Epigenetics And Gene Expression In Cancer Inflammatory And Immune Diseases

Author : Barbara Stefanska,David J. MacEwan
Publisher : Methods in Pharmacology and To
Page : 212 pages
File Size : 54,7 Mb
Release : 2018-12-28
Category : Medical
ISBN : 1493982893

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Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases by Barbara Stefanska,David J. MacEwan Pdf

This practical collection examines methodologies originating from the benefits of genome-wide approaches to studying epigenetics, which has opened the emerging field of epigenomics. Focusing on the areas of cancer, inflammatory and autoimmune disorders, chapters discuss three main components of the epigenome and their role in the regulation of gene expression and present a detailed method section specific to studying each component, including data analyses, troubleshooting, and feasibility in different experimental settings. The main topics are high-throughput and targeted methods for DNA methylation analysis, nucleosome position mapping, studying epigenetic effects of gut microbiota, optical imaging for detection of epigenetic aberrations in living cells, methods for microRNA, and histone code profiling. Written for the Methods in Pharmacology and Toxicology series, the book includes the kind of detail and implementation advice to encourage success in the lab. Authoritative and easily applicable, Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases aims to provide pharmacologists, molecular biologists, bioinformaticians, and toxicologists with a vital background on epigenetics and state-of-the-art techniques in epigenomics.

Author : Rongxin Zhang
Publisher : Academic Press
Page : 432 pages
File Size : 54,8 Mb
Release : 2018-04-25
Category : Medical
ISBN : 9780128099285

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The Epigenetics of Autoimmunity by Rongxin Zhang Pdf

The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high. To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS) and autoimmune thyroid diseases (AITDs). These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment. Provides the accurate and cutting-edge information on autoimmunity epigenetics Wide coverage appeals to those interested in fundamental epigenetics and inheritance to those with more clinical interests Critical reviews of the mean of deriving and analysing autoimmunity epigenetics information as well as its translational potential Up-to-date coverage of emerging topics in autoimmunity epigenetics

Author : Moncef Zouali
Publisher : John Wiley & Sons
Page : 472 pages
File Size : 53,8 Mb
Release : 2009-04-01
Category : Medical
ISBN : 0470743565

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The Epigenetics of Autoimmune Diseases by Moncef Zouali Pdf

The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases. Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field. Specific coverage includes: How highly developed epigenetic mechanisms are involved in several aspects of normal immune regulation, in addition to maintaining immune tolerance to self-determinants. Specific epigenetic aspects of human autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, autoimmune diabetes, thyroid autoimmunity, inflammatory bowel disease and autoimmune hepatitis. How understanding epigenetic mechanisms can lead to therapeutic strategies based on manipulation of this previously unexploited facet of immune regulation. Discussion of the novel approaches that are being investigated to prevent or treat autoimmune diseases. This book is an essential resource for those actively involved in the field. It is also of interest to basic researchers interested in understanding the origin of autoimmunity and clinical specialists interested in gaining in-depth understanding of the pathogenesis of autoimmune diseases and their treatment.

Author : Nilanjana Maulik,Tom Karagiannis
Publisher : Springer
Page : 505 pages
File Size : 48,7 Mb
Release : 2014-05-31
Category : Medical
ISBN : 9781493907069

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Molecular mechanisms and physiology of disease by Nilanjana Maulik,Tom Karagiannis Pdf

In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.

Author : Gaurav Gupta,Brian G. Oliver,Kamal Dua,Md Khadem Ali,Piyush Dave
Publisher : Springer Nature
Page : 276 pages
File Size : 50,5 Mb
Release : 2024-01-21
Category : Medical
ISBN : 9789819947805

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Targeting Epigenetics in Inflammatory Lung Diseases by Gaurav Gupta,Brian G. Oliver,Kamal Dua,Md Khadem Ali,Piyush Dave Pdf

This book discusses the role of epigenetics in pathogenesis of different pulmonary diseases, including chronic obstructive pulmonary disease, lung cancer, pulmonary tuberculosis, idiopathic pulmonary fibrosis and pulmonary infections. It also explores post-translational modifications in DNA and histones for improving the understanding of lung diseases. This book helps in understanding the epigenetic mechanisms towards the development of novel diagnostic and therapeutic approaches. Further, the book provides insight into the underlying molecular mechanisms involved in the epigenetic regulation of inflammation, which may have novel implications in designing small molecule inhibitors that target the epigenetic machinery for the effective treatment of a variety of inflammation‐related diseases. This book is a valuable resource for academics, research and industry professionals working in respiratory biology.

Author : Janos Minarovits,Hans Helmut Niller
Publisher : Springer Science & Business Media
Page : 472 pages
File Size : 54,6 Mb
Release : 2012-06-14
Category : Medical
ISBN : 9781461433453

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Patho-Epigenetics of Disease by Janos Minarovits,Hans Helmut Niller Pdf

In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences. Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to “remember” their proper cellular identity. An alternative system of epigenetic memory, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression via modification of histone tails. The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of epigenetic alterations in malignant tumors. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that epigenetic dysregulation forms the basis of a wide spectrum of human diseases.

