children by Institute of Medicine,Division of Health Sciences Policy,Roundtable on Research and Development of Drugs, Biologics, and Medical Devices,Jonathan R. Davis,Sarah Pitluck,Peter Bouxsein,Ronald W. Estabrook Pdf

The Institute of Medicine's (IOM's) Roundtable on Research and Development of Drugs, Biologics, and Medical Devices evolved from the Forum on Drug Development, which was established in 1986. Sponsor representatives and IOM determined the importance of maintaining a neutral setting for discussions regarding long-term and politically sensitive issues justified the need to revise and enhance past efforts. The new Roundtable is intended to be a mechanism by which a broad group of experts from the public* and private sectors can be convened to conduct a dialogue and exchange information related to the development of drugs, biologics, and medical devices. Members have expertise in clinical medicine, pediatrics, clinical pharmacology, health policy, health insurance, industrial management, and product development; and they represent interests that address all facets of public policy issues. From time to time, the Roundtable requests that a workshop be conducted for the purpose of exploring a specific topic in detail and obtaining the views of additional experts. The first workshop for the Roundtable was held on April 14 and 15, 1998, and was entitled Assuring Data Quality and Validity in Clinical Trials for Regulatory Decision Making. The summary on that workshop is available from IOM. This workshop summary covers the second workshop, which was held on May 24 and 25, 1999, and which was aimed at facilitating the development and proper use of drugs, biologics, and medical devices for infants and children. It explores the scientific underpinnings and clinical needs, as well as the regulatory, legal, and ethical issues, raised by this area of research and development.

Author : Aparajita Dey
Publisher : Springer Science & Business Media
Page : 269 pages
File Size : 54,5 Mb
Release : 2013-02-12
Category : Medical
ISBN : 9789400758810

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Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism by Aparajita Dey Pdf

The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.

Author : Penny North-Lewis
Publisher : Unknown
Page : 348 pages
File Size : 52,9 Mb
Release : 2008
Category : Medical
ISBN : UOM:39015073936794

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Drugs and the Liver by Penny North-Lewis Pdf

This practical guide covers background information on liver function, the principles of drug use in liver disease and includes a section of worked examples of commonly asked questions. It will be invaluable to clinical pharmacists and anyone making medicine choices in patients with liver impairment.

Author : G. Gordon Gibson,Paul Skett
Publisher : Nelson Thornes
Page : 268 pages
File Size : 52,6 Mb
Release : 2001
Category : Medical
ISBN : UOM:39015054182251

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Introduction to Drug Metabolism by G. Gordon Gibson,Paul Skett Pdf

Of drug-metabolising reactions. p. 25.

Author : Harish Dureja,Narasimha Murthy,Peter Wich,Kamal Dua
Publisher : Academic Press
Page : 527 pages
File Size : 44,6 Mb
Release : 2022-08-26
Category : Business & Economics
ISBN : 9780323996334

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Drug Delivery Systems for Metabolic Disorders by Harish Dureja,Narasimha Murthy,Peter Wich,Kamal Dua Pdf

Drug Delivery Systems for Metabolic Disorders presents the most recent developments on the targeted delivery of drugs to deal with metabolic disorders in a safe, compliant and continuous way. The book covers recent developments in advanced drug delivery systems in various metabolic disorders, including disturbances in protein, lipid, carbohydrate and hormone metabolism and lysosomal and mitochondrial disorders. It provides a brief introduction to metabolic disorders, along with a focus on the current landscape and trends in understanding disease pathology using different in vitro and in vivo models required for clinical applications and developments of new therapeutics. Each subsequent chapter covers drug delivery systems dedicated to metabolic diseases caused by disturbances in protein, lipid, carbohydrate and hormone metabolism. Then, it moves on to cover lysosomal storage disorders and applications of phytopharmaceuticals in this context. This is the perfect reference for researchers in pharmaceutical science who are interested in developing new treatments for metabolic diseases. Offers comprehensive coverage of drug delivery to treat metabolic diseases Provides insights into how advanced drug delivery systems can be effectively used for the management of various types of metabolic disorders Includes the most recent research on diagnostic methods and treatment strategies using controlled drug delivery systems

Author : Muhammad Sajid Hamid Akash,Kanwal Rehman
Publisher : Academic Press
Page : 588 pages
File Size : 43,7 Mb
Release : 2022-05-28
Category : Medical
ISBN : 9780323951210

