Organic Chemistry Of Enzyme Catalyzed Reactions Revised Edition

Author : Richard B. Silverman
Publisher : Elsevier
Page : 800 pages
File Size : 46,6 Mb
Release : 2002-03-07
Category : Science
ISBN : 9780080513362

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Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition by Richard B. Silverman Pdf

The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style

Author : Richard B. Silverman
Publisher : Unknown
Page : 717 pages
File Size : 46,9 Mb
Release : 2012
Category : Enzymes
ISBN : 9381269793

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The Organic Chemistry of Enzyme-catalyzed Reactions by Richard B. Silverman Pdf

Author : Karlheinz Drauz,Harald Gröger,Oliver May
Publisher : John Wiley & Sons
Page : 2143 pages
File Size : 51,5 Mb
Release : 2012-03-26
Category : Science
ISBN : 9783527325474

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Enzyme Catalysis in Organic Synthesis, 3 Volume Set by Karlheinz Drauz,Harald Gröger,Oliver May Pdf

This comprehensive three-volume set is the standard reference in the field of organic synthesis, catalysis and biocatalysis. Edited by a highly experienced and highly knowledgeable team with a tremendous amount of experience in this field and its applications, this edition retains the successful concept of past editions, while the contents are very much focused on new developments in the field. All the techniques described are directly transferable from the lab to the industrial scale, making for a very application-oriented approach. A must for all chemists and biotechnologists.

Author : Vicente Gotor,Ignacio Alfonso,Eduardo García-Urdiales
Publisher : John Wiley & Sons
Page : 348 pages
File Size : 52,8 Mb
Release : 2008-03-31
Category : Science
ISBN : 3527318259

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Asymmetric Organic Synthesis with Enzymes by Vicente Gotor,Ignacio Alfonso,Eduardo García-Urdiales Pdf

Perfect for biochemists, synthetic and organic chemists, this book covers all important reactions, including C-C coupling reactions, oxidation reactions and many more. Divided into two parts, the first section on methodology presents new innovative methods for enzymatic catalysis optimization, including such new trends as medium engineering, directed evolution and computer-aided prediction of enantioselectivity. The second and main section deals with applications to synthesis, showing important reaction types and their applications. Only those reactions with very high selectivity are presented, allowing readers to improve their own reaction yields.

Author : Dennis Piszkiewicz
Publisher : Unknown
Page : 262 pages
File Size : 46,6 Mb
Release : 1977
Category : Electronic
ISBN : 8210379456XXX

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Kinetics of Chemical and Enzyme-Catalyzed Reactions by Dennis Piszkiewicz Pdf

Author : Daniel L. Purich
Publisher : Elsevier
Page : 920 pages
File Size : 40,7 Mb
Release : 2010-06-16
Category : Science
ISBN : 9780123809254

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Enzyme Kinetics: Catalysis and Control by Daniel L. Purich Pdf

Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also focusing on the persuasive power of kinetic isotope effects, the design of high-potency drugs, and the behavior of regulatory enzymes. Historical analysis of kinetic principles including advanced enzyme science Provides both theoretical and practical measurements tools Coverage of single molecular kinetics Examination of force generation mechanisms Discussion of organic and inorganic enzyme reactions

Author : Gertz I. Likhtenshtein
Publisher : Springer Science & Business Media
Page : 230 pages
File Size : 48,5 Mb
Release : 2007-05-08
Category : Science
ISBN : 9780306481109

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New Trends in Enzyme Catalysis and Biomimetic Chemical Reactions by Gertz I. Likhtenshtein Pdf

"This book is a view of enzyme catalysis by a physico-chemist with long-term experience in the investigation of structure and action mechanism of biological catalysts. This book is not intended to provide an exhaustive survey of each topic but rather a discussion of their theoretical and experimental background, and recent developments. The literature of enzyme catalysis is so vast and many scientists have made important contribution in the area, that it is impossible in the space allowed for this book to give a representative set of references. The author has tried to use reviews, and general principles of articles. He apologizes to those he has not been able to include. . ... The monograph is intended for scientists working on enzyme catalysis and adjacent areas such as chemical modeling of biological processes, homogeneous catalysis, biomedical research and biotechnology. The book can be use as a subsidiary manual for instructors, graduate and undergraduate students of university biochemistry and chemistry departments."--Pages ix-x.

Author : Eduardo Garcia-Junceda
Publisher : John Wiley & Sons
Page : 256 pages
File Size : 50,7 Mb
Release : 2008-11-21
Category : Science
ISBN : 9783527623396

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Multi-Step Enzyme Catalysis by Eduardo Garcia-Junceda Pdf

The first comprehensive coverage of this unique and interdisciplinary field provides a complete overview, covering such topics as chemoenzymatic synthesis, microbial production of DNA building blocks, asymmetric transformations by coupled enzymes and much more. By combining enzymatic and synthetic organic steps, the use of multi-enzyme complexes and other techniques opens the door to reactions hitherto unknown, making this monograph of great interest to biochemists, organic chemists, and chemists working with/on organometallics, as well as catalytic chemists, biotechnologists, and those working in the pharmaceutical and fine chemical industries.