Author : Trygve O. Tollefsbol
Publisher : Academic Press
Page : 618 pages
File Size : 41,5 Mb
Release : 2012-07-26
Category : Medical
ISBN : 9780123884152

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Epigenetics in Human Disease by Trygve O. Tollefsbol Pdf

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Author : Tapas Kumar Kundu
Publisher : Springer Science & Business Media
Page : 689 pages
File Size : 43,6 Mb
Release : 2012-11-13
Category : Medical
ISBN : 9789400745254

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Epigenetics: Development and Disease by Tapas Kumar Kundu Pdf

Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.

Author : Karin B. Michels
Publisher : Springer Science & Business Media
Page : 450 pages
File Size : 50,8 Mb
Release : 2012-01-03
Category : Medical
ISBN : 9789400724945

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Epigenetic Epidemiology by Karin B. Michels Pdf

The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!

Author : Wesley H. Brooks,Yves Renaudineau,Marina I. Arleevskaya
Publisher : Frontiers Media SA
Page : 159 pages
File Size : 52,9 Mb
Release : 2022-09-22
Category : Science
ISBN : 9782832500262

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Epigenetic Aspects of Autoimmune Diseases by Wesley H. Brooks,Yves Renaudineau,Marina I. Arleevskaya Pdf

Author : Katherine Chiappinelli,Alejandro Villagra,Lidia Karabon
Publisher : Frontiers Media SA
Page : 308 pages
File Size : 48,7 Mb
Release : 2021-11-30
Category : Medical
ISBN : 9782889717309

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Genetic and Epigenetic Control on Immune Responses Regulating Molecules in Cancer Development, Progression, and Treatment by Katherine Chiappinelli,Alejandro Villagra,Lidia Karabon Pdf

Author : Deepavali Chakravarti,Chandrima Das,Lolitika Mandal
Publisher : Frontiers Media SA
Page : 148 pages
File Size : 50,6 Mb
Release : 2023-04-03
Category : Science
ISBN : 9782832519820

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Epigenetic Regulation of Inflammatory Pathways in Cancer and Aging by Deepavali Chakravarti,Chandrima Das,Lolitika Mandal Pdf

Author : Kai Wang,Chao Yang,Haiyong Wang,Bailong Tao,Shicheng Guo
Publisher : Frontiers Media SA
Page : 172 pages
File Size : 46,7 Mb
Release : 2024-03-13
Category : Medical
ISBN : 9782832546055

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Epigenetic Regulation of Autophagy in Inflammatory Diseases by Kai Wang,Chao Yang,Haiyong Wang,Bailong Tao,Shicheng Guo Pdf

Epigenetics refers to changes in the expression of heritable genes or cellular phenotypes caused by regulating DNA methylation, histone modification, chromatin remodeling, and noncoding RNA expression, without altering the DNA sequence. It plays a critical role in the regulation of many physiological and pathological processes, such as inflammation, immunity, and tumor. In particular, many epigenetic modifiers have been found to affect innate cell development, infection, and inflammatory responses by regulating gene-specific expression. Epigenetic abnormalities often result in changes in gene expression and its function, which in turn promote the process of inflammation and even tumorigenesis. Autophagy is a highly conserved subcellular degradation process by which some damaged organelles, misfolded proteins, nucleic acids, and pathogenic microorganisms are digested to maintain homeostasis. Autophagy dysregulation has been implicated in multiple diseases, including inflammation, tumors, and neurodegenerative diseases. It is not only a cytoplasmic event, but also involved in the regulation of nuclear components, including histone modifications, microRNA, and transcription factors. Methyltransferase-mediated histone modifications (H3K9me2, H3R17me2, and H3K27me3), miRNAs, and DNA methylation catalyzed by DNA methyltransferase are the key nuclear factors involved in the regulation of autophagy. In addition, some autophagy-related genes (Atgs) promote or inhibit the autophagic process through epigenetic modifications, such as histone modifications and DNA methylation, affecting the occurrence and development of inflammatory diseases. Studying the role of epigenetic regulation of autophagy in inflammatory diseases may help identify novel drug targets and develop potential diagnostic and therapeutic approaches. Although the biological and clinical significance of epigenetic modification of autophagy has attracted more and more attention from researchers, this regulation is very complex and its role and mechanism in inflammatory diseases are still unclear.

Author : Qianjin Lu,Christopher C. Chang,Bruce C. Richardson
Publisher : Academic Press
Page : 520 pages
File Size : 54,5 Mb
Release : 2015-02-16
Category : Science
ISBN : 9780128012727

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Epigenetics and Dermatology by Qianjin Lu,Christopher C. Chang,Bruce C. Richardson Pdf

Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable. Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy

Author : Michel Neidhart
Publisher : Academic Press
Page : 552 pages
File Size : 42,7 Mb
Release : 2015-08-11
Category : Science
ISBN : 9780127999203

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DNA Methylation and Complex Human Disease by Michel Neidhart Pdf

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases