Enzyme Catalysis In Organic Synthesis

Author : Karlheinz Drauz,Harald Gröger,Oliver May
Publisher : John Wiley & Sons
Page : 2143 pages
File Size : 47,7 Mb
Release : 2012-03-26
Category : Science
ISBN : 9783527325474

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Enzyme Catalysis in Organic Synthesis, 3 Volume Set by Karlheinz Drauz,Harald Gröger,Oliver May Pdf

This comprehensive three-volume set is the standard reference in the field of organic synthesis, catalysis and biocatalysis. Edited by a highly experienced and highly knowledgeable team with a tremendous amount of experience in this field and its applications, this edition retains the successful concept of past editions, while the contents are very much focused on new developments in the field. All the techniques described are directly transferable from the lab to the industrial scale, making for a very application-oriented approach. A must for all chemists and biotechnologists.

Author : Karlheinz Drauz,Harald Gröger,Oliver May
Publisher : Unknown
Page : 1985 pages
File Size : 53,5 Mb
Release : 2012
Category : Enzymes
ISBN : OCLC:780278457

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Enzyme Catalysis in Organic Synthesis by Karlheinz Drauz,Harald Gröger,Oliver May Pdf

Author : Vicente Gotor,Ignacio Alfonso,Eduardo García-Urdiales
Publisher : John Wiley & Sons
Page : 348 pages
File Size : 46,5 Mb
Release : 2008-03-31
Category : Science
ISBN : 3527318259

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Asymmetric Organic Synthesis with Enzymes by Vicente Gotor,Ignacio Alfonso,Eduardo García-Urdiales Pdf

Perfect for biochemists, synthetic and organic chemists, this book covers all important reactions, including C-C coupling reactions, oxidation reactions and many more. Divided into two parts, the first section on methodology presents new innovative methods for enzymatic catalysis optimization, including such new trends as medium engineering, directed evolution and computer-aided prediction of enantioselectivity. The second and main section deals with applications to synthesis, showing important reaction types and their applications. Only those reactions with very high selectivity are presented, allowing readers to improve their own reaction yields.

Author : Karlheinz Drauz,Herbert Waldmann
Publisher : Wiley-VCH
Page : 380 pages
File Size : 52,7 Mb
Release : 2002-07-26
Category : Science
ISBN : UOM:39015051562745

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Enzyme Catalysis in Organic Synthesis by Karlheinz Drauz,Herbert Waldmann Pdf

Organic synthesis with enzymes - the only way This comprehensive set gives reliable answers to all questions on enzyme catalysis - from searching for suitable catalytic systems via choosing the optimal reaction conditions to implementing modern synthesis strategies. The long-awaited new edition has been greatly expanded to include new topics and to reflect the latest research, yet retains the clear and practice-oriented presentation found in the first edition. More than a mere data collection, the three volumes provide synthetic chemists with easy access to all the first-hand information necessary for successfully using enzymes: - the latest synthesis methods - example applications arranged according to reaction type - a table of all the important, commercially available enzymes - comprehensive registers for targeted searching according to enzyme, compound, or reaction - current references to the literature In short, an indispensable reference that should be on the shelf of every modern synthesis laboratory.

Author : Karlheinz Drauz,Herbert Waldmann
Publisher : Unknown
Page : 704 pages
File Size : 48,9 Mb
Release : 2002
Category : Catalysis
ISBN : UOM:39015051562737

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Enzyme Catalysis in Organic Synthesis by Karlheinz Drauz,Herbert Waldmann Pdf

Author : Richard B. Silverman
Publisher : Academic Press
Page : 737 pages
File Size : 51,9 Mb
Release : 2002-02-28
Category : Science
ISBN : 9780126437317

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Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition- by Richard B. Silverman Pdf

The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style

Author : C.H. Wong,G.M. Whitesides
Publisher : Elsevier
Page : 389 pages
File Size : 44,5 Mb
Release : 2013-10-22
Category : Science
ISBN : 9780080505824

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Enzymes in Synthetic Organic Chemistry by C.H. Wong,G.M. Whitesides Pdf

This book covers the most recent development of enzymatic organic synthesis, with particular focus on the use of isolated enzymes. It is organized into one introductory chapter dealing with the characteristics of enzymes as catalysts, and five chapters dealing with different types of chemical transformations. Methods for enzyme immobilization and stabilizaton, the use of enzymes in extreme environments, and the alteration of enzyme properties by chemical modification and site-directed mutagenesis for synthetic purposes are covered.

Author : Animesh Goswami,Jon D. Stewart
Publisher : Academic Press
Page : 438 pages
File Size : 41,6 Mb
Release : 2015-09-06
Category : Science
ISBN : 9780124115422

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Organic Synthesis Using Biocatalysis by Animesh Goswami,Jon D. Stewart Pdf

Organic Synthesis Using Biocatalysis provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas. The book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules. Provides a concise background of the application of biocatalysis for the synthesis of organic compounds Expert contributors present recipes for carrying out biocatalytic reactions, including subject worthy discussions on biocatalysis in organic synthesis, biocatalysis for selective organic transformation, enzymes as catalysis for organic synthesis, biocatalysis in Industry, including pharmaceuticals, and more Contains detailed, separate chapters that describe the application of biocatalysis

Author : Gavin Williams,Mélanie Hall
Publisher : Royal Society of Chemistry
Page : 594 pages
File Size : 52,7 Mb
Release : 2018-05-31
Category : Science
ISBN : 9781788014533

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Modern Biocatalysis by Gavin Williams,Mélanie Hall Pdf

The synergy between synthetic biology and biocatalysis is emerging as an important trend for future sustainable processes. This book reviews all modern and novel techniques successfully implemented in biocatalysis, in an effort to provide better performing enzymatic systems and novel biosynthetic routes to (non-)natural products. This includes the use of molecular techniques in protein design and engineering, construction of artificial metabolic pathways, and application of computational methods for enzyme discovery and design. Stress is placed on current ‘hot’ topics in biocatalysis, where recent advances in research are defining new grounds in enzyme-catalyzed processes. With contributions from leading academics around the world, this book makes a ground-breaking contribution to this progressive field and is essential reading for graduates and researchers investigating (bio)catalysis, enzyme engineering, chemical biology, and synthetic biology.