Author : A. Koskinen,A. Klibanov
Publisher : Springer Science & Business Media
Page : 327 pages
File Size : 49,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401106115

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Enzymatic Reactions in Organic Media by A. Koskinen,A. Klibanov Pdf

The outlook of organic synthesis has changed many times during its tractable history. The initial focus on the synthesis of substances typical of living matter, exemplified by the first examples of organic chemistry through the synthesis of urea from inorganic substances by Liebig, was accepted as the birth of organic chemistry, and thus also of organic synthesis. Although the early developments in organic synthesis closely followed the pursuit of molecules typical in nature, towards the end of the 19th century, societal pressures placed higher demands on chemical methods appropriate for the emerging age of industrialization. This led to vast amounts of information being generated through the discovery of synthetic reactions, spectroscopic techniques and reaction mechanisms. The basic organic functional group transformations were discovered and improved during the early part of this century. Reaction mechanisms were elucidated at a growing pace, and extremely powerful spectroscopic tools, such as infrared, nuclear magnetic resonance and mass spectrometry were introduced as everyday tools for a practising organic chemist. By the 1950s, many practitioners were ready to agree that almost every molecule could be syn thesized. Some difficult stereochemical problems were exceptions; for example Woodward concluded that erythromycin was a "hopelessly complex target". This frustration led to a hectic phase of development of new and increasingly more ingenious protecting group strategies and functional group transformations, and also saw the emergence of asymmetric synthesis.

Author : N.S. Punekar
Publisher : Springer
Page : 562 pages
File Size : 52,6 Mb
Release : 2018-11-11
Category : Science
ISBN : 9789811307850

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ENZYMES: Catalysis, Kinetics and Mechanisms by N.S. Punekar Pdf

This enzymology textbook for graduate and advanced undergraduate students covers the syllabi of most universities where this subject is regularly taught. It focuses on the synchrony between the two broad mechanistic facets of enzymology: the chemical and the kinetic, and also highlights the synergy between enzyme structure and mechanism. Designed for self-study, it explains how to plan enzyme experiments and subsequently analyze the data collected. The book is divided into five major sections: 1] Introduction to enzymes, 2] Practical aspects, 3] Kinetic Mechanisms, 4] Chemical Mechanisms, and 5] Enzymology Frontiers. Individual concepts are treated as stand-alone chapters; readers can explore any single concept with minimal cross-referencing to the rest of the book. Further, complex approaches requiring specialized techniques and involved experimentation (beyond the reach of an average laboratory) are covered in theory with suitable references to guide readers. The book provides students, researchers and academics in the broad area of biology with a sound theoretical and practical knowledge of enzymes. It also caters to those who do not have a practicing enzymologist to teach them the subject.

Author : Valerian T. D'Souza,Joseph Feder
Publisher : CRC Press
Page : 232 pages
File Size : 49,6 Mb
Release : 1991-12-10
Category : Science
ISBN : 0849368235

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The Biorganic Chemistry of Enzymatic Catalysis by Valerian T. D'Souza,Joseph Feder Pdf

This volume grew out of a symposium organized by the students of Professor Myron L. Bender. His research focused on the mechanisms of enzymatic catalysis and was instrumental in showing that enzymes do not possess magical powers to accelerate reactions a trillion times on an average, but follow simple rules of chemistry. A group of scientists who were trained by Bender have contributed some of their work to this book to pay homage to their mentor. The range of topics covered is such that researchers and industry with interest in biological chemistry will gain knowledge from the advances being made in related fields. The book shows organic chemists what advances have taken place in biological chemistry and biochemists will discover how principles of organic chemistry can be applied to reveal the powers of enzymatic catalysis.

