Epigenetic Landscapes

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Epigenetic Landscapes

Susan Merrill Squier
Epigenetic Landscapes Book PDF

Author : Susan Merrill Squier
Publisher : Duke University Press Books
Page : 0 pages
File Size : 45,9 Mb
Release : 2017-12-01
Category : Science
ISBN : 0822368609

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Epigenetic Landscapes by Susan Merrill Squier Pdf

Devised in the 1940s by the biologist C. H. Waddington, the epigenetic landscape is a metaphor for how gene regulation modulates cellular development. As a scientific model, it fell out of use in the late 1960s but returned at the beginning of the twenty-first century with the advent of big-data genomic research because of its utility among scientists across the life sciences to think more creatively about and to discuss genetics. In Epigenetic Landscapes Susan Merrill Squier follows the model’s cultural trail, from its first visualization by the artist John Piper to its use beyond science. Squier examines three cases in which the metaphor has been imaginatively deployed to illustrate complex systems that link scientific and cultural practices: graphic medicine, landscape architecture, and bioArt. Challenging reductive understandings of epigenetics, Squier boldly reclaims the broader significance of the epigenetic landscape as a figure at the nexus of art, design, and science.

Epigenetic Landscapes

Susan Merrill Squier
Epigenetic Landscapes Book PDF

Author : Susan Merrill Squier
Publisher : Duke University Press
Page : 280 pages
File Size : 43,5 Mb
Release : 2017-11-03
Category : Science
ISBN : 9780822372608

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Epigenetic Landscapes by Susan Merrill Squier Pdf

Devised in the 1940s by the biologist C. H. Waddington, the epigenetic landscape is a metaphor for how gene regulation modulates cellular development. As a scientific model, it fell out of use in the late 1960s but returned at the beginning of the twenty-first century with the advent of big-data genomic research because of its utility among scientists across the life sciences to think more creatively about and to discuss genetics. In Epigenetic Landscapes Susan Merrill Squier follows the model’s cultural trail, from its first visualization by the artist John Piper to its use beyond science. Squier examines three cases in which the metaphor has been imaginatively deployed to illustrate complex systems that link scientific and cultural practices: graphic medicine, landscape architecture, and bioArt. Challenging reductive understandings of epigenetics, Squier boldly reclaims the broader significance of the epigenetic landscape as a figure at the nexus of art, design, and science.

Epigenetics in Psychiatry

Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
Epigenetics in Psychiatry Book PDF

Author : Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
Publisher : Academic Press
Page : 848 pages
File Size : 50,5 Mb
Release : 2021-08-21
Category : Science
ISBN : 9780128235782

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Epigenetics in Psychiatry by Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos Pdf

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field

The Epigenetics Revolution

Nessa Carey
The Epigenetics Revolution Book PDF

Author : Nessa Carey
Publisher : Columbia University Press
Page : 353 pages
File Size : 49,6 Mb
Release : 2012-03-06
Category : Science
ISBN : 9780231530712

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The Epigenetics Revolution by Nessa Carey Pdf

Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.

Epigenetics

C. David Allis,Thomas Jenuwein,Danny Reinberg,Marie-Laure Caparros
Epigenetics Book PDF

Author : C. David Allis,Thomas Jenuwein,Danny Reinberg,Marie-Laure Caparros
Publisher : CSHL Press
Page : 503 pages
File Size : 43,5 Mb
Release : 2007
Category : Epigenesis, Genetic
ISBN : 9780879697242

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Epigenetics by C. David Allis,Thomas Jenuwein,Danny Reinberg,Marie-Laure Caparros Pdf

The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

Prognostic Epigenetics

Anonim
Prognostic Epigenetics Book PDF

Author : Anonim
Publisher : Academic Press
Page : 442 pages
File Size : 55,7 Mb
Release : 2019-11-01
Category : Medical
ISBN : 9780128142608

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Prognostic Epigenetics by Anonim Pdf

This volume provides comprehensive information on how mapping an individual’s epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for translational scientists, clinicians, and students to gain a better understanding about epigenetic mechanisms that are associated with a particular disorder; and to be able to effectively identify biomarkers that can be applied in drug development and for better diagnosis and prognosis of diseases. Prognostic Epigenetics is the most-inclusive volume to-date specifically dedicated to epigenetic markers that have been developed for prognosis of diseases, recent advances in this field, the clinical implementation of this research, and the future outlook. Compiles all known information on prognostic epigenetics and its role in preventive medicine and drug discovery Covers the basic functionality of epigenetic mechanisms involved in early disease prognosis and diagnosis, and provides tools for the identification and development of these biomarkers for a wide range of diseases Enables clinicians, researchers, and pharmacologists to improve preventive medicine and precision therapeutics throughout a person’s lifetime Features chapter contributions from leading international researchers