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Biochemistry of Drug Metabolizing Enzymes by Muhammad Sajid Hamid Akash,Kanwal Rehman Pdf

Biochemistry of Drug Metabolizing Enzymes: Trends and Challenges is a complete and well-integrated reference on their mechanisms of action, their role in diseases, agents responsible for their deactivation, and their malfunction. Chapters explain the biochemistry of DMEs, including biochemical activation, functions, computational approaches, different contaminants on the action and function of DMEs, and describe the importance of DMEs in the drug development process. Conditions covered include metabolic diseases, cardiovascular diseases, neurological diseases, physiological diseases, xenobiotics and inflammatory responses, and their contribution in the malfunctioning of drug metabolizing enzymes. This book is the perfect resource for pharmacology and biochemistry researchers to understand the principles of DMEs. Researchers in the corporate environment will also benefit from the comprehensive list of diseases associated with malfunction of DMEs. Includes extensive classification of DMEs, their mechanism of action and computational analysis Covers the biotransformation of drug by DMEs and the possible impact of environmental contaminants Discusses the activity of DMEs in different clinical conditions such as cardiovascular disease, metabolic disorders, inflammation and neurotoxicity Includes modern and novel bioanalytical techniques to predict the effect of DMEs

Author : Anonim
Publisher : Academic Press
Page : 288 pages
File Size : 55,8 Mb
Release : 2019-07-13
Category : Medical
ISBN : 9780128173176

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Drug-Induced Liver Injury by Anonim Pdf

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Author : Anonim
Publisher : Academic Press
Page : 304 pages
File Size : 41,6 Mb
Release : 2012-11-27
Category : Medical
ISBN : 9780123983596

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Current Concepts in Drug Metabolism and Toxicology by Anonim Pdf

This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. Explores the current concepts in drug metabolism and toxicology Chapters cover such areas as the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity An essential resource for pharmacologists, immunologists and biochemists alike

Author : Muhammad Sajid Hamid Akash,Kanwal Rehman,Muhammad Zaffar Hashmi
Publisher : Springer Nature
Page : 526 pages
File Size : 40,8 Mb
Release : 2020-08-04
Category : Science
ISBN : 9783030459239

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Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies by Muhammad Sajid Hamid Akash,Kanwal Rehman,Muhammad Zaffar Hashmi Pdf

This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics.

Author : Peter Jenner,Bernard Testa
Publisher : Unknown
Page : 646 pages
File Size : 42,6 Mb
Release : 1980
Category : Drugs
ISBN : UCLA:31158007827370

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Concepts in Drug Metabolism by Peter Jenner,Bernard Testa Pdf

Author : Vinod Rustgi
Publisher : Elsevier Health Sciences
Page : 276 pages
File Size : 46,8 Mb
Release : 2016-11-16
Category : Medical
ISBN : 9780323496629

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Drug Hepatotoxicity, An Issue of Clinics in Liver Disease, E-Book by Vinod Rustgi Pdf

Dr. Rustgi has assembled the leading experts in the management of Heptatitis B to present the current treatment and clinical course for diagnosis and management of the disease. Articles are devoted to: Drug metabolism in the liver; Mechanism of Liver Damage including the RUCAM scale; Drug-induced acute liver failure; Epidemiology and genetic risk factors; Adverse drug reactions: type A (intrinsic or pharmacological) or type B (idiosyncratic); Pathology of injury including phenotypes; The clinical course of drug-induced liver disease; Environmental factors of drug hepatotoxicity; Newer agents in drug hepatotoxicity; Drug hepatotoxicity: herbal products; Drug hepatotoxicity: models including “human on a chip and zebrafish; Acute and chronic liver failure from drugs: impact on the kidney; and Management of acute hepatotoxicity including medical agents and liver support systems. Readers will come away with the cutting edge science behind the latest innovations in the treatment of Hepatitis B.

Author : G. Gordon Gibson,Paul Skett
Publisher : Nelson Thornes
Page : 274 pages
File Size : 41,5 Mb
Release : 2001
Category : Medical
ISBN : 0748760113

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Introduction to Drug Metabolism by G. Gordon Gibson,Paul Skett Pdf

Of drug-metabolising reactions. p. 25.