Author : Karlheinz Drauz,Herbert Waldmann
Publisher : Wiley-VCH
Page : 540 pages
File Size : 48,5 Mb
Release : 1995-04-17
Category : Science
ISBN : STANFORD:36105024917689

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Enzyme Catalysis in Organic Synthesis by Karlheinz Drauz,Herbert Waldmann Pdf

How to succeed with enzymes in organic synthesis Comprehensive in coverage, this handbook provides a thorough understanding of enzyme-catalyzed organic transformations. Using it, readers can easily apply the principles of enzyme catalysis to new chemical reactions. All techniques described are directly transferable to applications, from laboratory to industrial scale. Benefits for the user: * synthetic applications organized according to reaction type * tabular survey of all commercially available enzymes * two indexes offering easy access to enzymes, compounds, and reaction types * the latest synthetic methods, including use of catalytic antibodies and protein engineering

Author : Hrvoj Vančik
Publisher : Springer Nature
Page : 213 pages
File Size : 52,7 Mb
Release : 2022-01-18
Category : Medical
ISBN : 9783030924386

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Basic Organic Chemistry for the Life Sciences by Hrvoj Vančik Pdf

This textbook is designed for students of biology, molecular biology, ecology,medicine, agriculture, forestry and other professions where the knowledge of organic chemistry plays an important role. The work may also be of interest to non-professionals, as well as to teachers in high schools. The book consists of 13 chapters that cover the essentials of organic chemistry, including - basic principles of structure and constitution of organic compounds, - the elements of the nomenclature, - the concepts of the nature of chemical bond, - introductions in NMR and IR spectroscopy, - the concepts and main classes of the organic reaction mechanisms, - reactions and properties of common classes or organic compounds, - and the introduction to the chemistry of the natural organic products followed by basic principles of the reactions in living cells. This second edition includes revisions and suggestions made by the readers of the first edition and the author's colleagues. In addition, it includes substantial changes compared to the first edition. The chapter on Cycloaddition has been completed by including the other pericyclic reactions (sigmatropic rearrangements, electrocyclic reactions). The chapter on Organic Natural Products has been extended to include new section covering the principles of organic synthesis. New chapter "Organic Supramolecular and Supermolecular Structures" is added. This chapter covers the basic knowledge about the molecular recognition, supramolecular structures, and the mechanisms of the enzyme catalyzed reactions.

Author : Cheanyeh Cheng
Publisher : John Wiley & Sons
Page : 719 pages
File Size : 54,8 Mb
Release : 2022-02-03
Category : Science
ISBN : 9781118995150

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Enzyme-Based Organic Synthesis by Cheanyeh Cheng Pdf

Enzyme-Based Organic Synthesis An insightful exploration of an increasingly popular technique in organic chemistry In Enzyme-Based Organic Synthesis, expert chemist Dr. Cheanyeh Cheng delivers a comprehensive discussion of the principles, methods, and applications of enzymatic and microbial processes for organic synthesis. The book thoroughly explores this growing area of green synthetic organic chemistry, both in the context of academic research and industrial practice. The distinguished author provides a single point of access for enzymatic methods applicable to organic synthesis and focuses on enzyme catalyzed organic synthesis with six different classes of enzyme. This book serves as a link between enzymology and biocatalysis and serves as an invaluable reference for the growing number of organic chemists using biocatalysis. Enzyme-Based Organic Synthesis provides readers with multiple examples of practical applications of the main enzyme classes relevant to the pharmaceutical, medical, food, cosmetics, fragrance, and health care industries. Readers will also find: A thorough introduction to foundational topics, including the discovery and nature of enzymes, enzyme structure, catalytic function, molecular recognition, enzyme specificity, and enzyme classes Practical discussions of organic synthesis with oxidoreductases, including oxidation reactions and reduction reactions Comprehensive explorations of organic synthesis with transferases, including transamination with aminotransferases and phosphorylation with kinases In-depth examinations of organic synthesis with hydrolases, including the hydrolysis of the ester bond Perfect for organic synthetic chemists, chemical and biochemical engineers, biotechnologists, process chemists, and enzymologists, Enzyme-Based Organic Synthesis is also an indispensable resource for practitioners in the pharmaceutical, food, cosmetics, and fragrance industries that regularly apply this type of synthesis.

Author : Bruce Palfey,Rebecca L. Switzer
Publisher : American Chemical Society
Page : 172 pages
File Size : 47,9 Mb
Release : 2022-04-20
Category : Science
ISBN : 9780841299399

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Kinetics of Enzyme Catalysis by Bruce Palfey,Rebecca L. Switzer Pdf

Kinetics of Enzyme Catalysis provides an introduction to the fundamentals of understanding an enzyme's catalytic mechanism and how activity is regulated, which is key to understanding biology and many diseases. Kinetics is at the core of enzymology, as it must be for the study of catalysts. Kinetics of Enzyme Catalysis examines simple kinetics and then applies those ideas to enzyme mechanisms, leading to rate equations for several key mechanisms and, as important, illustrating some key principles. A reader should therefore come away empowered with some mathematical tools allowing the analysis of catalytic cycles not discussed here and also with the understanding to predict some behaviors of enzyme kinetics without any math. Methods are discussed in some detail, and with them some considerations for avoiding pitfalls and collecting reliable data. In addition, introductions are presented to the important areas of studying inhibitors, of the origins of the catalytic power of enzymes, and the use of rapid-reaction technology.