Organic Synthesis Using Biocatalysis

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Organic Synthesis Using Biocatalysis

Animesh Goswami,Jon D. Stewart
Organic Synthesis Using Biocatalysis Book PDF

Author : Animesh Goswami,Jon D. Stewart
Publisher : Academic Press
Page : 438 pages
File Size : 43,7 Mb
Release : 2015-09-06
Category : Science
ISBN : 9780124115422

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Organic Synthesis Using Biocatalysis by Animesh Goswami,Jon D. Stewart Pdf

Organic Synthesis Using Biocatalysis provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas. The book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules. Provides a concise background of the application of biocatalysis for the synthesis of organic compounds Expert contributors present recipes for carrying out biocatalytic reactions, including subject worthy discussions on biocatalysis in organic synthesis, biocatalysis for selective organic transformation, enzymes as catalysis for organic synthesis, biocatalysis in Industry, including pharmaceuticals, and more Contains detailed, separate chapters that describe the application of biocatalysis

Biocatalysis in Organic Synthesis

Nicholas J. Turner,Luke Humphreys
Biocatalysis in Organic Synthesis Book PDF

Author : Nicholas J. Turner,Luke Humphreys
Publisher : Royal Society of Chemistry
Page : 416 pages
File Size : 55,9 Mb
Release : 2018-02-08
Category : Science
ISBN : 9781782625308

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Biocatalysis in Organic Synthesis by Nicholas J. Turner,Luke Humphreys Pdf

The application of biocatalysis in organic synthesis is rapidly gaining popularity amongst chemists. Compared to traditional synthetic methodologies biocatalysis offers a number of advantages in terms of enhanced selectivity (chemo-, regio-, stereo-), reduced environmental impact and lower cost of starting materials. Together these advantages can contribute to more sustainable manufacturing processes across a wide range of industries ranging from pharmaceuticals to biofuels. The biocatalytic toolbox has expanded significantly in the past five years and given the current rate of development of new engineered biocatalysts it is likely that the number of available biocatalysts will double in the next few years. This textbook gives a comprehensive overview of the current biocatalytic toolbox and also establishes new guidelines or rules for “biocatalytic retrosynthesis”. Retrosynthesis is a well known and commonly used technique whereby organic chemists start with the structure of their target molecule and generate potential starting materials and intermediates through a series of retrosynthetic disconnections. These disconnections are then used to devise a forward synthesis, in this case using biocatalytic transformations in some of the key steps. Target molecules are disconnected with consideration for applying biocatalysts, as well as chemical reagents and chemocatalysts, in the forward synthesis direction. Using this textbook, students will be able to place biocatalysis within the context of other synthetic transformations that they have learned earlier in their studies. This additional awareness of biocatalysis will equip students for the modern world of organic synthesis where biocatalysts play an increasingly important role. In addition to guidelines for identifying where biocatalysts can be applied in organic synthesis, this textbook also provides examples of current applications of biocatalysis using worked examples and case studies. Tutorials enable the reader to practice disconnecting target molecules to find the ‘hidden’ biocatalytic reactions which can be applied in the synthetic direction. The book contains a complete description of the current biocatalyst classes that are available for use and also suggests areas where new enzymes are likely to be developed in the next few years. This textbook is an essential resource for lecturers and students studying synthetic organic chemistry. It also serves as a handy reference for practicing chemists who wish to embed biocatalysis into their synthetic toolbox.

Modern Biocatalysis

Gavin Williams,Mélanie Hall
Modern Biocatalysis Book PDF

Author : Gavin Williams,Mélanie Hall
Publisher : Royal Society of Chemistry
Page : 594 pages
File Size : 42,6 Mb
Release : 2018-05-31
Category : Science
ISBN : 9781788014533

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Modern Biocatalysis by Gavin Williams,Mélanie Hall Pdf

The synergy between synthetic biology and biocatalysis is emerging as an important trend for future sustainable processes. This book reviews all modern and novel techniques successfully implemented in biocatalysis, in an effort to provide better performing enzymatic systems and novel biosynthetic routes to (non-)natural products. This includes the use of molecular techniques in protein design and engineering, construction of artificial metabolic pathways, and application of computational methods for enzyme discovery and design. Stress is placed on current ‘hot’ topics in biocatalysis, where recent advances in research are defining new grounds in enzyme-catalyzed processes. With contributions from leading academics around the world, this book makes a ground-breaking contribution to this progressive field and is essential reading for graduates and researchers investigating (bio)catalysis, enzyme engineering, chemical biology, and synthetic biology.