Organisers & Genes

Conrad Hal Waddington
Organisers Genes Book PDF

Author : Conrad Hal Waddington
Publisher : Unknown
Page : 182 pages
File Size : 48,7 Mb
Release : 1940
Category : Embryology
ISBN : UOM:39015007521993

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Organisers & Genes by Conrad Hal Waddington Pdf

Conrad Hal Waddington's Organisers and Genes, published in 1940, is a summary of available research and theoretical framework for many concepts related to tissue differentiation in the developing embryo. The book is composed of two main conceptual sections. The first section explores the action and nature of the organizer, while the second section delves into genes and their influence on development. In this book Waddington explored organizers in terms of their capacity and method of induction. First he examined the nature of induction, discussing crucial experiments concerning the organizer, including Hans Spemann's discovery of the organizer, and his own research into organizers in higher birds and mammals. Waddington separated the action of the organizer into two distinct categories, evocation and individuation, discussed below. The main experimental approach discussed in this book involved grafting organizing tissue from one embryo or region of an embryo to another. Waddington described evocation as non-assimilative induction, or a one-way inducing signal. He presented this as a chemical signal and illustrated evocation with the dead organizer experiment. The dead organizer was shown to be capable of inducing differentiation of neural tissue in the ectoderm. He also included chemical induction by estrogens and steroids as other evocative signals. An important aspect of any signal of evocation, as presented by Waddington, is that the signal is specific to the differentiation of a certain tissue type.

Impressionable Biologies

Maurizio Meloni
Impressionable Biologies Book PDF

Author : Maurizio Meloni
Publisher : Routledge
Page : 218 pages
File Size : 51,8 Mb
Release : 2019-01-10
Category : Social Science
ISBN : 9781351689380

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Impressionable Biologies by Maurizio Meloni Pdf

During the twentieth century, genes were considered the controlling force of life processes, and the transfer of DNA the definitive explanation for biological heredity. Such views shaped the politics of human heredity: in the eugenic era, controlling heredity meant intervening in the distribution of "good" and "bad" genes. However, since the turn of the twenty-first century, this centrality of genes has been challenged by a number of "postgenomic" disciplines. The rise of epigenetics in particular signals a shift from notions of biological fixedness to ideas of plasticity and "impressionability" of biological material. This book investigates a long history of the beliefs about the plasticity of human biology, starting with ancient medicine, and analyses the biopolitical techniques required to govern such permeability. It looks at the emergence of the modern body of biomedicine as a necessary displacement or possibly reconfiguration of earlier plastic views. Finally, it analyses the returning of plasticity to contemporary postgenomic views and argues that postgenomic plasticity is neither a modernistic plasticity of instrumental management of the body nor a postmodernist celebration of potentialities. It is instead a plasticity that disrupts clear boundaries between openness and determination, individual and community, with important implications for notions of risk, responsibility and intervention.

Introducing Epigenetics

Cath Ennis
Introducing Epigenetics Book PDF

Author : Cath Ennis
Publisher : Icon Books Ltd
Page : 285 pages
File Size : 47,7 Mb
Release : 2017-02-02
Category : Science
ISBN : 9781848319035

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Introducing Epigenetics by Cath Ennis Pdf

Epigenetics is the most exciting field in biology today, developing our understanding of how and why we inherit certain traits, develop diseases and age, and evolve as a species. This non-fiction comic book introduces us to genetics, cell biology and the fascinating science of epigenetics, which is rapidly filling in the gaps in our knowledge, allowing us to make huge advances in medicine. We'll look at what identical twins can teach us about the epigenetic effects of our environment and experiences, why certain genes are 'switched on' or off at various stages of embryonic development, and how scientists have reversed the specialization of cells to clone frogs from a single gut cell. In Introducing Epigenetics, Cath Ennis and Oliver Pugh pull apart the double helix, examining how the epigenetic building blocks and messengers that interpret and edit our genes help to make us, well, us.

The Epigenetics Revolution

Nessa Carey
The Epigenetics Revolution Book PDF

Author : Nessa Carey
Publisher : Columbia University Press
Page : 354 pages
File Size : 50,9 Mb
Release : 2013-10-01
Category : Science
ISBN : 9780231161176

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The Epigenetics Revolution by Nessa Carey Pdf

Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism’s genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the field’s arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.