Author : Manfred T. Reetz
Publisher : John Wiley & Sons
Page : 320 pages
File Size : 52,7 Mb
Release : 2016-12-19
Category : Science
ISBN : 9783527316601

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Directed Evolution of Selective Enzymes by Manfred T. Reetz Pdf

Authored by one of the world's leading organic chemists, this authoritative reference provides an overview of basic strategies in directed evolution and introduces common gene mutagenesis, screening and selection methods. Throughout the text, emphasis is placed on methodology development to maximize efficiency, reliability and speed of the experiments and to provide guidelines for efficient protein engineering. Professor Reetz highlights the application of directed evolution experiments to address limitations in the field of enzyme selectivity, substrate scope, activity and robustness. He critically reviews recent developments and case studies, takes a look at future applications in the field of organic synthesis, and concludes with lessons learned from previous experiments.

Author : Manfred P. Schneider
Publisher : Springer
Page : 422 pages
File Size : 53,7 Mb
Release : 2012-02-12
Category : Science
ISBN : 9401085838

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Enzymes as Catalysts in Organic Synthesis by Manfred P. Schneider Pdf

Proceedings of the NATO Advanced Research Workshop, Reisensburg/Ulm, Donau, Germany, June 16-22, 1985

Author : Giacomo Carrea,Sergio Riva
Publisher : John Wiley & Sons
Page : 328 pages
File Size : 48,5 Mb
Release : 2008-04-09
Category : Science
ISBN : 9783527621736

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Organic Synthesis with Enzymes in Non-Aqueous Media by Giacomo Carrea,Sergio Riva Pdf

Closing a gap in the literature, this comprehensive book examines and discusses different non-aqueous systems from organic solvents to ionic liquids for synthetic applications, thus opening the door to new successful methods for biocatalytic reactions. It gathers into one handy source the information otherwise widely spread throughout the literature, combining useful background information with a number of synthetic examples, including industrial scale processes for pharmaceutical and fine chemicals. Extremely well structured, the text introduces the fundamentals of non-aqueous enzymology, before going on to new reaction media and synthetic applications using hydrolases and non-hydrolytic enzymes. The one-stop reference for everyone working in this hot field.

Author : Ruth Porter,Sarah Clark
Publisher : John Wiley & Sons
Page : 192 pages
File Size : 54,5 Mb
Release : 2009-09-14
Category : Science
ISBN : 9780470718629

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Enzymes in Organic Synthesis by Ruth Porter,Sarah Clark Pdf

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Author : A. Koskinen,A. Klibanov
Publisher : Springer Science & Business Media
Page : 327 pages
File Size : 42,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401106115

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Enzymatic Reactions in Organic Media by A. Koskinen,A. Klibanov Pdf

The outlook of organic synthesis has changed many times during its tractable history. The initial focus on the synthesis of substances typical of living matter, exemplified by the first examples of organic chemistry through the synthesis of urea from inorganic substances by Liebig, was accepted as the birth of organic chemistry, and thus also of organic synthesis. Although the early developments in organic synthesis closely followed the pursuit of molecules typical in nature, towards the end of the 19th century, societal pressures placed higher demands on chemical methods appropriate for the emerging age of industrialization. This led to vast amounts of information being generated through the discovery of synthetic reactions, spectroscopic techniques and reaction mechanisms. The basic organic functional group transformations were discovered and improved during the early part of this century. Reaction mechanisms were elucidated at a growing pace, and extremely powerful spectroscopic tools, such as infrared, nuclear magnetic resonance and mass spectrometry were introduced as everyday tools for a practising organic chemist. By the 1950s, many practitioners were ready to agree that almost every molecule could be syn thesized. Some difficult stereochemical problems were exceptions; for example Woodward concluded that erythromycin was a "hopelessly complex target". This frustration led to a hectic phase of development of new and increasingly more ingenious protecting group strategies and functional group transformations, and also saw the emergence of asymmetric synthesis.

Author : Eduardo Garcia-Junceda
Publisher : John Wiley & Sons
Page : 256 pages
File Size : 42,8 Mb
Release : 2008-11-21
Category : Science
ISBN : 9783527623396

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Multi-Step Enzyme Catalysis by Eduardo Garcia-Junceda Pdf

The first comprehensive coverage of this unique and interdisciplinary field provides a complete overview, covering such topics as chemoenzymatic synthesis, microbial production of DNA building blocks, asymmetric transformations by coupled enzymes and much more. By combining enzymatic and synthetic organic steps, the use of multi-enzyme complexes and other techniques opens the door to reactions hitherto unknown, making this monograph of great interest to biochemists, organic chemists, and chemists working with/on organometallics, as well as catalytic chemists, biotechnologists, and those working in the pharmaceutical and fine chemical industries.