Organic Synthesis with Enzymes in Non-Aqueous Media

Giacomo Carrea,Sergio Riva
Organic Synthesis with Enzymes in Non Aqueous Media Book PDF

Author : Giacomo Carrea,Sergio Riva
Publisher : John Wiley & Sons
Page : 328 pages
File Size : 43,9 Mb
Release : 2008-04-09
Category : Science
ISBN : 9783527621736

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Organic Synthesis with Enzymes in Non-Aqueous Media by Giacomo Carrea,Sergio Riva Pdf

Closing a gap in the literature, this comprehensive book examines and discusses different non-aqueous systems from organic solvents to ionic liquids for synthetic applications, thus opening the door to new successful methods for biocatalytic reactions. It gathers into one handy source the information otherwise widely spread throughout the literature, combining useful background information with a number of synthetic examples, including industrial scale processes for pharmaceutical and fine chemicals. Extremely well structured, the text introduces the fundamentals of non-aqueous enzymology, before going on to new reaction media and synthetic applications using hydrolases and non-hydrolytic enzymes. The one-stop reference for everyone working in this hot field.

Enzyme Biocatalysis

Andrés Illanes
Enzyme Biocatalysis Book PDF

Author : Andrés Illanes
Publisher : Springer Science & Business Media
Page : 398 pages
File Size : 40,9 Mb
Release : 2008-06-19
Category : Technology & Engineering
ISBN : 9781402083617

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Enzyme Biocatalysis by Andrés Illanes Pdf

This book was written with the purpose of providing a sound basis for the design of enzymatic reactions based on kinetic principles, but also to give an updated vision of the potentials and limitations of biocatalysis, especially with respect to recent app- cations in processes of organic synthesis. The ?rst ?ve chapters are structured in the form of a textbook, going from the basic principles of enzyme structure and fu- tion to reactor design for homogeneous systems with soluble enzymes and hete- geneous systems with immobilized enzymes. The last chapter of the book is divided into six sections that represent illustrative case studies of biocatalytic processes of industrial relevance or potential, written by experts in the respective ?elds. We sincerely hope that this book will represent an element in the toolbox of gr- uate students in applied biology and chemical and biochemical engineering and also of undergraduate students with formal training in organic chemistry, biochemistry, thermodynamics and chemical reaction kinetics. Beyond that, the book pretends also to illustrate the potential of biocatalytic processes with case studies in the ?eld of organic synthesis, which we hope will be of interest for the academia and prof- sionals involved in R&D&I. If some of our young readers are encouraged to engage or persevere in their work in biocatalysis this will certainly be our more precious reward.

Biocatalysis

W.-D. Fessner
Biocatalysis Book PDF

Author : W.-D. Fessner
Publisher : Springer Science & Business Media
Page : 254 pages
File Size : 47,9 Mb
Release : 2003-09-05
Category : Science
ISBN : 9783540681168

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Biocatalysis by W.-D. Fessner Pdf

Here, leading contributors from the forefront of this exciting technology present authoritative and timely reviews on the state of the art of biocatalysis. They cover the whole spectrum from the discovery of novel enzymes - by modern screening, evolutionary or immunological approaches - through immobilization techniques for technical processes, to their use in the asymmetric synthesis of important target compounds.

Biotransformations in Organic Chemistry

Kurt Faber
Biotransformations in Organic Chemistry Book PDF

Author : Kurt Faber
Publisher : Springer Science & Business Media
Page : 329 pages
File Size : 41,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642974236

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Biotransformations in Organic Chemistry by Kurt Faber Pdf

The use of natural catalysts - enzymes - for the transformation of non-natural is not at all new: they have been used for more man-made organic compounds than one hundred years, employed either as whole cells, cell organelles or isolated enzymes [1]. Certainly, the object of most of the early research was totally different from that of the present day. Thus the elucidation of biochemical pathways and enzyme mechanisms was in the foreground of the reasearch some decades ago. It was mainly during the 1980s that the enormous potential of applying natural catalysts to transform non-natural organic compounds was recognized. What started as a trend in the late 1970s could almost be called a fashion in synthetic organic chemistry in the 1990s. Although the early euphoria during the 'gold rush' in this field seems to have eased somewhat, there is still no limit to be seen for the future development of such methods. As a result of this extensive, recent research, there have been an estimated 5000 papers published on the subject [2]. To collate these data as a kind of 'super-review' would clearly be an impossible task and, furthermore, such a hypothetical book would be unpalatable for the non-expert.

Biocatalysis in Organic Synthesis

Kurt Faber,Wolf-Dieter Fessner,Nicholas Turner
Biocatalysis in Organic Synthesis Book PDF

Author : Kurt Faber,Wolf-Dieter Fessner,Nicholas Turner
Publisher : Thieme/Houben-Weyl Series
Page : 0 pages
File Size : 41,9 Mb
Release : 2015
Category : Science
ISBN : 3131741317

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Biocatalysis in Organic Synthesis by Kurt Faber,Wolf-Dieter Fessner,Nicholas Turner Pdf

The three Science of Synthesis volumes on Biocatalysis in Organic Synthesis present a broad contemporary overview on the state-of-the-art in enzymatic methods for asymmetric synthesis suitable for academics and industrial researchers working in the field of organic synthesis. The goal is to start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. Biocatalysis in Organic Synthesis offers critical reviews of organic transformations by experts, including experimental procedures. The organization is based on the type of reaction performed under biocatalysis. Volume 1 begins with chapters discussing the historical development of the field, sources of enzymes and appropriate selection of catalysts, and general strategies employed in biocatalysis. This is followed by reviews of the biocatalytic hydrolysis of various substrates. The volume concludes with chapters devoted to biocatalytic isomerizations, and the synthesis of glycosides.

Science of Synthesis: Biocatalysis in Organic Synthesis Vol. 2

Kurt Faber,Wolf-Dieter Fessner,Nicholas J. Turner
Science of Synthesis Biocatalysis in Organic Synthesis Vol 2 Book PDF

Author : Kurt Faber,Wolf-Dieter Fessner,Nicholas J. Turner
Publisher : Thieme
Page : 1000 pages
File Size : 55,8 Mb
Release : 2015-03-11
Category : Science
ISBN : 9783131766410

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Science of Synthesis: Biocatalysis in Organic Synthesis Vol. 2 by Kurt Faber,Wolf-Dieter Fessner,Nicholas J. Turner Pdf

The three Science of Synthesis volumes on "Biocatalysis in Organic Synthesis" present a broad contemporary overview on the state-of-the-art in enzymatic methods for asymmetric synthesis suitable for academics and industrial researchers working in the field of organic synthesis. The goal is to start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. "Biocatalysis in Organic Synthesis" offers critical reviews of organic transformations by experts, including experimental procedures. The organization is based on the type of reaction performed under biocatalysis. Volume 2 covers reactions involving the formation of C-C bonds. Addition of carbon nucleophiles at C-O and C-N double bonds are reviewed, as are methods for the formation of C-C bonds at arenes and additions to C-C double bonds. Other chapters present transamination and reductive amination reactions, reduction of carbonyl compounds, and the uses of epoxides in biocatalysis.

Future Directions in Biocatalysis

Tomoko Matsuda
Future Directions in Biocatalysis Book PDF

Author : Tomoko Matsuda
Publisher : Elsevier
Page : 460 pages
File Size : 49,8 Mb
Release : 2017-08-11
Category : Technology & Engineering
ISBN : 9780444637505

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Future Directions in Biocatalysis by Tomoko Matsuda Pdf

Future Directions in Biocatalysis, Second Edition, presents the future direction and latest research on how to utilize enzymes, i.e., natural catalysts, to make medicines and other necessities for humans. It emphasizes the most important and unique research on biocatalysis instead of simply detailing the ABC’s on the topic. This book is an indispensable tool for new researchers in the field to help identify specific needs, start new projects that address current environmental concerns, and develop techniques based on green technology. It provides invaluable hints and clues for conducting new research on enzymes, with final sections outlining future directions in biocatalysis further expanding the science into new applications. Gives future directions in the area of biocatalysis research Presents research topics based on their uniqueness, originality, and novelty Includes many explanatory figures to demonstrate concepts to both organic chemists and biochemists Shows that there is no boundary between organic chemistry and biochemistry

Enzyme Catalysis in Organic Synthesis, 3 Volume Set

Karlheinz Drauz,Harald Gröger,Oliver May
Enzyme Catalysis in Organic Synthesis 3 Volume Set Book PDF

Author : Karlheinz Drauz,Harald Gröger,Oliver May
Publisher : John Wiley & Sons
Page : 2143 pages
File Size : 44,8 Mb
Release : 2012-03-26
Category : Science
ISBN : 9783527325474

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Enzyme Catalysis in Organic Synthesis, 3 Volume Set by Karlheinz Drauz,Harald Gröger,Oliver May Pdf

This comprehensive three-volume set is the standard reference in the field of organic synthesis, catalysis and biocatalysis. Edited by a highly experienced and highly knowledgeable team with a tremendous amount of experience in this field and its applications, this edition retains the successful concept of past editions, while the contents are very much focused on new developments in the field. All the techniques described are directly transferable from the lab to the industrial scale, making for a very application-oriented approach. A must for all chemists and biotechnologists.

Enzyme-Based Organic Synthesis

Cheanyeh Cheng
Enzyme Based Organic Synthesis Book PDF

Author : Cheanyeh Cheng
Publisher : John Wiley & Sons
Page : 719 pages
File Size : 45,8 Mb
Release : 2022-02-03
Category : Science
ISBN : 9781118995150

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Enzyme-Based Organic Synthesis by Cheanyeh Cheng Pdf

Enzyme-Based Organic Synthesis An insightful exploration of an increasingly popular technique in organic chemistry In Enzyme-Based Organic Synthesis, expert chemist Dr. Cheanyeh Cheng delivers a comprehensive discussion of the principles, methods, and applications of enzymatic and microbial processes for organic synthesis. The book thoroughly explores this growing area of green synthetic organic chemistry, both in the context of academic research and industrial practice. The distinguished author provides a single point of access for enzymatic methods applicable to organic synthesis and focuses on enzyme catalyzed organic synthesis with six different classes of enzyme. This book serves as a link between enzymology and biocatalysis and serves as an invaluable reference for the growing number of organic chemists using biocatalysis. Enzyme-Based Organic Synthesis provides readers with multiple examples of practical applications of the main enzyme classes relevant to the pharmaceutical, medical, food, cosmetics, fragrance, and health care industries. Readers will also find: A thorough introduction to foundational topics, including the discovery and nature of enzymes, enzyme structure, catalytic function, molecular recognition, enzyme specificity, and enzyme classes Practical discussions of organic synthesis with oxidoreductases, including oxidation reactions and reduction reactions Comprehensive explorations of organic synthesis with transferases, including transamination with aminotransferases and phosphorylation with kinases In-depth examinations of organic synthesis with hydrolases, including the hydrolysis of the ester bond Perfect for organic synthetic chemists, chemical and biochemical engineers, biotechnologists, process chemists, and enzymologists, Enzyme-Based Organic Synthesis is also an indispensable resource for practitioners in the pharmaceutical, food, cosmetics, and fragrance industries that regularly apply this type of synthesis.

Organocatalysis

Maurizio Benaglia
Organocatalysis Book PDF

Author : Maurizio Benaglia
Publisher : Walter de Gruyter GmbH & Co KG
Page : 606 pages
File Size : 41,9 Mb
Release : 2021-07-19
Category : Science
ISBN : 9783110588729

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Organocatalysis by Maurizio Benaglia Pdf

Organocatalysis is considered today one of the three pillars in asymmetric catalysis, along with biocatalysis and organometallic catalysis. The current book gives an overview of the new reactions, the catalysts and their activation strategies reported in recent years. In addition, the applications of organocatalysis in total synthesis, radical reactions, flow chemistry and industrial practice are discussed.

Biotransformations in Organic Chemistry

Kurt Faber
Biotransformations in Organic Chemistry Book PDF

Author : Kurt Faber
Publisher : Springer Science & Business Media
Page : 466 pages
File Size : 51,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642185373

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Biotransformations in Organic Chemistry by Kurt Faber Pdf

After a basic introduction spanning the principles of stereoselective transformations, kinetics and enzyme properties, the different types of reactions are explained. Special techniques, such as the use of enzymes in organic solvents, immobilization techniques and the use of modified enzymes, are also treated. This new edition features an improved didactic style and includes new developments, such as dynamic resolution, stereo-inversion and enantio-convergent processes.

Biotransformations in Organic Chemistry — A Textbook

Kurt Faber
Biotransformations in Organic Chemistry A Textbook Book PDF

Author : Kurt Faber
Publisher : Springer Science & Business Media
Page : 368 pages
File Size : 41,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642976070

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Biotransformations in Organic Chemistry — A Textbook by Kurt Faber Pdf

The use of natural catalysts - enzymes - for the transformation of non-natural man-made organic compounds is not at all new: they have been used for more than one hundred years, employed either as whole cells, cell organelles or isolated enzymes [1]. Certainly, the object of most of the early research was totally different from that of the present day. Thus the elucidation of biochemical pathways and enzyme mechanisms was the main reason for research some decades ago. It was mainly during the 1980s that the enormous potential of applying natural catalysts to transform non-natural organic compounds was recognized. What started as a trend in the late 1970s could almost be called a fashion in synthetic organic chemistry in the 1990s. Although the early euphoria during the 'gold rush' in this field seems to have eased somewhat, there is still no limit to be seen for the future development of such methods. As a result of this extensive, recent research, there have been all estimated 8000 papers published on the subject [2-14]. To collate these data as a kind of 'super-review' would clearly be an impossible task and, furthermore, such a hypothetical book would be unpalatable for the non-expert.