Epigenetics: Development and Disease

Tapas Kumar Kundu
Epigenetics Development and Disease Book PDF

Author : Tapas Kumar Kundu
Publisher : Springer Science & Business Media
Page : 689 pages
File Size : 45,8 Mb
Release : 2012-11-13
Category : Medical
ISBN : 9789400745254

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Epigenetics: Development and Disease by Tapas Kumar Kundu Pdf

Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.

Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications

Raúl Alvarez-Venegas,Clelia De la Peña,Juan Armando Casas-Mollano
Epigenetics in Plants of Agronomic Importance Fundamentals and Applications Book PDF

Author : Raúl Alvarez-Venegas,Clelia De la Peña,Juan Armando Casas-Mollano
Publisher : Springer
Page : 152 pages
File Size : 53,8 Mb
Release : 2014-07-22
Category : Science
ISBN : 9783319079714

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Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications by Raúl Alvarez-Venegas,Clelia De la Peña,Juan Armando Casas-Mollano Pdf

Over the past decades, chromatin remodelling has emerged as an important regulator of gene expression and plant defense. This book provides a detailed understanding of the epigenetic mechanisms involved in plants of agronomic importance. The information presented here is significant because it is expected to provide the knowledge needed to develop in the future treatments to manipulate and selectively activate/inhibit proteins and metabolic pathways to counter pathogens, to treat important diseases and to increase crop productivity. New approaches of this kind and the development of new technologies will certainly increase our knowledge of currently known post-translational modifications and facilitate the understanding of their roles in, for example, host-pathogen interactions and crop productivity. Furthermore, we provide important insight on how the plant epigenome changes in response to developmental or environmental stimuli, how chromatin modifications are established and maintained, to which degree they are used throughout the genome, and how chromatin modifications influence each another.

Cancer through the Lens of Evolution and Ecology

Jason A. Somarelli,Norman A. Johnson
Cancer through the Lens of Evolution and Ecology Book PDF

Author : Jason A. Somarelli,Norman A. Johnson
Publisher : CRC Press
Page : 306 pages
File Size : 46,6 Mb
Release : 2024-05-29
Category : Medical
ISBN : 9781040027684

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Cancer through the Lens of Evolution and Ecology by Jason A. Somarelli,Norman A. Johnson Pdf

Cancer cells exist in an ever-changing “ecology” and are subject to evolutionary pressures just like any species in nature. This edited book explores the following themes: 1) how the dynamics of mutation, epigenetics, and gene expression noise are sources of genetic diversity; 2) how scarce resources influence cancer therapy resistance; 3) how predator-prey dynamics are mirrored in immune-cancer cross-talk; 4) how cancer cells parallel niche construction theory; 5) how changing fitness landscapes enable cancer growth; and 6) how cancer cells interact within the body. The book is a resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms. Key Features Bridges disciplines exemplifying the ways disparate fields create new perspectives when integrated. Offers insights from leading scholars in cancer biology, ecology and evolutionary biology. Provides a timely recognition by oncologists that evolutionary paradigms are crucial for breakthroughs in cancer treatment. Integrates basic and applied sciences of oncology and evolutionary biology.

Epigenetic Drug Discovery

Wolfgang Sippl,Manfred Jung
Epigenetic Drug Discovery Book PDF

Author : Wolfgang Sippl,Manfred Jung
Publisher : John Wiley & Sons
Page : 480 pages
File Size : 49,9 Mb
Release : 2018-11-26
Category : Medical
ISBN : 9783527809264

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Epigenetic Drug Discovery by Wolfgang Sippl,Manfred Jung Pdf

This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease. Epigenetic Drug Discovery is an important resource for medicinal chemists, pharmaceutical researchers, biochemists, molecular biologists, and molecular geneticists.

Epigenetics

Benedikt Hallgrimsson Ph.D.,Brian K. Hall Ph.D.
Epigenetics Book PDF

Author : Benedikt Hallgrimsson Ph.D.,Brian K. Hall Ph.D.
Publisher : Univ of California Press
Page : 472 pages
File Size : 45,7 Mb
Release : 2011-04-11
Category : Science
ISBN : 9780520948822

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Epigenetics by Benedikt Hallgrimsson Ph.D.,Brian K. Hall Ph.D. Pdf

Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in development, disease, and evolution. Chapters cover such topics as morphogenesis and organ formation, conceptual foundations, and cell differentiation, and together demonstrate that the integration of epigenetics into mainstream developmental biology is essential for answering fundamental questions about how phenotypic traits are produced.